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Pteridine C-6 Side Chain 에서 C-2 치환에 따른 Pteroic Acid 유도체 합성에 관한 연구
류성렬,유의경,변윤섭 ( Seoung Ryuall Ryu,Euy Kyung Yu,Youn Seop Byoun ) 한국공업화학회 1995 공업화학 Vol.6 No.4
새로운 amethopterin 유도체를 합성하기 위해서 pteridine의 C-2 탈아미노화와 C-2 methyl로 치환된 새로운 pteroic acid 유도체인 4-[[(4-amino-2-desaminopteridin-6-yl)methyl]thio]benzoic acid와 4-[[(4-amino-2-methyl-teridin-6-yl)methyl]thio]benzoic acid 합성을 시도하였다. 즉 p-aminobenzoic acid의 amino기를 SH로 치환하고 이 화합물을 에스테르화하였다. 그리고 이것을 2-amino-3-cyano-5-chloromethylpyrazine (11)과 결합하여 benzylester 화합물인 pyrazine 유도체 (14)를 얻었다. 따라서 이 화합물 (14)를 formamidine HCl, acetamidine HCl과 각각 cyclization시켜 화합물 4-[[(4-amino-2-desaminopterindin-6-yl)methyl]thio]benzoic acid benzylester와 4-[[(4-amino-2-methylpteri-din-6-yl)methyl]ohio]benzoic acid benzylester를 얻었으며, 이를 알칼리 가수분해 하여 71%, 36%의 수율로 pteroic acid 유도체인 7a와 7b를 합성하였다. In order to produce new amethopterin derivatives, We tried to synthesized 4-[[(4-amino-2-desaminopteridin-6-yl)methyl]thio]benzoic acid of and 4-[[(4-amino-2-methyl-pteridin-6-yl)methyl]thio]benzoic acid of new pteroic acid derivative substituted with C-2 desamino and C-2 desamino-2-methyl. That is, We substituted SH group for amino of p-aminobenzoic acid, and esterificated it. Then we coupled the compound with 2-amino-3-cyano-5-chloromethylpyrazine(11) and obtained a benzyl ester compound, pyrazine derivative(14). Consequently the compound (4) was cyclizated with formamidine HCl and acetamidine HCl respectively, and so a compound of 4-[[(4-amino-2-desaminopterindin-6-yl)methyl]thio] benzoic acid benzylester and a compound of 4-[[(4-amino-2-methylpteri-din-6-yl)methyl]thio]benzoic acid benzylester were obtained. Finally we hydrolyzed them and obtained (7a) and (7b) of pte roic acid derivative by yield 71% and 36% respectively.
새로운 Azole 항진균제의 합성과 항균활성에 관한 연구
유의경,류성렬,변윤섭 ( Euy Kyung Yu,Seoung Ryuall Ryu,Youn Seop Byoun ) 생화학분자생물학회 1992 BMB Reports Vol.25 No.2
Reaction of cis-and-trans-2-(Bromomethyl)-2-(2,4-dichlophenyl)-1,3-dioxolane-4-methanol(11) with 1-Ethyl-6-fluoro-1,4-dihyddro-4-oxo-7-(1-thiomorpholinyl)quinoline-3-carboxylic acid(8), afforded Azole Ester compounds(12). These Compounds were tested for antifungal and antibacterial activity against Gram-positive and Gram-negative bacteria including Pseudomonas aeruginosa.
알칼리염과 니켈염의 혼합물을 촉매로 한 역청탄 촤의 수증기 가스화 반응특성
송병호,장용원,변윤섭 한국화학공학회 2003 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.41 No.3
호주산 역청탄 촤의 수증기 가스화반응에서 알칼리염과 니켈금속염의 혼합물(K_2So_4=Ni(NO_3)_2)이 나타내는 촉매활성을 상압하의 열천칭반응기를 사용하여 온도 650-850℃ 범위에서 조사하였다. 알칼리염 촉매에 니켈금속염을 부가하면 가스화반응속도의 상승효과를 얻을 수 있는데, 반응온도가 낮을수록 그 효과가 크게 나타나 650 ℃에서 약 2배의 반응속도를 얻었다. 본 혼합물은 가스화반응에서 뛰어난 활성을 보이는 K_2CO_3의 활성에는 미치지는 못하지만 경제적인 촉매물질로서의 가능성을 보였다. 가스화반응에서 뛰어난 활성을 보이는 K_2CO_3의 활성에는 미치지는 못하지만 경제적인 촉매물질로서의 가능성을 보였다. 가스화반응의 kineic인자를 도출하기 위하여 여러 가지 기-고체 반응모델을 적용한 결과 화학반응 율속인 수축핵모델과 수정된 체적모델이 가스화반응의 거동을 잘묘사하였다. 역청탄의 촤-수증기 가스화반응의 겉보기 활성화에너지는 99kJ/mol로 얻어졌으며 혼합물촉매를 사용한 촉매가스화반응에서는 84kJ/mol이 얻어졌다. 촤-제조시의 열처리 온도가 가스화반응속도 및 촉매의 활성에 미치는 영향도 고려하였다. The catalytic actibityof a salt mixture of potassium sulfate and nikel nitrate on the steam gasification of a bituminous char at 650-850 ℃ has been measured in an atmosheric themobalance reactor. The mixture of K_2SO_4 and Ni(NO_3)_2 exhibits a synergic effect on the activity and the effect is more pronounced at low temperatures. Double the reaction rate could carbonate which is known to be one of the best catalysts in coal gasification, the mixture does nor reach that of potassium carbonate which is known to be one of the best catalysts in coal grasification, the mixture does not reach that of potassium carbonate which is known to be one of the best catalysts in coal grasification, the mixture seems to be an economically kinetic parameters, the shrinking core model in chemical reaction controlled regime and the modified volumetric model well describe the gasification behavior. The apparent activation energy of non-catalytic gasification was found to be the catalytic activity was also cinsidered.
이복렬,박영삼,변윤섭,송경선 한국공업화학회 1998 응용화학 Vol.2 No.2
Recently municipal sewage and faculty-effluents containing considerable nitrogen and phosphate are flowing at river and coastal sea area, eutrophication-phenomenon is altered, and it is more and more advanced. As the method of municipal sewage-treatment is a activated sludge process in this nation, only organic carbon and suspended solids are being removed, however, N and P-compds are not being entirely treated, eutrophication phen-omenon is more and more aggravated. From Jan. of 1996, N and P compounds are being controlled, in the nation however, moderate treatment-system does not yet exist. Then, in this study, anaerobic -$gt; anoxic -$gt; aerobic process was used as N and P compounds removal system. P compds-removal is conducted as follows; at anaerobic tank, it is released, and it is intaked into bacteral cells at aerobic tank. N compds-removal is as follows; nitrification reaction is occurred at aerobic tank, denitrification reaction is establised at anaerobic tank. In general, under the N-removal reaction, organic carbon and alkalinity are needed, in this research, without those chemicals, N and P-removal reaction is found possible.