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- 저자 : 全奎榮 (검색결과 136 건)
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간 문맥 하공정맥 문합술에 의한 간 혈류 증가 및 면역억제제 사용에 따른 면역기능 흉선 아세포 분화
신규택,이광수,전규영 한양대학교 의과대학 1991 한양의대 학술지 Vol.11 No.1
The liver has remarkable regeneration potential and the hepatic graft has beneficial immunological behavior compared with other organs. The immune response to allografts is an extremely complex process and not caused by a single mechanism. Particularly, it is thought that the thymus as a central lymphoid organ is responsible for the T-cell response. This study was carried out to clarify the mechanism of the immune regulatory effedct of liver regenerating factors which were liberated from the increased liver blood flow. In 25 LEW rats, a side-to-side portacaval shunt(3mm stoma size)was constructed by microsurgical technique, and the infrahepatic inferior vena cava at the proximal of the stoma was ligated to increase the portal blood flow. The other 10 LEW rats were treated by cyclosporine A and 10 LEW rats by prednisolone. In the animals of each groups, the weight and cell count of the thymus were examined. Furthermore, the T-cell and B-cell ratio and T-cell subpopulations of the thymocytes were studied by mouse anti-rat monoclonal antibodies of W3/13, OX-12, W3/25, and OX-8. 1. The thymus cells of the normal and sham operated animals contained more than 90% of T-cells reacting to monoclonal antibody W3/13, and there were no B-cells to OX-12. Approximately 90% of the normal thymocytes reacted to both W3/25 and OX-8, i.e., they could not be differentiated into T-cell subpopulations by these two antibodies. 2. The weight of the thymus was reduced to 3/4 of the normal value 3 days after con-structing the portacaval shunt, to 3/5 of normal 5 days after, and increased to normal thymus weight 7 days after. Five days after increasing the liver blood flow, thymocytes we5re partially reacting to W3/25(62±2%)and to OX-8(71±3%). Ten days after, maximal differentiation of the thymocytes were observed, i.e., the helper cells were 59±1% and the suppressor/cytotoxic cells were 64±3%. 3. In the animals which were treated with CsA 15mg/kg per day for 5days, T-and B-cell and T-cell subpopulation ratios in the thymus did not show any significant difference compared with those of the normal rats (p〉0.05). However, after 5-day and 7-day treatments with CsA 40mg/kg per day, the T-cell subpopulation ratio in the thymus showed complete differentiation, i.e., the helper cells were 41±4% and the suppressor/cytotoxic cells were 52±4%.
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全奎榮 漢陽大學校 1977 論文集 Vol.11 No.-
Acute panperitonitis is one of many critical surgical disease, and there are many problems in its treatment, though the an ibiotics therapy and fluid and electroyte therap, etc. are employed: The development of antobiotics made an epoch in the management of acute panperitonitis, and so surgical infections can be prevented without any difficulty. But the overuse of antibiotics and the appearance of antibiotic resistant strains have made new problems in surgical infection. To achieve the most effective management of acute panperitonitis, a culture of peritoneal fluid on exploratory laparotomy and an antibiotic sensitivity test to microorganisms are needed. In this paper, 188 cases of abdominal surgery (107 cases of non-peritonitis and 81 cases of acute panperitonitis) were examined using bacterial cultures of peritoneal fluid with 5% sheep blood agar in each case to study the kinds of bacteria, the detection rate of bacteria,the relation between the time from hollow viscus rupture to operation, would infection and mortality rate, and the antobiotics sensitivity test to microorganisms. The results obtained are as follows: 1. In 107 cases of non-peritonits, 97 cases (90.7%) were negative, and 10 cases (9.3%), positive. A total of 14 strains were found in 10 positive cases, E.coli being in 8 strains (51.7%), which was the largest in number. 2. 45 caese (55.6%) were positive, and 36 cases (44.4%), negative, in 81 cases of acute panperitonitis. Teh detection rate of bacteria in the following diseases was 12 cases (85.7%) out of 14 cases of typhoid perforation, 8 cases (80.0%) out of 10 cases of traumatic intestinal perforation, 11 cases (40.7%) out of 27 cases of perforated appendictis and 8 cases (38.1%) out of 21 cases of peptic ulcer perforation. 3. In 81 cases of acute panperitonitis, a total of 61 strains were found these consisted of 40 strains (65.6%) of E. coli, 5 strains (4.9%) of pseudomonas aeruginosa, etc. 4. 4 strains (36.7%) of β-hemolytic streptococcus, 3 strains (20.0%) of staphylococcus aureus were found in a total of 13 strains of peptic ulcer perforation, and it was noticed that the detection rate (46.7%) of Gram positive group in this disease was higher than the rate of other kinds of acute panperitonitis. 5. In acute panperitonitis due to hollow viscuc rupture, the relation between the time of perforation and that of operation showed a tendency of increasing the detection rate of bacill in the peritoneal fluis and the wound infection rate over 60 percent in about 24 hours. The mortality sfter operation was 3 cases (3.7%) whole operations were performed after 72 hours. Out of the three, two died of typhoid perforation and the cause of death was septicemia. 6. In sensivity test to the microorganisms, staphylococus auresus and β-hemolytic streptococcus were most sensitive to penicillin and geopen, and E. coli was most sensitive to gentamycin, geopen and kanamycin, and pseudomonas aeruginosa, to geopen and gentamycin.
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全奎榮 大韓法醫學會 1985 대한법의학회지 Vol.9 No.1-2
Postoperative wound infection is one of the most common complication surgical practice primarily depends upon the healing of wounds without serious complications, and infections occurring in postoperative wounds can have significant effects on the patient's morbidity, prolongation of convalescence, unpleasant dressings, ugly scars and cost of medical services. The severity of nosocomial infection has increased with following problems, e.g., complexity of hospital, antibiotic abuse, use of immunosuppressive agent, malnutrition, increment of chronic disease, use of invasive devices and multiplicity of operations. Efforts to decrease the incidence of wound infection postoperatively have included modification of the operating room procedure, methods of preparation of the surgical field, skillful operation, prophylactic systemic antibiotics and delayed closure of contaminated wound.
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