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김영재,김희종,김은화,송은섭,김문중,김귀완,한기옥,류영근,유제윤 대한내과학회 1991 대한내과학회지 Vol.41 No.5
Rifampicin is a widely used drug for the treatment of mycobacterium tuberculosis infections. This drug, among others, is a potent inducer of the hepatic mixed oxygenase enzymes involved in drug metabolism. Therefore, the effects of drugs or hormones metabolized by liver enzymes may be influenced by rifampicin administration. Thus, concurrent treatment of rifampicin and the glucocorticoid hormone can lead to decreased bioavailability of the glucocorticoid hormone and to icreased requirement. With a brief review of the literature, we report a case of rifampicin-induced adrenal crisis, in which the patient received a physiologic maintenance dose of prednisolone and rifampicin.