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유방암세포 성장과 Bmi-1 발현에 대한 레스베라트롤의 억제 효과
박현주(Hyun-Joo Park),박광제(Kwang Je Bak),옥창엽(Chang Youp Ok),장혜옥(Hye-Ock Jang),배문경(Moon-Kyoung Bae),배수경(Soo-Kyung Bae) 한국생물공학회 2017 KSBB Journal Vol.32 No.3
Resveratrol has been actively investigated as an anticancer drug since it induces cell growth inhibition and apoptosis in many cancer cells. Resveratrol acts through modulation of multiple pathways and genes. In this study, we found resveratrol reduced cell growth and mammosphere formation in MDA-MB-231 triple-negative human breast cancer cells. This suppressive effect of resveratrol is accompanied by a reduction in Bmi-1 gene expression. We also observed that knockdown of Bmi-1 gene by small interfering RNA effectively sensitizes breast cancer cells to resveratrol treatment. Our data demonstrate, for the first time, that resveratrol down-regulates Bmi-1 expression in human breast cancer cells and suggest that specific molecular targeting of Bmi-1 can be combined with a chemotherapeutic strategy to improve the response of breast cancer cells to resveratrol.
이경재(Kyung-Jae Lee),문윤근(Yun-Keun Mun),김창용(Chang-Yong Kim),박광제(Kwang-Je Park),김동윤(Dong-Yoon Kim),김영권(Young-Kwon Kim),배재학(Jae-Hak J. Bae) 한국정보과학회 2000 한국정보과학회 학술발표논문집 Vol.27 No.1B
본 논문에서는 학교 본연의 업무인 교수학습 활동을 효과적으로 지원할 수 있는 교육 정보화 방안을 모색하였다. 이를 위해, 기업에서 적용되고 있는 학습조직의 지향점과 제 7차 교육과정의 지향점을 비교하였다. 이를 토대로, 학교의 본원적 활동을 정보기술로써 어떻게 지원할 것인가를 제시하였다.
이성규(Lee, Seong-Gyu),문태헌(Moon, Tae-Heon),박광제(Park, Kwang-Je) 한국주거환경학회 2010 주거환경(한국주거환경학회논문집) Vol.8 No.2
This study aims to analyse the situation of apartment management system and suggest improvement strategies. In Korea, rapid industrialization and economic growth had caused population concentration into urban area, which led to a housing shortage. In order to cope with this problem, government established and promoted housing supply policy like two million housing units plan in 1990's. Though mass supply of apartments could lessen the housing shortage problem, but this proliferation of apartments resulted in management problems. Considering these, this study tried to find several solutions and suggest policy directions for the effective apartment management. As research method, questionnaire survey was conducted in case study city, Jinju City, from Oct. 12th to Nov. 10th, 2009. In order to compare the opinions, the questionnaire was distributed separatedly to apartment managers and residents. According to analysis, apartment management system is not systemized yet and there are still frequent conflicts between apartment managers and residents. Thus many cases in questionnaire pointed out that management system must be flexible to meet the challenges ahead. However, the most important thing is to have good dialogue among residents, management and relevant authorities from local government. Moreover the establishment and amendment of Housing Law and introducing a mediation committee, education and fostering specialized personnels in college program were also suggested.