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- 저자 : 노영석 ( Sang Jin Kwon (검색결과 3 건)
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권상진,박찬금,노영석 ( Sang Jin Kwon,Chan Kum Park,Young Suck Ro ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.3
Angiomatoid fibrous histiocytoma(AFH) is a rare cutaneous tumor showing distinctive clinical and histological features. It occurs as a slowly growing nodular or cystic mass of the dermis or subcutis, on the extremities of children and young adults. One of the most characteristic histological features is the presence of irregular blood-filled cystic spaces. The histogenesis of AFH is still controversial, with histiocytes, fibroblasts and endothelial cells all having been proposed as the main proliferating cell. A twenty-year-old woman was seen for a nodular lesion on the right forearm of 1 yeat duration. Initially, the lesion was asymptomatic and had recently increased slightly in size. The excisional biopsy specimen showed a relatively well circumscribed tumor mass in the dermis and subcutis. There were large blood-filled cystic spaces and areas of hemorrhage in addition to the solid sheets of fibroblast-like and histiocyte-like cells. Xanthoma cells, siderophages and Touton type giant cells were also present. On immunohistochemistry, most of the tumor cells strongly expressed histiocyte markers, although some of the tumor cells showed positive reactions for smooth muscle actin, muscle specific actin, desmin, and factor Ⅷ-associated antigen.
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선상 태선과 편평 태선의 면역조직화학적 소견에 대한 비교 연구
노영석,권상진 한양대학교 의과대학 2000 한양의대 학술지 Vol.20 No.1
Lichen striatus(LS) is an uncommon linear eruption characterized by discrete, flat-topped lichenoid papules resembling lichen planus(LP). The histologic picture of LS is nonspecific and shows so many remarkable variations that it can be easily misinterpreted. In the present study, we have evaluated the immunohistochemical aspects of 10 cases of LS and 4 cases of LP using paraffin-embedded section to evaluate if they are useful when differentiating LS from LP is difficult in clinically and histopathologically. There was no significant difference of CD4 and CD8 expression between LS and LP. In all cases focal reactivity for HLA-DR was confined to keratinocytes adjacent to the HLA-DR+ dermal lymphoid infiltrates except one case of LS in which HLA-DR was expressed on the surface of keratinocytes in diffuse pattern. There was a marked increase in S-100^- epidermal Langerhans cell in LP rather than LS.
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단순 남성 임균성 요도염에서의 levofloxacin과 ofloxacin의 치료 효과 비교
김재홍,권상진,유희준,노영석 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.4
Ofloxacin의 광학적 L-isomer 활성체로서 광범위한 항균 파장을 가지며 항균 활성이 약 2배로 알려져 있는 levofloxacin의 단순 남성 임균성 요도염에 대한 유용성을 평가하고자 단순 남성 임균성 요도염의 치료 약제로 그 효과가 입증된 ofloxacin을 대조약으로 하여 그 치료 효과를 비교 분석하였다. 1995년 8월부터 1996년 6월까지 요도 배농을 주소로 서울 중구 보건소 성병질료실에 내원한 환자중 요도 분비물의 그람염색이나 임균 배양 검사로 단순 임균성 요도염으로 진단된 환자중 치료 효과를 추적 관찰 할 수 있었던 남자 환자 79명을 대상으로 하여, 이들 환자를 levofloxacin 200㎎ 1회 경구 복용 환자군과 ofloxacin 400㎎ 1회 경구 복용 환자군으로 나누어 치료 효과에 대한 연구를 시행한 결과 이미 알려져 있던 ofloxacin의 임균성 요도염에 대한 효과와 마찬가지로 levofloxacin 200㎎ 1회 경구 복용 치료의 경우에도 단순 남성 임균성 요도염에 우수한 치료 효과를 보였으며, 부작용도 발견되지 않았다. PPNG가 높은 빈도로 발생하고 있는 국내의 현상황에서 levofloxacin은 임균성 요도염의 치료시 1회 복용의 간편함뿐만 아니라 적은 용량 투여로도 우수한 치료 효과를 보이고, 부작용의 발현도 없는 안전하게 추천할 만한 우수한 경구용약제라고 생각된다. Background : The gonococcal urethritis is one of the most widely distributed sexually transmitted disease in the world. Recently, there are needs of new effective antibiotics for the development of the resistant strains of gonococcus. So we evaluated the effect of levofloxacin on uncomplicated male gonococcal urethritis. Methods : According to the random number sheet, we divided the patients into the group A and group B. The group A were treated with a single 200mg oral dose of levofloxacin and the group B with a single 400mg oral dose of ofloxacin. Results : 38 out of 39 patients(97.4%) treated with levofloxacin were successful in the treatment and 39 out of 40 patients(97.5%) treated with ofloxacin. Postgonococcal Urethritis noted in 9 patients(23.1%) from group A, and 10 patients(25.0%) from group B. Conclusion : As a results of this, it is considered that a single dose of 200mg levofloxacin has an excellent effect like a single dose of 400mg ofloxacin for the treatment of the uncomplicated male gonococcal urethritis.
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