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The Evolution and Value of Diphtheria Vaccine
배경동,Bae, Kyung-Dong The Korean Society for Biotechnology and Bioengine 2011 KSBB Journal Vol.16 No.3
This review article provides an overview of the evolution of diphtheria vaccine, its value and its future. Diphtheria is an infectious illness caused by diphtheria toxin produced by pathogenic strains of Corynebacterium diphtheriae. It is characterized by a sore throat with membrane formation due to local tissue necrosis, which can lead to fatal airway obstruction; neural and cardiac damage are other common complications. Diphtheria vaccine was first brought to market in the 1920s, following the discovery that diphtheria toxin can be detoxified using formalin. However, conventional formalin-inactivated toxoid vaccines have some fundamental limitations. Innovative technologies and approaches with the potential to overcome these limitations are discussed in this paper. These include genetic inactivation of diphtheria toxoid, innovative vaccine delivery systems, new adjuvants (both TLR-independent and TLR-dependent adjuvants), and heat- and freeze-stable agents, as well as novel platforms for producing improved conventional vaccine, DNA vaccine, transcutaneous (microneedle-mediated) vaccine, oral vaccine and edible vaccine expressed in transgenic plants. These innovations target improvements in vaccine quality (efficacy, safety, stability and consistency), ease of use and/or thermal stability. Their successful development and use should help to increase global diphtheria vaccine coverage.
굽힘각도를 고려한 원형 감육이 발생한 중수로 피더관의 한계하중
배경동(Kyung Dong Bae),제진호(Jin Ho Je),김종성(Jong Sung Kim),김윤재(Yun Jae Kim) 대한기계학회 2012 大韓機械學會論文集A Vol.36 No.3
캐나다형 중수로에서 피더관은 중수로 압력관에 중수를 공급하고 가열된 중수를 증기발생기로 보내는 배관으로 가동 중에 유동 가속 부식현상에 의해 감육이 발생한다. 배관에 감육이 발생하게 되면 배관의 건정성이 떨어진다는 결과는 앞선 연구에서 확인하였다. 본 논문에서는 45 도와 60 도의 굽힘각도를 갖는 피더관의 한계하중을 제시하고 제시된 연구결과를 바탕으로 임의의 굽힘각도를 갖는 피더관에서 감육이 발생했을 경우의 한계하중을 예측 할 수 있는 식을 제시하였다. 본 연구에서는 유한요소해석을 통하여 굽힘 하중과 내압을 받는 경우에 대하여 연구를 진행하였고 특히 굽힘 하중의 경우 면내열림 방향과 면내 닫힘 방향으로 나누어 진행하였다. 재료는 대변형 효과를 고려하고 탄성-완전소성 재료로 가정하였다. In CANDU, feeder pipes supply heavy water to pressure tube and steam generator. Under service conditions, Flow-Accelerated Corrosion (FAC) produces local wall-thinning in the feeder pipes. The wall-thinning in these pipes affects the integrity of the piping system, as verified in previous research. This paper provides limit loads for wallthinned feeder pipes with 45° and 60° bend angles, and proposes an equation that predicts the limit loads for wallthinned feeder pipes with arbitrary bend angles. On the basis of finite element limit analyses, limit loads are obtained for wall-thinned feeder pipes under in-plane bending and internal pressure. There are two cases of in-plane bending: the in-plane closing direction and the in-plane opening direction. The material is considered the effect of the large deformation, so an elastic-perfectly-plastic material is assumed in the calculations.
재조합 Pichia pastoris GS115에서 Δ5-desaturase의 발현과 그 활성
배경동(Bae, KyungDong) 한국생물공학회 2011 KSBB Journal Vol.26 No.6
It has been known that Δ5-desaturase (TAD5) in the biosynthetic pathway of long chain polyunsaturated fatty acids of Thraustochytrium aureumis responsible for the conversion of di-homo-γ-linolenic acid (C20:4) into arachidonic acid (C20:4). The genetic sequence analysis on TAD5 of Thraustochytrium aureum ATCC34304 used in this study showed that it has two amino acid changes when compared to that of Thraustochytrium aureum TAD5 first reported in 2003. Accordingly, Thraustochytrium aureum ATCC34304 TAD5 was named TAD5_1. TAD5_1-inserted methylotropic Pichia pastoris was prepared and then cultured with a precursor fatty acid, di-homo-γ-linolenic acid. GC analysis confirmed that a certain amount of the precursor fatty acid was converted into arachidonic acid. In this study, not only a recombinant Pichia pastoris with the typical activity of Δ5-desaturase which plays an essential role in the biosynthesis of LCPUFAs was successfully made but also the preparationpotential of a recombinant Pichia pastoris strain which may synthesize eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) that are important in maintaining and improving human’s brain function was proposed.