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변성완(Sung Wan Byun),김춘동(Chun Dong Kim),홍순관(Soon Kwan Hong),성명훈(Myung Whun Sung),김광현(Kwang Hyun Kim) 대한두경부종양학회 1998 대한두경부 종양학회지 Vol.14 No.1
재발, 추시 중 소실, 다른 원발성 암의 병발 등으로 복잡해질 수 있는 두경부암 환자 등록에 있어서, '단일등록양식다중항목체제'라는 새로운 체제로, 서울대학교 병원에서 진단한 486명의 두경부암 환자를 대상으로 하여, 데이터베이스를 구성하고, 이의 운용을 '다중등록양식체제'라는 기존의 체제와 비교하였다. 새로운 방법의 구조와 흐름이 보다 간단하고 자료의 검색이 더 효율적이었다. 두경부암 환자 등록의 전용 프로그램 개발에도 이 체제의 도입이 필요할 것으로 사료된다. Objectives: Many complicated problems exist in establishing head and neck cancer(HNCa) patient registry system. In this study, a newly devised and simplified approach named as 'Single Sheet Multiple Event System' was compared with a conventional approach named as 'Multiple Sheet System'. Material and Method: According to several kinds of registry sheets in the two systems, data were collected from 486 patients with HNCa diagnosed at Department of Otolaryngology, Seoul National University Hospital from 1979 through 1994. Results: The new system produced more simple and efficient data retrieval. Conclusion: It could make the implementation of HNCa patient registry system more simple and efficient.
편측 성대마비 22례에 적용한 피열연골내전술과 갑상연골성형술의 비교
변성완,김춘동,홍순관 梨花女子大學校 醫科大學 醫科學硏究所 1998 EMJ (Ewha medical journal) Vol.21 No.3
연구목적: 편측 성대마비의 임상상을 파악하고, 이에 대해 시행되는 갑상연골성형술과 피열연골내전술의 성적을 비교해보고자 하였다. 방법: 다양한 원인으로 발생한 22례의 편측 성대마비에 대해서 피열연골성형술 또는 갑상연골성형술을 시행하고, 주관적인 만족도 및 수술 전후의 최대발성시간의 변화를 통계적으로 비교하였다. 결과: 1) 원인으로는 특발성이 7례, 흉부병소에 의한 것이 6례, 갑상선 수술에 후발한 것이 3례, 경부종괴절제수술에 후발한 것이 3례, 경부 외상에 의한 것이 2례, 디프테라이가 1례였고, 좌측 성대마비가 15례, 우측 성대 마비가 7례였다. 2) 갑상연골성형술에서 최대발성시간은 술전 평균 4초에서 술후 평균 6초로 유의하게(p=0.006)증가하였으며, 피열연골내전술에서도 술전 평균 5초에서 술후 평균 10.5초로 유의하게(p=0.014)증가하였다. 주관적인 만족도와 최대발성시간에 있어서 피열연골내전술이 더 좋은 결과를 보였다(p=0.0011). 합병증은 없었다. 결론: 편측 성대마비의 치료에 있어서 갑상연골성형술과 피열연골내전술은 모두 유용한 방법이지만, 환자의 만족도에서나 최대발성시간으로 볼 때 피열연골내전술에서 더 좋은 결과를 관찰하였다. Objectives : This study was performed to compare postoperative results of thyroplasty typeⅠ and arytenoid adduction, which were recent phonosurgical procedures for the management of unilateral vocal cord paralysis. Methods : Twenty-two cases of unilateral vocal cord paralysis with several etiologies were managed with thyroplasty typeⅠ and/or arytenoid adduction. The subjective and MPT(maxi-mum phonation time) improvements after those procedures were compared statistically. Results : The cause of paralysis were idiopathic(7 cases), thoracic lesion(6 cases) thyroi-dectomy(3 cases), neck mass excision(3 cases), neck trauma(2 cases) and diphtheria(case). The left side(15 cases) was paralyzed more frequently than the right(7 cases). There were significant increase(p=0.006) in MPT from 4 seconds preoperatively to 6 seconds postoperatively in thyro-lasty cases, and also significant increase(p=0.014) from 5 seconds to 10.5 seconds in arytenoid adduction cases. Better result were observed in subjective improvement and MPT(p=0.0011) with arytenoid adduction. There was no significant complication. Conclusion : Both arytenoid adduction and thyroplasty were effective and safe phonosurgical procedures for unilateral vocal cord paralysis. Better results were observed in arytenoid add-uction cases.
두경부편평상피암 연구의 3차원적 In Vitro 실험 모델 확립 : Spheroid 모델과 Raft 배양모델 Spheroid Model and Raft Culture Model
변성완,김춘동 梨花女子大學校 醫科大學 醫科學硏究所 2001 EMJ (Ewha medical journal) Vol.24 No.1
Objectives : To establish new in vitro model systems that better reflect in vivo condition, multicellular tumor spheroids(MTS) and raft culture were developed using cell lines of squamous cell carcinoma(SCCHN) of the head and neck in these 3-dimensional systems. Materials and Methods : Four SCCHN cell lines were used for MTS and raft culture. Results : All cell lines formed MTS, but only Tu-138 showed a good stratification at the airliquid interface in the raft culture system. Conclusion : MTS and raft culture system were established successfully from the SCCHN cell lines.
변성완,김승철,조선희,배영숙 梨花女子大學校 醫科大學 醫科學硏究所 1998 EMJ (Ewha medical journal) Vol.21 No.4
목적: 이화여자대학교 의과대학의 홈페이지를 개발하는 과정에서 있었던 경험을 문서화하여 향후의 정보화 매체 제작에 참고자료를 제시하고자 한다. 방법: 인적 및 하드웨어 자원을 효율적으로 활용하여, 홈페이지의 내용과 형식을 구성하도록 몇가지의 개발 원칙을 세웠다. 결과: 홈페이지는 이화여자대학교 소속의 web server(mm.ewha.ac.kr)에 구현되었으며, 구현된 계층구조와 내용은 개발 원칙에 부합하였다. 결론: 향후 유사한 정보화 매체의 개발과 각 교실의 홈페이지에 대한 유지, 보수 작업에 도움이 될 자료로 사료된다. Objectives : Experience in development of home pages for Ewha Womans University College of Medicine were documented to present references for future development of informatics media. Methods : Development principles were established for the optimal allocation of human and hardware resources, and for the effective construction of contents and structures of the home pages. Results : Home pages were implemented on a web server(mm.ewha.ac.kr) in Ewha Womans University. Their structural hierarchy and contents were determined according to the principles described earlier. Conclusion : The author's experiences will be helpful for the enhancement and maintenance of the home page of each department and for the future development of similar informatics media.
김춘동,변성완 梨花女子大學校 醫科大學 醫科學硏究所 2001 EMJ (Ewha medical journal) Vol.24 No.1
Objectives : There are controversial evidences that children gain weight to a significant extent after adenotonsillectomy, usually associated with a general improvement in health. This study is aimed to evaluate the growth disturbance in children with adenotonsillar hypertrophy and the effect of adenotonsillectomy on subsequent growth in them. Methods : Ninty-one children adenotonsillectomized had their weights recorded preoperatively, and reweighted twelve months after surgery. Results : The results showed the patients were generally not underweighted before surgery. Their median weight was on the 59.5 percentile. Their weights after surgery had increased by an average of 20 percent over what would have been expected. This increase in weight was not confined to underweight children but to the entire group. Conclusion : Upper airway obstruction resulting from adenotonsillar hypertrophy might be suspected as a possible cause in the workup of children with suboptimum growth.
두경부암 세포주에서 항체의존성 세포독성의 확립과 Prostaglandin이 항체의존성 세포독성에 미치는 영향
김춘동,변성완,홍순관 梨花女子大學校 醫科大學 醫科學硏究所 1998 EMJ (Ewha medical journal) Vol.21 No.3
Background : Head and neck squamous cell carcinoma(HNSCC) has been associated with host immunosuppression, including depressed T-lymphocyte and natural killer cell function. This immunosuppression has been shown to be most pronounced in the locoregional environment of the tumor and appears to be mediated by soluble suppressor factor prostaglandinE_2(PGE_2). PGE_2 is a product of cell membrane phospholipid metabolism that is known to have potent immunoregulatory activity including inhibition of natural killer cell activity and antibody dependent cell mediated cytotoxicity(ADCC). Method : In our experiment, we have established an ADCC assay with IgGl cMAB SF-25, 323A/3 using human squamous cell carcinoma of the head and neck cell line(PCI-50) as target. The measurement of cytotoxicity was determined by measuring the release of ^51Chromium from the target cells after 4 hour incubation. Result : PGE_2 inhibited antibody dependant cell mediated cytotoxicity. Conclusion : It thus implies that the production of prostaglandins by tumor cells may constitute a means by which the tumor cells subvert the effect of a cellular immune response that is directed against them and arming of NK cells with chimeric antibody could be considered in developing means for treatment of human SCCHN in adjuvant setting.