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심전도상 이상 소견환자의 심박변이도(HRV)에 관한 고찰
민성순,이은형,김종득,이상희,권오순,김영균,권정남,Min, Sung-Soon,Lee, Eun-Hyoung,Kim, Jong-Deuk,Lee, Sang-Hee,Kwon, O-Sun,Kim, Young-Kyun,Kwon, Jung-Nam 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.4
Objectives : This study was designed to investigate heart rate variability(HRV) in patients with abnormality on EKG by power spectrum analysis of HRV. Methods : The patient group consisted of 147 patients diagnosed as abnormal on EKG at the Oriental Medical Hospital of Dong-eui University from November 2003 to September 2005. We divided the patient group into 9 subgroups (bradycardia, arrhythmia, PVC, AF, AV block, RBBB, LVH, cardiac ischemia, LAD ). The control group consisted of 117 patients who were diagnosed as normal on EKG at the same hospital during the same period. We checked HRV of the two groups over 5 minutes and compared the HRV index between groups. Results and Conclusions : In the time domain analysis, SDNN was significantly higher in the PVC and AF groups than control group and RMSSD was significantly higher in the all patient group and the bradycardia, PVC and AF groups than in the control group. In the frequency domain analysis, Ln(LF) was significantly higher in the all patient group and the PVC and AF groups than the control group but lower in the LAD group. Ln(HF) was significantly higher in The all patient group and bradycardia, PVE and AF groups than control group. LF/HF ratio was significantly lower in the all patient group and bradycardia, arrhythmia, AF, AV block and LAD groups than control group. The autonomic nerve system and parasympathetic nerve system were higher in the patient group with abnormal EKG compared with the control group.
TCD를 이용한 정상군과 중풍원인질환군의 혈류측정에 관한 비교연구
허정은,권정남,신원탁,김종득,이상희,손연희,김영균,Heo, Jeong-Eun,Kwon, Jung-Nam,Shin, Won-Tak,Kim, Jong-Deuk,Lee, Sang-Hee,Son, Yeoun-Hui,Kim, Young-Kyun 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.2
Objectives : The purpose of this study was to evaluate the blood flow using doppler ultrasound of the MCA, ACA, PCA, BA, ICA in the patients with risk factor for stroke. Methods : 110 patients with risk factor for stroke were selected who had hypertension, diabetes mellitus, hyperlipidemia, or heart disease, as well as 89 healthy adults who did not have any symptoms of those diseases. To evaluate the blood flow, the Vs and Vm of the MCA, ACA, PCA, BA, and ICA in the two groups were measured. Result : In normal healthy adults, subjects showed a decrease in the Vs and Vm: with advancing in age, there was a significant difference in the Vs of MCA, PCA, BA, and ICA. There was a significant difference in the Vm of MCA, PCA, BA, and ICA. In normal healthy adults, females showed high velocities in all examined vessels. There was a significant difference in the Vs of BA. There was a significant difference in the Vm of BA, and ICA. There was a decrease in the Vs, and Vm of all examined vessels of patients with risk factors for stroke in comparison with normal healthy adults. There was no significant difference in the Vs. There was a significant difference in the Vm of MCA, ACA, and PCA. Results were the same between patients aged under 50 and total patients in the Vs and Vm of examined vessels. There were differences between patients aged over 50 and total patients in the Vs of MCA, PCA, BA and for patients aged over 50; patients with risk factor for stroke who had hypertension, diabetes mellitus, hyperlipidemia, or heat disease has higher Vs than healthy adults. Conclusions : There was a significant difference in the blood flow velocity between patients with risk factors for stroke and healthy adults. However, this result was different from results of comparison of TCD findings between patients and healthy individuals by age. Therefore, more detailed studies about aged patients are needed.
수정진동자를 이용한 프탈로시아닌 LB박막의 NO2 감지 특성
권현정,이영진,장용근,김종득 ( H . J . Kwon,Y . J . Lee,Y . K . Chang,J . D . Kim ) 한국센서학회 1998 센서학회지 Vol.7 No.4
Multilayer Langmuir-Blodgett (LB) films coated on quartz crystal microbalance (QCM) of octa-substituted metallophhtalocyanines (MPc(OEH)_8, M = Cu, Co, and Sn) and dihydrogen phthalocyanines (H₂Pc(OEH)_8) were used to quantify NO₂ concentrations. They were exposed to various concentrations of NO₂ in dry N₂. Among the four phthalocyanines we tested, the metal-free H₂Pc(OEH)_8 was observed to be m48t sensitive to NO₂. However, its LB film showed a partially irreversible behavior, that is part of the frequency change due to NO₂ adsorption could not be recovered even after purging with pure N₂ gas for an extended period. Examining the spectra of NMR and FTIR revealed fact that the irreversible portion of frequency change was due to ether groups in the linkage between side chains and the Pc unit. In order to remove the effect of such initial deactivation, on NOD quantification experiment, a freshly fabricated LB film was treated at a high concentration of NO₂ so that the ether sites were saturated. A pretreated LB film showed a reproducible performance for repeated uses. The CuPc(OEH)_8 LB film showed a satisfactory sensing performance down to as low as 4 ppm. For the H₂Pc(OEH)_8 LB film, the lower detection limit was found to be 35 ppb of N02. In order to make the experimental condition more realistic, the carrier gas, dry nitrogen, was replaced by air. It was observed that the presence of oxygen, a weak electron acceptor, reduced the sensitivity and thus increased the sensing limit to hundreds of ppb. Results of experiments with moisture added showed that the interference of moisture was quite severe.
소복축어탕(小腹逐瘀湯)이 흰쥐 흉부대동맥의 혈관운동성에 미치는 영향
정용식,권정남,민성순,김종득,이상희,김재규,허정은,김영균,Jung, Yong-Sik,Kwon, Jung-Nam,Min, Sung-Soon,Kim, Jong-Deuk,Lee, Sang-Hee,Kim, Jae-Kyu,Heo, Jeong-Eun,Kim, Young-Kyun 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.3
This study was carried out to examine the relaxational response to the water extract of Sobokchuko-tang (SCT) in rat thoracic aorta. Segments of thoracic aorta obtained from rats immediately after delivery were mounted in organ baths superfused on a polygraph. It was found that the thoracic aorta segments responded to the SCT with dose-dependent vasorelaxation. At $10^{-7}M$ phenylephrine-induced contraction, the contractile response of thoracic aortic rings were inhibited by 99.2%. 75.3%. 42.4% and 35.8% after addition of the respective concentration (1O. 30. 100. $300{\mu}g$/ml) of SCT. This vasorelaxation of rat thoracic aorta was endothelium-dependent. The action mechanisms of vasorelaxation are thought to be concerned with the role of NO. cAMP and cyclooxygenase. but not with cGMP.
변미권,김진영,심성흠,김기탁,김종득,박동일,감철우,Byun, Mi-Kwon,Kim, Jin-Young,Sim, Sung-Heum,Kim, Ki-Tak,Kim, Jong-Deuk,Park, Dong-Il,Kam, Cheol-Woo 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.4
Amyotrophic lateral sclerosis (ALS) is a progressive disorder that causes degeneration of motor neurons of the brain and spinal cord. ALS is a progressive, fatal neuromuscular disease characterized by loss of motor neurons leading to muscle weakness. Sensation and mental function stay intact during the course of the disease. ALS is characterized by both upper and lower motor neuron damage. Diagnosis includes magnetic response imaging (MRI) electromyogram (EMG), muscle biopsy, and blood test. There is no cure for ALS. We recently observed three cases of ALS. The patients were diagnosis with ALS by EMG and symptoms. This report was conducted to evaluate how oriental medical treatment can affect ALS. We report the change of their symptoms through oriental medical treatment compared with taking riluzole.
김기영,김종민,권영수,이범종,장용근,김종득,장상목 ( Ki Young Kim,Jong Min kinm,Yung Soo Kwon,Burm Jong Lee,Yong keun Chang,Jong Deuk Kim,Sang Mok Chang ) 한국센서학회 1994 센서학회지 Vol.3 No.2
The use of preformed polymers and their cross-linking has been attempted in order to improve the intrinsic fragility of monolayers and Langmuir-Blodgett(LB) films. The evaluation of the characteristics of the LB multi-layer by using an AT-cut quartz crystal has been also attempted. This study reveals that the polyether pendants of 2C18VE3 lie at thee air-water interface at low surface pressures and are forced down into the subphase when the monolayers are compressed. This characteristic behavoir of the pendant polyethers is very clear on aqueous poly allyl amine(PAA) and is also observeable on saturated aqueous NaCl and CaCl₂. And the characteristics of LB multi-layers could be evaluated by using AT-cut quartz crystal in situ .