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제산제와 항궤양제 복합제제의 In Vitro 및 In Vivo 제산력 평가
김종국,안혜진,정은주,오경희,나운용,Kim, Chong-Kook,Ahn, Hye-Jin,Jeong, Eun-Joo,Oh, Kyung-Hee,Lah, Woon-Lyong 한국약제학회 1993 Journal of Pharmaceutical Investigation Vol.23 No.4
The combined products of antacid and anti-ulcer agent were prepared with antacid composed of aluminium hydroxide dried gel, magnesium hydroxide and simethicone with a ratio of 1:1:0.1 (M) and anti-ulcer agent, aceglutamide aluminium (AGA). The efficacy of antacid was evaluated in vitro with Fuchs, Johnson-Duncan and Rosset-Rice methods and in vivo using an aspiration method in rat. The addition of anti-ulcer agent did not affect the neutralizing capacity of M significantly. The combined products with the M/AGA ratios of 2.3:1 and 3.4:1 produced the maximum pH of $4.0{\sim}5.8$ and the duration time of $64{\sim}137$ min in vitro test. The in vivo neutralizing test in rats showed the rapid increase of gastric pH up to 3.5 within 30 min and the gastric pH of $4{\sim}6$ was kept for 5 hr.
김종국,황수원,황성주,나운용,Kim, Chong-Kook,Hwang, Su-Won,Hwang, Sung-Joo,Lah, Woon-Lyong 한국약제학회 1989 Journal of Pharmaceutical Investigation Vol.19 No.2
In order to develop a pediatric liquid preparation with sustained release properties, dextromethorphan hydrobromide (DEXT) was complexed with strong cation exchange resin (CG 120) and the-complex was coated with Eudragit RS using a phase separation method by non-solvent addition. The effect of pH, ionic strength of the release medium and drug/resin ratio on the release rate of DEXT was studied. The release rate of free drug from the uncoated complex, and coated complexes with 9.5 and 18.5% Eudragit RS in artificial gastric juice were measured. The release rate from the uncoated complex was faster with higher pH, higher ionic strength of the release medium and higher drug/resin ratio. The release rate from the coated complex could be controlled by the amount of coating material, and the surface after release did not rupture into.
Picric acid에 의한 지방족 아민류와 4급 암모늄 염류의 이온쌍 추출
김박광(Bak Kwang Kim),이종숙(Jong Sook Rhee),장성기(Sung Ki Jang),나운용(Woon Lyong Lah),옥치완(Chi Wan Jang) 대한약학회 1991 약학회지 Vol.35 No.3
Systematic study on the extraction of ion pair by the use of picric acid (PCA) as an ion pair forming reagent to the aliphatic amines has not be done by spectrophotometric method. The extraction of ion pair by the use of PCA and 23 kinds of the aliphatic amines was examined. The procedure is as follows; Elving''s buffer solution (pH 1.3-10, ionic strength 0.5) each amine solution, and PCA solution were taken into a test tube. The mixture was shaken mechanically with chlorform. The organic phase was filtered through a filter paper to remove water droplets. The absorbance was examined at lambdamax against a reagent blank. Primary and secondary whose carbon number were more than 7 or 6, respectively, are extractable as ion pairs with PCA, while tertiary amines and quaternary ammonium salts are also extractable without the correlation of carbon number. It was considered that the ion pair extraction of primary and secondary amines was affected by the number of carbon of amines, but its extraction of tertiary amines or quaternary ammonium salts was affected by kind of aliphatic amines rather than pKa values or carbon number of amines.
카바프로스타싸이클린의 중간체로 이용가능한 히드록시싸이클로펜탄의 합성
서영거(Young Ger Suh),구본암(Bon Am Koo),정재경(Jae Kyung Jung),조윤상(Young Sang Cho),나운용(Woon Lyong Lah) 대한약학회 1993 약학회지 Vol.37 No.3
An efficient synthetic route to the trisubstituted cyclopentane as an useful synthetic intrermediate for carbaprostacyclin is described. Ireland Claisen rearrangement of a hydroxylactone has been employed as a key reaction.
Sublimatography에 依한 無機藥品의 分離硏究(第2報) : 白靈砂의 成分確認에 對하여 Study on the Identification of Baek-Yong-Sa
羅雲龍,金良培 최신의학사 1969 最新醫學 Vol.12 No.4
The aspect of sublimatography and vacuum condensing points of mercury chlorides were studied in the previous work. Through the above research, the sublimatographic identifiication and separation of Baek-yong-sa (the Inorganic Chinese Drug in Korea) were attempted. As a result, it was found that Baek-Yong-sa was the pure mercurous chloride and the sublimatographY seems to be a capable detective method of some compounds in the mixed compounds.
점안제중 4 - Morpholine Carboximidoylguanidine Hydrochloride 의 분리정량
나운용 한국약제학회 1974 Journal of Pharmaceutical Investigation Vol.4 No.1
The isolative determination of 4-Morpholine carboximidoylguanidine Hydrochloride in the ophthalmic solutions was examined by means of colorimetric method using oxidized nitroprusside and sodium hypobromite. According to the results, the following could be summerzied. 1) The wave length of maximun absorption in 650 mμ. 2) Beer's Lew is obeyed for 20∼80 mcg/㎖ in colored solutions. 3) Absorptions of colored solutions must be measured 5 minutes after the addition of oxidized and 5 minutes after the completion of sodium hypobromite. 4) 4-Morpholine carboximidoylguanidine hydrochloride can be determined within standard deviation 2.0%.
합성규산알루미늄의 제산능 및 흡착능에 미치는 제조조건의 영향
나운용 한국약제학회 1985 Journal of Pharmaceutical Investigation Vol.15 No.2
The effects and the optimum manufacturing conditions for the preparation of synthetic aluminum silicate which has acid-consuming power and adsorbing capacity were investigated. The results are as follows: 1. The adsorbing capacity was affected by the mixing order of the reactants, that is, the excellent ones were obtained by the method which add the sodium silicate solution to the potassium alum solution. 2. Even though preparing by the same manufacturing condition, the acid-consuming power is superior to the adsorbing capacity. 3. According to the Box-Wilson Plan, the optimum reaction conditions are concentration of sodium silicate solution; 38% w/w, settling time; 43 hours at room temperature, drying time; 13 hours at 110℃
이온교환수지 - 브롬화수소산덱스트로메토르판 복합체의 서방성 마이크로캅셀 개발에 관한 연구
나운용,김종국,황수원,황성주 한국약제학회 1989 Journal of Pharmaceutical Investigation Vol.19 No.2
In order to develop a pediatric liquid preparation with sustained release properties, dextromethorphan hydrobromide (DEXT) was complexed with strong cation exchange resin(CG 120) and the complex was coated with Eudragit RS using a phase separation method by non-solvent addition. The effect of pH, ionic strength of the release medium and drug/resin ratio on the release rate of DEXT was studied. The release rate of free drug from the uncoated complex, and coated complexes with 9.5 and 18.5% Eudragit RS in artificial gastric juice were measured. The release rate from the uncoated complex was faster with higher pH, higher ionic strength of the release medium and higher drug/resin ratio. The release rate from the coated complex could be controlled by the amount of coating material, and the surface after release did not rupture into.
나운용,안경란,한관섭,이계주 한국약제학회 1976 Journal of Pharmaceutical Investigation Vol.6 No.1
Dicalcium phosphate dihydrate (DCPD) is the most widely-used dentifrice abrasive in non-therapeutic tooth-paste requiring, low abrasive level, high stability and excellent compatibility with other formulation ingredients. One of the difficulties encountered in the use of this material in tooth-paste is that unless storage of the product is maintained at a relative low temperature there is a distinct tendency to lose water of crystallization. Another difficulty which has been encountered is that there is a tendency for the product to become lumpy. Various means have been proposed for increasing the stability and overcoming the lumping tendency, most of which means comprise the addition of stabilizing agent. But there is not any report about the relationships between the mechanism of dehydration, physical properties, structure and manufacturing condition. In this experiment, DCPD were manufactured by methods of Moss' patent, its two varied and J. P. VIII, these were studied by means of stability test, IR spectra, and DTA. According to the manufacturing conditions, DCPD has different physical properties and structures, i.e., monoclinic system of low drying temperature, triclinic system of high drying temperature. Dehydration of DCPD may be supposed one step dehydration at about 100° and it finaly converts to γ-pyrophosphate at about 465° and if the drying temperature is high it becomes DCP anhydrous. DCPD made by Moss' patent is thought of the best polishing agent of tooth-paste.