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우유무기질을 첨가하여 제조한 칼슘 강화 요구르트의 품질 특성
박동준,오세종,임지영,Park, Dong June,Oh, Sejong,Imm, Jee-Young 한국낙농식품응용생물학회 2022 Journal of Dairy Science and Biotechnology (JMSB) Vol.40 No.2
This study was conducted to evaluate the potential use of milk mineral (MM) as the calcium source for the production of calcium-fortified yogurt. MM was composed of 83% minerals, 7.5% lactose, 3.3% protein, and < 1% fat. Calcium (Ca) content in MM was about 46%; calcium: phosphorous ratio was 1.28:1. The aqueous solubility of Ca increased with the decrease in pH; the solubility at pH 4 and 5 was 98% and 53%, respectively. Ca-fortified yogurt with up to 200 mg Ca/100 mL did not show significant differences in acid production and number of viable cells; however, the viscosity increased significantly (p<0.05) with the increase in Ca levels. Microstructure analysis of Ca-fortified yogurt using confocal scanning laser microscopy indicated that the protein network became denser with increasing fortification with MM. There was no significant difference in the sensory quality between the control and Ca-fortified yogurts. Therefore, MM could be used for the production of Ca-fortified yoghurt without compromising the quality characteristics of yogurt.
흰쥐 대뇌세포의 저산소증 모델에서 석창포(石菖浦 Acori graminei rhizoma. AGR)에 의한 유전자 표현 변화의 microarray 분석
박동준,정승현,문일수,이원철,신길조,Park, Dong-Jun,Jung, Seung-Hyun,Moon, Il-Soo,Lee, Won-Chol,Shin, Gil-Jo 한국생명과학회 2007 생명과학회지 Vol.17 No.1
Acori graminei Rhizomn (AGR) is a perennial herb which has been used clinically as a traditional oriental medicine against stroke, Alzheimer's disease, and vascular dementia. We investigated the effect of AGR on the modulation of gene expression profile in a hypoxic model of cultured rat cortical cells. Rat cerebrocortical cells were grown in Neurobasal medium. On DIV12, cells were treated with AGR $(10ug/m\ell)$, given a hypoxic shock (2% $O_2$, 3 hr) on DIV14, and total RNAs were prepared one day after shock. Microarray analyses indicated that the expression levels of most genes were altered within the global M values +0.5 and -0.5, i.e., 40% increase or decrease. There were 750 genes which were upregulated by < global M +0,2, while 700 genes were downregulated by > global M -0.2. The overall profile of gene expression suggests that AGR suppresses apoptosis (upregulation of anti-apopotic genes such as TEGT, TIEG, Dad, p53, and downregulation of pro-apopotic genes such as DAPK, caspase 2, pdcd8), ROS (upregulation of RARa, AhR), and that AGR has neurotrophic effects (upregulation of Aktl, Akt2). These results provide a platform for investigation of the molecular mechanism of the effect of AGR in neuroprotection.
박동준,Park Dong-Joon 한국통계학회 2006 응용통계연구 Vol.19 No.2
SAS의 PROC MIXED를 사용하면 일반적인 ANOVA 추정량뿐만 아니라 더 많은 장점을 갖는 제한최대우도추정법 또는 최대우도추정법으로 모수들을 추론할 수 있다. 혼합모형에 속하는 불균형중첩오차구조를 갖는 선형회귀모형에서 랜덤효과와 관련된 그룹간 분산의 신뢰 구간과 고정효과에 해당되는 회귀 계수들에 대 한 신뢰구간을 구하기 위하여 세 가지 크기를 갖는 표본에 대하여 PROC MIXED를 사용하였다. 모의실험을 실행한 결과, 대표본인 경우에는 모수들의 신뢰 구간을 구하기 위하여 PROC MIXED를 활용할 수 있지만, 소표본인 경우에는 PROC MIXED를 사용할 경우, 그룹간 분산의 신뢰 구간과 회귀계수 가운데 절편항의 신뢰구간은 주어진 신뢰계수를 지키지 못하는 것을 보인다. PROC MIXED in SAS can be utilized to make inferences on parameters in a mixed model by use of Restricted Maximum Likelihood Estimation Method or Maximum Likelihood Estimation Method which has more merits than ANOVA method. A regression model with unbalanced nested error structure that belongs to a mixed model is used to construct confidence intervals on variances among groups, within groups, and regression coefficients in the model. PROC MIXED is applied to three different sample sizes for simulation. As a result of the simulation study, PROC MIXED generates confidence intervals on parameters that maintain the stated confidence coefficient in a large sample size. However, it does not generate confidence intervals that maintain the stated confidence coefficient for variance components among groups and intercept in a small sample size.