Temozolomide-Associated Bronchiolitis Obliterans Organizing Pneumonia Successfully Treated with High-Dose Corticosteroid

김태옥,오인재,Hyun-Wook Kang,Su Young Chi,Hee Jung Ban,권용수,Kyu-Sik Kim,Yu-Il Kim,Sung-Chul Lim,Young-Chul Kim 대한의학회 2012 Journal of Korean medical science Vol.27 No.4

Temozolomide is an oral alkylating agent with clinical activity against glioblastoma multiforme (GM). It is generally well-tolerated and has few pulmonary side effects. We report a case of temozolomide-associated brochiolitis obliterans organizing pneumonia (BOOP) requiring very high-dose corticosteroid treatment. A 56-yr-old woman presented with a 2-week history of exertional dyspnea. For the treatment of GM diagnosed 4 months previously, she had undergone surgery followed by chemoradiotherapy, and then planned adjuvant chemotherapy with temozolomide. After the 1st cycle, progressive dyspnea was gradually developed. Chest radiograph showed diffuse patchy peribronchovascular groundglass opacities in both lungs. Conventional dose of methylprednisolone (1 mg/kg/day) was begun for the possibility of BOOP. Although transbronchial lung biopsy findings were compatible with BOOP, the patient’s clinical course was more aggravated until hospital day 5. After the dose of methylprednisolone was increased (500 mg/day for 5 days) radiologic findings were improved dramatically.

대입 복수지원제도의 문제점과 해결 방안

김태옥,Kim, Tae-Ok 한국대학교육협의회 1999 大學敎育 Vol.99 No.-

무가온 시설재배 감귤에서 계절초기 목화진딧물 개체군의 정착경로에 관한 연구

김태옥,권순화,박정훈,오성오,현승용,김동순,Kim, Tae Ok,Kwon, Soon Hwa,Park, Jeong Hoon,Oh, Sung Oh,Hyun, Seung Young,Kim, Doog-Soon 한국응용곤충학회 2015 한국응용곤충학회지 Vol.54 No.3

목화진딧물(Aphis gossypii Glover) (Hemiptera: Aphididae)은 감귤에서 그을음병을 유발하여 감귤 과실에 경제적으로 피해를 주는 해충이다. 본 연구는 무가온 하우스 감귤에서 계절초기 목화진딧물이 어떠한 경로를 거쳐서 감귤나무에 정착하는지 구명하기 위하여 수행하였다. 감귤나무에서 진딧물 월동알 조사결과 가을순이 난 여름순에서 많이 발견되었는데 월동알은 대부분 조팝나무진딧물이었으며, 목화진딧물 월동알은 발견되지 않았다. 봄순에 정착하는 목화진딧물 유시형 성충은 크게 4월 하순(조기비산)과 5월 하순(지연비산)에 두 차례 관측되었다. 지연비산은 완전생활형 간모세대에서 유시형이 출현하는 시기와 일치하였다. 조기비산 시기에 황색수반트랩에서도 목화진딧물 유시형 성충이 유살되었는데 확실하지는 않으나 월동잡초에서 잔존하고 있던 불완전세대 개체군으로 추정되었다. 결과적으로 무가온 하우스 감귤에서 목화진딧물의 정착은 불완전생활형의 조기비산과 완전생활형의 지연비산으로 일어난다는 것이 확인되었다. The cotton aphid, Aphis gossypii Glover (Hemiptera: Aphididae) infests citrus orchards, causing sooty mold damage to the fruits. This study was conducted to investigate the colonizing route of A. gossypii in citrus orchards in a non-heating plastic-film house during the early season. The overwintering eggs of the aphids are frequently found on summer shoots of the citrus trees. The eggs were mostly those of Aphis citricola, without any A. gossypii when hatched. The colonization of citrus trees by alate A. gossypii in non-heating plastic-film houses was mainly observed twice, with advanced flight in late April and delayed flight in late May. The delayed flight was synchronized with the timing of the emergence of alate A. gossypii from the fundatrix generation in the holocyclic life cycle. During advanced flight in closed citrus orchards, alate A. gossypii were caught in yellow water traps installed in the fields, and the populations were found to originate from the surviving populations of the anholocyclic life cycle. Consequently, we concluded that citrus tree colonization with A. gossypii occurred during the advanced flight of the anholocyclic and the delayed flight of the holocyclic life cycle.

교반조에서 비혼화성 액상 ( n - 헥산 / 물 ) 계의 액 - 액분산

김태옥,김동욱,전종한 ( Tae Ok Kim,Dong Uk Kim,Jong Han Chun ) 한국공업화학회 1993 공업화학 Vol.4 No.3

N-헥산과 증류수로 이루어진 비혼화성 액상계에서 교반에 의한 액-액분산을 해석하였다. 교반기는 blade형태가 flat, 60mesh와 40mesh의 금망, 그리고 60mesh금망의 외부에 금속띠를 두른 4가지의 6-bladed turbine 교반기를 사용하였다. 실험결과, 동일한 교반속도에서 유기상의 분산정도와 교반기의 소요동력은 blade형태가 flat>solid edged>60mesh>40mesh의 순서이었으며 유기상의 부피비가 증가할수록 완전분산에 필요한 최소교반속도가 증가되었다. 또한 분산상의 액적의 평균직경은 교반속도의 증가에 따라 감소하였으며 동일한 교반속도에서는 solid edged<flat<60mesh<40mesh의 순서이었다. 완전분산에서 최소소요동력은 blade형태에 무관하게 거의 동일하였으나 금속띠를 두른 금망의 교반기가 가장 작고 균일한 크기의 액적으로 분산되어 우수한 액-액분산의 성능을 나타내었다. 이때 난류영역에서 Power number는 Reynolds number에 무관하게 일정하였고 액적의 Sauter평균직경(d_(32))은 다음과 같이 유기상의 부피비(Φ)와 Weber number(N_(We))의 함수로 나타낼 수 있었다. d_(32)/D=a(1+bΦ)N_(We)^(-0.6) The effect of agitation on liquld-liquid dispersion was investigated in an immisible liquid phase(n-hexane/water) system. Four different types of six-bladed turbine impellers were used: a flat blade, two screen blades and a solid edged 60 mesh screen blade. We found that the extent of dispersion of organic phase and power consumption of agitator were decreased in the order of flat, solid edged, 60 mesh, and 40 mesh blades at same agitation speed. And the minimum agitation speed for complete dispersion of organic phase was increased with increasing volume fraction of organic phase. Also, mean diameter of liquid droplets of dispersed phase was decreased with increasing agitation speed and it was increased in the order of solid edged, flat, 60 mesh, and 40 mesh screen blades at same agitation speed. At complete dispersion, the minimum power consumption was not vary significantly with impeller blade types, but the solid edged screen blade impeller gave the smallest and uniform sizes of liquid droplets, and it had a good performance for liquid-liquid dispersion. In this condition, Power number was not affected by Reynolds number and it was constant in turbulent flow region, and Sauter mean diameter(d_(32)) of liquid droplets was expressed as a function of volume fraction of organic phase(Φ) and Weber number(N_(We)) as follows: d_(32)/D =a(1+bΦ)N_(We)^(-0.6)

제22회 한국원자력기술상 수상기 - 원전의 안전 운영을 위한 설비 설계 개선 및 비상 운영 체제 구축

김태옥,Kim, Tae-Ok 한국원자력산업회의 2015 원자력산업 Vol.35 No.3

n - 헥산 / p - TSA 수용액계에서 교반에 의한 유기상의 분산

김태옥,전종한 ( Tae Ok Kim,Jong Han Chun ) 한국공업화학회 1991 공업화학 Vol.2 No.3

n-핵산과 40 wt % p-TSA수용액으로 이루어진 비흔화성 액상계에서 교반에 의한 유기상의 분산을 해석하였다. 사용된 교반기는 blade의 형태가 flat와 금망으로 된 4가지 형태의 6-bladed turbine 교반기를 사용하였다. 실험결과, 동일한 교반속도에서 유기상의 분산정도는blade의 형태가 flat, 60 mesh, 40 mesh, 20 mesh의 순서로 감소하였고 계면활성제인 TBA의 농도가 증가할수록, 그리고 유기상의 부피비가 작을수록 유기상은 잘 분산 되었다. 또한 완전분산에 필요한 최소교만속도는 flat, 60 mesh, 40 mesh, 20 mesh의 순서로 증가하였으나 최소소요동력은 거의 동일하였다. 이때 Power number와 Reynolds number와의 관재는 N_p = _aN_(Re)^b이었으며 교반기의 형태에 따른 상수 a와 흔합계의 종류에 따른 상수 b의 값은 각각 2200∼4100, -0.69∼-0.63 범위이었다. The effect of agitation on the dispersion of organic phase was investigated in an immiscible liquid system (n-hexane/40 wt % p-TSA aqueous solution). Four different types of six-bladed turbine impellers were used : a flat blade type and three screen blade types. The experimental results showed that the extent of dispersion of organic phase at the same agitation speed was decreased in the order of flat blade, 60 mesh 40 mesh, and 20 mesh screen blades. Otherwise, it was increased with increasing the concentration of TBA as a surfactant agent and with decreasing volume fraction of organic phase. Also, the minimum agitation speed for a complete dispersion was increased in the order of flat blade, 60 mesh, 40 mesh, and 20 mesh screen blades. However, the minimum power consumption did not vary significantly. In this condition, the relationship between Power number and Reynolds number was expressed as N_p = _aN_(Re)^b, where the values of constant a and constant b were ranged 2200∼4100 and -0.69∼-0.63 respectively.

결핵에 의한 급성호흡곤란증후군의 사망률 및 예후 예측인자

김태옥 ( Tae ok Kim ),강현욱 ( Hyun Wook Kang ),지수영 ( Su Young Chi ),반희정 ( Hee Jung Ban ),오인재 ( In Jae Oh ),김규식 ( Kyu Sik Kim ),김유일 ( Yu Il Kim ),임성철 ( Sung Chul Lim ),김영철 ( Young Chul Kim ),권용수 ( Yong Soo 대한내과학회 2011 대한내과학회지 Vol.81 No.4

Background/Aims: Acute respiratory distress syndrome (ARDS) due to tuberculosis (TB) is a rare disease, but its mortality is believed to be high. The aim of this study was to evaluate the mortality rate and prognostic factors of ARDS. Methods: We retrospectively reviewed the demographic, clinical, radiologic, and laboratory data of 19 patients with ARDS due to active pulmonary TB at Chonnam National University Hospital between January 2000 and December 2010. Results: The median age of patients was 71.1 (interquartile range [IQR] 51-74) years. None had a history of TB treatment. The most common symptoms were dyspnea (90%), fever (68%), and cough (53%). The overall in-hospital mortality was 73%. The median acute physiologic assessment and chronic health evaluation (APACHE) III score and pneumonia severity index (PSI) were 81.9 (IQR 59.0-92.0) and 111.0 (IQR 77.0-131.0), respectively. The PSI was significantly higher in non-survivors than in survivors (55.0 vs. 122.0; p=0.016). The rate of TB treatment before admission was significantly higher in survivors than in non-survivors (75% vs. 13%; p=0.037). The time from admission to treatment initiation was significantly longer in non-survivors than in survivors (3 vs. 0 days; p=0.049). The median duration of mechanical ventilation was 11 days (IQR 5-16 days). The most common cause of death was a refractory shock (53%). Conclusions: The overall mortality rate of ARDS due to pulmonary TB was high. A high PSI score and delay of TB treatment may be risk factors for a poor outcome of ARDS due to pulmonary TB. (Korean J Med 2011;81:458-463)

풍력발전기용 요베어링 설계 기술

김태옥(T. O. Kim),김국주(K. J. Kim),김남용(N. Y. Kim),이진모(J. M. Lee),박영준(Y. J. Park),염종택(J. T. Yeom) 한국소성가공학회 2010 한국소성가공학회 학술대회 논문집 Vol.2010 No.10

초내열합금 링제품의 형상링 압연 제조 기술

김태옥(T. O. Kim),김국주(K. J. Kim),김남용(N. Y. Kim),이진모(J. M. Lee),염종택(J. T. Yeom) 한국소성가공학회 2009 한국소성가공학회 학술대회 논문집 Vol.2009 No.10

Aerospace engine application needs to stand high temperature and pressure. Because of its mechanical properties such as high strength at high temperature, Alloy 718 is used aerospace engine application about 80%. But ally 718’s mechanical properties cause some problem to manufacturing profile ring like damage of material and mold. In this study, alloy 718’s mechanical properties investigated for knowing its formability and using FE-Simulation for designing profile ring roll process and mold shape. Profile ring rolling processing is designed with “Initial material→Blank→Linear Ring→Profile ring”. Blank’s heating temperature is setting 1100℃ for manufacturing a trial profile ring on the basis of FE-Simulation. As a result of manufacturing alloy 718 profile ring, it is possible to make near target profile shape ring with all of the processing condition which gives in this study.

약물요법을 받고 있는 성인 천식환자에서 폐기능의 종적 변화

김영일 ( Young Il Kim ),김태옥 ( Tae Ok Kim ),김동현 ( Dong Hyun Kim ),김승훈 ( Seung Hun Kim ),고영일 ( Young Il Koh ) 대한천식알레르기학회 2012 천식 및 알레르기 Vol.32 No.1

Background: Lung functions in asthmatics may depend on various factors: reversible airway obstruction, irreversible airway obstruction associated with airway remodeling, more rapid decline in lung functions than non-asthmatics, and medication effect on decline in lung functions. This study aimed to investigate longitudinal changes in lung functions in adult asthmatics. Methods: Fifty-one adult asthmatics were included in the study. Their medical records were retrospectively reviewed. Lung functions were obtained at baseline, and visits 1, 2, 3 and 4, with intervals of 10∼15 months. Asthmatics were classified into those with forced expiratory volume in 1 second (FEV1)≥80% predicted (normal lung function) and those with FEV1<80% (decreased lung function) in reference to baseline lung functions. Results: Annual decline rates of FEV1 were ?12.4±10.1 mL/yr in all asthmatics, ?25.9±12.6 mL/yr in asthmatics with normal lung functions, and 14.7±13.8 mL/yr in asthmatics with decreased lung functions. FEV1 did not significantly change at visits 1, 2, 3 and 4 compared to the baseline value in all asthmatics and asthmatics with normal or decreased lung functions. FEV1 values at visits 1, 2, 3, and 4 decreased only in 8.3%∼ 18.2% of asthmatics with normal lung functions and normalized only in 16.7%∼30% of asthmatics with decreased lung functions. Conclusion: In adult asthmatics treated with medications, irreversible airway obstruction may not occur in those with normal lung functions, while reduced functions may not normalize in those with decreased lung functions, in whom airway remodeling may have occurred early in the disease state. (Korean J Asthma Allergy Clin Immunol 2012;32: 34-42)