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        간내담관암의 임상적 고찰

        김규환(Gyu Hwan Kim),표지수(Ji Soo Pyo),김양욱(Yang Ook Kim),류승환(Seung Hwan Ryoo),이상혁(Sang Hyuk Lee),설상영(Sang Yong Seol),정정명(Jung Myung Chung),최하진(Ha Jin Choi) 대한내과학회 1995 대한내과학회지 Vol.48 No.6

        N/A Objectives: Because it is difficult to differentiate the intrahepatic bile duct carcinoma from hepatocellular carcinoma by the general clinical features and the post-operative survival rate of intrahepatic bile duct carcinoma may he better than the one of hepatocellular carcinoma, we studied the clinical characteristics of the intrahepatic bile duct carcinoma. Methods: We studied 41 patients with intrahepatic bile duct carcinoma diagnosed by untrasonoguided liver biopsy or operation from January 1990 to December 1993 at our hospital. Results. 1) 178 patients were diagnosed as hepatocellular carcinoma with the ratio to intrahepatic bile duct carcinoma of 4.3:1 and the number of patients with extrahepatic bile duct carcinoma is 44 with the ratio to intrahepatic bile duct carcinoma of 1.1: 1 in the same duration. 2) Of the 41 cases, the peak incidence was in 6th decade and the average age was 58.8 years. The male to female ratio was 3.1: l. 3) Abdominal pain was the most common complaint on admission(75.6%). For the duration from symptom onset to admission, the most common duration was less than 1 month(48.8%) and hepatomegaly was the most common physical finding(51.2%). 4) On the laboratory findings, leukocytosis was seen in 25 cases(61.0 %). AST was elevated in 20 cases(48.8 %) and ALT was elevated in 12 cases(29.3). 5) The Clonorchiasis was the most commonly associated disease(34.1%). AFP was elevated in 12.8%, CEA and CA19-9 also were elevated in 57.1% and 78.3% respectively. 6) Abdominal ultrasonography showed hyperechogenicity in 13 cases(31.7%), isoechagenicity in 9 cases(22.0%), and hypoechogenicity in 19 cases(46.3 %). Celiac angiography showed hypervascularity in one case out of seven cases(14.3%). 7) Of the 41 cases, the mean survival was 6.3 months and the longest survival was 31 months, The mean survival of 14 casess with surgery was 9 months. Conclusion: If the curative resection of intrahepatic bile duct carcinoma is performed in more early clinical course with the above characteristics, the better prognosis would be expected.

      • 젊은 성인에게서 발생한 담낭선종 1례

        류승환,김인호,오경석,이상혁,설상영,정정명,최하진,최영길,한상석 인제대학교 1995 仁濟醫學 Vol.16 No.1

        담낭 선종의 빈도는 드물지만 악성변이의 가능성을 가지고 있다. 저자들은 젊은 성인에게서 초음파로 진단된 다양한 크기(0.3-2.5cm)의 담낭용종을 악성종양으로 의심하여 외과적 절제술을 시행한 결과 악성의 증거가 없었던 담낭선종 1례를 경험하였기에 이에 보고하는 바이다. Gall bladder adenoma is very rare, but it has possibility of malignant transformation. We had experienced a case of large gall bladder adenoma in young adult, iris finding was multiple variable sized(0.3-2.5cm), fixed echogenic density without sonic shadow in ultra sonogram. Because it had been highly suspected malignancy, surgical intervention was done. Postoperative microscopic finding shows compact glandular structure intervening delicate fibrous stroma, and there is no evidence of malignant characteristics such as stromal invasion or anaplasia. So, we report one case of large gall bladder adenoma treated by surgical intervention.

      • 뇌정맥 혈전증과 습관성 자연유산이 각각 합병된 발작성 야간 혈색소뇨증 2례

        김인호,류승환,김규환,조길현,김호철,손창학 인제대학교 1995 仁濟醫學 Vol.16 No.4

        발작성 야간 혈색소뇨증은 후천성 만성 용혈성 혈액질환으로서 다양한 임상 경과를 취하므로 진단이 늦어지거나 다른 질환으로 진단되는 경우가 많으며, 혈전증은 치명적인 합병증이다. 저자들은 뇌정맥 혈전증과 습관성 자연유산 후 2번의 자궁내 태아사망이 합병된 발작성 야간 혈색소뇨증 2례를 경험하였기에 보고하는 바이다. Paroxysmal nocturnal hemoglobinuria(PNH) is an uncommon acquired clonal disorder characterized by sensitive populations of erythrocytes, granulocytes, and platelets with increased susceptibility to complement-mediated lysis. Thrombosis, as complication of PNH, are common in the extremities, mesentery, portal system, or the cerebral venous system. Cerebral thrombosis is a major cause of death in patient with PNH, but only a few cases have been reported. Pregnancy in patient with PNH has been reported to have increased frequency of miscarriage, spontaneous abortion, hemolytic crisis, worsening of bone marrow aplasia and deep vein thrombosis. We report two cases of PNH complicated with cerebral thrombosis or spontaneous abortion. The first case is 21-year-old female who developed cerebral venous thrombosis during clinical follow-up. The second case is 36-year-old female who was admitted because of iron deficiency anemia with 5 times repeated spontaneous abortion.

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