Clinical Significance of Plasma CEA Levels in the Patients with Cervical Carcinoma during Follow-Up

반성범,김주영,최명선,나중열,이민재,Ban, Sung-Beom,Kim, Joo-Young,Choi, Myung-Sun,Rha, Joong-Yeol,Lee, Min-Jae The Korean Society for Radiation Oncology 1991 Radiation Oncology Journal Vol.9 No.2

CEA 측정으로 부인과 영역 악성종양의 치료결과나 재발 여부의 조기 진단을 할 수 있나를 연구한 결과이다. 1985년 1월부터 1989년 12월까지 239명의 자궁경부암 환자를 대상으로 치료전과 치료후 CEA치를 체계적으로 측정했고 이를 비교하기 위하여 정상군으로 아무런 증상이 없는 건강한 부인 65명과 양성종양을 가진 18명의 부인을 상대로 CEA치를 측정하였다. 혈장내 CEA치는 종양의 진행정도와 기의 직접관계가 있는 것을 알 수 있고 종양의 기가 진행되면 될수록 CEA치가 비정상인 경우가 높아지고 있다. 또한 CEA치가 비정상인 경우 편평상피종 환자보다는 선세포나 선세포와 편평세포가 혼합된 경우 더욱 증가되는 것을 볼 수 있었다. 결론으로 혈장내 CEA을 체계적으로 측정함으로써 치료 끝난 후 추적검사시 재발의 조기발견 및 치료결과를 확인할 수 있는 좋은 방법이라는 결론을 얻었다. Carcinoembryonic antigen (CEA) has been studied in the field of gynecologic malignancy to determine whether it can be used as a tumor marker for early detection of recurrence or evaluation of therapeutic results. From January 1985 through December 1989, a total of 239 cervical cancer patients were entered for an analysis of plasma CEA level in the group with conical cancer compared to the control group consisting of 65 normal healthy women and 18 women with benign gynecologic disease. Plasma CEA levels appear to be directly related with the tumor extension and as stages advance, the incidence of patients with abnormal plasma CEA levels is increased. Also, there seems to be a little higher incidence of abnormal CEA levels in patients with adenocarcinomas or adenosquamous carcinoma but not statistically significant because of small number of patients. When the patients developed recurrence, plasma CEA levels are markedly elevated in the majority, particularly in patients with hepatic metastases, In conclusion, serial plasma CEA checks could be used to detect recurrence during follow-up after treatment of cervical cancer.

시스톨릭 어레이를 이용한 블럭정합 알고리즘의 VLSI 구조

반성범,채승수,박래홍 대한전자공학회 1996 전자공학회논문지-B Vol.b33 No.6

In this paper, we propose VLSI architectures for the full search block matching algorithm (FS BMA) and two-stage BMA using integral projections that reduce greatly computational complexity with its performance comparable to that of the FS BMA. The proposed VLSI architectures are faster than the conventional ones with lower hardware complexity. Also the proposed architectures of the FS BMA and two-stage BMA are modeled in VHDL and simulated to show their functional validity.

상악동 임파종의 방사선 치료

반성범,김철영,최명선,Ban, Sung-Beom,Kim, Chul-Young,Choi, Myung-Sun The Korean Society for Radiation Oncology 1986 Radiation Oncology Journal Vol.4 No.1

부비동의 악성임파종은 매우 빈도가 적으나 방사선치료로 완치가 가능한 종양이다. 내원당시 병변은 부비동과 그 주위에 국한되어 있으며, 전신적인 임파종으로의 변환은 흔치 않다. 대부분 부비동 임파종은 병리조직학적으로 조직구성 임파종이다. 원발병소와 경구임파절의 방사선 치료가 가장 적절한 치료이며 $50\~70\%$의 생존율을 기대할 수 있다. Malignant lymphoma of the sinus is very rare but potentially radiocurable neoplasm. The disease is tend to be localized to the sinus and spread to adjacent local structures on initial presentation, and change to generalized lymphoma is uncommon. Most of sinus lymphoma is diffuse histiocytic type. Radiotherapy to the primary and neck nodes is the treatment of choice, and a survival rate of $50-70\%$ can be expected.

생체인식 기술 동향

반성범,정용화,정교일,김재희 대한전자공학회 2002 전자공학회지 Vol.29 No.5

Radical Radiotherapy of Head and Neck Cancer

반성범,김철영,최명선,서원혁,Ban Sung Beom,Kim Chul Young,Choi Myung Sun,Suh Won Hyuck The Korean Society for Radiation Oncology 1986 Radiation Oncology Journal Vol.4 No.1

1981년 3월부터 1986년 3월까지 고려대학교 의료원 혜화병원 치료방사선과에서 60명의 두경부 환자를 대상으로 방사선치료후의 임상적인 병기에 따른 생존율 및 국소종양 억제율을 후향적으로 재조사하였다. 근치적 방사선 치료전에, 이학적 검사와 방사선학적 검사로 흉부X-선, 후두촬영 및 콤퓨터 단층촬영 등을 시행하였고 AJC의 임상병기에 따라 분류하였다. 치료는 방사선 치료 단독 시, 7,200cGy를 8주에, 그리고 수술후 방사선 치료시는 6,000cGy를 7주에 각각 분할 조사하였다. 이에 저지들은 다음과 같은 결과를 얻었다. 1) 남녀의 성비는 3.6:1이었고 50대의 연령군에서 가장 높은 빈도를 보였다. 2) 방사선 치료를 받은 환자에서, 병리조직하적으로 편평상피암이 비 편평상피암에 비해 3.5배의 높은 빈도를 보였다. 3) 원발병소의 해부학적 위치는 후두가 22예, 부비동이 12예, 비인후강이 7예, 구강인두가 6예, 하인두가 3예였다. 4) AJC의 병기에 따라 분류하면 I기가 4예, II기가 7예, III기가 19예, 그리고 IV기가 27예였다. 5) 경부임파절로의 국소전이는 전체적으로 $43\%$였고 subdigastric과 submaxillary임파절이 가장 않은 것으로 나타났다. 6) 방사선 치료 후 국소종양의 억제는 치료 환자의 $48\%$에서 관찰되었다. 7) 원격전치는 7예에서 관찰되었는데 그중 4예에선 폐로의 원격전이를 보였다. 8) Life-table방식에 의한 5년 생존율은 $43\%$로 나타났다. Study patients with head and neck carcinoma were studied retrospectively to assess the impact of treatment on survival and local control rate by stage in the Dept of Radiation Therapy, Korea University Hae Wha Hospital between March 1981 and March 1986. Prior to definite radiotherapy, patients were evaluated by physical examination and radiologic studies including chest, laryngogram and CT scan and then these patients were grouped according to the American Joint Committee (AJC) staging system. They were treated with RT alone or postoperative irradiation to the dose of 7,200 cGy/8 weeks and 6,000 cGy/7 weeks respectively. The results were obtained and as follows; 1. Overall male to female sex ratio was 3.6:1. The peak age of patients with head and neck cancer was 6th decade. 2. In all patients treated by RT, the ratio of squamous cell 1 carcinoma to non-squamous cell carcinoma was 3.5:1 (60/77 patients). 3. The incidence according to the anatomic site of primary tumor was 22 cases in the larynx, 12 cases in PNS, 7 cases in nasopharynx, 6 cases in oropharynx, and 3 cases in hypopharynx. 4. According to AJC staging system,4 cases were Stage 1,7 in Stage II, 19 in Stage III and 27 in Stage IV. 5. The overall incidence of cervical lymph node metastases was $43\%$ and subdigatric and submaxillary triangle lymph nodes were the most frequent site of metastases. 6. Local control was achieved in $48\%$ of patients treated by radio-therapy. 7. The lung was the most common site for distant metastases, comprising 4 cases among 7 cases in which distant metastases occured. 8. The overall estimated 5-year survival rate was $43\%$ in the head and neck cancer treated with radiotherapy by life-table analysis.

보안토큰을 이용한 생체인증

반성범,정용화,Ban, Seong-Beom,Jeong, Yong-Hwa 한국정보통신집흥협회 2002 정보화사회 Vol.159 No.-

어레이 프로세서를 이용한 DCT의 하드웨어 구현 ( Hardware Design of the DCT Using Array Processors )

반성범,박래홍 대한전자공학회 1994 대한전자공학회 학술대회 Vol.1994 No.1

추골혈관종의 방사선 치료 -증례 보고-

반성범,김우선,손승재,김병국,Ban Sung Beom,Kim Woo Sun,Sohn Seung Jae,Kim Byung Kuk The Korean Society for Radiation Oncology 1989 Radiation Oncology Journal Vol.7 No.2

추골 혈관종은 대개의 경우 증상이 없으며, 증상이 있는 환자의 치료는 주로 외과적인 방법에 의해 행하여졌다. 저자들은 신경학적인 증상이 동반된 추골 혈관종 환자에서 방사선치료 후 증상의 호전을 보인 예를 경험하였기에 보고하는 바이다. Vertebral hemangiomas are rarely symptomatic and have been treated by surgical managementsin patients with symptoms. A case of symptomatic vertebral hemangioma which was treated by radiotherapy successfully is presented.

이산 웨이브렛 변환을 위한 효율적인 VLSI 구조

반성범,박래홍,Pan, Sung-Bum,Park, Rae-Hong 대한전자공학회 1999 電子工學會論文誌, S Vol.s36 No.6

본 논문은 1차원 DWT 계산을 위한 효율적인 VLSI 구조를 제안한다. 제안한 구조는 $a_nh_m$을 이용하여 웨이브렛 저주파 및 고주파 성분을 계산한다. 반면에 기존의 구조는 $a_nh_m$과 $a_ng_m$을 이용하여 계산한다. an, hm, 그리고 gm은 각각 입력 시퀸스, 웨이브렛 저주파 및 고주파 계수를 나타낸다. 제안한 구조는 Daubechies 웨이브렛 필터 사이의 계수 관계식을 이용하여 좀 더 효율적으로 Daubechies 웨이브렛을 구할 수 있다. 제안한 구조와 기존 구조의 성능을 비교하여 제안한 구조는 부가적인 블록이 필요없는 반면에 기존의 구조는 부가 블록이 필요함을 제시하였다. 또한 VHDL를 이용하여 모델링하고 시뮬레이션하여 제안한 구조가 정상적으로 동작함을 확인하였다. This paper proposes efficient VLSI architecture for computation of the 1-D discrete wavelet transform (DWT). The proposed VLSI architecture computes the wavelet lowpass and highpass output sequences using the product term anhm, $n,m{\ge}0$, where an and hm denote the imput sequence and the wavelet lowpass filter coefficient, respectively. Whereas the conventional architectures compute the lowpass and highpass output sequences using the product terms anhm and angm, respectively, where gm denotes the wavelet highpass filter coefficient. The proposed architecture is applied to computation of the Daubechies 4-tap wavelet transform using the relationships between the Daubechies wavelet filter coefficients. Performance comparison of various architectures for computation of the 1-D DWT are presented. Note that the proposed architecture does not require extra processing units whereas the conventional architectures need them. Also it is modeled in very high speed integrated circuit hardware description language (VHDL) and simulated to show its functional validity.

기관지확장증에서 동방된 폐실질 이상의 고해상 CT소견 : 폐기능검사와 연관하여

반성범 대한영상의학회 1996 대한영상의학회지 Vol.34 No.3

Purpose : The purpose of this study was to evaluate the high-resolution CT(HRCT) appearance of abnormalitiesof small airways and lung parenchyma associated with bronchiectasis and to correlate HRCT appearance and theresults of pulmonary function tests. Materials and Methods : The author retrospectively reviewed medical recordsand HRCT scans of 33 patients with bronchiectasis. Abnormalities of small airways and lung parenchyma in lobeswith bronchiectasis were assessed on HRCT scan. The findings on HRCT were correlated with the results of pulmonaryfunction tests in 20 patients. In two specimens obtained at lobectomy, histologic examinations were conducted todetermine the pathologic basis for CT findings of disease of small airways. Results : Patchy areas of lowattenuation(n=27), centrilobular nodules or branching opacities(n=20), irregular hyperattenuation(n=16), and areasof ground-glass attenuation(n=4) were observed on HRCT scans. In the lobar evaluation, areas of low attenuationwere observed in 66(76%) of the 87 lobes with bronchiectasis. Areas of low attenuation were also identified inseven(9%) of the 75 lobes without bronchiectasis. On expiratory HRCT, the lung parenchyma with areas of lowattenuation did not show a normal increase in CT attenuation and remained more lucent than surrounding normallung, which suggested that air was trapped in the lung parenchyma. Of the 20 patients who underwent pulmonaryfunction tests, six showed an obstructive pattern. These six had more lobes with bronchiectasis and with areas oflow attenuation than the other 14 patients, who did not have an obstructive pulmonary function pattern(p<.01). Intwo patients who had undergone lobectomy, pathologic examination showed bronchiolities obliterans in small airwaysperipheral to the dilated bronchi. Conclusion : In bronchiectasis, areas of low attenuation and centrilobularnodules or branching opacities are commonly observed in the lung parenchyma peripheral to the dilated bronchi onHRCT. These HRCT findings correspond pathologically to bronchiolitis obliterans and to lung parenchyma withtrapped air. The number of loves with bronchiectasis and with areas of low attenuation correlate significantlywith an obstructive pattern on pulmonary function tests.