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흰쥐에서 Adriamycin - 유발 신독성에 대한 Thromboxane A2 수용체 길항제인 KT2-962 의 효과
문삼영(Sam Young Moon),이순복(Soon Bok Lee),신현진(Hyun Jin Shin),고현철(Hyun Chul Koh),엄애선(Ae Son Om),강주섭(Ju Seop Kang) 한국응용약물학회 2000 Biomolecules & Therapeutics(구 응용약물학회지) Vol.8 No.3
The present study was designed to assess the protective effect of a selective thromboxane A₂ receptor antagonist, KT2-962 (KT2) and possible mechanisms of adriamycin(AD)-induced nephrotoxicity in rats. The male Wistar rats were given either of AD (7.5 mg/kg, i.v.) alone in the AD-group (n=5) or in KT2+ADgroup (n=5) which is a combination of AD and KT2 (30 mg/kg/day, i.p.) for 10 days from 3 days before and 7 days after AD injection. The body weight, 24-hours urine volume, urine protein and urinary N-acetyl-β-D-glucosaminidase (NAG) activity were measured with an interval of 2 days during 1 week. BUN, serum creatinine and creatinine clearance were measured on the 7th day. KT2 has significantly suppressed AD-induced change of body weight, 24-hours urine volume, urine protein and urinary NAG activity in the KT2+AD-group. The change of BUN, serum creatinine and creatinine clearance were significantly inhibited in the KT2+AD-group. Based on these results, it is concluded that KT2 prevents AD-induced nephrotoxicity and suggests that endogenous thromboxane A2 may play an important role in AD-induced nephrotoxicity in rats.
흰쥐에서 심혈관 조절기전에 대한 척수의 Adenosine A2 수용체의 역할
문삼영(Sam Young Moon),신현진(Hyun Jin Shin),신인철(In Chul Shin),고현철(Hyun Chul Koh),엄애선(Ae Son Om),박정로(Jung Ro Park),김범수(Bum Soo Kim),강주섭(Ju Seop Kang) 한국응용약물학회 2000 Biomolecules & Therapeutics(구 응용약물학회지) Vol.8 No.4
The present study was designed to assess the role of spinal adenosine A2 receptor in the regulation of cardiovascular functions such as mean arterial pressure (MAP) and heart rate (HR) in male Sprague-Dawley rats. Rats (250∼300 g) were anesthetized with urethane and paralyzed with d-tubocurarine and artificially ventilated. blood pressure and HR were continuously monitored via a femoral catheter connected to a pressure transducer and a polygraph. Drugs were administered intrathecally using injection cannula through guide cannula which was inserted inthrathecally at lower thoracic level through a puncture of an atlantooccipital membrane. Intrathecal injection of an adenosine A₂ receptor agonist, 5`-(N-cyclopropyl)-carboxamaidoadenosine (CPCA; 1, 2 and 3 nmol, respectively), produced a dose-dependent decrease in MAP and HR. Pretreatment with N^G-nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase inhibitor or 10 nmol of MDL-12,330, an adenylate cyclase inhibitor blocked significantly the depressor and bradycardic effect of 2 nmol of CPCA. But, Pretreatment with 3 nmol of bicuculline, gamma-aminobutyric acid A (GABA_A) receptor antagonist, or 50 nmol of 5-aminovaleric acid, GABA_B receptor antagonist did not inhibit the depressor and bradycardic effect of 2 nmol of CPCA. These results indicate that adenosine A₂ receptor in the spinal cord plays an inhibitory role in the regulation of cardiovascular function and that the depressor and bradycardic action of adenosine A₂ receptor are mediated via the synthesis of nitric oxide and the activation of adenylate cyclase in the spinal cord of rats.
저탄소 녹색성장을 위한 공군 친환경 경제운전 교육사례 및 효과 분석
정병호,박삼영,우맹호,이상문 대한교통학회 2012 교통 기술과 정책 Vol.9 No.1
지난 100년간 세계 기온은 0.74°C 상승하였으 며, 그 상승 속도는 날로 증가하여 금세기 말에는 6.4°C가 상승할 것으로 예상된다. 지구온난화와 관련한 기후변화는 지구촌을 심각하게 위협하고 있으며, 국제적 위기상황을 반영하듯 세계는 ‘녹색 성장’이라는 주제에 국가적 역량을 집중하고 있다. 이러한 국제적 위기상황을 공동대처하기 위해 1992년에 유엔 기후변화협약(UNFCC)이 체결 된 이후, 국가간 이행 협약인 교토의정서가 정식 으로 발효되면서 온실가스 감축은 선택이 아닌 의 무가 되었다. 이에 주요 선진국들은 투자지원, 세 금 감면 등의 혜택을 통해 친환경 차량 및 바이오 연료 개발과 같은 환경친화적 신기술 개발을 장려 하는 한편, 첨단기술을 활용한 교통관리방안과 직⋅간접적으로 통행혼잡에 의한 환경적, 경제적 외부 발생비용을 부담하도록 하여 수요자체를 감 소시키는 정책도 병행하여 추진하고 있다.