인참양영탕(人參養榮湯)이 장기간 고용량 스테로이드 투여 hairless mice의 피부장벽에 미치는 영향

남혜정,김윤범,Nam, Hae-Jeong,Kim, Yoon-Bum 대한한방안이비인후피부과학회 2008 한방안이비인후피부과학회지 Vol.21 No.2

Objective : The side effect of prolonged use of topical corticosteroids to skin is well-known. Moreover, resent studies have shown that prolonged use of systemic corticosteroids also negatively impacts skin barrier function. Corticosteroids have a major role in the practical management of many variable conditions. So, it is important to find the drug or the method which could protect the skin from the damage caused by corticosteroids. At former study, we investigated that Insamyangyoung-tang has some effect on skin barrier function of DNCB induced contact dermatitis hairless mice. So, this study was performed to research the effect of Insamyangyoung-tang on the TEWL with high dose steroid injected hairless mice. Method : Hairless mice were divided into 4 groups ; Control group, Group A, Group B and Group C. All groups were injected triamcinolone O.4mg for 10 times. Control group was medicated distilled water during the experimental period. Group A was medicated distilled water for 5 days before the $1^{st}$ injection day, and then medicated Insamyangyoung-tang extract during the experimental period. Group B was medicated Insamyangyoung-tang extract for 5 days before the $1^{st}$ injection day, and then medicated distilled water during the experimental period. Group C was medicated Insamyangyoung-tang extract for 5 days before the $1^{st}$ injection day, and then medicated Insamyangyoung-tang extract during the experimental period. TEWL of each group was measured for 5 times. After the $10^{th}$ injection, the tissue sample was made and the damage of epithelial cell was examined. Statistical significance was set at p<0.05 by using non parametric methods and repeated-anova.. Results : Group C showed significant effect on TEWL change of hairless mice evoked by triamcinolone injection. Group A and Group B also showed some effect, but there was no statistical significance.

노화와 피부노화에 대한 고찰

남혜정,김윤범,Nam Hae-jeong,Kim Yoon-bum 대한한의진단학회 2004 大韓韓醫診斷學會誌 Vol.17 No.1

In Oriental medicine, aging is just a natural process like change of seasons. Ancient Oriental people accepted it as a natural thing to be growing older and to die at last. The science of aging has advanced dramatically. In the last 2 decades, advances in genetics and molecular biology have led to extraordinary new understandings in how cells age, how apoptosis programs cells to die, and how neuroendocrinology plays a role in the lifespan of organisms. Today, the matter of primary concern about aging is a cellular and mitochondrial damage of human body induced by reactive oxygen species(ROS). The skin aging can be divided into two areas, intrinsic(chronologic)-aging and photo-aging. There are lots of photo damage about skin aging. The skin is increasingly exposed to ultraviolet(UV) irradiation in life. Therefore, the risk of photo-oxidative damage of the skin induced by reactive oxygen species(ROS) has increased substantially. Nowadays, many people believe that they can stop or at least delay the process of aging. There are lots of treatments that promise to slow the process of aging and the associated ailments. Many of these treatments, for example, exercise, Vit E, Vit C therapy, hormone therapy, restrict diet, are gradually being subjected to clinical trials. But in spite of all efforts, researches and investigations, there is no single method or treatment which is revealed to be truly effective for delaying progress of aging. Every methods insisted on effect for delaying aging process, has its dark side. All we can do is just keeping ourself healthy until the time of death.

酒차鼻의 韓方治驗

남혜정,Nam, Hae-Jeong 대한한방안이비인후피부과학회 2002 한방안이비인후피부과학회지 Vol.15 No.2

Persistent facial telangiectasia, erythema and flushing are the major cosmetic problems in patients with rosacea. However various therapeutic modalities for rosacea are not effective. Five patients who had a history of rosacea which poorly controlled by oral and topical medications, were given Herb-medication and Acupuncture treatment. The size of erythema and the number of papules had been gradually decreased and finally all the symptoms were gone except telangiectasia.

태반이 피부장벽에 미치는 영향

남혜정,박외숙,김희정,김규석,차재훈,김윤범,Nam, Hae-Jung,Park, Owe-Suk,Kim, Hee-Jeong,Kim, Keoo-Seok,Cha, Jae-Hoon,Kim, Yoon-Bum 대한한방안이비인후피부과학회 2006 한방안이비인후피부과학회지 Vol.19 No.2

Objectives : This experimental study was performed to investigate the effects of the Hominis placenta extracts on skin barrier. Methods : Male hairless mice, average weight 20g, were divided into two groups, intact and treatment group(paired, n=15). Intact group was not applied YB-301(an ointment including Hominis placenta). Treatment group was applied YB-301(an ointment including Hominis placenta) two times a day for 8 days. We observed skin melanin, skin erythema, skin pH, skin humidity, transepidermal water loss. Statistical analysis was performed by using paired sample T-test. Statistical significance was achieved if the probability was less than 5%(p<0.05) or 1%(p <0.01) Results : 1. YB-301(an ointment including Hominis placenta) showed statistically significant effect on skin melamin, skin pH, skin humidity(p<0.05). 2. YB-301(an ointment including Hominis placenta) showed statistically significant inhibitory effect on transepidermal water loss(p<0.01). 3. YB-301(an ointment including Hominis placenta) showed statistically no significant effect on skin erythema(p<0.05). conclusions : YB-301(an ointment including Hominis placenta) was effective m skin melanin, skin pH, skin humidity, transepidermal water loss in our study, so we suggest that Hominis placenta can be used as a ointment ingredient for strengthening the function of skin barrier.

理中湯과 理中湯加味方의 抗알레르기 效果에 관한 實驗的 硏究

남혜정,채병윤,Nam, Hae-Jeong,Chae, Byung-yoon 대한한방안이비인후피부과학회 2000 한방안이비인후피부과학회지 Vol.13 No.1

Experimental studies were done to research effects of Leejungtang and Leejungtanggamibang on the anti-allergic effects. We studied the vacular permeability response induced by histamine and serotonin, homologous PCA provoked by IgE-like antibody against EWA, contact dermatitis induced by picryl chloride and delayed type hypersensitivity response to SRBC. The results were obtained as follows: 1. In effects of the Leejungtang and Leejungtanggamibang on the vascular permeability responses to intradermal serotonin, the Leejungtang revealed insignificant effect and Leejungtanggamibang revealed significantly inhibitory effect. 2, In effects of the Leejungtang and Leejungtanggamibang on the vascular permeability responses to intradermal histamine, the Leejungtang revealed insignificant effect and Leejungtanggamibang revealed significantly inhibitory effect. 3. In the homologous PCA provoked by IgE-like antibody against white albumin, the Leejungtang revealed insignificant effect and Leejungtanggamibang revealed significantly inhibitory effect. 4. In the delayed type hypersensitivity responses to picryl chloride, the Leejungtang revealed insignificant effect and Leejungtanggamibang revealed significantly inhibitory effect. 5. In the delayed type hypersensitivity responses to sheep red blood cell the Leejungtang revealed insignificant effect and Leejungtanggamibang revealed significantly inhibitory effect.

과루인(瓜蔞仁)이 장기간 고용량 corticosteroid 투여 hairless mouse의 피부장벽에 미치는 영향

남혜정,김규석,김윤범,Nam, Hae-Jeong,Kim, Kyu-Seok,Kim, Yoon-Bum 대한한방안이비인후피부과학회 2008 한방안이비인후피부과학회지 Vol.21 No.3

Objective : Prolonged use of systemic corticosteroids negatively impacts skin barrier function. Corticosteroids have a major role in the practical management of many diseases, so it is necessary to find the drug or supplement which could keep the skin healthy during the systemic corticosteroids therapy. Seed of Trichossnthcs kiiilowii was commonly used for pulmonary disease in traditional Chinese medicine. Many studies have investigated and found that seed of Trichosanthes kirilowii has anti-bacterial, anti-HIV, anti-tumor and immunoregulatory functions. This study was performed to investigate the effect of seed of Trichosmthes kirilowii on the Skin Barrier Method : Triamcinolone 0.4mg was injected male hairless mice for 5 weeks ( 2 times a week, totally 10 times), Just before the first injection, hairless mice were divided into 3 groups; Control ( normal saline medicated group ), GroupA( seed of Trichosuuhes kirilowii qd/day medicated group ) and GroupB( seed of Trichosuuhes kiiilowii bid/day medicated group ), Body weight of all the groups were checked during the experiment, After $10^{th}$ injection, TEWL (Transeidermal water loss) of 3 groups were artificially increased by 9 times tape stripping and the changes of TEWL were checked at before stripping, right after, 2h, 4h, 6h, 24h, 48 and 72h later after stripping, AST, ALT and CBC were also checked. Indeed, stratum corneum of 3 groups were also examined and compared with that of normal hairless mouse. Results : 1. GroupB showed significantly lower body weight among three groups 2, There was no statistical difference at AST, ALT and CBC among three groups 3. GroupB was showed significantly lower TEWL than TEWL of Control at 48h later. 4 GroupB recovered it's TEWL of before tape stripping at 24h later, GroupA recovered that at 48h and Control recovered that at 72h later at the same condition 5. Stratum corneum of GroupA and GroupB were looked almost normal and healthy. On the contrary, stratum corneum of Control was looked thin and unhealthy. Conclusions : Seed of Ttichossnthes kirilowii has some effects on skin barrier function, especially TEWL of high dose corticosteroids injected hairless mouse and the efficacy seemed to be related with the dosage.

頭痛이 主訴인 소아 부비동염 환자의 치험 1例

남혜정,김윤범,Nam, Hae-jeong,Kim, Yoon-bum 대한한방안이비인후피부과학회 2003 한방안이비인후피부과학회지 Vol.16 No.1

Paranasal sinusitis has many different kinds of symptoms ; rhinorrea, cough. post nasal drip. headache, etc. In some cases, patients, mostly adults, had no symptom except headache. We treated a 8-year-old child who only complained headache without any other symptoms related in nasal disease. Her symptoms ; headache, nausea, vomiting and general weakness, showed typical type of disease which were due to phlegm. So we diagnosed her headache as a " Headache due to phlegm". Interestingly, her PNS images were diagnosed as bilateral maxillary sinusitis. After one and a half month treatment with herb-med and Aroma oil, the patient got free from all symptoms and her PNS images showed no abnormality.

만형자(蔓荊子), 시호(柴胡)의 알레르기성 비염에 대한 효과

남혜정,박외숙,김희정,김규석,차재훈,김윤범,Nam, Hae-Jeong,Park, Owe-Suk,Kim, Hee-Jeong,Kim, Keoo-Seok,Cha, Jae-Hoon,Kim, Yoon-Bum 대한한방안이비인후피부과학회 2006 한방안이비인후피부과학회지 Vol.19 No.2

Background and Objectives : In oriental Medicine, there is a concept that herb works only in it's own specific site called 'Guikyung(歸經)'. If two herbs have same effect and different Guikyung, two herbs would work at different site respectively. so we want to prove that whether Guikyung has significance or not in experimentally. Methods : In order to investigate the effects of Victicis Fructus & Bupleuri Radix on the Allergic rhinitis, BALB/c mouse was used. Control and experimental group 1, 2 were induced allergic rhinitis. Experimental group 1 was administered Victicis Fructus for 28 days and group 2 was administerd Bupleuri Radix for same period. WBC, neutrophil, lymphocyte, monocyte, IL-4 and $IFN-{\gamma}$ were measured and histological examination was performed. The statistical significance was examined by Independent Samples T test. Results : 1. WBC, neuoophil, lymphocyte, monocyte, IL-4 and $IFN-{\gamma}$ showed no statistically significant differences in three groups. 2. Histological examination had no differences in three groups. Conclusion: Victicis Fructus & Bupleuri Radix have no effect on allergic rhinitis and the reason is estimated that Guikymg plays a important roll to determine the effect of herb from the viewpoint of oriental medicine.

배당지급 손실기업의 이익의 질에 대한 연구

남혜정(교신저자) ( Hye Jeong Nam ) 한국회계학회 2016 회계학연구 Vol.41 No.2

본 연구는 당기순손실을 보고한 기업을 대상으로 이익의 질이 배당의사결정에 미치는 영향을 검증하였다. 배당의사결정은 기업의 경영성과를 주주들에게 배분하고 미래성과에 대한 긍정적인 정보를 전달하는 점에서 중요한 의사결정 중에 하나이다. 그러나 손실기 업임에도 배당을 지급하는 기업들이 증가하고 있으며, 이들 기업들은 이익기업과 달리 배당의사결정에 있어 상대적인 비용과 혜택이 다를 것이다. 특히 경영성과인 이익이 배당의 사결정에 영향을 미치는 중요 요인임을 감안하면(Lintner 1956), 손실기업은 이익자체보다는 이익의 질이 중요할 것으로 예측된다. 즉, 기업의 현재의 성과가 좋지 않은 상황에서 경영자는 우수한 이익의 질에 대한 확신을 바탕으로 이를 시장에 알리기 위해 배당을 결정할 것으로 예측하였다.본 연구는 2002년부터 2013년까지 손실기업을 대상으로 배당의사결정에 이익의 질이 미치는 영향을 검증하였다. 이익의 질은 Dechow and Dichev(2002)와 Francis etal.(2005)의 발생액모형을 이용하여 발생액의 질을 측정하였으며, 더불어 양의 영업이익더미를 함께 사용하였다. 분석결과, 손실기업에 있어, 발생액의 질이 우수할수록 배당을 지급하는 경향이 높았다. 또한, 양의 영업이익을 보고한 기업일수록 배당을 지급하고 있음을 발견하였다. 이는 손실기업의 경우 이익의 질이 우수한 기업일수록 배당을 통하여 미래성과에 대한 정보를 시장에 전달하고 있음을 알 수 있다. 추가적으로 당기순손실에서 영업이익이 차지하는 비율을 이용한 분석, 영업이익의 지속성에 따른 분석, 전년도 손실여부에 따른분석, 손실크기에 따른 분석, K-IFRS도입 이전기간만을 이용한 분석을 하였으며, 결과는 대체로 일관되게 나타났다. 본 연구는 손실기업의 배당의사결정에 발생액의 질이 영향을 미치고 있다는 실증적인 결과를 제시하였다는 점에서 의의가 있다. 특히 손실기업의 비중이 증가하고, 배당행태에 대한 투자자들의 관심이 높아지는 상황에서 본 연구의 결과는 손실기업의 배당의사결정에 대한 이해도를 높이고, 투자자뿐만 아니라 잠재적인 투자자인 자본시장 참여자들에게 유용한 정보를 제공할 것이다. 또한 손실기업에 대한 연구가 미미한 상황에서 본 연구의 결과는 손실기업에 대한 관련 연구에도 유용한 정보를 제공할 것이며, 손실기업에 대하여 관심을 가지고 있는 학계 및 유관기관에게도 중요한 시사점을 제공할 것으로 기대된다. This paper examines the effect of earnings quality on dividend payments of loss firms. Decision on dividend payout is one of the important business decisions in terms of signaling about a firm’s future performance and distributing a firm’s performance to shareholders. However. even loss firms that report a negative earnings pay dividend to shareholders and the number of loss firms with dividend payout increases over time. When it comes to the costs and benefits of dividend payout, loss firms have different incentives compared to profit firms. Taking on the notion that a firm’s positive earnings is the main factor of dividend payout(Lintner 1956) into consideration, earnings itself does not a main factor for loss firm. This paper expects that earnings quality rather than earnings itself is a influential factor for loss firm in dividend policy. Joo and Plesko(2004) documents that the effect of dividend signaling is greater for loss firms with negative cash flow than loss firms with positive cash flow. Skinner and Soltes(2011) reports a positive relationship between the portion of special items on loss and dividend payout, suggesting that temporary loss is not a signal to stop dividend payout. According to prior studies, loss firms that have a incentive to signal a firm’s internal information are more likely to pay dividend and their bad performances are relatively temporary. To test the effect of earnings quality on dividend payments of loss firms, we use 5,128 observations from 2002 to 2013 in Korean Stock Market. The hypothesis of this paper is to test the effect of earnings quality on dividend payout of loss firms. We predict that loss firms with high earnings quality are more likely to pay dividend. Earnings quality is measured by accruals quality from Dechow and Dichev(2002) and Francis et al.(2005)’s model. Accruals quality is a standard deviation from each model and denote AQ1 from DD‘s model and AQ2 from Francis et al.(2005). We use accruals quality as a proxy for earnings quality because accruals volatility is a superior proxy among other proxies such as persistence, smoothness, predictability, and so on in accruals accounting (Francis et al. 2005). We also use a dummy variable that 1 if a firm reports a positive operating income, otherwise 0. This proxy may capture whether loss firms with a positive operating income are more likely to pay dividend or not. Even though a firm reports a negative earnings, when earnings from regular and usual activities are positive, the firm expects that this negative earning does not persist and then decides dividend payout. We find that loss firms with high accruals quality are more like to pay dividend compared to loss firms with low accruals quality. And firms with positive operating income are more likely to pay dividend. These findings suggest that even firms report a negative earnings, firms with high level of earnings quality tend to pay dividend and signal a firm’s future performance. As robustness tests, we perform analyses with alternative variable of operating income and observations with pre-K-IFRS(Korea adopted International Financial Reporting Standards) adoption. We also examine the effect of level of negative earnings and find that the group with high level of negative earnings and high earnings quality are more likely to pay dividend while the group with low level of negative earnings and high earnings quality are less likely to pay dividend. In sum, our results indicate that earnings quality is one of the important factors in dividend payout of loss firms. Take into consideration that there is little study about loss firms and the proportion of loss firm in the economy increases, this paper contributes to the understanding of the dividend decision of loss firms. And the findings of this paper contribute to the literature on dividend and loss firms by providing empirical results. The findings of this paper also provide an important implication and valuable insights for accounting researchers, practitioners, and regulators who are interested in business decision of loss firms. This study is subject to certain limitations, Although the analyses reported in this study controls many variables that affect dividend payout, it is possible that omitted variables that we are not considered may exist. However, this problem is inevitable in empirical studies. Future studies may wish to consider this issue in more detail.

상장여부 및 감사인 규모가 회계정보의 질적 특성에 미치는 영향 -중소기업을 대상으로-

남혜정 ( Hye Jeong Nam ) 한국회계학회 2010 회계저널 Vol.19 No.3