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나답·아비후의 죽음에 관한 주석적 연구 : 레위기 9:22-10:11을 중심으로
The aim of this paper stemmed from the fact that there seems to be no specific explanation for the death of Nadab and Abihu in Leviticus 8-10. Unlike previous approaches using a historical perspective, this paper tried to illuminate this incident fully with biblical evidence by conducting a close reading of Lev. 9:22-10:11. Closer examination of the text found a significant possibility that Lev. 9:22-10:11 was written or intended to be read as one literary work. There are four reasons for this theory. First, it was easier to understand what the text describes regarding the deaths when reading the context encircling the incident. The closeness of the two different events, God's official announcement for priesthood (Lev. 9:22-24) and the false behavior of Aaron's two sons (Lev. 10:1), suggests that they were very near the presence of God and this must have caused serious consequences for them. These two events create conflict together in the narrative. Second, the repeated use of the same arrangement of certain words in different texts suggests Lev. 9:22-10:11 was written by one author. The phrase “ (and fire came forth from before the Lord and consumed)" heightens the mood in both Lev. 9:24 and 10:2. Third, there is intentional usage of the same word in different texts. The word “ (fire)" appears constantly throughout the entire narrative. Although it was not a burning fire that consumed the two sons, considering “ (in their coats)" in Lev. 10:5, Lev. 10:2 presents the cause of their deaths using “ (fire)." It seems that the author of this narrative intended to reinforce opposite consequences resulting from the same divine origin in Lev. 9:24 and 10:2. Fourth, there is repetition of the same pattern. A pattern, "Act-Response-Reaction," is found in Lev. 9:22-24 and 10:1-3: the act of Moses and Aaron (9:22-23α), the glory of God as a response (9:23β-24α), and the Israelite's reaction (9:24β), and the act of Nadab and Abihu (10:1), the fire and words of God as a response (10:2-3α), and Aaron's reaction (10:3β). Meanwhile, another pattern, "Order-Obedience," which is found in Lev. 10:4-7, flows through the entire narrative in Lev. 8-10. One of the greatest outcomes of this literary approach to the deaths of Nadab and Abihu is clarifying the complexity of this incident. The reasons for their deaths can be sorted into three aspects as follows. Their deaths involve their obvious faults. The adjective phrase "which He had not commanded them" strengthens the obviousness of their guilt, presented just as "strange fire." The focus of the text is on the careless behavior, not on what kind of fire they offered. The deaths are also connected with their official status and mission. Their status was officially given by God (Lev. 9:24), thus they had to implement their mission in very close proximity to God's presence (10:3). Finally, their deaths are related to the situation in which they were involved. They burned the incense right after God's official announcement had taken place. They were very close to the presence of God. Additionally, the place where they did their duty was considered to all of Israelite (10:3β). If this first step went in the wrong direction, the correct attitude of all Israelites, including priests, toward God in the future would not have been guaranteed, thus He responded instantly and severely. Like a montage effect, two seemingly independent and inconsistent narratives (Lev. 9:22-24, 10:1-11) comprise one complete story, which proves the complexity of the guilt of Nadab and Abihu. The fundamental lacking resulted from their unsound mind shows how important God's constant kingship in our daily life is.
Background/Aims: Many candidate gene studies have revealed that polymorphisms of the 5’-flanking controlled SERT gene linked polymorphic region (5HTT-LPR) gene and G-protein β3 C825T gene might be associated with functional dyspepsia (FD) and irritable bowel syndrome (IBS). This study was performed to investigate polymorphisms of the 5HTT-LPR gene and G-protein β3 C825T gene in FD and IBS in Korean children. Methods: In total, 102 patients with FD, 72 patients with IBS based on the Rome III criteria and 148 healthy controls without gastrointestinal symptoms were included in the study to analyze 5HTT-LPR and G-protein β3 C825T polymorphisms. Results: 5HTT-LPR genotype analysis revealed no significant differences in FD and IBS patients compared with controls. The GNβ3 C825T genotype distribution for CC, CT, and TT was 23.6%, 53.4%, and 23.0% in controls, 36.3%, 38.2%, and 25.5% in FD and 37.5%, 38.9%, and 23.6% in IBS, respectively. The CC genotype was more common in FD and IBS patients than controls (p<0.05). When the IBS patients were grouped according to IBS subtypes, CC genotype GNβ3 C825T was common in diarrhea-dominant IBS, and the TT genotype was common in constipation-dominant IBS (p<0.05). Conclusions: The CC genotype of G-protein β3 C825T may be associated with FD and diarrhea-predominant IBS. The TT genotype may be associated with constipation-predominant IBS.
관류강조 자기공명영상을 이용한 대뇌 좌우반구 간 비대칭성의 평가
본 연구에서는 DSC PW-MRI를 이용하여 국소 뇌혈류량(regional Cerebral Blood Volume, 이하 rCBV라 함), 국소 뇌혈류(regional Cerebral Blood Flow, 이하 rCBF라 함), 평균통과시간(Mean Transit Time, 이하 MTT라 함)과 이러한 변수값들에 대한 좌우 대뇌반구 간의 비대칭 지수(Asymmetry Index, 이하 AI라 함)를 구하고 이의 임상적 의의를 모색하고자 하였다. AI는 핵의학에서 사용되는 지수로서 좌우반구의 평균값에 대한 좌우반구 간 차이의 비를 나타낸다. 임상적으로 정상 진단을 받은 3명의 환자, 일과성뇌허혈증(transient ischemic attack)을 진단 받은 1명의 환자, 좌반구 측면삼각(collateral trigone) 부분에 맥락막총 유두종(choroid plexus papilloma)을 진단받은 1명의 환자의 영상을 비교하였다. 이를 위하여 GRE-EPI(Gradient Echo-Echo Planar Imaging) sequence의 영상 변수를 TR(repetition time)=2000msec, TE(echo time)=60msec, 매트릭스 크기= 128×128, 슬라이스 두께=8mm, 슬라이스 간격=2mm, FOV(field of view)=23.9cm로 하여 총 40장의 영상에서 시간의 변화에 따라 슬라이스별로 각각의 화소(pixel)에 대해 신호-시간 그래프를 구성하였다. 구성한 그래프를 농도-시간 그래프로 변환하여 모든 화소에 대한 rCBV, rCBF, MTT 값을 구하였다. 최초 통과 시점(first pass point)까지의 rCBV, rCBF, MTT 값 계산으로 맥락막총 유두종을 가진 환자의 슬라이스에서는 각각 -17.25%, -18.49%, 10.24%로, 정상 환자의 슬라이스에서는 -4.94%, -4.66%, 2.46%로 AI가 측정되었다. 이러한 결과는 종양의 혈관생성(angiogenesis) 효과나 종양 근방의 혈관 확장(vasodilation)의 결과로 여겨진다. 좌우 대뇌 반구의 비교와 같은 간단한 방법을 통하여 DSC-MRI가 가지는 상대적 측정방법으로써의 한계에서 벗어나 보다 정량적 평가에 가까운 결과를 얻을 수 있다. In this study, inter-hemispheric asymmetry index(AI) obtained from regional Cerebral Blood Volume(rCBV), regional Cerebral Blood Flow(rCBF), Mean Transit Time(MTT) were calculated using Dynamic Susceptibility Contrast(DSC) Perfusion Weighted(PW)-MRI was propose to grope for some clue to clinical significance. The AI is an index mainly used in the nuclear medicine and represents the ratio of differences to mean values between bilateral hemispheres. Images from one patient with the choroid plexus papilloma within the left hemisphere and one case of the transient ischemic attack were compared with normal cases. For this, the sequence parameter for the GRE-EPI sequence were as follows: TR=2000msec, TE=60msec, matrix size=128×128, slice thickness=8mm, slice gap=2mm, FOV=23.9cm. Then time-signal curves were reconstructed for each pixel from 40 image slices over time. These curves were converted to time-concentration corves and rCBV, rCBF, MTT values for each pixel were calculated. AI's were evaluated from ROI by integrating the 1st-pass time. Results showed considerable differences between normal and abnormal cases of rCBV from patient with the choroid plexus papilloma are -17.25%. In four normal cases, -4.94%, -3.23%, -1.86%, -2.54% were showed. And some cases came from the angiogenesis effect of tumor or the vasodilation. Simple method like a comparison between inter-hemispheres results in more quantitative evaluation than limited DSC-MRI relative measurement.