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In vivo hair growth-promoting efficacies of herbal extracts and their cubosomal suspensions
서승리,김진철,강구,하정욱 한국공업화학회 2013 Journal of Industrial and Engineering Chemistry Vol.19 No.4
In vivo hair growth-promoting efficacies of 6 kinds of herbal extracts (obtained from Poria cocos, Thuja orientalis, Espinosilla, Lycium chinense Mill, Coix lacryma-jobi and Polygonum multiflorum Thunberg) and monoolein cubosomal suspensions containing the extracts were investigated after they were daily applied on the backs of C57BL/6 male mice for 20 days in the herbal extract concentration of 3% and the cubosome concentration of 1%. The hair growth-promoting efficacies were evaluated 0 day, 10 days, 15days, and 20 days after the application through the hair re-growth area and the histological observation of hair follicles. Among them, Thuja orientalis extract, Polygonum multiflorum Thunberg extract, and Espinosilla extract showed some hair-growth promoting efficacy. Cubosomes significantly enhanced the efficacies of the herbal extracts, and the cubosomal suspensions containing the extracts were as potent as Minoxidil solution (2.4%) in propylene glycol/water/ethanol (20/30/50, v/v/v). Cubosome is believed to enhance the skin permeation of the herbal extracts.
서승리,최유원,임연순,최혜영,명기범 ( Seung Lee Seoi,Yoo Won Choi,Yeon Soon Lim,Hae Young Choi,Ki Bum Myung ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.6
Papular xanthoma is a persi;tent normolipemic, nonconfluent, eruptive xanthomatosis located on the face, trunk and rnucous m,mbranes with no internal involvement, which exclusively occurs in adults. Histologically there is an infiltration of foamy histiocyte-like cells and a few Touton giant cells in the upper dermis and middermis without inflammatovy cells or a pure histiocytic component. Papular xanthomas in the childhood age group were recently described and charact.erized by their self- healing course, leaving, anetoderma-like scars. We report a case of papylar xanthoma in a 21-month-old infant with typical clinical, histopathologic and immunohistochemical findings. The positive immunohistochemical staining with factor XIIIa confirms that papular xanthorna is included in the group of dermal dendrocytic disorder. (Korean J Dermatol 1997;35(6): 1230-1233)