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문승욱(Seung Wook Moon),장영동(Yurng Dong Jahng),서병천(Byeong Chon Seoh) 대한약학회 1992 약학회지 Vol.36 No.1
2-Substituted benzimdazoles were prepared by reaction o-phenylenediamine with acid chlorides, which has advantages over the known synthetic procedures. The compounds prepared Showed no significant antiinflammatory activity, thus are of no interest as antiinflammatory agents.
HMG-CoA환원효소의 저해제로서 2-치환-벤즈이미다졸 유도체의 합성
문승욱(Seung Wook Moon),장영동(Young Dong Jahng) 대한약학회 1993 약학회지 Vol.37 No.1
Designed system, in which the beta-hydroxy-delta-lactone moiety is connected to benzimdazole ring by ethylene bridge, was propared from 2-sustd. benzimidazole as a potential HMG-COA reductase inhibitor.
2-(o,m,p)-Chlorophenylureido-6-methyl, ethylcarboxy-benzothiazole 類의 合成과 그 抗菌力에 關한 硏究
李萬佶,閔庚鎭,文勝煜 嶺南大學校附設 基礎科學硏究所 1982 基礎科學硏究 Vol.2 No.-
Twelve new benzothiazolyl-and N-6-carbomethoxy, ethoxybenzothiazolyl-N'-phenylureas have been synthesized by reacting 2-aminobenzothiazole and 2-amino-6-carbomethoxy, ethoxybenzothiazole with three or four phenyl and chlorophenyl isocyanate, respectively. The structures of these compounds were determined by the elementary analysis, UV spectrophotometry, NMR and IR spectrophotometry. Antimicrobial activities of the synthesized compounds were, in vitro, examined against Escherichia coli APCC 25922, Shigella flexneri NIH, Salmonella typhi H 901, Staphylococcus aureus APCC 65389 and Sarciana lutea APCC 9341. The compounds generally exhibited antibacterial activity against Gram negative bacteria in concentration of 500mcg/㎖. The compounds containing carbomethoxy group exhibited stronger antibacterial activity than those containing carboethoxy group against Salmonella typhi. The compounds containing m-chlorophenyl groups, on the whole, exhibited more potent growth-inhibitory activity against Shigllea flexneri and Salmonella typhi.
문승욱,장영동,서병천 영남대학교 약품개발연구소 1992 영남대학교 약품개발연구소 연구업적집 Vol.2 No.-
2-Substituted benzimdazoles were prepared by reacting o-phenylenediamine with acid chlorides, which has advantages over the known synthetic procedures. The compounds prepared showed no significant antiinflammatory activity, thus are of no interest as antiinflammatory agents.
HMG-Co환원효소의 저해제로서 2-치환-벤즈이미다졸 유도체의 합성
문승욱,장영동 영남대학교 약품개발연구소 1993 영남대학교 약품개발연구소 연구업적집 Vol.3 No.-
Designed system, in which the β-hydroxy-δ-lactone moiety is connected to benzimda-zole ring by ethylene bridge, was propared from 2-sustd. benzimidazole as a potential HMG-CoA reductase inhibitor.