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일 도시 시설노인들과 지역노인들의 건강관련 삶의 질 비교
박경수,서용길,남해성,손석준,이정애,Park, Kyeong-Soo,Seo, Yong-Gil,Nam, Hae-Sung,Sohn, Seok-Joon,Rhee, Jung-Ae 대한예방의학회 1998 예방의학회지 Vol.31 No.2
The purpose of this study is to compare the level of health-related quality of life and relating factor between institutional elderly and community living elderly. The subjects were 390 from Sanatorium or Nursing home and 467 from the community in Kwangju. The results are followed : 1) A comparison of ADL between two groups, institutional elderly and community living elderly, resulted in that community elderly were more significantly independent in the areas of bathing and transfer than institutional elderly. 2) A comparison of IADL between two groups resulted in that : Community elderly were more independent in the areas of using telephone and transportation, food preparation, house keeping, and doing laundry. Institutional elderly were more independent in the area of handling finances. 3) In the case of poor health-related quality of life, institutional elderly showed 2.4 times in the dimension of physical fitness, 1.8 times in daily activity, 2 times in social activity, 2 times in pain, 26.7 times in social support, and 0.4 times in subjective quality of life higher than community elderly There was no significant differences in the rest of dimensions. 4) In institutional elderly, the analysis of variables related to the health-related quality of life resulted in that; The relating factors were sex, education, and chronic illness in the dimension of physical function. Direct contact with family or significant others in the dimension of social activity. Chronic illness in the dimension of pain and perceived health status. Direct or indirect contact with family or significant others over the phone or through letters in the dimension of social support. 5) The analysis of variables related to the health-related quality of life showed that community elderly has more relating variables in each area than institutional elderly. The relating factors were age, sex, and chronic illness in the dimension of physical function. Education and chronic illness in the dimension of emotional status. Age and chronic illness in the dimension of daily activity and social activity Education and chronic illness in the dimension of pain and perceived health status. Sex, education, family size in the dimension of social support. Education and chronic illness in the dimension of subjective quality-of-life. Throughout general daily activity, community elderly showed more satisfactory results than institutional elderly, but in the subjective area of health-related quality of life, such as subjective quality of life, institutional elderly group showed more positive results. And community elderly had more relating factors than institutional elderly. For the health care of the elderly that focused on quality of life, new approaches considering the characteristics of both group, institutional and community living elderly, are needed.
Multiple Low Dose Streptozotocin으로 유도된 당뇨 흰쥐에서 백삼, 홍삼, 화기삼의 항당뇨 활성 비교
박경수(Kyeong Soo Park),고성권(Sung Kwon Ko),정성현(Sung Hyun Chung) 고려인삼학회 2003 Journal of Ginseng Research Vol.27 No.2
This study was designed to compare the antidiabetic activities between Ginseng Radix Alba (GRA), Ginseng Radix Rubra (GRR) and Panax Quinquefoli Radix (PQR) in multiple low dose (MLD) streptozotocin (STZ) (20 mg/kg i.p injection for 5 days) induced diabetic rats. In the glucose tolerance test, 500 mg/kg of each ginseng ethanol extract was administered intraperitoneally 30 min before glucose challenge. While GRA failed to lower blood glucose level, GRR and PQR both significantly prevented the hyperglycemia when compared with the control group. In the MLD STZ-induced<br/> diabetic rats, 300 mg/kg of each ginseng ethanol extract was administered intraperitoneally for 2 weeks. Plasma glucose<br/> and insulin levels were markedly improved in all treatment groups. While GRR showed the highest antidiabetic activity, and GRA and PQR revealed somewhat equipotent antidiabetic activities, but less than that in GRR-treated group as far as blood parameters and diabetic symptoms such as polyphagia and polydipsia are concerned. Blood glucose levels were closely associated with plasma insulin levels, and this result may suggest that ginseng ethanol extracts showed the activity to enhance insulin secretion as well as preventing destruction of pancreatic islet cells. To elucidate the relationship between antidiabetic activity and ginsenoside profiles, seven major ginsenosides were quantified by HPLC. We figured out the fact that protopanaxatriol (PPT): proptopanaxadiol (PPD) ratio might play an important role in its hypoglycemia<br/> effects.
Multiple Low Dose Streptozotocin으로 유도된 당뇨 흰쥐에서 투여 시기에 따른 인삼의 항당뇨 활성 비교
박경수(Kyeong Soo Park),이동억(Dong Eok Lee),성종환(Jong Hwan Sung),정성현(Sung Hyun Chung) 고려인삼학회 2002 Journal of Ginseng Research Vol.26 No.4
In this study, we like to examine whether Panax ginseng water extract (PGWE) exerts antidiabetic activities in prevention and treatment modes in multiple low dose (MLD) streptozotocin (STZ) (20 mg/kg i.p injection for 5 days) induced diabetic SD rats. In the prevention mode, 150 mg/kg of GRWE was administered intraperitoneally with STZ for 3 weeks, and this group is called CO150. In the treatment mode, we started to administer the same dose of PGWE on day 8 and for 3 weeks, and this group is called POST150. PGWE exerted significant hypoglycemic activities in both prevention (normal control, 97±6 mg/dl; diabetic control, 331±23; CO150, 211±37) and treatment groups (normal control,128±4 mg/dl; diabetic control, 392±33; POST150, 263±44). Of great importance is the fact that plasma insulin levels in both groups were markedly increased as compared to the diabetic control (normal control, 428.7±62.1 pg/dl; diabetic control, 167.0±91.7; CO150, 377.6±68.7 in prevention mode, and in treatment mode normal control 417.9±<br/> 84.6 pg/dl; diabetic control, 166.1±104.7; POST150, 315.2±47.4). Blood glucose levels were closely associated with plasma insulin levels, and this result may suggest that PGWE showed the activity to enhance insulin secretion as well as preventing destruction of pancreatic islet cells. Food and water intakes were also determined at the last week of treatment in both groups. Characteristic symptoms of diabetes were significantly improved in both groups. In the prevention mode, water intake (ml/rat/day) in normal control was increased from 30.6±1.5 to 122.2±3.4 in diabetic control rats. In the CO150-treated group, water intake was dramatically reduced to 68.3±4.4 (p<0.001 vs. diabetic control). In the treatment mode, POST-treated group also reduced the water intake from 128.9±2.2 to 113.3±1.7. Taken together, our data suggest<br/> that PGWE showed comparable antidiabetic activities in prevention and treatment modes. Therefore, PGWE may have a potential as a prophylactic as well as therapeutic agent for type 2 diabetes mellitus (T2DM).
박경수 ( Kyeong Soo Park ),박원 ( Won Park ),송정수 ( Jung Soo Song ),배성권 ( Sung Kwon Bae ),이용한 ( Yong Whan Lee ),이돈 ( Don Lee ),최승원 ( Seung Won Choi ) 대한류마티스학회 1999 대한류마티스학회지 Vol.6 No.4
Pyoderma gangrenosum may be associated with underlying systemic diseases. The most frequently associated condition is inflammatory bowel disease. Other associations include chronic active and chronic persistent hepatitis, rheumatoid arthritis, leukemia, myeloma, ployarthritis, monoclonal gammopathy, myeloproliferative disorders, systemic lupus erythromatosus and Behcet`s disease. Multiple extensive pyoderma gangrenosum associated with Behcet`s disease has rarely been reported in Korea. Thus, we report a case of multiple pyoderma gangrenosums occurring as pathergy phenomenon at intravenous and intramuscular injection sites in a patient with Behcet`s disease.
박요섭,박경수,나백주,남해성,신준호,손석준,최진수,김병우,Park, Yo-Seop,Park, Kyeong-Soo,Na, Baeg-Ju,Nam, Hae-Sung,Shin, Jun-Ho,Shon, Seok-Joon,Choi, Jin-Su,Kim, Byong-Woo 대한예방의학회 1997 Journal of Preventive Medicine and Public Health Vol.30 No.3
In other to study relationship of anxiety and serum cholesterol in general population, we performed the interview survey and screening test for the Ju-am cohort and residents in controlling area at 1995. Among them, 622 people are selected for this analysis. The results were summarized as follows. 1. Anxiety and total serum cholesterol related each other in the group of anxiety. Correlation coefficient was 0.39(p<0.01). 2. According to the result of multiple regression that the total serum cholesterol regarded as the dependent variable, anxiety and total serum cholesterol were related each other positively in the group of anxiety(p<0.05). 3. As the symptoms of anxiety was dichotomized affective and somatic symptom. There was no relationship of 2 symptoms and total serum cholesterol in all subjects, but there was more relationship on the affective symptom than on the somatic symptom in the group of anxiety(p<0.05). The above results show that anxiety and total serum cholesterol related each other significantly in the anxiety group. And the relationship of psychological factors and serum cholesterol could be applied significantly in general population as well as in the special group.
일부 농촌지역 사망신고자료에 기재된 사인에 관한 연구 -사망신고사인과 조사사인의 비교-
남해성,박경수,선병환,신준호,손석준,최진수,김병우,Nam, Hae-Sung,Park, Kyeong-Soo,Sun, Byeong-Hwan,Shin, Jun-Ho,Sohn, Seok-Joon,Choi, Jin-Su,Kim, Byong-Woo 대한예방의학회 1996 예방의학회지 Vol.29 No.2
This study was conducted to evaluate the accuracy of the official death registry in rural area. The base data used for the study was 379 deaths registered during the period of 1993 and 1994 in 4 rural townships of Chonnam province. The interview survey for cause-of-death was performed on the next of kin and/or neighbor. Additional medical informations were collected from hospitals and medical insurance associations for the purpose of verification. The underlying cause-of-death of 278 cases presumed by the survey was compared to the cause on official death registry. There was a prominent disagreement of cause-of-death between the survey data and the registry data(agreement rate: $38.9\sim44.6%$, according to disease classification method). These results may be caused by extremely low rates of physicians' certification, which were mostly confined to the poisoning and injury. Symptoms, signs, and ill defined conditions on death registry could be classified into circulatory disease(32.3%), neoplasm(21.2%), digestive disease(7.1%), injury and poisoning(7.1%) and so on. These results suggest that careful attention and verification be required on utilization of death registry data in rural area.
Diethylhexyl Phthalate 처치후 건양단이 정자 생성능 및 운동성에 미치는 영향 연구
남창욱,박경수,마진열,Nam, Chang-Uk,Park, Kyeong-Soo,Ma, Jin-Yeul 한국한의학연구원 2006 한국한의학연구원논문집 Vol.12 No.1
We treated KunYangDan (KYK) in SD rats in order toexamine the protective effect against cell damage induced by diethylhexyl phthalate (DEHP). KYD reduced DEHP toxicity by increasing the function of immune cell numbers weight increase of spleen.red blood cells,HB,and HCT content,sperm number and mobility,resulting in improving reproductive function by judging from the recovery of testosterone content. Interestingly the hormone change of testosterone by KYD significantly recovered the decreased its leve. Taken together,these results suggest that KYD specifically affect the reproductive function induced by DEHP,an endocrine disruptor.