심장 파열 수술치험 10례에 대한 분석

손영상,최영호,김학제,Son, Yeong-Sang,Choe, Yeong-Ho,Kim, Hak-Je 대한흉부심장혈관외과학회 1995 Journal of Chest Surgery (J Chest Surg) Vol.28 No.11

From January, 1990 to December, 1994, we have operated 10 patients with cardiac rupture. The patients are divided into two groups according to their clinical manifestation ; five patients in each hemorrhage and tamponade group. The patients in both groups could maintain their vital signs with closed thoracostomy and fluid resuscitation. The effect of pericardiocentesis was especially dramatic in three patients of tamponade group. The average time from injury to admission was 101 minutes and that of the patients who came our hospital via one or two other hospitals was 170 minutes comparing 31 minutes of those who came directly. The average time from admission to operation was 211 minutes. Considering 98 minutes for the diagnosis and preoperative management and another 30 minutes for the preparation for operation, operations were delayed by 83 minutes to get permission. We conclude that this delaying time for transport and operation of heart-ruptured patients should be shortened in order to manage them more effectively.

St. Jude Medical 기계판의 임상적 연구

손영상 대한흉부심장혈관외과학회 1989 The Korean Journal of Thoracic and Cardiovascular Vol.22 No.6

Results of St. Jude Medical valve replacement are presented in 171 patients who underwent operation from January 1983 through June 1989. The patients were 79 males and 92 females with ages ranging from 12 to 71 years. Total 211 of St. Jude Medical valves were implanted: 148 in mitral position, 57 in aortic position, 6 in tricuspid position. The follow-up was from 2 to 76 months with a cumulative period of 375 patient-year. The actuarial survival at 1 year, 3 year and 5 year were 92.1 %, 87.6 % and 86.3% respectively. The linearlized incidences of valve failure, thromboembolism, thrombotic obstruction, anticoagulation related hemorrhage and all valve related complication were as follows: 0.5 %/pt-yr, 0.5 %/pt-yr, 0.5 %/pt-yr, 1.1 %/pt-yr, and 2.4 %/pt-yr, respectively. The performance of the St. Jude Medical valve compares most favorably with other artificial valves. But it remains still hazards of mechanical prostheses such as thromboembolism and thrombotic obstruction.

소아에서 체외 막형산화기의 이용

손영상 한국소아심장연구회 2004 소아심장 Vol.8 No.1

둔형 폐동맥 폐쇄증 1

손영상 대한흉부심장혈관외과학회 1987 Journal of Chest Surgery (J Chest Surg) Vol.20 No.2

Pulmonary atresia with intact ventricular septum is a extremely rare congenital cardiac anomaly. With the history of cyanosis and failure to thrive, this anomaly should not be excluded and emergency management is necessary. Our patient was 69 day-old male with pulmonary atresia which was confirmed by cardiac angiography. Prostaglandin E1 was used for maintenance of pulmonary blood flow preoperatively. Right ventricular outflow reconstruction with pericardial patch and concomitant pulmonary valvotomy were done on beating heart for palliation. With this method, growing of right ventricle and tricuspid annulus are highly expected.

상대정맥에 발생한 평활근육종의 수술 - 1례 보고 -

손영상,류세민,손호성,조원민,황재준,최영호,김학제,심재정,조성준 대한흉부외과학회 2002 Journal of Chest Surgery (J Chest Surg) Vol.35 No.3

=SVC Syndrome Caused by Leiomyosarcoma of SVC-A Case Report- 상대정맥 증후군을 유발하는 여러 가지 원인들 중에 상대정맥 자체에서 발생하는 종양은 매우 드물다. 저자들은 상대정맥에 발생하여 혈류 장애를 초래한 평활근육종 1례를 수술 치료 하고 추적 관찰하여 보고하는 바이다.환자는 39세 여자 환자로 내원 전 6주 동안의 안면 부종 및 두통을 주소로 내원하였다. 내원 시 안면 부종과 더불어 경부 및 상지의 정맥 충혈을 보였고, 중심정맥압은 측정 치 않았으나 경부 및 상부 흉벽의 측부혈행로도 보였다. 단순 흉부 사진 상 우상부 종격동의 연부조직 종괴의 음영을 확인하고 흉부 전산화 단층 촬영 및 상대정맥 조영술을 시행하여 혈류장애를 초래하고 있는 커다란 종괴를 확인하였다. 수술은 흉골 정중 절개를 통해 체외 순환의 도움 하에 상대정맥을 종절개 하였다. 종양은 무명정맥입구에서 시작해서 우심방-상대적맥 접합부 약 1-2cm 우심방 안까지 위치하고 있었다. 먼저 종괴를 제거한 후 우경정맥의 혈전은 풍선 카테타를 이용하여 완전히 제거하였다. 조직검사상 상대정맥에서 발생한 평활근육종을 진단하였고, 수술 후 14개월 추적 관찰하는 중에 별다른 문제는 없었으며, 상대정맥 조영에서도 정상적인 소견을 보였다.5. Hines OJ, Nelson S, Quinones-Baldrich WJ, Eilber FR. Leiomyosarcoma of the inferior vena cava: prognosis and comparison with leiomyosarcoma of other anatomic sites. Cancer 1999;85(5):1077-83.

DiGeorge증후군에 동반된 선천성 심장기형 치험 1례

손영상,김태식,황재준,김학제,박선화 대한흉부심장혈관외과학회 1999 Journal of Chest Surgery (J Chest Surg) Vol.32 No.6

DiGeorge증후군은 드문 선천성 기형으로 3번째와 4번째 인후낭의 발생과정 이상에 의한 흉선과 부갑상선의 형성부전과 관련이 있다. 이 증후군은 흔히 선천성 심장기형과 안면기형을 동반한다. 저자들은 DiGeorge증후군을 동반한 선천성 심장기형을 1례 수\ulcorner 치험하였다. 환아는 생후 1개월된 남아로 몸무게는 3.5kg이었다. 동반된 선천성 심장기형은 심실중격결손증, 심방중격결손증, 대동맥축착증 및 동맥관 개존증이었다. 수술은 좌측방 개흉 및 흉골 정중절개를 통하여 일차에 거쳐 시행하였고 환아는 수술 후 별다른 문제없이 회복하였다. 현재 6개월 째 외래 추적관찰 중에 있으며 양호한 상태로 성장하고 있다. The DiGeorge syndrome is a rare congenital abnormality consisting of aplasia or hypoplasia of the thymus and parathyroid glands resulting from malformation of the third and fourth pharyngeal pouches. This syndrome usually includes congenital cardiac anomalies and abnormal facial features. We experienced a case of congenital cardiac anomaly associated with DiGeorge syndrome. The patient was 1 month old boy weighing 3.5 kg. The congenital cardiac anomalies included ventricular septal defect, atrial septal defect, coactation of aorta, and patent ductus arteriosus. We performed one-stage operation with two separate incisions for these cardiac anomalies. Postoperative course was uneventful and the patient at 6 months of follow up is doing well.

중증 근무력증의 치료에 있어서 종격동내 조직의 광범위 절제술

손영상 대한흉부심장혈관외과학회 1989 Journal of Chest Surgery (J Chest Surg) Vol.22 No.5

There has been arguing in the proper surgical treatment of myasthenia gravis. But the ultimate goal of operation is complete removal of thymic tissues. In view of previous surgical-anatomic studies that there are frequently thymic tissues from the level of thyroid gland to the diaphragm and from hilum to hilum, en bloc resection of thymus, mediastinal fat including both sheets of pleura and pericardium is reasonable. We experienced four myasthenic patients with radical thymectomy from 1989. As compared to the result of previous simple thymectomy group, the 23 patients who were operated from 1976 to 1988[Group I ], excellent surgical outcome was obtained in radical thymectomy group[Group II ].

중증 근무력증의 외과적 치료

손영상 대한흉부심장혈관외과학회 1988 Journal of Chest Surgery (J Chest Surg) Vol.21 No.3

Myasthenia gravis is a functional neuromuscular disorder with characteristic voluntary muscle weakness. The role of thymus in pathogenesis of this disorder has become apparent that thymectomy in treatment has gained acceptance. Between January 1976 and June 1987, twenty patients underwent thymectomy for myasthenia gravis at the Department of Thoracic and Cardiovascular Surgery, College of Medicine, Korea University. A clinical study that is focused on the factors affecting the operative results was analyzed and the following results were obtained. Among the 20 patients, male to female ratio was 8:12 and the age of onset was ranged from 3 years to 67 years. The chief complaints in order of frequency were as follows; ocular symptoms such as ptosis and diplopia[7 cases], general weakness[4 cases], swallowing difficulty[3 cases], dyspnea[3 cases], dysphasia[1 case], headache[1 case] and dizziness[1 case]. The severity of disease was classified by modified Osserman`s method that Group IIa was 8 cases, Group IIb; 7 cases, Group IIc; 3 cases and Group I; 2 cases. In histopathology of thymus, the most frequent finding was hyperplasia[11 cases] followed by thymoma[4 cases], normal tissue[3 cases] and malignant` thymoma[2 cases]. There were two cases of postoperative complications; one case was wound infection and the other was mediastinitis. One case of malignant thymoma died due to respiratory failure with pulmonary metastasis. There was 16 cases[80%] of improvement after thymectomy as follows; complete remission was 4 cases[20%], marked improvement was 9 cases[45%] and subjective improvement only was 3 cases[15%]. The effect of severity and duration of disease on operative result has statistically significant. The effect of thymus histopathology on operative result was not statistically significant. But there were comparable results between thymoma cases and non-thymoma cases.

일본 국립 순환기 센타형 전기유압식 인공심장의 개발과 동물실험

손영상 대한의용생체공학회 1998 의공학회지 Vol.19 No.2

인공심장의 주된 합병증인 혈전과 감염의 문제를 줄이고 장착 환자의 삶의 질을 높이기 위하여 체내 완전 매립형 전기 유압식 인공심장을 개발하고 있는 것과 이 모델을 이용한 동물실험에 대하여 보고하는 바이다. 이 인공심장은 혈액펌프, 유압구동기, 구동제어회로, 경피적 에너지-정보 전송시스템, 체내 받테리 등으로 구성되어 있다. 실험동물은 체중 62Kg의 송아지를 이용하였다. 흉강내 이식하는데 어려움은 없었고, 수술 후 생존하는 동안 혈역학적으로 문제는 없었으며 특이한 합병증도 발생하지 않았다. 그러나 이식 11일째 기계적인 결함으로 작동이 정지하였다. 앞으로 기계적 수명이나 생체적 합성 등의 문제 등히 해결되어야 할 것이다. The ultimate goal of total artificial heart is permanent substitute for a failed heart in a patient without any other therapeutic modality. Until now, infection has been the main problem related to the mechanical circulatory support system. The best way to solve this catastrophic complication and to improve the quality of life of TAH patients in terms of tethering must be implantation of TAH totally. The EH-TAH has been developed in NCVC from 1987 for this purpose. The system consists of an energy converter and pumps, which are designed to be placed in abdomen and pericardial space separately for a good anatomical fit. To evaluate the anatomical fit and hemodynamic performance of the EH-TAH, in vivo test was done. General condition of the animal and hemodynamic status had been stable until the TAH stopped on the 11th pumping day. The estimated cardiac output was about 7.7L/min. The values of mean aortic pressure, left and right atrial pressure were 93$\pm$10, 19$\pm$3 and 15$\pm$4 mmHg, respectively. The correlation coefficient between left and right atrial pressure was 0.96, which represents the dynamic function of the interatrial shunt in controlling left-right imbalance of cardiac output. During pumping days, the temperature on the surface of actuator had been maintained at 39.7$\pm$0.4$^{\circ}C$, less than 1$^{\circ}C$ higher than the rectal temperature. The TAH stopped on the 11th day due to mechanical problems. We concluded that the EH-TAH possessed satisfactory basic performance including anatomic fit and hemodynamic adequacy, although there were several mechanical problems to be solved yet.

반하후박탕엑기스와 Tetracycline-HCl의 병용투여에 관한 연구 : 항균 및 항염 효과에 미치는 영향

손영상(Young Sang Sohn),김기호(Ki Ho Kim) 한국생약학회 1984 생약학회지 Vol.15 No.1

In this studies, the antimicrobial and anti-inflammatory effects of Banhahubak-Tang water extract (hereinafter, Banhahubak-Tang) were examined by administrating Banhahubak-Tang alone and concurrently with tetracycline-HCl in vitro and in vivo. In the antibacterial activities, Banhahubak-Tang ethanol extract showed tobe more effective than water extract against 6 Bacterial strains. The mixtures of tetracycline-HCl and Banhahubak-Tang showed 2 to 4 times as effective as Tetracycline-HCl or Banhahubak-Tang respectively. In the anti-inflammatory activities, all of the experimental groups showed significant effectiveness with exception of group administered in dose of BanhahubakTang 100㎎/㎏. After the combinistration of Banhahubak-Tang with tetracycline-HCl in dose of 400㎎/㎏ with 25㎎/㎏ respectively during 2, 5 days after infection with Staph. aureus, the most significant results were obtained as the values of the inhibitory rate, 58.37%, 53.84% as compared with 51.46%, 50.32% of tetracycline-HCl 50㎎/㎏ respectively.