http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Topiramate로 유발된 호중구 감소증 : A case report
박헌구,고대관,우종민 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.4
A-29-year-old woman suffering from borderline personality disorder and bulimia nervosa developed neutropenia and leukopenia after treatment with topiramate. The patient received 50㎎/day of topiramate. Three weeks later, she developed a neutropenia and leukopenia. WBC and neutrophil count was normalized after discontinuation of topiramate. Although such adverse drug reactions can be considered rare events, due to the potentially serious nature of these reactions, we emphasize the regular blood examination after initiation of treatment with topiramate.
남성 공황장애 환자에서의 monoamine oxidase A 프로모터 유전자 다형성의 연합 연구
최영희,우종민,박헌구,조우연,윤혜영,윤경식,조대연,홍경수 白中央醫療院 2004 仁濟醫學 Vol.25 No.1
Objectives: Genetic variation of the monoamine oxidase (MAO) A promoter gene polymorphism has been associated with its functional capacity. The authors tried to find the association between MAO A promoter polymorphism and panic disorder. Methods: 317 patients with panic disorder and 92 normal controls were enrolled in this study. 308 patients and 84 normal controls were completed study. Results: There was significant difference in allele frequencies of MAO A promoter polymorphism between male panic patients and normal controls (s allele: 60.7% vs. 44.3%, 1 allele: 39.3% vs 55.7%, x^(2)=10.008, df=1, p=0.002). The frequencies of MAO A promoter alleles between panic disorder and normal controls were 2 repeat (1.1% vs. 1.2%), 3 repeat (58.3% vs. 45.8%), 4 repeat (40.6% vs. 53.0%)(x2=8.368, df=2, p=0.015). Conclusion: Our results suggest that MAO A promoter gene may be related to panic disorder.
한국인 공황장애 환자의 트립토판 가수분해 효소와 세로토닌 전달체 유전자 다형성
최영희,우종민,박헌구,윤경식,조대연,이민수,Choi, Young Hee,Woo, Jong Min,Park, Hun Ku,Yoon, Kyung Sik,Cho, Dae Yeon,Lee, Min Soo 대한생물정신의학회 2004 생물정신의학 Vol.11 No.2
Objectives:Genetic variations of the tryptophan hydroxylase(TPH) gene and the serotonin transporter linked polymorphic region(5-HTTLPR) polymorphism have been associated with its functional capacity. The authors investigated whether the allelic constitution of the TPH gene and 5-HTTLPR are associated in Korean panic patients. Methods:244 Korean patients with panic disorder and 227 normal healthy controls were tested for a genetic polymorphism of TPH A218C and 5-HTTLPR polymorphism. To assess the severity of panic disorder during the last one month, anticipatory anxiety, panic difficulty, panic distress, agoraphobic difficulty and agoraphobic distress were measured with visual analogue scale(VAS) score, STAI-S & T, BDI, SCL-90-R, ASI-R, CGI, PDSS, and HAMD. Results:There was no significant difference in genotype and allele frequencies of TPH A218C and 5-HTTLPR polymorphism between panic patients and controls. Although we observed some differences in genotype and allele frequencies of TPH A218C polymorphism among male subjects, these differences disappeared after Bonferroni correction. And there were no significant differences in clinical variables. Conclusion:Our results suggested that there are no association between the genetic polymorphism of TPH gene and 5-HTTLPR with panic disorder.