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폐암과 폐결핵환자의 기관지폐포 세척액의 면역글로불린의 동향
안상용(S . Y . Ahn),김인호(I . H . Kim),양동호(D . H . Yang),어수택(S . T . Uh),김태준(T . J . Kim),박춘식(C . S . Park) 대한내과학회 1986 대한내과학회지 Vol.30 No.6
N/A The immune status changes in patients with lung cancer, but there is controversy about the degree and mechanism of changes in local humoral immune response. To evaluate 1) that the local immune response of lung cancer(Ca) is different from that of benign lung disease and 2) how the local immune response changes according to the extent of lung cancer. We measured immunoglobulin G.A.M. level in bronchoalveolar lavage(BAL) fluid of 25 patients with lung cancer and 16 patients with pulmonary tuberculosis(Tbc) 1) There was no difference in the concentration of serum IgG.A.M. between lung Ca and pulmonary Tbc. 2) In the BAL fluid, IgA concentration of lung Ca was higher than that of pulmonary Tbc(p<0.05), IgA concentration of lung Ca stage Ⅲ was higher than that of lung Ca stage I, Ⅱ (p<0.05) and lgM concentration of lung Ca stage, I , Ⅱ was higher than that of stage Ⅲ(p<0.05) 3) In the ratio of Ig to Albumin in BAL fluid. IgG and IgM of lung Ca was higher that those of pulmonary Tbc(p<0.05) and IgA of lung Ca stage g was higher than that of stage I, Ⅱ(p< 0.05) and IgM of lung Ca stage I, Ⅱ was higher than that of stage Ⅲ(p<0.05) 4) In the ratio of Ig to albumin-ratio of BAL to serum[(Ig/Alb) BAL/(Ig/Alb) Serum], IgA, M,G. of lung cancer and pulmonary Tbc were above l.0 but those of lung Ca was higher that those of pulmonary Tbc and IgM of lung Ca-stage I, Ⅱ was higher than that of lung Ca stage Ⅲ. In conclusion, local immune response of lung Ca is higher than that of pulmonary Tbc and the more extensive is the lesion of lung Ca, the higher is the local response of IgA and the less is the local response of IgM.
FRTL-5 세포의 세포주기(Cell Cycle)에 TSH 및 그레이브병 IgG가 미치는 영향에 관한 Flow Cytometry를 이용한 분석
박춘식,김극배,유명희,이희발 대한내분비학회 1992 Endocrinology and metabolism Vol.7 No.3
Controversy exists in the question that Graves' disease TSI (Thyroid stimulating immunoglobuin) and TGI (Thyroid growth immunoglobulin) coexist as different molecules or are the properties of a single IgG and current methods measuring TGI activity had been criticized, We tried to measure TGI activitty using FRTL-5 cells by flow ytometric analysis. The results were as follows. 1) Cell cycle analysis of FRTL-5 cells cultured without hormones (5% CS) showed 85.5±0.5% cells in Go and GI phase, 8.6±0.4% cells in S phase and 5.4±0.2% cells in G2M phase. When cultured with TSH(6 hormone medium), cells were 64.0±1.1% in Go and GI phase, 26.2±0.7% in S phase and 9.8±1.2% in G2M phase which means increased cell division. 2) When cultured with untreated Graves' IgG, the cell cycle analysis showed variable patterns. S phase percent in patients with goiter volume more than 40 ml was increasd (GII, 11.96±2.70 %) when compared with that of the patients with goiter volume less than 40 ml(GI, 9.90±2.57%). Overall, i8) of GI and 43%(7/16) of GII, Graves' IgG increased S phase percents when compared with normal IgG. These resluts suggested that flow cytometric analysis of the cell cycle might be a valuable method of TGI assay providing direct measurements of cell division.(J Kor Soc Endocrinol 7:228~233.1992)