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- 저자 : 김종숙 ( Young Jo Kim (검색결과 10 건)
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김영조,강신덕,박실무,이기환,김종숙 ( Young Jo Kim,Shin Durk Kang,Sill Moo Park,Ki Whan Lee,Chong sook Kim ) 대한소화기학회 1979 대한소화기학회지 Vol.11 No.1
\We have presented a clinical review oE 200 established cases of acuce pancreatiris during the period betiveen Angust 1972 and August 1977, The results are as folloivs; There was no significant difference in occurrence between both sexes; 46,j were males and wcre females. The G7, 5,y of the patients were in tl.e 3rd-5th decade of the life. In our series of acute pancreatitis, the frequent etiologic factors were dieury factors in 16 5,., biliary tract clisease in 15. 0,' and alcoholics in 9. 5:j. The 48, 5, of the patients app- earently had no underlying etiologic factor. 3. In acute pancreatitis the v.pper abdominal pain was a major symptom in 99, Oy, raciiating pain was present in 25. 7,.y, nausea and vomiting in 65, 5p, and fever in 1S. Op, On laboratory tests, more than 250 S.unit/100ml of serum emia in 35. 2,, hyperbilirubinemia in 41, 3,: and hypocalcemia acute pancreatitis were noted. 5, 41 3. Of the patients with acute pancreatitis showed the findir.gs, contained T wave change in 17, 3y, S-T segment change in 7. Ly. Amylase in 55. 64lo, hyperglyc- in 31. 3,,> of che patients with abnormal electrocardiographic in S. 2o and sinus bradycardia Q. The radiologic examinations in acute pencreatitis revealed pleural elt'usion in 10. 9py, para- lytic ileus in 71, 2z<, nonvisualized gallbladder in 27, 5, and compression the stomach and duodeniim in 8,84g<, 7. 'In oral cholecystography, which performed at 3-or 4th day after resolution of symptoms, the discrimination betneen normal and abnormal biliary tract was enah]ed in 86. 7,. I'he gQ, 5,j; of the patients with acute pancreatitis had medical treatnient an2 9. 5yji had surgical treatment g, The complications developed in 21. 5,.y of the patients with acute pancreatitis
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Cysteamine과 Indomethacin투여로 인한 흰쥐의 혈중 및 위 십이지장 점막내 Gastrin과 Somatostatin 농도의 변화
김영조,김종숙 중앙대학교 의과대학 의과학연구소 1985 中央醫大誌 Vol.10 No.3
To clarify the interrelationship between gastrin and somatostatin, concentration of gastrin and somatostatin in blood and antral or duodenal mucosa of rats treated with cysteamine and/or indomethacin was measured, using radioimmunoassay kits. The results were as follows; 1. The pH of gastric juice was significantly lower (p<0.005), serum, antral and duodenal gastrin concentration was significantly higher(p<0.005), and plasma, antral and duodenal somatostatin concentration was significantly lower in rats treated with cysteamine. 2. The pH gastric juice was significantly lower(p<0.005), serum and duodenal gastrin concentration was significantly higher(p<0.005), and plasma, antral and duodenal somatostatin concentration was significantly lower(p<0.005) in rats treated with indomethacin. 3. The tendency to increase the change of gastrin and somatostatin concentration in blood and tissues was noted in rats treated with cysteamine and indomethacin simultaneously. 4. In all experimental rats, there was a. the inverse relationship between gastrin and somatostatin concentration in blood and duodenal mucosa. b. the negative linear relationship between pH of gastric juice and serum gastrin concentration, and between pH of gastric juice and antral gastrin. c. the positive linear relationship between pH of gastric juice and plasma somatostation concentration, and between pH of gastric juice and antral somatostatin concentration. d. the positive linear relationship between serum and antral gastrin, between plasma and antral somatostatin concentration, and between plasma and duodenal somatostatin concentration. It was suggested that cysteamine and indomethacin influence on gastrin and somatostatin concentration in blood and mucosa, and there is the functional interrelationship between acid secretion, gastrin and somatostatin concentration in blood and tissues.
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김삼용,김현수,김종숙,박상준,최지영,윤환중,조덕연 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2
Objectives : Clinical management of patient with lymphadenopathy requires judicious judgement of clinicians. Careful evaluation of lymph node enlargement by various clinical parameters will help to disclose the etiology of lymph node enlargement. This study was conducted to identify the clinical manifestations and etiology of lymphadenopathy in korean patients. Methods : A total 192 patients with lymph node enlargement were studied retrospectively. All patients who underwent excisional lymph node biopsy during the period from January 1992 to July 1994 were included. The lymph node biopsy and clinical records were reviewed and patient characteristics were analyzed by various clinical parameters. Results : A female predominance was noted in lymphadenopathy of tuberculosis (58.5%), Kikuchi's syndrome (70%). In lymphadenopathy of nonspecific, tuberculosis, kikuchi syndrome, per centage of patients younger than 40 years of age were 84.5%, 75.6%, 100%, respectively. In lymphadenopathy of tuberculosis and metastatic cancer, the duration of lymphadenopathy below 30days were 51.2%, 73.9%, respectively. The two most common etiology of cervical lymphadenopathy were nonspecific lymphadenitis (47.7%) and tuberculous (26.8%). The two most frequent etiology of supraclavicular lymphadenopathy were nonspecific lymphadenitis (46.3%) and metastatic lymphadenopathy (26.8%) and the most common etiology of axillary lymphadenopathy was nonspecific lymphadenopathy (34.5%). The most common frequent of lymph node enlargement with size below 1㎠ was nonspecific lymphadenitis, while above 2.25㎠ it was metastatic lymphadenopathy. Conclusion : Careful evaluation regarding patient age, sex, size of lymph node, consistency, location of lymph node, presence or absence of systemic symptoms should be pursued before performing a biopsy and management.
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악성종양에서 혈청 Intercellular Adhesion Molecule-1의 혈청
조덕연,김현수,박상준,김종숙,최지영,윤환중,김삼용 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.1
Intercellular adhesion molecule-1 (ICAM-1) is a glycoprotein serving as ligands for leukocyte intergrin receptors, i.e. LFA-1, MAC-l. It has been suggested that the expression of ICAM-1 and the levels of circulating ICAM-1 were increased in several malignancies. We measured serum ICAM-1 by ELISA in patients with stomach cancer (n=25), acute lymphoblastic leukemia (n=7), non-Hodgkin's lymphoma (n=14), and metastasis of unknown origin (n=5). Serum levels of circulating ICAM-1 in all malignancies were significantly higer than in normal controls. And serum level of ICAM-1 in stomach cancer ptients having metastatic disease was higher than in patients with localized disease (p=0.027). These results suggest that elevated serum ICAM-1 is a rather common feature for malignancies, not unique for certain types of cancer such as malignant melanoma. It remains to be clalified whether marked increase of serum ICAM-1 in metastatic stomach cancers simply reflect tumor burden or this molecule plays a role in progression in stomach cancer.
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Caerulein 이 흰쥐 위액분비(胃液分泌)에 미치는 경향
김영조,김종숙,박실무,강신덕 대한소화기학회 1979 대한소화기학회지 Vol.11 No.2
We observed the effects of caerulein somewhat agonist, on gastric secretion of rats with pylorus ligation. Results as follows; 1. In experimental group, gastric perforation incidence was increased but ulcer index and ulcer incidence was not different. 2. The amount of gastric secretion was significant]y increased in experimental group at 16 hours. 3. The pH of gastric secretion was decreased in experimental group at 4 hours. 4. The titratable acidity of gastric secretion was not different and titratable acid output was significantly increased in experimental group at 4 hours. 5. The protein of gastric secretion was not different but mucoprotein of gastric secretion was significantly increased in experimental group at 16 hours. 6. The pepsin activity of gastric secretion was not different. 7. The H-LDH percentage in fundic mucosa was increased at 4 hours and H-LDH percentage of antral mucosa was increased at 4 and 16 hours in experimental groups.
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FCL(5-FU, Carboplatin, Leucovorin) 항암 화학요법에서 Gm-CSF의 효과
최지영,김현수,김종숙,박상준,윤환중,조덕연,남상륜,김삼용 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1
Background: One of the major side effects of cancer chemotherapy is myelosuppression. Neutropenia and/or thrombocytopenia are dose-limiting factors in chemotherapy. Colony-stimulating factor induces proliferation and functional maturation of hematopoietic progenitor cells. GM-CSF is primarily active on progenitor cells of granulocytic and monocytic lineage. Methods: Fifteen patients with histologically proven malignancy diagnosed at Chungnam National University Hospital from January 1993 to August 1995 were included in this study. We could evaluate the clinical efficacy of GM-CSF in 13 patients undergoing FCL(5-FU, Carboplatin and Leucovorin) chemotherapy; the first cycles involved no GM-CSF while the second cycles involved GM-CSF on day 6 through 15 of chemotherapy. Results: 1) The subjects were fifteen patients in all, there were five patients with head and neck cancer, which was the most common types of maligancy. There were four patients with colon cancer, two patients with stomach cancer, and one patient with breast cancer, gallbladder cancer, cervix cancer and cholangiocarcinoma respectively, two patients, who did not complete two cycles of chemotherapy were excluded. 2) Age distribution was from 38 years to 78 years with a median age of 57. 3) In FCL chemotherapy cycles with GM-CSF, the duration of neutropenia(<500/μL) was 0.5±0.3 day, while FCL chemotherapy cycles without GM-CSF, it was 2.9±0.7 day(P=0.008). 3) There was no significant difference in platelet count between the two chemotherapy cycles(P=0.133). 4) Febrile duration without GM-CSF was 4.9±2.1 day, but with GM-CSF the duration was 1.3±0.7 day, which was significantly different(P=0.003). The duration of antibiotics use with GM-CSF was 1.7±1.2 day and without GM-CSF was 6.8±3.2 day, also significantly different(P=0.002). But hospital stay between the two cycles were not significantly different(P=0.064). Conclusion: GM-CSF was effective in preventing or restoring bone marrow depression after FCL chemotherapy.
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