보론강 핫 프레스 포밍 공정에 대한 가상생산 응용 및 검증

서영성(Yeong Sung Suh),지민욱(Min Wook Ji),이경훈(Kyung Hoon Lee),김영석(Young Suk Kim) 한국자동차공학회 2010 한국 자동차공학회논문집 Vol.18 No.2

한국인에서 Kir6.2 유전자 E23K 다형성과 체지방 분포의 연관성 연구

박채린(Chae-Rin Park),서영성(Young-Sung Suh),김대현(Dae-Hyun Kim),김대광(Dae-Kwang Kim) 대한체질인류학회 2010 대한체질인류학회지 Vol.23 No.1

비만은 에너지소비, 음식 섭취량 및 신체활동 등의 상호작용으로 발생하며 각각의 요소들은 유전자의 영향을 받기도 한다. 현재까지 알려진 비만관련 유전자는 200가지 이상이며, 이중 Kir6.2는 이자 β-세포의 KATP 통로구멍을 둘러싸는 요소로, 이곳의 변이는 K 통로의 능력이 감소되고 인슐린 분비능력을 감소시켜 제2형 당뇨에 걸리기 쉽게 된다. 또한 2형 당뇨와 비만과의 관계도 잘 알려져 있는데, 이에 한국인에서 Kir6.2 유전자 중 E23K의 다형성과 비만과의 관계와 혈당 및 혈중 지질과의 관계에 대해서 알아보았다. 비만클리닉을 방문한 환자 중 본 연구에 동의한 164명을 대상으로 하였다. 총몸지방량, 배 피부밑지방 및 내장 지방량 신체계측을 시행하였고, 공복시 혈당, 지질, 혈중 C-reactive protein를 측정하였다. Kir6.2 유전자 E23K 다형성은 각각 E/E, E/K, K/K 변이 군으로 나누었다. E/E, E/K, K/K 변이는 각각 24, 79, 61명이었고, 이들의 분산분석 결과 K/K 변이는 E/E 야생형군에 비해 내장지방(P<0.05), 총콜레스테롤(P<0.05)과 유의한 차이가 있었다. 그러나 공복혈당, 총 콜레스테롤이외의 혈중지질 및 피부밑지방량은 다형성에 따른 차이가 없었다. 일부 한국인에 있어서 Kir6.2 E23K 다형성에 따라 내장지방 분포와 혈중 콜레스테롤에서 유의한 차이가 있었다. Obesity is caused by interactions of energy consumption, amount of food intake, physical activity and etc, and these elements are influenced by genetic factors. Obesity related genes which have been known by now are over 200. One of these is Kir6.2 which forms the pore region of KATP channel, and genetic variation of which may result in altered β-cell electrical activity, insulin secretion, glucose homeostasis, and increased susceptibility to type 2 diabetes. Therefore, the purpose of this study was to examine the relationship between Kir6.2 E23K polymorphism and fat distribution or metabolic profiles in Korean. A total of 164 patients who visited Dongsan Medical Center Obesity Clinic from February 2004 to December 2005, were enrolled in this study. Screening for Kir6.2 polymorphism carried out by PCR-RFLP analyses. We divided this group into three groups E/E, E/K, K/K. Serum lipid and blood glucose were measured by autoanalyzer. Visceral fat amount and subcutaneous fat by abdominal CT, total fat mass by DEXA were measured. The subjects of E/E, E/K, K/K genotypes were 24, 79, and 61, respectively. The results of ANOVA analysis was that subjects with the K/K genotypes had more visceral fat amount (P<0.05) and higher total cholesterol levels (P<0.05) than E/E subjects group. Visceral fat amount and serum total cholesterol were significantly different according to Kir6.2 E23K polymorphism. Therefore, Kir6.2 polymorphism may act on fat distribution in Koreans.

지역사회 거주 노인에서 12주 건강걷기 프로그램의 보행자세와 우울 개선 효과

김대현(Dae Hyun Kim),서영성(Young Sung Suh),이동환(Dong Hwan Lee) 대한임상노인의학회 2007 대한임상노인의학회지 Vol.8 No.4

Background: Moderate intensity regularly exercise was known to improve cognitive function and mood. We evaluate the effect of 12 weeks walking program on gate and mood of community elderly. Methods: Community dwelling elderly (n=85, mean age 72.8) was included to 1 hour, 5∼6 times/week walking program through public health center in Gyeongbuk province area. Gate was analysed by foot-scanner (Gateview, Alpus TM) and body composition and depression was measured by Genius 220 TM and geriatric depression scale. Results: Posture deviation (>10%) was 56.4% (48/85, right 32, left 18), into-gate was 27.1% (23/85), pes planus and pes cavum was 9.4% and 16.8%. After 12 week walking program, posture deviation was improved in 56.2% (27/48), and into-gate was normalized in 34.8% (8/23). Depressive GDS scores were statistically improved program (P=0.005). Concusion: Regular walking exercise can improve posture and depressive mood in community dwelling elderly. The walking exercise program should be evaluated and applied in elderly to prevent immobility and sedentary of elderly. 연구배경: 지역사회 거주 노인을 대상으로 규칙적인 중등도의 신체활동(regular moderate-intensity physical activity)인 건강 걷기 프로그램을 시행하여 체성분, 보행자세, 정서의 변화를 알아보았다. 방법: 보건소에서 걷기운동 프로그램에 참여하기를 원하는 지역사회거주 60세 이상 노인 85명을 선정하여 주 5회 회당 60분의 걷기운동을 12주간 시행하였다. 걷기 프로그램은 12주간 주 1회 걷기자세 단체 교육과 걷기를 시행하고 주 5∼6회 자율적으로 걷도록 유도하였다. 체성분 검사는 체성분측정기(Genius 220)로, 보행자세 측정은 foot scanner (Gait-view, Alps)로, 우울정도 측정은 30개 항목의 노인우울척도(Geriatric depression scale, GDS)로 측정하였다. 결과: 평균연령은 72.8세, 키 151.4 cm, 체중 60.1 kg, 체질량지수 26.1 (kg/㎡), 체지방률 35.1%, 근육량 35.5%, 허리둘레 91.6 cm였다. 보행자세 측정기(Foot scanner)로 측정한 노인 걷기프로그램 참여자 85명 중 보행자세측정기로 측정한 좌우 압력의 차이가 10% 이상인 사람은 56.4% (48/85명)으로 우측편향이 66.7% (32/48), 좌측편향이 33.3% (18/48)였으며 발모양은 요족(pes cavus)이 14명(16.5%), 평발(pes planus)이 8명(9.4%)이었다. 보행자세측정에서 진행 방향은 내보행(into-gate)이 27.1% (23/85)로 많았다. 걷기 프로그램 후 선자세 측정에서 좌우차가 21/48명(43.8%)에서 교정되었으며 보행자세 측정에서 내보행은 34.8% (8/23)에서 호전되었다. 걷기 운동 프로그램 전보다 프로그램 후에 측정한 우울증척도 점수가 10.1±6.5점에서 8.3±5.2점으로 감소하였다. 결론: 걷기 프로그램 후 자세 측정을 통한 좌우 편위 자세가 교정되고, 보행 발압력의 진행에서는 내보행이 개선되었으며 우울증이 개선되었다. 걷기 운동은 노인 건강증진과 질병예방, 와병상태 예방을 통해 장애를 예방할 수 있을 것이다. 대상과 기간을 확대한 걷기 프로그램의 개발과 효과 검증이 필요하다.

한국 노인에서 악력 저하와 관련된 요인

오병택(Byung Taek Oh),황영시(Young Si Hwang),이준영(Jun Young Lee),박상균(Sang Kyun Park),홍승완(Seung Wan Hong),서영성(Young Sung Suh),김대현(Dae Hyun Kim) 대한임상노인의학회 2017 대한임상노인의학회지 Vol.18 No.1

Background: Hand grip strength is important to identify old people with functional limitation. The objective of this study was to investigate the factors related with Reduction of Hand grip strength in Korean elderly. Methods: Korean community-dwelling elderly (n=3,598, male/female 1,577/2,021) at the first wave (2006) of KLoSA (Korean Longitudinal Study on Aging) were used for analysis. Hand grip strength was assessed with Dynamometer for 2times each arm and we calculated hand grip index. Hand grip strength, Socioeconomic status, Health related status was assessed through personal interviews by a trained interviewer with Computer Assisted Personal Interviewing (CAPI). Results: 1,684 subjects (46.8%) were classified as Low hand grip strength group (<26 kg for male, <18 kg for female). Age, sex, MMSE score, education, employment, living with spouse, social activity, depression scale (Center for epidemiologic studies depression scale, CESD-10), function (Activity of daily living, ADL), smoking, drinking, BMI (Body mass index), hypertension and diabetes was significantly related with low hand grip strength. Low hand grip strength ratio for age 70∼74 and ≥75 were 1.68 (1.40∼2.02) and 2.89 (2.39∼3.50) compare to younger age group, female was 2.04 (1.73∼2.40), cognitive impairment was 1.84 (1.57∼2.16), no exercise group was 1.34 (1.13∼1.58). Among health-related factors, alcohol consumption and diabetes were significantly higher in low grip strength group. Among physical/psychological factors, cognitive impairment (MMSE≤23), function (ADL), depression scale (CESD-10), obesity were significantly different after multivariates adjustment. Conclusion: Age, sex, education, employment, alcohol consumption, diabetes, cognitive impairment, depression scale (CESD-10), function (ADL), exercise, obesity were significantly related with cognitive decline in Korean elderly.

중년 남성의 자아존중감, 사회적 지지, 스트레스에 따른 우울성향

안경남(Kyung-Nam An),김민선(Min-Sun Kim),김동구(Dong-Gu Kim),서영성(Young-Sung Suh),김대현(Dae-Hyun Kim) 대한임상노인의학회 2012 대한임상노인의학회지 Vol.13 No.4

연구배경: 여성에 비해 사회활동이 많은 중년 남성의 경우 신체적 변화 이외에도 직장 내 대인관계, 업무 스트레스와 같은 사회구조적, 심리적 및 인지적 요인이 우울에 미치는 영향이 클 것이다. 본 연구에서는 중년 남성의 자아존중감, 사회적 지지 및 스트레스와 우울과의 연관성에 대해 조사하였다. 방법: 대구 시내 일개 직장 40∼60세까지 중년 남성 173명을 대상으로 일반적 특성과 자아존중감, 사회적 지지, 스트레스 및 우울 정도를 Rosenberg 자아존중감척도, Karasek 직무 긴장 모델, BEPSI-K, BDI를 이용하여 설문 조사하였다. 결과: 대상자의 평균 자아존중감, 사회적 지지, 스트레스, BDI 점수는 38.5±5.49, 27.2±4.49, 9.5±3.03, 9.1±7.44로 나타났다. 자아존중감과 사회적 지지 및 스트레스와 BDI 간의 상관분석에서 자아존중감(r=−0.578, P<0.001)과 사회적 지지(r=−0.662, P<0.001)는 BDI와 음의 상관관계를 보였고, 스트레스는 BDI와 양의 상관관계(r=0.717, P<0.001)를 보였다. 단변량 회귀분석에서 자아존중감과 사회적 지지가 낮을수록, 스트레스가 많을수록 BDI 점수는 높아져 각 변인들이 우울에 미치는 영향력은 모두 유의하게 나타났다. 이 세가지 변수에 대한 단계적 다중회귀분석을 시행한 결과 BDI에 영향을 미치는 가장 중요한 변수로 스트레스(R²=0.51, P<0.001), 사회적 지지(R²=0.63, P<0.001), 자아존중감(R²=0.67, P<0.001)순으로 나타났다. 결론: 본 연구를 통해 중년 남성의 우울에 있어 높은 스트레스와 낮은 사회적 지지 및 자아존중감이 유의한 상관관계를 가짐을 알 수 있었다. 따라서 증가하고 있는 중년 남성들의 우울증의 중재를 위해 자아존중감과 사회적 지지의 향상, 스트레스 관리를 위해 노력해야 할 것이다. Background: The prevalence of major depressive disorder (MDD) is increasing in the 40’s and 50’s male in Korea. In middle-aged men, sociocultural factors contribute to depression, as well as physical factors. There have been several reports in middle-aged men’s occupational stress burden but there were a few reports of its relationship with depression. In this study, we investigated depression in middle-aged men and its relationship with self-esteem, social support and stress. Methods: Between July 4th and 23rd 2001, a self-reporting questionnaire survey was administrated to 173 employees, aged from 40 to 60 at a company located in Daegu city, Korea. The Rosenberg’s self-esteem scale, Kasrasek’s job strain model, BEPSI-K and BDI were used to evaluate the self-esteem, social support, stress and depression. Results: Mean age of participants was 48.1±4.36 and the scores of self-esteem, social support, stress and BDI were 38.5±5.49, 27.2±4.49, 9.5±3.03, 9.1±7.44. As a major variable, self-esteem and social support showed negative correlation with severity of depression (r=−0.578, P<0.001 vs. r=−0.662, P<0.001). In contrast stress showed positive correlation (r=0.717, P<0.001). In univariate regression analysis, lower self-esteem, lower social support and higher stress, were correlated with higher BDI scores. Stress was the most important variable affecting severity of depression (R²=0.51, P<0.001). And the social support (R²=0.63, P<0.001), self-esteem (R²=0.67, P<0.001) were followed. Conclusion: Depression in middle-aged male had significant relationship with high degree of stress, low level of social support and low self-esteem.

폐쇄성 수면 무호흡증에 있어 두부 규격 방사선 계측학적 기여 인자

권대근(Tae-Geon Kwon),조용원(Yong-Won Cho),안병훈(Byung-Hoon Ahn),서영성(Young-Sung Suh) 대한구강악안면외과학회 2003 대한구강악안면외과학회지 Vol.29 No.5

Purpose : This study was intended to perform cephalometric comparison between the patients with and without obstructive sleep apnea (OSA). The factors influencing the OSA in the lateral cephalogram was also investigated. Patient and Method : Twenty four patients who visited Sleep Disorder Clinic in Dongsan Medical Center, Keimyung University and evaluated with polysomnograph(PSG) and cephalogram were included in the study. The patients had apnea-hypopnea episode(AHI) over 10 times per hour was diagnosed as OSA after overnight PSG. To evaluate hard and soft tissue profile, cephalometric radiogram were taken at maximal intercuspation(P1) and mandibular protruding position(P2). The diffefence between the OSA and normal group were evaluated statistically and the stepwise regression analysis was applied to analyse the cephalometric influencing factors to OSA. Result : The OSA Group(n=14) had significantly higher Body Mass Index(BMI) than control group(n=10). Lower facial height(ANSGn) was longer in OSA group. However statistically significant difference was not detected in other anteroposterior craniofacial measurements. The soft palate lenth (PNS-P), hyoid position (MP-Hyoid) had positive correlation between AHI (r=0.496, r=0.413, respectively, p<0.05). However, the measurements of oropharyngeal airway was not different between the two groups. The hypothesis, the antero-posteriorly narrow oropharyngeal airway might aggravate the airway resistance and can give rise to higher AHI, was not accepted in the study. This can be attributed by inclusion of the patients performed uvulopalatopharyngoplasty because of the tonsilar or soft palate hypertrophy in the present study. The results of regression analysis revealed that PNS-P, upper airway width(Nph1), upper facial heght(N-ANS), and lower facial height(ANS-Gn) could influence the degree of AHI (F value < 0.0001, R2 = 0.829). Conclusion : We suggest lateral cephalogram may utilized as a useful method to evaluate OSA. The patient with long soft palate, narrow upper airway width, long upper & lower facial height can be expected to have high risk of OSA. However, it should be emphasized the comphrehensive intraoral inspection including soft palate and tonsilar hypertrophy because lateral cepahlogram cannot visualize oropharyngeal status completely

아토바스타틴의 새로운 약물 적응증 탐색을 위한 비정형 데이터 분석

정휘수 ( Hwee-soo Jeong ),강길원 ( Gil-won Kang ),최웅 ( Woong Choi ),박종혁 ( Jong-hyock Park ),신광수 ( Kwang-soo Shin ),서영성 ( Young-sung Suh ) 한국보건정보통계학회(구 한국보건통계학회) 2018 한국보건정보통계학회지 Vol.43 No.4

Objectives: In recent years, there has been an increased need for a way to extract desired information from multiple medical literatures at once. This study was conducted to confirm the usefulness of unstructured data analysis using previously published medical literatures to search for new indications. Methods: The new indications were searched through text mining, network analysis, and topic modeling analysis using 5,057 articles of atorvastatin, a treatment for hyperlipidemia, from 1990 to 2017. Results: The extracted keywords was 273. In the frequency of text mining and network analysis, the existing indications of atorvastatin were extracted in top level. The novel indications by Term Frequency-Inverse Document Frequency (TF-IDF) were atrial fibrillation, heart failure, breast cancer, rheumatoid arthritis, combined hyperlipidemia, arrhythmias, multiple sclerosis, non-alcoholic fatty liver disease, contrast-induced acute kidney injury and prostate cancer. Conclusions: Unstructured data analysis for discovering new indications from massive medical literature is expected to be used in drug repositioning industries.