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저골수 충실성 급성 골수성 백혈병의 치료방침 화학 요법과 골수이식
김영균(Young Kyoon Kim),노진탁(Jin Tark Nho),박은영(Eun Young Park),한치화(Chi Wha Han),박종원(Chong Won Park),김춘추(Choon Choo Kim),김동집(Dong Jip Kim),한경자(Kyung Ja Han),김원일(Won Il Kim) 대한내과학회 1988 대한내과학회지 Vol.35 No.6
N/A There have been a few repots of acute myelogenous leukemia (AML) presenting hypocellular bone marrow. Most physicians are reluctant to give these patients intensive chemotherapy because of the potential risk of serious bone marrow failure. We experienced 10 patients with hypocellular AML (HAML) that could be difined by the criteria of 30% or more atypical blasts and 50% or less cellularity in the bone marrow. There were six men and four women and their ages ranged from 20 to 67 years. Various regimens including low dose ara-C alone (4 cases) and low dose ara-C with modified TAD (1case), with mitoxanthrone (1 case) or with mithramycin (1 case) were applied. Of the remaming three patlents; one received supportive care only, another mithramycin alone and the third allogeneic bone marrow transplantation. As a result, the three cases who received either allogeneic bone marrow transplantation or low dose ara-C with modified TAD or that with mitoxanthrone entered into complete remission. However, only the patient who received allogeneic bone marrow transplantation is still alive. The duration of survival ranged from 2 months to 18 months; the median was 8 months. One of the most common complications during chemotherapy was severe bone marrow suppression and the major cause of death was various severe infections during the pancytopenic period. Though the most favorable therapy for HAML is still controversial, bone marrow transplantation is considered to be the choice of treatment at the present time for young patients with HLA-identical donors. If bone marrow transplantation is not available, a more aggressive form of therapy in addition to low dose ara-C will be preferable.
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최상욱,박성학,정진우,김부성,박두호,이창돈,김주철,노진탁 대한내과학회 1987 대한내과학회지 Vol.34 No.1
Caroli's disease was first described by Caroli in 195S French literature. The character of this disease entity is diffuse cystic, saccular dilatation of the intrahepatic bile ducts. Recently we experienced a case of Caroli's disease associated with renal tubular ectasia in a 16-year-old man. The diagnosis was performed by ERCP and I.V. P. So, we report the case with review of the related literature.
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윤건호,김철민,박동준,구완서,심규식,노진탁,강문원 대한감염학회 1988 감염 Vol.20 No.1
We studied the effect of Naproxen as an antipyretic agent of fever in malignancies, autoimmune disease and infectious diseases for the differentiation of causes for fever. 1) 8 out of 13 malignancies showed complete response (61.8%) and 4 showed partial response (30.7%). 2) 3 out of 6 other disease (autoimmune diseases 4 angioimmunoblastic lymph adenopathy 2) showed complete response (50%) and 2 showed partial response (33.3%). 3) Only 1 out of 13 infectious disease showed complete response (7.7%) and 10 showed no response (76.9%). 4) The complete response rate in malignancies showed statistically higher than that in infectious disease (p<0.005). The complete response rate in malignancies showed statistically higher than that in infectious disease (p<0.05). The complete response rate in malignancies was slightly higher than that in other disease, but there was no statistical difference between in both group (p>0.1). These results suggested that Naproxen was an effective antipyretic in patients with cancer. It may be useful as a means of differentiating fever secondary to malignancy from that due to infection.
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