재발성 음경지속발기증 1례

박성환,백선호,한수련,안영민,안세영,이병철,Park, Sung-Hwan,Paik, Sun-Ho,Han, Su-Ryun,Ahn, Young-Min,Ahn, Se-Young,Lee, Byung-Cheol 대한한방내과학회 2011 大韓韓方內科學會誌 Vol.32 No.1

Priapism is a persistent penile erection that continues for more than 4 hours beyond, or is unrelated to, sexual stimulation. Because priapism is a medical emergency, all patients with priapism should be evaluated and treated urgently. Subtypes of priapism are ischemic, non-ischemic and stuttering priapism. Stuttering type is a recurrent form of ischemic priapism in which unwanted painful erections occur repeatedly with intervening periods of detumescence. The etiology of this type is often idiopathic and the treatments are still not clearly established. We present one case of stuttering priapism which occurred after suppression of his sexual desire. A 23-year-old man visited our clinic complaining of recurrent pain and erections persisting for about 5 weeks. We performed evaluation and confirmed the diagnosis of Rigid swollen penis. Jibaekjihwang-tang gamibang (ZhiBaiDihuang-Tang Jiaweifang) was administerd to the patient for 9 days. After the treatment, duration of erections and pain showed remarkable improvements. This will be recorded as the first case report of treating priapism with a Korean medical approach and suggests that Korean medicine therapy can be efficient to treat priapism.

전침 및 봉약침치료를 시술한 양성전립선비대증 환자의 임상증상개선에 대한 후향적 단면연구

박성환,한수련,강지석,안영민,안세영,이혜정,이병철,Park, Sung-Hwan,Han, Su-Ryun,Kang, Ji-Suck,Ahn, Young-Min,Ahn, Se-Young,Lee, Hye-Jung,Lee, Byung-Cheol 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.3

Obejectives : To investigate the clinical effect of electroacupuncture and bee venom acupuncture for benign prostatic hyperplasia(BPH) symptoms. Methods : Among 39 outpatients who were treated at a BPH clinic, 8 were finally selected for analysis by charts-review, retrospectively. They were treated by electroacupuncture and bee venom acupuncture more than 3 times. We estimated the effectiveness of the treatments by using the International Prostate Symptom Score (IPSS) questionnaire and checking their nocturia frequency. On the basis of these variables, we analyzed the statistical significations of symptom improvements. Results : Among 8 patients, the IPSS and nocturia frequency showed significant improvement after the final treatment compared with baseline (P = .0078, P = .0078). The IPSS significantly decreased even after the 1st treatment and also after the 2nd treatment compared with the baseline (P = .0078, P = .0078). The IPSS at post final-treatment, post 1st- and post 2nd treatment also showed significant improvement compared with IPSS at baseline in 6 severe symptomatic patients(P = .031, P = .031, P = .031). Nocturia frequency decreased after the 1st treatment compared with baseline and showed significant improvement between baseline and post 2nd treatment (P = .0078). Conclusions : In a retrospective and cross-sectional study investigating the clinical effects of electroacupuncture and bee venom acupuncture on BPH, these treatments proved to have significant therapeutic effects, particularly for various symptoms involving frequent nocturia.

류마티스 관절염의 예방과 관리

박성환,Park, Seong-Hwan 한국건강관리협회 2004 한국건강관리협회지 Vol.2 No.2

Rheumatoid arthritis(RA) is the most common inflammatory joint disease and a major cause of disability, morbidity, and mortality. It occurs worldwide, affecting approximately one percent of adults. Inflammation of the synovial membrane surrounding a joint leads to swollen, tender, and stiff joints RA has no known cure and the diagnosis is made based on clinical criteria and many different options exist for treatment. All of these factors magnify the importance of the patient-physician interaction and place a premium on the art rather than the science of medicine. The major goals of therapy for RA are to relive pain, swelling, and fatigue; improve joint function; stop joint daage, and prevent disability and disease-related morbidity. Some combination of nonsteroidal anti-inflammatory drugs(NSAIDs), steroids, and DMARDs is necessary in almost patients. In many combinations of different DMARDs or DMARDs plus biologicals are necessary for optimal control. Additionaly, all patients with RA should be educated about their disease and the therapies that will be used. Patient education is essentially early in the disease course and on going basis Much research is focused on the further development of biological agent for treatment of RA. Elucidation of the trigger or trigers for RA may allow us to begin to think about prevention of RA.

콩으로부터 상처 유도 beta-amyrin synthase 유전자의 동정 및 발현분석

박성환,이재헌,Park, Seong-Whan,Lee, Jai-Heon 한국식물생명공학회 2002 식물생명공학회지 Vol.29 No.2

Suppression subtractive hybridization (SSH)를 통해 상처에 의해 발현이 유도되는 cDNA들을 분리하였고, 그 중 하나인 gmwi33은 $\beta$-amyrin synthase 유전자들과 높은 유사성을 보였다. gmwi33의 전장 cDNA인 GmAMS1은 2416 bp 길이에 739개 아미노산으로 구성된 긴 open reading frame(ORF)를 포함하고 있었다. GmAMS1 단백질은 감초의 $\beta$-amyrin synthase인 GgbAS와 89%, 완두의 OSCPSY와 86%의 유사성을 보였다. 암조건 하에 5일간 기른 콩나물에서, GmAMS1는 빛을 쪼여주었을 때 가장 강하게 발현되었고 methyl jasmonate 처리와 저온처리 시에도 발현이 유도된 반면, UV-B나 elicitor를 처리하였을 때는 발현이 유도되지 않았다. 이러한 GmAMS1의 발현양상은 사포닌의 활성산소 제거기능과 밀접한 연관이 있을 것으로 추측된다. Suppression subtractive hybridization (SSH) was used to isolate wound-induced cDNAs from wounded soybean. One of wound-induced cDNA, gmwi33 showed high homology with genes encoding $\beta$-amyrin synthase. The full length cDNA of gmwi33, designated GmAMS1, is 2416 bp long and contains an open reading frame consisted of 739 amino acids. GmAMS1 protein showed 89% identity with licorice GgbAS1 and 86% identity with pea OSCPSY. In 5 day-old, dark-grown seedlings, the expression of GmAMS1 was most strongly induced by light and weakly induced by methyl jasmonate and by low temperature. However, GmAMS1 was not induced by elicitor or UV-B treatment. Such expression pattern might be closely related with the oxygen-radical scavenging activity of soyasaponin.

국내 외국인투자기업의 연구개발 투자에 대한 OLI우위 영향성 연구

박성환,조현정,지일용,Park, Sunghwan,Cho, Hyunjung,Ji, Ilyong 기술경영경제학회 2016 Journal of Technology Innovation Vol.24 No.4

다국적기업의 해외 연구개발 활동은 현지 국가에 최신 기술 지식 이전, 고급 일자리 창출 등의 긍정적 효과를 가져다주는 것으로 알려져 있다. 이에 각국 정부는 해외 다국적기업의 연구개발 투자를 유치하기 위한 많은 노력을 진행해 왔으며, 한국 정부 역시 관련 대책을 마련해 왔다. 그러나 국내에 진출한 외투기업의 연구개발 투자 비율은 여전히 미미하고, 이들 기업의 연구개발 투자 관련 연구 역시 부족한 실정이다. 이에 본 연구에서는 국내 외투기업의 연구개발 투자에 대한 이해를 높이기 위해, Dunning의 절충이론에 기반하여 한국 내 외국자본 국적별로 외투기업 연구개발 규모에 대한 OLI 우위의 영향성을 선형회귀모형 및 Tobit 회귀모형으로 분석하였다. 분석 결과, 한국의 산업 기술력 수준과 지분율은 국적 별 공통적으로 연구개발 규모에 영향을 주는 것으로 나타났고, 나머지 우위 요소 관련 가설은 부분 채택 되어 국내에 진출한 외투기업 별 다양성이 존재하는 것으로 분석 되었다. 즉 외투기업들은 L 우위(입지우위)가 있는 분야에서 연구개발을 수행하는데, O 우위(소유자 우위) 및 I 우위(내부화 우위) 고려 여부는 기업 및 국적별로 다르다는 것을 의미한다. 이러한 연구 결과는 해외 다국적기업의 국내 연구개발 투자 유치 및 외투기업의 연구개발 투자 확대 관련 정책을 위한 시사점을 제공할 수 있을 것이다. Multinational corporations' overseas R&D activities bring host countries positive effects such as knowledge spillover, technology transfer, job creation and etc. For this reason, many countries have made efforts to attract foreign firms' R&D investment in their national territories. Korean government have also implemented some policy measures to expedite foreign firms operating in Korea to increase R&D activities. However, the firms' R&D investment in Korea has still been unsatisfactory, and only few studies have examined this issue. Therefore, this study attempts to explain the R&D investment of foreign firms operating in Kore, from the perspective Dunning's eclectic paradigm. Utilizing linear regression and Tobit model, this study analyzes the influence of OLI advantages on R&D intensity of foreign firms in Korea. The result shows that locational advantages of Korea (such as revealed technological advantage) had positive influences on foreign firms' R&D intensity. However, the influence of other OLI advantages were different by foreign firms' nationalities. For instance, internalization advantages had influences on R&D intensity, but the directions were different between Japanese and other nationalities. Based on the results, we provided some discussion and attempted to draw implications for Korean government's FDI and R&D policy.

저온 스트레스에 발현이 유도되는 콩의 L-asparaginase 유전자의 분리

박성환,김기영,진량,이재헌,Park, Seong-Whan,Kim, Kee-Young,Chen, Liang,Lee, Jai-Heon 한국식물생명공학회 2002 식물생명공학회지 Vol.29 No.2

Suppression subtractive hybridization (SSH)를 통해 저온에 의해 발현이 유도되는 cDNA들을 분리하였고, 그 중 하나인 slti182는 asparaginase 유전자들과 높은 유사성을 보였다. Slti182의 전체 cDNA인 GmASP1은 1258 bp 길이에 326개 아미노산으로 구성된 긴 Open reading frame (ORF)를 포함하고 있었다. GmASP1 단백질은 애기장대의 putative asparaginase (AB012247)와 84%의 유사성을 보였으나, 애기장대의 다른 isoform(Z34884)와는 55%의 유사성을 나타내었다. GmASP1 유전자는 저온 처리 후 3시간째부터 발현이 유도되어 6시간째에 최대발현을 나타내었고, 이후 점차 감소하여 48시간에는 저온처리전 수준으로 되돌아왔다. 또한, 식물체를 저온에서 48시간 둔 후에 다시 상온으로 옮겼을 때, 정상수준으로 떨어진 GmASP1의 발현이 다시 증가하는 양상을 보였다. 이러한 결과로 볼 때, GmASP1이 저온 스트레스에 반응 초기의 단백질 합성 촉진에 중요한 역할을 할 것으로 사료된다. Suppression subtractive hybridization (SSH) was used to isolate wound-induced cDNAs from wounded soybean. One of low-temperature-inducible cDNA, slti182 showed high homology with genes encoding 1-asparaginase. The full length cDNA of slti182, deginated GmASP1, is 1258 bp long and contains an open reading frame consisted of 326 amino acids. CmASP1 protein showed the highest identity (84%) with putative asparaginase from A. thaliana (AB012247), but it showed only 55% identity with another isoform of A. tathaliana (Z34884). The expression of GmASP1 during low temperature stress started to increase 3 hours after treatment, reached the maximum at 6 hour, and then decreased to the initial level at 48 hours. The amount of GmASP1 transcripts increased again when low-temperature-treated plants were transferred to room temperature, The present study suggests that GmASP1 may function to accelerate the protein synthesis which is important in the early response to low temperature.

한국에서의 시보업무 고찰

박성환,Park, Seong-Hwan 한국과학기술단체총연합회 1976 과학과 기술 Vol.9 No.9

시간은 일상 생활에서 중요한 비중을 차지하고 있다. 천문관측을 기초로하여 시민 생활과 항해항공에 필요한 표준시간의 유지관리 및 경위도를관측하는 시보업무는 천문대에서 중요한 비중을 차지하며 일상 생활과 밀접한 관례가 있다.

EHA의 특징 및 활용분야

박성환,Park, S.H. 유공압건설기계학회 2009 드라이브·컨트롤 Vol.9 No.2

학령전 아동을 대상으로한 유치열기 치주조직의 임상적 연구

박성환,김성조,최점일,Park, S.H.,Kim, Seong-Jo,Choe, Jeom-Il 대한치주과학회 1992 Journal of Periodontal & Implant Science Vol.22 No.2

정보보안문화와 경영진 리더십이 조직 구성원의 정보보안 행동에 미치는 영향

박성환,김범수,박재영,Park, Sunghwan,Kim, Beomsoo,Park, Jaeyoung 한국정보보호학회 2022 정보보호학회논문지 Vol.32 No.2

This research investigates the impacts of information security (IS) culture and management leadership styles on employee's security behaviors (IS policies compliance, IS participation) in financial institutions. This study use the survey data collected from 236 employees of financial institutions. This research shows that IS culture has a positive effect on both behavioral intentions to comply with IS policies and the intentions to actively participate in information security activities. Transactional leadership has a positive impact on the IS policies compliance intentions and to participate in information security activities. In contrast, transformational leadership has a positive impact on the intentions to participate in information security activities, but not on the IS policies compliance intentions.