비만, 폐쇄성 수면무호흡증과 대사장애

김진관 ( Jinkwan Kim ),표상신 ( Sang Shin Pyo ),윤대위 ( Dae Wui Yoon ) 대한임상검사과학회 2021 대한임상검사과학회지(KJCLS) Vol.53 No.4

수면은 필수적인 생리적 기능일 뿐만 아니라 인간의 성장, 성숙 및 전반적인 건강을 증진시키는 데 중요한 역할을 한다. 수면과 수면 장애가 대사성 질환에 미치는 영향에 대한 관심이 높아지고 있다. 폐쇄성 수면무호흡증은 일반적인 건강 문제이며, 지난 10년 동안 비만율의 증가로 인해 더 두드러진 대사 질환과 함께 폐쇄성 수면무호흡증의 유병률이 현저하게 증가했다. 폐쇄성 수면무호흡증에 의한 대사성 질환을 유발하는 근본적인 메커니즘은 다인성일 가능성이 높으며, 완전히 밝혀지지 않고 있지만, 염증과 산화 스트레스의 활성화와 식욕 조절 호르몬의 조절장애는 폐쇄성 수면무호흡증 환자에게 나타나는 대사 기능 장애와 비만의 중요한 병리 생리학적 성분으로 나타났다. 본 연구에서는 폐쇄성 수면무호흡증과 대사질환의 연관성에 대한 연구 현황과 폐쇄성 수면무호흡증이 이러한 질병을 유발하는 병리생리학적 메커니즘에 대해 검토하고자 한다. 이를 통해 폐쇄성 수면 무호흡증과 비만, 그리고 폐쇄성 수면무호흡증과 대사 기능 장애 사이의 잠재적인 상호작용을 이해할 수 있다. Sleep plays an important role in maintaining overall human health. There is increasing interest regarding the impact of sleep related disorders on metabolic diseases. Obstructive sleep apnea (OSA) is a common health problem, and in the last decade, the emergence of increasing obesity rates has further led to a remarkable increase in the prevalence of OSA, along with more prominent metabolic diseases. Obesity is the strongest risk factor for OSA. However, OSA is also known to cause obesity, suggesting an interaction between OSA and obesity. Although the underlying mechanisms leading to OSA-induced metabolic diseases are probably multi-factorial and are yet to be fully elucidated, the activation of inflammation and oxidative stress and the dysregulation of appetite-regulating hormones have emerged as important pathophysiological components of metabolic dysfunction and obesity observed in patients with OSA. Here, we will review the current state of research regarding the association of OSA with metabolic diseases and the possible pathophysiological mechanisms by which OSA could lead to such diseases. This will enhance our understanding of the potential interactions between OSA and obesity and between OSA and metabolic dysfunction.

사람 백혈구 Cytoglobin에 관한 연구

김진관(JinKwan Kim),신철(Chol Shin),이승관(SeungGwan Lee),이창규(ChangKyou Lee),김성욱(SuhngWook Kim),조경진(KyungJin Cho),김순기(SoonKi Kim) 고려대학교 보건과학연구소 2006 보건과학논집 Vol.32 No.1

  Cytoglobin(Cygb) is a newly recognized globin type, which are almost ubiquitously present in human tissues. Cytoglobin is reported to function as an oxygen scavanging and distribution protein and induced by hypoxia. The physiological role of cytoglobin is not yet clearly understood. We investigated cytoglobin in human blood leukocyte from obstructive sleep apnea patients(n=5) and normal controls(n=5). Immunoreactivity to anticytoglobin in OSA patients were much higher than that in normal control. These results suggest that cytoglobins of leukocyte might be overexpressed in obstructive sleep apnea.

수면 무호흡증 환자에서 Angiotensin converting enzyme, Angiotensinogen M235T의 유전적 다형성

김진관(JinKwan Kim),신철(Chol Shin),이승관(Seung-Gwan Lee),이창규(Chang-kyou Lee),김순기(SoonKee Kim) 고려대학교 보건과학연구소 2004 보건과학논집 Vol.30 No.1

Obstructive sleep apnea(OSA) occcurs when tissues in the upper airway collapse during sleep, and is accompanied by hypoxemia and EDS(excessive daytime sleepiness). Also OSA is related to hypertension and cardio-vascular disease. According to recent study, OSA possibility is estimated through partial gene"s predispoding factor. To study the correlation of OSA and angiotensin converting enzyme and angioten-sinogen genotype, this study examined genetic polymorphism of OSA patient and normal case using PCR and restriction enzyme digestion. We found significant differences between most sevene obstructive sleep apnea and normal control in the ACE genotypes. The freguency of genotypes in MSO was: DD : 15.5%, ID : 82.2%, Ⅱ : 2.2%(p<0.05) The freguency of genotypes in Normal group(NO) was: DD : 8.5%, ID : 71.8%, Ⅱ : 19.7%. But there were no significant differences between obstructive sleep group and normal control in the AGT(M235T) genotypes. The freguency of genotypes in MSO was : MM : 8.9%, MT : 13.3%, TT : 77.8%. In normal group was: MM : 5.6%, MT : 25.4% TT : 69.0%. Our data suggest some effect between ACE polymorphism and OSA but no effect between AGT polymorphism and OSA.

GM:S의 풍부한 API와 낮은 진입 장벽의 교육적 활용 방법

김진관 ( Jinkwan Kim ),이희준 ( Heejun Lee ) 한국컴퓨터교육학회 2017 한국컴퓨터교육학회 학술발표대회논문집 Vol.21 No.2

기존의 프로그래밍 교육용 프로그램(스크래치, 엔트리)들은 프로그래밍의 진입장벽을 낮춰 교육의 효율을 높일 수 있었다[1][2]. 하지만 그러한 접근 방식은 실용적인 프로그래밍에 대한 지표가 되기에는 좋지 않다. 우리는 교육용 프로그램으로 게임메이커 스튜디오(이하 GM:S)를 사용하는 것을 제안 하고, 기존 지표의 단 점을 풍부한 스크립팅 API와 네이티브 라이브러리 링크 등으로 극복한 GM:S를 교육적 목적으로 사용하는 방법에 대해 알아보고자 한다.

플라스틱 ETC 하우징의 치수변형 해결 방법에 대한 연구

김보경(Bokyeong Kim),김진관(Jinkwan Kim),김경환(Kyunghwan Kim) 한국자동차공학회 2019 한국자동차공학회 학술대회 및 전시회 Vol.2019 No.11

As global environmental regulations for vehicles are intensifying, it is necessary to reduce the weight of a vehicle. This trend has led to the emergence of technology to replace metal parts with engineering plastics. Electronic throttle control valves that control the intake air volume of gasoline internal combustion engines are normally made of aluminum, but some use engineering plastics for additional weight reduction. However, in order to apply engineering plastics, problems such as poor dimensional stability than metal machining must be improved. This paper presents effects of changing injection molding conditions such as injection pressure, mold temperature, gate position, as a means to solve the above problem.

염증 반응과 수면 장애

이석준 ( Suk Jun Lee ),김진관 ( Jinkwan Kim ) 대한임상검사과학회 2015 대한임상검사과학회지(KJCLS) Vol.47 No.3

Sleep is not only an essential physiological function, but also serves important roles in promoting growth, maturation, and overall health of humans. There is increasing interest regarding the impact of sleep and its disorders on the regulation of inflammatory processes and end-organ morbidities, particularly in the context of metabolic and cardiovascular diseases (CVD) and their complications. Obstructive sleep apnea syndrome (OSAS) is an increasingly common health problem in children. In the last decade, the emergence of increasing obesity rates has further led to remarkable increases in the prevalence of OSAS, along with more prominent neurocognitive, behavioral, cardiovascular and metabolic morbidities. Although the underlying mechanisms leading to OSAS-induced morbidities are likely multifactorial and remain to be fully elucidated, activation of inflammatory pathways by OSAS has emerged as an important pathophysiological component of the end-organ injury associated with this disorder. To this effect, it would appear that OSAS could be viewed as a chronic, low-grade inflammatory disorder. Furthermore, the concurrent presence of obesity and OSAS poses a theoretically increased risk of OSAS-related complications. In this study, we will critically review the current state of research regarding the impact of insufficient and disrupted sleep and OSAS on the immune processes and inflammatory pathways that underlie childhood OSAS as a distinctive systemic inflammatory condition in children, and will explore potential interactions between OSAS and obesity.

2차 창작기능과 사용자 자유도개선을 제공하는 음악 플레이어의 개발

이희준 ( Heejun Lee ),김진관 ( Jinkwan Kim ) 한국컴퓨터교육학회 2017 한국컴퓨터교육학회 학술발표대회논문집 Vol.21 No.2

본 연구에서 제작한 음악 플레이어인 Symphony(이하 심포니)는 사용자의 음악적인 공감을 돕고, 그에 따른 음악을 기반으로 한 2차 창작의 접근성과 자유도를 높여주는 기능을 포함하는 복합적인 프로그램이다. 기존 플레이어는 음원의 유통과 선별적 재생에만 초점을 두는 경향이 있는데, 심포니는 음악 플레이어의 개념을 사용자 입장에서 확장하여 가사 시스템, 춤 시스템, 플레이어 스킨, 사운드 비주얼라이저, DSP 설정 및 실시간 DSP 스크립팅 등을 추가하거나 개선하였다.

SiO₂가 모터구동 액추에이터에 미치는 영향성에 대한 실험적 연구

양준호(Joonho Yang),김보경(Bokyeong Kim),김진관(Jinkwan Kim),김경환(Kyunghwan Kim),이은열(Eunyeol Lee),송원곤(Wongon Song) 한국자동차공학회 2018 한국자동차공학회 학술대회 및 전시회 Vol.2018 No.11

The motor driven actuator in vehicle is demanded in ensuring the reliability of the motor, which is the main power source in the operating environment. Therefore, it is necessary to maintain a low and stable contact resistance of motor. In this paper, the effect of silicon oxide on the contact resistance between motor brush and commutator is analyzed, and a test mode that can detect it has been developed and validated.

폐쇄성 수면 무호흡증환자에서 HLA-DQ B1 0602와 HLA-DQA1 0102 유전자의 발현

이승관(Seung-Gwan Lee),이창규(Chang-kyou Lee),김진관(JinKwan Kim),신철(Chol Shin),김순기(Soonkee Kim) 고려대학교 보건과학연구소 2004 보건과학논집 Vol.30 No.1

  In the Obstructive sleep apnea(OSA), the probability of outbreak for the cardiovascular, hypertensive disease and the percentage of mortality rate for the heart atteck are highter in the hypertensive patient than in the healthy person. Recently, OSA have been reported at increased frequency in narcoleptic patients and narcolepry in known to be tightly associated with the HLA DQB1 0602. In this study we investigated the association of OSA with DQB1 0602 and HLA DQA1 0102. Thirty nine patients with OSA identified by polysomnography and sixty four normal controls without OSA were genotyped with respect to HLA DQB1 0602 using PCR-based assays. HLA DQB1 positivity were 74.4%(29/34) In OSA and 65.6%(42/64) in normal control(P<0.388). HLA DQA1 0102 positivity were 38.5%(15/39) in OSA and 37.5%(24/64) in normal control. But the difference between two groups was not statistically significant (P<0.923).

Analytical Method를 이용한 고체 추진제 그레인의 Burn-back 연구

손지현(Jihyun Sohn),장진성(Jinsung Jang),오석환(Seokhwan Oh),김진관(Jinkwan Kim),노태성(Taeseong Roh) 한국추진공학회 2013 한국추진공학회 학술대회논문집 Vol.2013 No.12

고체 추진기관의 성능은 내탄도 해석을 통해 예측이 가능하며, 내탄도 해석을 수행하기 위해서는 추진제의 형상변수와 관련된 그레인의 연소표면적 값이 필요하다. 본 연구에서는 그레인의 연소표면적을 산출하는 Burn-back 해석코드 개발을 위해 Analytical Method를 적용하였다. 그레인의 초기 형상에 따라 Analytical Method를 적용하기 위한 기하학적 변수를 선정하였고, 연소 과정에서의 그레인 형상 변화에 대해 정리하였다. 연소표면적의 변화와 관련된 Port Area와 Perimeter의 값을 산출하였고, 산출된 Perimeter 값을 Numerical Method로 부터 산출된 값과 비교하여 해석코드의 검증을 수행하였다. The value of change in the burning surface of the grain is required for performance analysis of the solid rocket propulsion system. In this study, the analytical method has been used for the code development to calculate the burning surface. Geometric parameters for application of the analytical method have been selected according to the initial configuration. Configuration change of the grain with combustion has been organized. Change of the port area and perimeter associated with change in the burning surface has been calculated. The developed code has been verified by comparison of results of the numerical method.