산부인과 환자에 있어서 정신건강에 관한 연구

노홍태,권선호 대한산부인과학회 1986 Obstetrics & Gynecology Science Vol.29 No.1

인삼이 항암제 투여 환자의 부작용에 미치는 임상적 연구

노홍태,이윤이,최영배,박현정 최신의학사 1992 最新醫學 Vol.35 No.2

자궁경부암 선별검사로서의 세포진 검사와 경부확대촬영술 병용의 유용성

노홍태,이석수 대한부인종양 콜포스코피학회 1999 Journal of Gynecologic Oncology Vol.10 No.1

Cervicography is used commonly in cervical cancer screening with a Pap smear. Many reports shows that the combination of these two methods is more accurate and helpful in cervical cancer screening. Objective: The purpose of this investigation was to evaluate the efficacy of conjoined methods in cervical cancer screening and to evaluate any difference between health care center and out-patient treatment. Methods: Pap smear and cervicogram data were obtained for 699 patients who visited the Department of Obstetrics and Gynecology, Chungnam National University Hospital from January 1997 to December 1997. Of these patients, 551 patients visited the health care center and 148 were out-patients. We exmined all pertinent information, including biopsy results, for patients with detected abnormalities. A total of 62 patients received a biopsy. Results: 1. Results for Papanicolaou smear were: sensitivity, 81.8%, specificity, 98.0%, positive predictive value, 83.7%, negative predictive value, 98.8%, false negative rate, 18.2%, and false positive rate, 2.0%. 2. Results for cervicography were: sensitivity, 86.4%, specificity, 97.8%, positive predictive value, 73.1%, negative predictive value, 99,1%, false negative rate, 13.6%, and false positive rate, 2.2%. 3. Results for the conjoined method were: sensitivity, 97.7%, specificity, 97.2%, positive predictive value, 70.5%, negative predictive value, 99.8%, false negative rate, 2,3%, and false positive rate, 2.8%. 4. When cervicography and Papanicolaou smear were used conjointly The sensitivity, specificity, negative predictive value, false negative rate, and false positive rate were statistically significant for Papanicolaou smear (P$lt;0.05). 5. There was no statistical significance difference between cervicography and the conjoined method. 6. Compared with out-patients, Health care center patients showed increased diagnostic error and failure to follow-up. Conclusion: When cervicography and Papanicolaou smear were used conjointly, cervical cancer detection rates were increased.

일반연제 발표 : 산부인과 환자에서의 Ureaplasma Urealyticum에 관한 연구

노홍태,양희찬,최대경 대한산부인과학회 1986 대한산부인과학회 학술대회 Vol.58 No.-

부인과 종양 환자의 진단에서 동결절편의 정확성

노홍태(Heung Tae Noh),이창환(Chang Hwan Lee),김진(Jin Kim) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.12

N/A Objective: Frozen-section evaluation of gynecologic tumors has historically been used to establish a histopatholgic diagnosis and to guide surgeons in appropriate surgical procedure. this study is to assess the clinical appropriation and accuracy of frozen-section biopsy in gynecologic tumors. Methods: This is a retrospective quality assurance study all of frozen-section biopsy done at Chungnam National University Hospital during a three year period (1995 to 1997). There were 125 cases out of 2310 surgical specimens for gynecologic tumors, and the results were compared with final diagnoses based on fixed tissue specimens. Results: Frozen section biopsy was accurate in 95.2% of all cases, in 96.3% (104/108) of ovarian tumor cases, and in 88.2% (15/17) of uterine tumor cases. Analysis of 6 inaccuracy cases revealed that most cases were sampling errors and occurred in mucinous tumor, belonging to all cases of ovarian tumors. Sensitivity, specificity, positive predictive value, and negative predictive value of frozen-section biopsy in ovarian tumors were 0.94, 1.00, 1,00, 0.97. Conclusion: Frozen section biopsy is an appropriate method as a basic guideline during operations of gynecologic tumors and this method can obtains the highest accuracy when there is cooperation between experienced surgeons and reliable and careful pathologists. The accuracy of frozen section diagnosis has important implications regarding the type and extent of the primary surgery for gynecologic tumors.

자궁경부종양과 Apoptosis 와의 상관 관계

노홍태(Heung Tae Noh),이창환(Chang Hwan Lee) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.2

N/A Objective: The kinetic indices of apoptosis and cell proliferation m a histopathologic spectrum of the cervical neoplasia were evaluated to clarify the correlation between cervical neoplasm and apoplasis. Specific lesioas included cervical intraepithelial neoplasia(CIN), catcinoma in situ(CIS), and invasive carcinama. Methods: Archival samples from normal cervical epithelium(n=7), low-grade squamous intraepithelial lesions(LGSIL, n=17), high-grade squamous intraepithelial lesions(HGSIL, n=17), invasive squamaus carcinoma(n=7) were evaluated for apoptosis and cell proliferation. Apoptotic cells were identified with terminal deoxynucleotidyl transferase-labeling of the 3'-OH end of DNA nucleosomes, and then apoptotic index(A.I sum of apoptotic bodies/ 1000 tumor cells) and total cell count(* 400 magnification) were calculated. Results: In normal squamous epitheliam, Apoptotic bodies were mainly localized in ial layers, for low-grade squamous intraepithelial lesions(HGSIL) in superficial and intermediated layers, for high-pade squamous intraepithelial lesions(HGSIL) in intermediated and parabasal layers, for invasive carcinoma in full thic of squamous epithelium. Apototic indces(AI) in invasive carcinoma(mean: 6.21) were significantly higher than indices for high-grade squamous intraepithelial lesions(HGSIL, mean: 0.98) and high-grade squamous intraepithelial lesions(HGSIL, mean: 0.98) were significantly higher than indices for low-grade squamous intraepithelial lesions(LGSIL, mean: 0.12)(p<0.01), the total cell counts increased significantly as the specimens progressed toward invasive disease. (p<0.01) Conclusion: Apoptosis in cervical neoplasia appears to be closely related to poliferation and progression of the cervical squamous epithelial cell. This phenotype may allow identification of premalignant lesions with the potential to transform to cervical cancer.

내배엽동(內胚葉洞) 종양(Endodermal Sinus Tumor)

권선호,노홍태 대한산부인과학회 1986 대한산부인과학회 학술대회 Vol.58 No.-

자궁근종 환자에 있어서 GnRH Agonist의 피료 효과

최재성,노홍태,임상혁 대한부인종양 콜포스코피학회 1996 Journal of Gynecologic Oncology Vol.7 No.4

Fifteen women with symptomatic uterine myomas, diagnosed by clinical examination and confirmed by pelvic ultrasonography, were treated with intranasal insufflation of Nafarelin acetate, 200 micrograms, twice a day, for a total treatment period of 6 months. Treatment was evaluated with respect to subjective symptoms, changes in myoma size and uterine volume, variations in blood estradiol, FSH, LH and CA 125, and side effects. The following results were obtained: 1. All patients showed a marked reduction(p$lt;0.001) in uterine volume. Before treatment volume measured 312.3+-24.2cm3, after 12 weeks volume was 132.4+-40.6cm3, and after 24 weeks it was 123.6+-48.3cm3. 2. Blood estradiol and LH levels were decreased significantly(p$lt;0.05) after treatment. The FSH level was decreased, but not significantly. 3. Blood CA 125 levels were increased 6 cases(40.0%) before treatment. The levels were normalized in all 6 cases after treatment. 4. Symptoms of uterine myoma disappeared or decreased. 5. Minor side effects, such as hot flushes, headache, general myalgia and fatigue, and vaginal dryness were encountered frequently although none necessitating discontinuation of treatment, These data suggest that Nafarelin acetate is useful for the treatment of uterine myoma. However, appropriate indications should be selected in the treatment of uterine myoma because the possible regrowth of uterine myoma after treatment limits the use of GnRH agonist.

부인과암에서 P-Glycoprotein 발현에 관한 면역조직화학적 연구

손영선,노홍태,류춘수,이오성 대한부인종양 콜포스코피학회 1997 Journal of Gynecologic Oncology Vol.8 No.1

The expression of P-glycoprotein in gynecological tissues was studied by immunohi-stochemical staining methods. Aspects of study included the expression of P-glycoprotein in different tissues throughout the clinical treatment regimen, the relationship between the expression of P-glycoprotein and the degree of pathologic malignancy, and the expression of P-glycoprotein in cancerous tissue before and after chemotherapy. Studies were based on patients who were admitted to the Department of Obstetrics and Gynecology of Chungnam National University Hospital from January 1988 to December 1993. Tissue samples collected prior to chemotherapy included 34 ovarian cancers, 73 cervical cancers, and ll endometrial cancers. Pre and post-chemotherapy tissue samples included 11 ovarian cancers and 15 cervical cancers. Normal tissue samples included 12 from the ovaries, 15 from the cervix, and 10 from the endometrium. Result are as follows : 1. P-glycoprotein was mainly found in the cytoplasm of both normal tissue cells and cells of tissuess prior to chemotherapy. After chemotherapy it was found more intensely in the cell membrane than in the cytoplasm. 2. For normal tissue, P-glycoprotein was found in 25% of ovarian tissues, 33.3% of uterine cervical tissues, and 40.0% of endometrial tissues. 3. For canverous tissues prior to chemotherapy, P-glycoprotein was found in 45.5% of ovarian cancer cases, 47.9% of uterine cervical cancer cases, and 45.5% of endometrial cancer cases. There was no stastically meaningful difference in these rates in cancerous normal tissues. 4. The expression of P-glycoprotein in cancerous tissues prior to chemotherapy was not related to histologic type. 5. For ovarian cancer tissue, P-glycoprotein was expressed in 45.5% of cases prior to chemotherapy, and 54.4% of cases subsequent to chemotherapy. For uterine cervical cancer tissue, P-glycoprotein expression rates before and after chemotherapy was 46.7% and 60.0% respectively and there was a statistically meaningful difference(p$lt;0.05) 6. There was no relationship between P-glycoprotein expression in cancer tissues after chermotherapy and the presense of cisplatin in chemotherapeutic drugs. 7. For uterine cervical cancer tissues prior to chemotherapy, there was no relationship between the degree histologic differentation and the expression of P-glycoprotein 8. For cancerous tissues there was no relationship between clinical stage and the expression of P-glycoprotein In conclusion, the expression of P-glycoprotein was identified in the tissues before the drug exposure. However, there was no relationship between the expression of P-glycoprotein and histologic type, clinical stage, and effectiveness of chemotherapy. This may be related to P-glycoprotein inducing a cellular resistance to chemotherapeutic agents, although the importance of this resitance is thought to be small. Futher studies of P-glycoprotein are needed to delineate its role in cellular anticancer drug resistance.

일반연제 발표 : 일부도시지역 여성의 월경에 관한 연구

권선호,노홍태 대한산부인과학회 1986 대한산부인과학회 학술대회 Vol.58 No.-