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      • KCI등재후보

        성인 급성 백혈병 환자의 항암화학요법 유발 오심 구토(chemotherapy-induced nausea and vomiting) 예방에 있어서 granisetron transdermal system patch제의 효과 분석

        두고은,한재은,은명온,이영희,박준성 한국병원약사회 2014 병원약사회지 Vol.31 No.1

        Background : Granisetron transdermal system patch offers convenient non-invasiveoption and could enable continuous antiemetic effects during multi-day chemotherapy for acuteleukemia patients. This study compare the effect and costs of granisetron transdermal systempatch with ramosetron treatment for control chemotherapy-induced nausea and vomiting. Methods : From January 2011 to September 2013, one-hundred fifty acute leukemia patientswere prescribed with antiemetic prophylaxis granisetron transdermal system patch andramosetron. These patients were classified into granisetron group(n=82) and ramosetrongroup(n=68) and the effect and costs of each group were evaluated. Results : Total response was achieved by 51.2% of granisetron group and 45.6% of ramosetrongroup, but the difference not statistically significant(p=0.492). The first emetic episode occurred median Day1(1-9) granisetron group and median Day3(1-7) ramosetron group including patientswith failure to emetic control. Conclusions : ranisetron transdermal system patch offers reliable antiemetic effect and preferabledosing for patients receiving multi-day chemotherapy with acute leukemia, and close dosingcontrol pharmacist is to achieve higher response.

      • KCI등재

        의료기관 의약품 부작용 발생 공유 및 중재, 약물안전카드 발급시스템 현황 조사

        두고은,석정연,조윤숙,조윤희,강래영,김현지,진현정,박소영,최민정,서영은,문보경,최지홍,강민규,강민경,민미나,김우경,강균화,이경은,김수진,이재천,김윤희,김홍태,유기동,서윤이,이경운,손현아,이영희,아영미,이주연 한국병원약사회 2022 병원약사회지 Vol.39 No.3

        Background : This study aimed to investigate the current status of adverse drug event (ADE) history sharing, intervention, and drug safety card issue system in medical institutions. Methods : A total of 126 member hospitals of the Korean Society of Health-System Pharmacists (response rate 25.9%) participated in this survey. Results : The survey results showed that 87.3% of the respondents had an ADE report system and most of them assessed causality (83.9%) and severity/seriousness (67.8%). About 85.6% of hospitals had a clinical alert or information system for prescriptions related to previous ADE history. Hard stop, soft stop, and passive alerts (information only) were generated in 11.0%, 38.1%, and 62.7% of the respondent hospitals, respectively. The criteria for generating alerts were mostly based on causality or severity/seriousness. Among hospitals with an ADE report system, 41.5% had a system issuing drug safety cards (Adverse drug reactions card, ADRs card). Among hospitals issuing ADR cards, 71.4% and 51.0% used causality and severity/seriousness assessment on the decision to issue, respectively. Frequent drug classes for which ADR cards were issued were contrast agents, antibiotics, and non-steroidal anti-inflammatory drugs. Identified barriers to implementing the ADR card issue system were the absence of standard guidelines, lack of awareness, and shortage of manpower. Conclusion : ADE report system was well established in 87% of respondent hospitals but around 40% of them had a system for issuing ADR cards. To extend the issuance and use of ADR cards, it is necessary to develop a standard procedure for recording, reporting ADRs, and issuing ADR cards.

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