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랫드에서 cyclophosphamide로 유발된 기형에 대한 홍삼추출물의 효과
이예은(Yea Eun Lee),변상국(Sang Kuk Byun),신선희(Sunhee Shin),장자영(Ja Young Jang),최병일(Byong-il Choi),박동선(Dongsun Park),전정희(Jeong Hee Jeon),임숙희(Sook Hee Lim),황석연(Seock-Yeon Hwang),김윤배(Yun-Bae Kim) 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.3
Effects of repeated treatment with red ginseng extract on the teratogenicity of cyclophosphamide were investigated in rats. Pregnant rats were orally treated with red ginseng extract (100 or 500 ㎎/㎏) for 7 days, from days 6 to 12 of gestation, and intraperitoneally challenged with cyclophosphamide (12 ㎎/㎏) 1 hr after the final treatment. On day 20 of gestation, the maternal and fetal abnormalities were examined. Cyclophosphamide, administered on day 12 of gestation, reduced fetal and placental weights to 70 - 80% and 50% of control, respectively, and induced 80% of malformations in live fetuses. The malformations include cranial defect and exencephaly (80.0%), micrognathia and tongue extrusion (20.9%), edema and hematoma (29.1%), ventricular dilatation (16.7%), vertebral defects (78.6%), costal defects (44.6%), and delayed skeletal ossification (80.4%). Interestingly, red ginseng extract further decreased the fetal weights and remarkably aggravated fetal defects in a dose-dependent manner, resulting in 96.7% of cranial defect and exencephaly, 64.8% of micrognathia and tongue extrusion, 49.5% of limb defects, 90.7% of vertebral defects, 88.4% of costal defects, and 83.7% of delayed skeletal ossification in rats administered with 500 ㎎/㎏ of red ginseng extract followed by cyclophosphamide. These results demonstrate that a long-term pretreatment with red ginseng extract substantially enhance body weight loss and malformations of fetuses induced by intrauterine exposure to cyclophosphamide.