Depressive Symptoms and Quality of Life in Age-related Macular Degeneration Based on Korea National Health and Nutrition Examination Survey (KNHANES)

류소정,이원준,Leslie Bishop Tarver,신용운,강민호,성민철,조희윤 대한안과학회 2017 Korean Journal of Ophthalmology Vol.31 No.5

Purpose: This study was conducted to investigate the depressive symptoms and quality of life (QOL) in patientswith age-related macular degeneration (AMD) using data obtained from the Korea National Health and NutritionalExamination Survey V-2 (KNHANES V-2) conducted in 2011. Methods: This was a population-based, cross-sectional study that selected 329 participants from the fifth KNHANES(2011) who were diagnosed with AMD by an ophthalmologist based on fundus photography. The prevalenceof depressive symptoms and the health-related QOL (using EuroQol indices) in this cohort were alsoestimated. Factors associated with depressive symptoms, including socioeconomic status, QOL indices, andassociated chronic diseases, were investigated using multivariate regression models. Results: Depressive symptoms were observed more frequently in AMD patients than in non-AMD controls (p= 0.013). Among the total 329 AMD participants, 65 (19.8%) had depressive symptoms. There were 16 males(24.6%) and 49 females (75.4%). Upon multivariate analysis, significant factors found to be associated with depressivesymptoms were female gender (odds ratio [OR], 2.082; 95% confidence interval [CI], 1.001 to 4.330),being in the “dependent” group for activities of daily living (OR, 4.638; 95% CI, 2.061 to 10.435), and having“some problems” in the “anxiety-depression” dimension of the EQ-5D (OR, 7.704; 95% CI, 1.890 to 31.408). Conclusions: Female gender and being dependent on others for activities of daily living increased the associationof depressive symptoms in this cohort of AMD participants. Screening for depressive symptoms in EastAsian AMD patients with these characteristics should be an important component of their care.

유리체강 내 약물주입술이 각막내피세포에 미치는 영향

류소정(So Jung Ryu),신용운(Yong Un Shin),강민호(Min Ho Kang),성민철(Min cheol Seong),조희윤(Hee Yoon Cho) 대한안과학회 2017 대한안과학회지 Vol.58 No.4

목적: 유리체강 내 약물주입술에 사용되는 다양한 약물이 각막내피세포에 미치는 영향을 알아보고자 하였다. 대상과 방법: 2016년 2월부터 2016년 10월까지 본원 안과에서 유리체강 내 주사 치료를 받은 환자 113명 118안(나이관련황반변성 61 안, 당뇨황반부종 40안, 망막정맥폐쇄에 동반된 황반부종 16안, 포도막염 1안)을 대상으로 주사 전후 중심각막내피세포의 변화 및 중심각막두께를 비접촉 경면현미경을 이용하여 후향적으로 분석하였다. 유리체강 내 주입한 약물(베바시주맙 21안, 라니비주맙 20안, 아플리버셉트 47안, 덱사메타손 이식제 30안), 수정체안과 위수정체안, 1회 주입안과 2회 이상 주입안으로 나누어 주사 전후 중심각막 내피세포 및 중심각막두께의 변화를 비교하였다. 결과: 전체 환자군에서 중심각막내피세포수는 술 전 2,693.2 ± 298.2 cells/mm2, 술 후 1개월에 2,686.8 ± 288.7 cells/mm2로 주사 전후의 차이가 통계적으로 유의하지 않았다(p = 0.731). 약물 종류에 따라 군을 나누었을 때, 네 군 모두에서 주사 전후의 중심각막내피세포수는 통계적으로 유의한 차이가 없었다. 수정체안에서 술 전 2,611.7 ± 470.2 cells/mm2에서 술 후 1개월에 2,480.0 ± 436.4 cells/mm2로, 위수정체안에서 술 전 2,778.0 ± 149.3 cells/mm2에서 술 후 2,608.2 ± 334.8 cells/mm2로 다소 감소하는 경향을 보였으나 두 군 모두 통계적으로 유의하지는 않았다. 결론: 본 연구에서는 유리체강 내 약물주입술이 중심각막내피세포 및 중심각막두께에 통계적으로 유의한 변화를 가져오지 않아, 각막 내피세포를 손상시킨다는 증거를 찾지 못하였다. Purpose: To evaluate the effect of intravitreal injection on the corneal endothelium according to the injected drug. Methods: The present study included 118 eyes of 113 patients who received intravitreal injection. Before each injection and 1 month after the injection, specular microscopy was performed to evaluate the corneal endothelial changes and central corneal thickness. We classified the patients according to the injected drug (bevacizumab 21 eyes, ranibizumab 20 eyes, aflibercept 47 eyes, dexamathasone implant 30 eyes), phakic or pseudophakic eyes, single or multiple injections and analyzed them retrospectively. Results: The mean corneal endothelial cell density was 2,693.2 ± 298.2 cells/mm2 before injection and 2,686.8 ± 288.7 cells/mm2 1 month after injection, and there was no statistically significant difference (p = 0.731). According to the kind of drug, the mean corneal endothelial cell density and central corneal thickness were not significantly different before and 1 month after injection in any of the 4 groups. Conclusions: There were no significant changes in corneal endothelium before and 1 month after intravitreal injection of the various drugs.

SNS 빅데이터의 상대 유사도를 반영한 감성 분석 시스템 설계

김봄(Bom Kim),류소정(Sojeong Ryu),오현주(Hyunju Oh),정윤영(Yoonyoung Jeong),김세진(Sejin Kim),김윤희(Yoonhee Kim) 한국정보과학회 2019 한국정보과학회 학술발표논문집 Vol.2019 No.6

HLA-B27 연관 앞포도막염의 형광안저혈관조영술 소견과 포도막염 재발과의 관련성

이종섭(Jong Sub Lee),류소정(So Jung Ryu),이병로(Byung Ro Lee),안성준(Seong Joon Ahn) 대한안과학회 2021 대한안과학회지 Vol.62 No.10

목적: HLA-B27 연관 앞포도막염의 형광안저혈관조영술 소견과 재발의 관련성을 연구하였다. 대상과 방법: 최초로 진단 받고 치료를 시작한 HLA-B27 연관 앞포도막염 환자 중 형광안저혈관조영술을 시행한 56명(56안)의 의무기록을 후항적으로 검토하였다. 형광안저혈관조영술상 시신경유두누출, 주변부혈관누출 유무와 초진 시 전방염증의 정도, 1년 내 재발과의 관련성, 재발까지의 시기에 영향을 미치는 요인과의 연관성에 대해 분석하였다. 결과: 총 56명(56안)의 환자 중 시신경유두누출이 발견된 경우는 23명(41.1%), 주변부혈관누출이 발견된 경우는 36명(64.3%)이었다. 시신경유두누출(p=0.841) 혹은 주변부혈관누출(p=0.775)과 전방염증의 정도는 유의한 관계를 보이지 않았다. 시신경유두누출이 있는 군의 1년 내 재발은 14명(60.9%), 없는 군의 1년 내 재발은 11명(33.3%)으로 두 군은 유의한 차이를 보였다(p=0.041). 반면 주변부혈관누출이 있는 군의 1년 내 재발은 19명(52.8%), 없는 군의 1년 내 재발은 8명(40.0%)으로 유의한 차이를 보이지 않았다(p=0.602). 하지만 첫 재발까지의 기간에 대해 나이(p=0.772), 전방염증 정도(p=0.841), 시신경유두누출(p=0.108), 전신 스테로이드 사용 여부(p=0.321)는 유의한 상관관계를 보이지 않았다. 결론: HLA-B27 연관 앞포도막염에서 형광안저혈관조영술상 누출과 1년 내 재발 여부 및 재발까지의 기간 사이의 관계를 확인하였다. 시신경유두누출이 있는 경우 1년간 면밀한 경과 관찰을 통해 재발 여부를 확인해야 할 것으로 생각된다. Purpose: To evaluate the associations of fluorescein angiographic findings with recurrence of human leukocyte antigen (HLA)-B27-associated anterior uveitis. Methods: Medical records of 56 eyes of 56 patients with first-onset, treatment-naive HLA-B27-associated anterior uveitis who performed fluorescein angiography was analyzed. We recorded the fluorescein angiographic findings of optic disc and peripheral vascular leakage and anterior chamber inflammation at the first visit. The 1-year recurrences and times to the first recurrences and the associations between them were investigated. Results: Fluorescein angiography revealed optic disc leakage in 23 patients (41.1%) and peripheral vascular leakage in 36 (64.3%). We found no significant association between the anterior chamber inflammation grade and either optic disc (p = 0.841) or peripheral vascular (p = 0.775) leakage. The 1-year recurrence rate in the optic disc leakage-positive group was significantly higher than in the leakage-negative group (14 patients, 60.9% vs. 11 patients, 33.3%) (p = 0.041), but peripheral vascular leakage status did not significantly affect the recurrence rate (19 leakage-positive patients, 52.8% vs. 8 leakage-negative patients, 40.0%) (p = 0.602). The time to first recurrence was not significantly associated with age (p = 0.772), anterior chamber inflammation (p = 0.841), optic disc leakage (p = 0.108), or systemic corticosteroid use (p = 0.321). Conclusions: We sought correlations between angiographic leakage in patients with HLA-B27-associated anterior uveitis, and the 1-year recurrence rate and the time to first recurrence. Careful follow-up for at least 1 year after initial diagnosis is essential to monitor possible recurrence in patients with optic disc leakage. J Korean Ophthalmol Soc 2021;62(10):1364-1369

항응고제 복용 중 발생한 자발성 맥락막상강 출혈

김지홍(Ji Hong Kim),류소정(So Jung Ryu),강민호(Min Ho Kang),성민철(Mincheol Seong),조희윤(Hee Yoon Cho),신용운(Yong Un Shin) 대한검안학회 2017 Annals of optometry and contact lens Vol.16 No.2

Purpose: To report a case of spontaneous suprachoroidal hemorrhage which occurred in case of a patient taking anticoagulant drug. Case summary: A 73-year-old male patient who was hospitalized because of being scheduled to have ileus surgery was requested to ophthalmologic department for joint treatment, since he emergently complained of sudden decrease of visual acuity and ocular pain. He had surgical history of small bowel resection about 5 months ago due to peritonitis caused by acute mesenteric artery occlusion and was currently in the process of periodic taking anticoagulant medication. According to the result from a medical examination by means of ocular ultrasonogram, massive suprachoroidal hemorrhage could be observed. In spite of cessation of anticoagulant medication and conservative treatment’s being exclusively continued, since the patient flatly rejected sorts of surgical treatment, suprachoroidal hemorrhage significantly decreased and his symptoms came right. Conclusion: Spontaneous suprachoroidal hemorrhage is primary to be regarded with suspicion especially when the patient who is elderly and in the middle of taking anticoagulant medication complains sudden plummeting of visual acuity accompanied by ocular pain. There is no necessity that the patients fallen in spontaneous suprachoroidal hemorrhage should exclusively take surgical treatment. Rather than surgical treatment, being treated with solely cessation of anticoagulant medication is hypothesized to be sufficiently effective way to alleviate the symptoms of suprachoroidal hemorrhage.

이미지 딥러닝을 통한 컨텐츠와 관련 반응 동영상의 감정 분석 시스템 설계

정윤영(Yoonyoung Jeong),김봄(Bom Kim),류소정(Sojeong Ryu),권나현(Nahyun Kwon),손규진(Gyujin Son),이소정(Sojeong Lee),김윤희(Yoonhee Kim) 한국정보과학회 2019 한국정보과학회 학술발표논문집 Vol.2019 No.12

Youtube 동영상 광고 댓글을 통한 광고 효과 분석 서비스 설계

김세진(Sejin Kim),김지은(Jieun Kim),성원영(Wonyoung Seong),김봄(Bom Kim),류소정(Sojeong Ryu),이은아(Euna Lee),이지윤(Jeeyoon Lee),정윤영(Yoonyoung Jeong),김윤희(YoonHee Kim) 한국정보과학회 2018 한국정보과학회 학술발표논문집 Vol.2018 No.12