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        정신분열병 입원 환자에서의 대사 증후군 유병률 연구

        노재우,조연수,조애화,Roh, Jae-Woo,Cho, Yeon-Soo,Cho, Ae-Hwa 대한생물정신의학회 2011 생물정신의학 Vol.18 No.1

        Objectives : The objective of this study is to assess the prevalence and risk factors of metabolic syndrome (MS) among inpatients with schizophrenia, and to compare with general population. Methods : Nine hundreds seventy inpatients were included to assess the prevalence of MS from two mental hospitals in Yong-in city. Assessment of MS was performed based on modified American Heart Association criteria with abdominal obesity threshold of 90cm for men, 85cm for women. Comparative analysis was performed using age- and gender matched sample from Korea Health and Nutritional Examination Survey III. For evaluating risk factors, analysis included 766 inpatients taking consistent medications at least for 30 days. Results : The prevalence of MS of inpatients with schizophrenia was 26.2%, in females it was 33.2%, compared to 20.2% in males(p < 0.001). Compared to general population, the prevalence of MS was significantly lower in male and higher in female patients. In terms of criteria prevalence, who met abdominal circumference criterion were more prevalent in patient group(p < 0.001). After multivariate analysis, female gender and old age remained as risk factors of MS. Conclusions : The prevalence of MS of inpatients with schizophrenia was 26.2% and significantly low compared to general population. Female gender and old age were risk factors of MS.

      • KCI등재

        일 정신병원에서의 알코올의존 입원 환자의 재발 방지 약물 처방 경향

        조연수(Yeon-Soo Cho),한은선(Eun-Seun Han),노재우(Jae-Woo Roh) 한국중독정신의학회 2011 중독정신의학 Vol.15 No.2

        Objectives : This study aimed to identify the prescription rates and prescribing patterns of relapse prevention medications for patients with alcohol dependence in an actual clinical field. Methods : In the present retrospective chart, we reviewed 109 in-patients with alcohol dependence in 2007 and 2008 ; and also carried out comparative analysis between the treatment group, who received anticraving medications and the group without the medications, with respect to their demographic and clinical characteristics and short-term treatment outcomes after hospital treatment. Results : Anticraving medications were prescribed to 36.7% of the patients at the time of day of discharge of the index admission and amongst them only 25% continued the medica-tion for more than a month after getting discharged. There was a tendency of higher prescription rate of benzodiazepine than anticraving medication and other medications such as hypnotics were also prescribed considerably. Anticraving medication group had significantly less number of admissions and shorter total period of admissions before index admission. The group also significantly exhibited more tendencies to participate in the CBT program than those without anticraving medications. The medication group took significantly more time for re-admission after discharge. Conclusions : This is the first study to provide details on the prescribing patterns of anticraving medications in Korea. There would be a need for further prospective studies to help motivate implementation of these medications.

      • KCI등재

        Lamotrigine과 Aripiprazole을 투여한 환자에서 발생한 과민성 반응 1예

        노재우,박혜진,강웅구 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.4

        We described a case of a 30-year-o1d female patient with bipolar disorder who experienced the anticonvulsant hypersensitivity syndrome (AHS) during treatment with lamotrigine and aripiprazole. She developed fever (38.4℃), leukopenia, skin rash, and elevated serum transaminase levels on the llth day of lamotrigine treatment (20th day of aripiprazole). Hypersensitivity to lamotrigine was suspected ; lamotrigine was discontinued and prednisolone (30mg/day) was administered to the patient. The clinical manifestations and laboratory findings showed improvement. However, on the llth day of lamotrigine discontinuation (7th day of prednisolone treatment), she developed maculopapular skin rash over the entire body except the mucosa. There were no other symptoms and the laboratory findings were within normal limits. Skin biopsy showed erythema multiforme. After prescribing 55 mg/day of predisolone for additional 8 days, the recovery was uneventful, and it took 4 weeks from the onset of the second skin rash. Lamotrigine induced AHS showed broad spectrum of presentation and some manifestations can be flared up several days after discontinuation as did in this case. If unexplained systemic symptoms or a skin rash of unknown cause develop during the use of lamotrigine, clinicians should discontinue lamotrigine promptly and monitor the patient carefully at least for several weeks.

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