섬유상활성탄에 의한 수용액중 페놀류의 흡착특성

정경락,장경환 全北大學校 1992 論文集 Vol.34 No.-

The adsorption characteristics of phenols by the surface-modified activated carbon fibers from its aqueous solution was examined. Cellulose activated carbon fiber(toyobo Co. KF-1500) was used as an adsorbent, and it was treated with heat, air and helium. Pore-size distribution, BET surface area and surfce acidity were measured. The adsorption isotherms were found to conform with the Freundlich equation and its k values were ranged from 1.5381 to 3.6076 mmol/ g and its 1/ n values were ranged from 0.1798 to 0.3144. The affinity of each adsorbate on activated carbon fiber increased in the order ; Phenol <PCP<PNP. The adsorption capacity decreased when oxidized carbon was used, while it increased when redused carbon was used. The adsorption capacity increased when its surface area increased. It is concluded that the adsorption capacity changes in relation with the surface oxides and the surface area of the activated carbon fiber.

건식 미분 분급장치의 특성에 관한 연구

장경환,김성종,정경락 全北大學校 1990 論文集 Vol.32 No.-

A new air classifier with cut size smaller than about 10㎛, which allowed rapid classification to avoid the disturbance of particles reagglomeration, was designed and manufactured. The characteristics of the air classifier for fine powders was experimentally investigated. The results of the experimentation could be summerized as follows. 1) As the velocity of laden air was increased, the entrainment of fine particles into the coarse side was impressed.. 2) When the velocity of clean air was equal to the velocity of laden air, the sharpness index was good. 3) By sucking a portion of clean air into the fine side, the entraintment of fine particles into the coarse side was effectively suppressed. 4) The cut size and the classification performance were not affected by feed concentration up to at least 0.3kg/㎥.

혈관 내 폐 보조장치에서 적혈구의 microencapsulation에 의한 산소전달속도의 향상

박재관,김기범,정경락,장경환 전북대학교 공학연구원 ( 구 전북대학교 공업기술연구소 ) 2002 工學硏究 Vol.33 No.-

In this study, we tried to improve oxygen transfer rate and reduce pressure drop on intravascular lung assist device with microencapsulation of red blood cells, because microcapsulation of red cells reduce blood hemolysis. Hemoglobin was purified from outdated human red blood cells used. Phospholipid was purified from egg yolk. The hemosome was prepared by encapsulation of hemoglobin with phospholipid multilayer, using rotary vacuum evaporator. The function of hemosome was tested by measuring oxygen dissociation curve using blood gas analyzer. Oxygen dissociation curve of hemosome showed the same figure as the curve of normal red blood cells. Pressure drop showed lower use of hemosome rather than normal blood, because viscosity of hemosome are lower than that of normal blood. Also, oxygen transfer rate showed lower use of hemosome rather than normal blood at 2 hour, but it showed higher use of hemosome rather than normal blood after 2 hour. Because microencapsulation of normal red blood cells prevent hemolysis of normal red blood cells.

수용액중에서 분산제가 초미립자의 분산과 응집에 미치는 영향

황성태,장경환,정경락 全北大學校 1996 論文集 Vol.42 No.-

The dispersibility of ultrafine particles is affected by the kinds and amount of dispersants. The optimum dispersive condition for ultrafine particles was determined from the measurement of the zeta-potential and particle size distribution at concentrations. The zeta-potential and the particle size distribution of dilute suspension was measured using the light scattering method. Also, the influence of kinds and amount of diapersants on the dispersion of TiO_2 fine particle in water is discussed by the DLVO theory. In particular it is shown that the optimum concentration of a dispersant obtained experimentally is approximately in accordance with the concentration of the dispersant showing the maximum total potential energy(V_Tmax) calculated from the DLVO theory which is coincident with the one showing the maximum zeta-potential.

혈관 내 폐 보조장치에서의 기체교환속도의 향상

김기범,나도춘,김성종,정경락 전북대학교 공학연구원 ( 구 전북대학교 공업기술연구소 ) 2003 工學硏究 Vol.34 No.-

We intended to develope an vibrating intravascular lung assist device(VIVLAD) in order to exchange of efficiently gas transfer of oxygen and carbon dioxide exchange requirements for end-stage acute respiratory distress syndrome (ARDS) patients. However, the clinical study, concluded that more gas exchange was needed for intravascular oxygenation to be clinically effective in ARDS treatment. In this study, we tried to enhance gas exchange on the VIVLAD by using microencapsulation of hemoglobin, as the microencapsulation of hemoglobin reduces blood hemolysis, and perfluorocarbon emulsion(PFC emulsion). As a result, it was shown that the oxygen transfer of hemosome and blood/hemosome mixed solution were higher than that of whole blood. Also, it showed that the carbon dioxide transfer of whole blood/PFC emulsion mixed solution was higher than that of others. Therefore, we determined that hemosome and PFC emulsion could increase oxygen transfer and carbon dioxide transfer, respectively.

헤모글로빈의 Microencapsulation에 의한 인공적혈구의 산소전달과 용혈도에 관한 연구

나도춘,김기범,김성종,정경락 전북대학교 공학연구원 ( 구 전북대학교 공업기술연구소 ) 2003 工學硏究 Vol.34 No.-

In this study, we tried to improve oxygen transfer rate and reduce pressure drop on intravascular lung assist device with microencapsulation of red blood cells, because microcapsulation of red cells reduce blood hemolysis. Hemoglobin was purified from outdated human red blood cells used. Phospholipid was purified from egg yolk. The hemosome was prepared by encapsulation of hemoglobin with phospholipid multilayer, using rotary vacuum evaporator. The function of hemosome and hemosome/blood mixed solution was tested by measuring oxygen dissociation curve using blood gas analyzer. Also we were measured about hemolysis of hemosome, hemosome/blood mixed solution and blood by absorptivity method. As a results, the oxygen dissociation curve of hemosome and hemosome/blood mixed solution showed the same figure as the curve of normal red blood cells. Also, the hemolysis of hemosome and hemosome/blood mixed solution was measured less than normal red blood cell. Therefore, the oxygen transfer rate showed high use of hemosome, and hemosome/blood mixed solution rather than normal blood. Because microen- capsulation of normal red blood cells prevent hemolysis of normal red blood cells.

혈관 내 폐보조장치에서의 압력손실 예측

박재관,김성종,이삼철,정경락 전북대학교 공학연구원 ( 구 전북대학교 공업기술연구소 ) 2002 工學硏究 Vol.33 No.-

The purpose of this study was making a equation to predict relationship between pressure drop and frontal area in 40% glycerol solution at 37 ℃. Before using whole blood, we estimated pressure drop with experimental equation, and compared the results with experimental results. Also, we tried to make module design that contained the maximum number of hollow fiber membranes in 3㎝diameter tube. We have observed pressure drop of 40% glycerol solution flow rate in each modules that have been changed by the number of the hollow fibers, and studied about the equation related between flow rate and pressure drop, friction factor and Reynolds number. The results showed that the pressure drop which was calculated with the various frontal area was similar to the pressure drop of using the equation obtained from the experimental. Also, the maximum number of hollow fiber is 675, which can be inserted in 3㎝diameter tube when the out side of diameter was 380㎛. It satisfied pressure drop(<15㎜Hg).

Perfluorocarbon 유화액에 의한 혈관 내 폐 보조장치에서의 압력손실과 산소전달

김기범,박재관,김성종,정인수,정경락 전북대학교 공학연구원 ( 구 전북대학교 공업기술연구소 ) 2002 工學硏究 Vol.33 No.-

The purpose of this study was to evaluate the effects of the perfluorocarbone emulsion in a novel membrane module that satisfied the limiting factor of minimizing the pressure loss in the intravascular blood flow pattern. It observed the mind on the viscosity that to mix with blood in the ratio of 1:4. The device used a bundle consisted of several hundred hollow fiber having the outside diameter of 380㎛. and the axial jacket length of 600 ㎜. The pressure drop of the membrane module device consisting of 300 hollow fibers was observed 10 ㎜Hg at the flow rate 4 ℓ/min and could be get sphere of pressure drop to apply equipment.

진동에 의한 혈관 내 폐 보조장치의 산소전달 특성

김기범,권대규,이삼철,김성종,정인수,오인혁,김기주,변윤섭,정경락 한국화학공학회 2004 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.42 No.2

본 연구는 급성호흡부전환자를 치료하기 위하여 사용되고 있는 혈관 내 폐 보조장치의 기체전달을 향상시키기 위하여 중공사막에 진동기법을 사용하여 기체전달을 향상시키고자 시도하였다. 그리고 혈관 내 폐 보조장치를 정맥에 삽입하기 전, 혈관 내 폐 보조장치의 설계조건을 실험적 모델을 통하여 기체전달을 예측할 수 있는 예측식을 만들고자 하였다. 실험결과, 본 연구에서는 진동기법이 기체전달을 향상시키는데 효과적임을 확인할 수 있었다. 뿐만 아니라, 충진율과 가징 주파수의 함수관계를 이용하여 기체전달을 예측 할 수 있었다. 실험에 의하여 얻어진 결과는 예측식에 의하여 얻어진 결과와 유사한 결과를 얻었다. 그러므로 본 연구에서는 충진율과 가진 주파수의 함수를 이용하여 VIVLAD의 기체전달을 예측할 수 있었다. In this paper, we tried to improve gas exchange of the vibrating intravascular lung assist device(VIVLAD) using vibrating method in the hollow fiber membrane, for the patients suffering from acute respiratory distress syndrome(ARDS). And we tried to formularize prediction equations to make a prediction about gas transfer for designing intravenous artificial lung assist device, and designed modules under various conditions were studied through an experimental modeling before inserted the artificial lung assist device into as venous. As a result, we are convinced that vibration method is very useful for the has transfer increasing. Also, we can estimate the gas transfer as a function of the packing density and excited frequencies. The gas transfer obtained from the experiment was similar to that from the prediction equation, confirming the usefulness prediction equation. Therefore, we can estimate the gas transfer of the VIVLAD as a function of the packing density and excited frequencies.

The Study of Pharmacokinetics of Toxic Chemicals and Anti-cancer Agents(1) : Basic Pharmacokinetic Principles 기초적 약역학의 원리

Jheong, Gyeong-Rak,Byun, Youn-Seop,Chung In-Soo,Kim, Seong-Jong,Chang, Gyeong-Hwan 全北大學校 1989 論文集 Vol.31 No.-

생체계내에서 약물과 독극물의 분포를 예측하기 위하여 생리학에 기초를 둔 약역학적 모델을 항암제와 유독성화합물에 적용하였다. 이 모델은 실험적인 관찰, 생화학적인 지식과 단순화하기 위한 가정을 단일화된 수학적인 토대에 결부시킴으로써 복잡한 생체계를 간단하게 표한할 수 있다. 기초적인 약역학의 원리가 우선 Lumped-parameter Bischoff-Derick type models의 수학적인 전개에 중점을 두고 검토하였다. 약물의 결합, 약물의 신진대사, 모세관과 세포막을 통한 약물전달, 조직내에서 약물의 확산과 대류에 대한 개념들의 구체화에 대해서 논의하였다.