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간질환환자에서 (肝疾患患者) 혈청 (血淸) Ferritin 식 측정의 의의
윤용범(Yong Bum Yoon),이원표(Won Pyo Lee),김정용(Chung Yong Kim),임정순(Jung Soon Im),박소배(So Bae Park),김선혁(Sun Hyuk Kim) 대한소화기학회 1982 대한소화기학회지 Vol.14 No.1
N/A Serum ferritin levels were determined by 2-site radioimmunoassay in 20 normal controls and 77 patients with acute viral hepatitis (AVH), chronic active hepatitis (CAH), liver cirrhosis (LC) and primary liver cancer (PLC). The results were as follows: 1) In AVH, CAH and LC, serum ferritin levels were found to be significantly raised with wide range, and good correlation was demonstrated between the serum ferritin levels and serum transaminase activity, which suggested that elevation of the serumz ferritin level was due to leakage of storage ferritin by hepatic necrosis. 2) In patients with liver disease, no correlation could be demonstrated between the serum ferritin levels and transferrin saturation ratio and absence or presence of occult blood in stool. In patients with liver disease it appeared impossible to use serum ferritin level as indrect measurement of storage iron. 3) In the differential diagnosis of PLC from other liver diseases, serum ferritin measurement showed low sensitivity, low predictive value and relatively high false positivity.
윤용범(Yong Bum Yoon),김정용(Chung Yong Kim),배순기(Soon Kie Bae),김창민(Chang Min Kim),김상준(Sang Joon Kim),지제근(Je Keun Chi) 대한소화기학회 1981 대한소화기학회지 Vol.13 No.2
Pancreatic cystadenocarcinoma is one of the rare malignant tumors, accounting for about 1% of all pancreatic malignancies. The lesion is seen about half as frequently as its benign counterpart; the cystadenoma. It's clinical feature are different from the solid pancreatic neoplasm. There is female predo- minance and it's prognosis is much better than the solid neoplasm of the pancreas. Accurate diagnosis and proper treatment. therefore, are very important to the pancreatic cystadenoarcinoma, However, there's no published report on this neoplasm yet in Korea. We experienced one case of pancreatic cystadenocarcinoma proved by histologic feature recently and report the case with the review of literature
원발성간암예에서 (原發性肝癌例) SGOT / SGPT 비 측정의 임상적 (臨床的) 의의
윤용범(Yong Bum Yoon),이원표(Won Pyo Lee),김정용(Chung Yong Kim),김선혁(Sun Hyuk Kim),배순기(Soon Ki Bae),김진호(Jin Ho Kim) 대한소화기학회 1982 대한소화기학회지 Vol.14 No.1
N/A To assess the clinical significance of SGOT/SGPT ratio in 301 cases of primary liver cancer (PLC), 284 cases of liver cirrhosis (LC), 231 cases of chronic active hepatitis (C.A.H.) and 104 cases of acute viral hepatitis (A.V.H.). Tne results were briefly summarized as follows: I. The SGOT/SGPT ratio was 0. 860. 47 in AVH group, I.22+-0.66 in C.A.H. group, 1.48+-0.53 in L.C. grop ad 2.53+-1.17 in PLC group. The highest ratio was observed in PLC group with a mean of 2. 53 which was significantly higher than the mean of other liver disease groups. 2. Th SGOT/SGPT ratio in patients with SGOT activity over 2QO units was higher than those of SGOT activity below 200 units, and the mean SGOT/SGPT ratio in the PLC group was also significantly higher than the mean of other liver disease group. 3. The SGOT/SGPT ratio greater than 3 with a serum GOT above 200 units was almost entirely restricted to patients with pr imary liver cancer. It is concluded from these results that a high SGOT/SGPT ratio greater than 3 in a patisnt with a SGOT above 200 units is highly suggestive of primary liver cancer.
십이지장궤양 활동기와 반흔기에서 미소융모막효소 활성도의 변화
윤용범(Yong Bum Yoon),송인성(In Sung Song),김정용(Chung Yong Kim),김해련(Hae Ryun Kim),이계희(Kyai Hi Lee),정형배(Hyung Bae Chung) 대한소화기학회 1986 대한소화기학회지 Vol.18 No.1
To identify the effect of the gastric acid on brush border membrane-bound enzyme on duodenal mucosa, sucrase and alkaline phosphatase activity were assayed in the duodenal bulb and 2nd portion of the duodenum. The results were as follows: 1) alkaline phosphatase activities of duodenal mucosa were not changed according to the stage of duodenal ulcer. 2) sucrase activities of duodenal mucosa in active stage of duodenal ulcer were decreased comparing with those of normal subject, which returned to normal level in scarring stage.
윤용범(Yong Bum Yoon),김정용(Chung Yong Kim),이효석(Hyo Suk Lee),전형식(Hyung ski Jun),최병인(Byung In Choi) 대한소화기학회 1984 대한소화기학회지 Vol.16 No.1
N/A In 149 patients with the pancreatic or biliary diseases including CBD stone, CBD cancer, pancreatic cancer and chronic pancreatitis, diagnostic values of clinical criteria, ultrasonography and ERCP were reviewed by the calculated sensitivity, specificity, predictive value positive and negative. The results are summarized as following; 1) Sensitivity, specificity, predictive value positive and negative of malignant clinical criteria were 67.9%, 83.9%, 71.7% and 81.3% respectively, while those of benign clinical criteria were 83.9%, 67.9%, 81.3%, 71.7% respectively. 2) Sensitivity, specificity, predictive value positive and negative of ultrasonography in detecting pancreatobiliary abnormalities were 71.7% 77.3%, 94.5%, and 32.1%, respectively. 3) Sensitivity, specificity, predictive value positive and negative of ERCP for diagnosis of CBD stone were 88.6%,98%, 97.8% and 98% respectively, and for CBD cancer 65%, 94.7%, 76.5% and 97.3% respectively, and for pancreatic cancer, 78.3 % 97.7 % 90% and 96.6% respectively, and for chronic pancreatitis, 85.7%, 99.0%, 85.7% and 99.0% prespectively. Predictive value positive of ERCP for diagnosis of CBD cancer is relatively low. In conclusion, clinical criteria still have quite significances in differentiating between malignant and benign diseases of pancreatobiliary tract, and ERCP shows high diagnostic values in patients with CBD stone, CBD cancer, pancreatic cancer and chronic pancreatitis. But the predictive value positive was relatively low for diagnosis of CBD cancer. Therefore, other additional diagnostic tests such as cytology of bile juice are necessary to increase the dialgnostic value of ERCP for CBD cancer.
Dubin - Johnson 증후군 (증후군) 10예에 대한 임상적 (임상적) 고찰
윤용범,이원표,김정용 ( Yong Bum Yoon,Won Pyo Lee,Chung Young Kim ) 대한소화기학회 1980 대한소화기학회지 Vol.12 No.1
The Dubin-Johnson Syndrome is characterized by chronic, mild, predominantly conjugated hyperbilirubinemia with a blcak liver and pigmentation of parenchymal liver cell. The disor- der result from an inherited abnormality in the excretion of various non-bile salt organic anion from the liver cell into the bile. It is benign non-progressive and not associated with any form of chronic hepatic or biliary tract disease. The diagnosis of the Dubin-Johnson synd- rome is established by secondary rise in BSP retension test and needle biopsy of the liver. The important consideration in managing patient with this disorder are the reassurrance that the abnormality is benign and leads to no disability or reduction in life expectancy and the avoidance of unnecessary biliary tract surgery. Clinical observation was made on 10 cases of Dubin-Johnson Syndrome admitted to department of internal medicine, Seoul Xatio- nal University Hospital from 1969 to 1979. The following results are obtained 1. The male to female ratio was 6: 4 and the majority of the caes are in 'rd decale 2. There avere 3 cases of jaundice on family history and 2 cases ,vere 'orother nd sister relationship The chief complaints on admission were in order of jaund!ce, Satigue, rigiit upper abd- ominal oain and darl- urine. Hepatomogaly was observed in 5 cases, but there was no case of splenomegaly The average serum total biliubin level was Z. 98+ l. 29mg/100ml and the average serum conjugated bilirubin level vas l. 7p0. 94 mg/lpQml. Other liver function tests revealed normal v lues. 6. HBsAg and aFP test were performed in 5 cases and the results wcre negative in all cases Oral cholecystography was performed in 6 cases and the gallbladder was visualized in 8 cases, suggesting that the important non-visualization of gall-bladder on oral cholecy- stography for the diagnosis of the disorders ought to be reconsidered.
내시경적 (內視鏡的) 역행성 췌담관조영술의 (膵膽管造影術) 합병증에 (合倂症) 대한 Gabexate mesilate ( FOY ) 의 예방적 (豫防的) 효과
송인성(In Sung Song),김정용(Chung Yong Kim),윤영범(Yong Bum Yoon),배순기(Soon Kie Bae),송제일(Je Il Song) 대한소화기학회 1981 대한소화기학회지 Vol.13 No.2
N/A The development and prevalence of endoscopic retrograde cholangiopancreatography(ERCP) has resulted in great progress in the diagnosis of the disease of the pancreas, and biliary tract. At the same time, however, the rise of serum amylase level has been often point out as the complication of ERCP. To assess the effect of synthetic protease inhibitor, Gabexate mesilate(FOY), in hyperamylasemia following ERCP, the authors carried out a controlled trial in 39 patients who were underwent ERCP under the impression of pancreatic or biliary system disease. Of them 20 patients were allocated to FOY@ treated group and 10 patients to control group. The following results were obtained: 1) There was no significant difference in serum amylase level between FOY treated group and control group before ERCP, however significant difference was observed in seram amylase level at 2 hour and 2 day after ERCP between FOY treated group and control group Before ERCP the serum amylase level was 107. 6 45. 1 I.U./dl in control group and 105. 7+-42.1 I.U./dl in FOY treated group.At 2hour after ERCP the serum amylase level was 186.7 +-150.1 I.U./dl in control group and 103.2+-47.9 I.U./dl in FOY treated group. On 2nd day after ERCP, the serum amylase level was 167.7+-84. 1 I.U,/dl in control group and 109.6+-59.1 I.U./dl in FOY treated group 2) The change in serum amylase levels at 2 hour and 2 day after ERCP by the extent of visualization showed a tendency that a greater extent of visualization was associated with a higher incidence of serum amylase levels. Such a tendency was more pronounced in control group and the mean serum amylase level was significantly higher in the control group. 3) FOY did not cause any serious side effect such as shock, fall of blood pressure, itching, eruption, chest pain etc. in all cases. 4) There was some report that FOY has a relaxant action on the Oddis sphincter and helps the cannulation to the opening of Papilla of Vater, however it more depended upon the skill of the endoscopist, anatomical variation of the Papilla of Vater and FOY did not give any great advantage to the cannulation.
양성 및 악성복수의 (惡性腹水) 의 감별에 있어서 복수 CEA 치 측정의 진단적 (診斷的) 의의
유병철 ( Byung Chul Yoo ),임정순 ( Jung Soon Im ),홍원선 ( Won Sun Hong ),윤용범 ( Yong Bum Yoon ),김정용 ( Chung Yong Kim ) 대한소화기학회 1981 대한소화기학회지 Vol.13 No.1
Cytologic examination of ascites has been widely used for the diagnosis of malignancy, but its sensitivity is limited, and false positive findings occur occasionally. Recently, it has been suggested that malignant ascites contains increased concentration of carcinoembryonic antigen. The present study analyzed CEA levels of serum and ascites in g9patients with benign or malignant ascites, and the results were as followings: The mean CEA level of R8 henign ascites was 2. () ng/ml with a standard deviation of I. 38ng/ml, and the highest CEA level did not exceed 10 ng/ml. Ascites CEA levels in Rl patients with malignant peritonitis(mean level with 142. 3 ng/ml) were significantly higher than in patients with benign ascites and in 18 patients the levels exceeded 10 ng/ml. In patients with primary liver cancer, ascites CEA levels were not higher significantly than in patients with benign ascites. 2 In the malignant peritonitis group, there was a good correlationship(correlation coeffic- ient; 0. V2) between serum and ascites CEA levels, and gastrointestinal tumors, usually cons- idered CEA-producers, tended most often to have increased CEA levels of ascites. 3. In the pl patients with malignant peritonitis, cytologic examination was positive in 10 patients(32%), whereas ascites CEA levels were above 10 ng/ml in 18 patients(58%). Combi- ning the two methods increased the diagnostic accuracy up to 77%. Fourteen of g1 malign- ant ascites were negative by cytologic examination and detected only by CEA assay of ascites. Weconcluded from these results that CEA assay of ascites is a useful diagnostic adjunct to cytologic examination in the differentiation of benign and malignant ascites.