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만성 (慢性) 무증상 (無症狀) B형 간염 (肝炎) 표면항원 (表面抗原) 보유자에 (保有者) 있어서 조직학적 (組織學的) 연구
조민구(Min Koo Cho),원남희(Nam Hee Won),서승봉(Seung Bong Suh),최종호(Jung Ho Choe),조경준(Kyeong Joon Cho),박병익(Byung Ick Park) 대한소화기학회 1985 대한소화기학회지 Vol.17 No.1
N/A We performed liver needle biopsies on 34 chronic asymptomatic hepatitis B surface antigen (HBsAg) carriers with normal liver function tests. Among them, 12 were found to carry HBeAg and 14 carried anti-HBe. The results were as follows: 1) Of the 34 chronic asymptomatic HBsAg carriers, normal histologies were found in 9, nonspecific reactive changes in 15, chronic persistent hepatitis (CPH) in 9 and chronic active hepatitis (CAH) in l. 2) Of the 12 HBeAg positive carriers, normal histologies were found in 2, nonspecific reactive changes in 6 and CPH in 4 and of the anti-HBe positive carriers, normal histologies were found in 4, nonspecific reactive changes in 6, CPH in 3 and CAH in 1. There was no significant difference between two groups. According to these results, a substantial proportion of chronic asymptomatic HBsAg carriers had histological abnormalities and the status of HBeAg and anti-Hbe did not correlate with liver histology. Qur opinion is liver biopsy is still remains the most useful approach in the evaluation of asymptomatic HBsAg carriers and further long-term clinical studies are needed to understand the prognosis of chronic asymptomatic carrier state.