겹치기 마찰교반접합 된 Al6061/HT590 합금의 기계적 특성 평가

김은혜,이광진,송국현,Kim, Eun-Hye,Lee, Kwang-Jin,Song, Kuk-Hyun 대한용접접합학회 2015 대한용접·접합학회지 Vol.33 No.2

This study was carried out to evaluate mechanical properties of the jointed Al6061/HT590 alloys by friction stir welding (FSW). FSW was conducted under the conditions with tool rotating speed of 500 RPM and traveling speed of 300 mm/min., where Ar gas was introduced to prevent the materials from corrosion during the welding process. Electron back-scattering diffraction (EBSD) was used to characterize microstructures such as grain size, misorientation angle and crystal orientation. Evolution of intermetallic compounds in Al6061 during the process were examined in terms of morphology, size and aspect ratio at three distinct zones Al base material, heat affected zone and stir zone, where transmission electron microscope (TEM) was used. It was revealed that FSW gave rise to refinement of grains as well as growth of intermetallic compounds in Al6061. The morphological changes of intermetallic compounds exerted an influence on mechanical properties, resulting in occurrence of fracture in the part of the base material instead of the jointed parts (heat affected zone and stir zone). This study systematically evaluated the microstructural evolutions during the FSW for joining Al6061 with HT590 and their effect on mechanical properties.

마찰접합 된 A6063 합금의 미세조직과 기계적 특성 평가

김은혜,조형환,송국현,Kim, Eun-Hye,Cho, Hyung-Hwan,Song, Kuk-Hyun 한국재료학회 2017 한국재료학회지 Vol.27 No.5

This study was carried out to evaluate the developed microstructures and mechanical properties of friction welded A6063 alloy. For this work, specimens were prepared at a size of 12 mm ${\O}{\times}80mm$, and friction welding was carried out at a rotation speed of 2,000 RPM, friction pressure of $12kgf/cm^2$ and upset pressure of $25kgf/cm^2$. To perform an analysis of the grain boundary characteristic distributions, such as the grain size, orientation and misorientation angle distributions, the electron back-scattering diffraction method was used. In addition, in order to identify the dispersed intermetallic compounds of the base and welded materials, transmission electron microscopy was used. The experimental results found that the application of friction welding on A6063 led to significant grain refinement of the welded zone relative to that of the base material. Besides this, intermetallic compounds such as AlMnSi and $Al_2Cu$ were found to be dispersed with more refined size relative to that of the base material. This formation retains the mechanical properties of the welds, which results in the fracture aspect at the base material zone. Therefore, based on the developed microstructures and mechanical properties, the application of friction welding on A6063 could be used to obtain a sound weld zone.

청소년이 지각한 사회적 자본이 유데모니아에 미치는 영향: 인권의식을 매개로

김은혜,손한결,Kim, Eun Hye,Sohn, Han Gyeol 한국학교ㆍ지역보건교육학회 2021 한국학교지역보건교육학회지 Vol.22 No.3

Objectives: The purpose of this study was to examine the mediating effect of human rights consciousness on the relationship between social capital and eudaimonia perceived by adolescents. Methods: The participants of this study were 9,021 adolescents, with data taken from the 6^th year(2018) panel survey. All variables were evaluated by self-report of adolescents. The data were analyzed by SPSS 21.0 and AMOS 21.0. Results: First, social capital perceived by adolescents had a direct effect on eudaimonia. Second, social capital perceived by adolescents had an indirect effect on the eudaimonia through human rights consciousness. Conclusions: This study highlighted that human rights consciousness was identified as important mediator in the relationship between capital perceived by adolescents and eudaimonia. These results can be used as an important contribution to further research and educational practices for promoting the eudaimonia in adolescents.

항암화학요법 유발 말초신경병증에 대한 한약의 치료 효과: 체계적 문헌고찰 및 메타 분석

김은혜,윤지현,이지영,윤성우,Kim, Eun Hye,Yoon, Jee-hyun,Lee, Jee Young,Yoon, Seong Woo 대한암한의학회 2020 大韓癌韓醫學會誌 Vol.25 No.2

Objective: This study was aimed to report the therapeutic effects of herbal medicine on chemotherapy-induced peripheral neuropathy (CIPN). Methods: The prior studies were searched from the databases included PubMed, Cochrane Library, EMBASE, CNKi, CiNii, KISS, NDSL, KMBASE, and OASIS until September 2020. The main search keywords were chemotherapy, peripheral neuropathy, and herbal medicine, and only randomized controlled trials that analyzed the therapeutic efficacy of herbal medicine were included. The Cochrane's Risk of Bias was used for assessment of the risk of bias and the Review Manager 5.3 program was used for meta-analysis. Meta-analyses were grouped by the administration routes of herbal medicines (oral administration or topical use). Results: Nine studies with a total of 563 participants were included. Compared with usual care, the effective rate was higher in oral administrated herbal medicine (RR 1.67, 95% CI 1.25 to 2.23; p<0.001, I2=31%). In addition, topical herbal medicine showed an significantly higher effective rate than placebo (RR 2.20, 95% CI 1.52 to 3.18; p<0.001, I2=0%) and usual care (RR 2.24, 95% CI 1.74 to 2.89; p<0.001, I2=66%). There was no severe adverse effect in all participants. Conclusions: Herbal medicine appears to improve neuropathy caused by chemotherapy in cancer patients more than conventional therapy of CIPN. However, as there is heterogeneity between the included studies and a lack of blinding, further well-designed researches are more needed.

전이 췌장암 환자의 Gemcitabine과 방암탕 가감방 및 건칠단 병용투여 치험 1례

김은혜,윤성수,이지영,윤성우,Kim, Eun Hye,Yoon, Sung Soo,Lee, Jee Young,Yoon, Seong Woo 대한암한의학회 2018 大韓癌韓醫學會誌 Vol.23 No.2

Objectives: This study was aimed to report a patient with metastatic pancreatic cancer treated with modified Bangam-tang and Gunchil-dan in conjunction with gemcitabine. There were better survival-related outcomes compared to gemcitabine alone. Methods: The patient with metastatic pancreatic cancer received gemcitabine as palliative chemotherapy since June 2016 concurrent with modified Bangam-tang and Gunchil-dan since October 2016 to October 2017. To evaluate the effect of treatment, tumor markers (carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA)), Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1, and overall survival were checked. Adverse events were evaluated according to the Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. Results: After 12 months with the combination treatment, levels of CA19-9 were decreased from 8747 to 265.7 ng/ml and CEA from 42.2 to 6.5 U/ml. Clinical partial response state was shown until May 2, 2017 and stable disease state was maintained from August 4, 2017. In March 2018, the patient got an operation including pancreatectomy and diagnosed with no evidence of disease state in September, 2018. In conclusion, it showed the overall survival of 29 months from June, 2016 to November, 2018. Serious adverse events were not identified. Conclusions: This study suggested that combined treatment with modified Bangam-tang and Gunchil-dan may show better outcome in patient with metastatic pancreatic cancer than gemcitabine alone.

한국 성인의 수면시간과 체성분 인자와의 연관성

김은영(Eun Young Kim),최윤선(Youn Seon Choi),김선미(Seon Mee Kim),최선영(Sun Young Choi),김은혜(Eun Hye Kim),김정은(Jung Eun Kim),김이연(E Yeon Kim),정재훈(Jae Hoon Jeong),진로사(Rosa Jin),정상아(Sang Ah Jung) 대한임상노인의학회 2014 대한임상노인의학회지 Vol.15 No.1

연구배경: 수면부족은 당 대사조절 등 체내 생리적 시스템에 영향을 주면서 비만의 유병률을 높일 것으로 생각되는데, 국내외적으로 수면시간과 비만과의 연관성을 다룬 연구는 많이 있으나 체지방량의 분포 등 체성분과의 연관성을 다룬 연구는 거의 없는 실정 이다. 이에 본 논문에서는 우리나라 성인의 수면시간과 체성분과의 연관성을 확인하고자 했다. 방법: 제 4기(2008∼2009)와 제 5기(2010) 국민건강영양조사 자료를 분석하였으며 고령, 미측, 갑상샘 질환, 신부전, 임신을 제외한 총 9880명을 대상으로 하였다. 체성분인자로 BMI, 허리둘레, 총체지방률, 몸통체지방률, 제지방률, 몸통제지방률, 근량을 사용하였고, 수면시간에 따른 체성분 분석의 연관관계를 보기 위해 선형 회귀분석 및 로지스틱 회귀분석을 이용하였으며, 나이, 흡연, 운동, 음주 등의 교란변수를 보정하여 다중 로지스틱 회귀분석을 실시하였다. 결과: 남성과 여성 모두 BMI, 허리둘레, 몸통체지방률, 근량에서 수면시간과 유의한 음의 상관관계를 보였으며, 비만 관련 위험도를 알아보기 위하여 BMI≥25 kg/㎡, 허리둘레(남자≥90 cm, 여자≥85 cm), 체지방률과 제지방률, 근량의 상위 25%값의 비율에 대해 다중 로지스틱 회귀분석을 실시하였을 때는, 남성에서만 유의한 교차비를 보였다. 남성에서 수면시간이 1시간 증가할수록 BMI 25이상의 위험은 0.89배, 허리둘레 90 cm이상 위험은 0.90배, 몸통 체지방률과 근량도 각각 0.93배, 0.89배 감소하였다. 결론: 우리나라 성인의 수면시간은 체성분인자 중 BMI, 허리둘레, 몸통 체지방률, 몸통 제지방률, 근량과 유의한 연관성이 있었으며, 남성에서는 수면시간이 부족할수록 BMI 25 kg/㎡ 이상, 허리둘레 90 cm이상 될 위험이 증가하고, 몸통체지방률이 증가할 위험도 높은 것으로 나타났다. 이러한 결과는 수면부족이 몸통에 체지방량의 분포를 증가시켜 중심비만을 야기시키는 원인이 될 수 있음을 뒷받침하며, 적절한 수면관리를 통해 이를 예방할 수 있을 것으로 사료되므로 이를 지키기 위한 노력이 필요하겠다. Background: Despite the large number of epidemiological studies linking obesity and short sleep duration, there is paucity of data carefully examining the relationship between body composition and sleep duration. So, through national undertaking Korea National Health and Nutrition Examination Surveys (KNHANES), we examined the relationship between sleep duration and BMI, waist circumference, and percent body fat in Korean adults. Methods: From the data of KNHANES in the year of 2008∼2010, over 19 years old 4337 men and 5543 women, relationship between sleep duration and indices of body composition was examined. Anthropometric and dual-energy X-ray absorptiometry (DXA) measures of body composition were used. Sleep duration was measured using information obtained from self-reported questionnaires. Results: The study results revealed a negative association between sleep duration and most of body composition variables - body mass index, waist circumference, truncal fat percentage, muscle mass - and positive association with truncal lean mass percentage. In men, increasing sleep duration 1 hour, prevalence of obesity (BMI≥25 kg/㎡) is decreasing (OR=0.89, CI:0.837-0.939), risk of waist circumference over 90 cm is decreasing (OR=0.90, CI:0.851-0.966), truncal fat percentage (OR=0.93, CI:0.869-0.992) and muscle mass (OR=0.89, CI: 0.835-0.949) are also decreasing. Conclusion: Our results are consistent with previous findings that sleep duration is associated with obesity. However, the relationship between sleep duration and body composition may be stronger in men than in women. Short sleep duration was associated with increased truncal fat. And it supports that short sleep duration may increase prevalence of central obesity in Korean men.

1990년대 중반 이후 일본의 도심회귀와 젠트리피케이션

김은혜(KIM Eun hye) 지역사회학회 2016 지역사회학 Vol.17 No.3

이 논문은 1990년대 중반 이후 일본 젠트리피케이션이 가져온 공간구조의 변화를 분석한 연구이다. 서구에서 젠트리피케이션은 주로 공간재편, 건조환경, 도시커뮤니티의 변화를 가져오면서, 학문적 평가 역시 개방도시론과 보복도시론으로 대립되었다. 반면, 일본의 도시화-교외화 현상은 고도성장기에 본격화되었고, 80년대 버블경제기에는 대도시권 도심의 지가상승이 재개발을 확대시켰다. 버블붕괴로 인한 지가 하락은 지난 20년간 도심 인구를 점차 회복시키면서, 맨션 주택의 증가, 대규모 상업시설 입지, 그리고 대학 캠퍼스 이전 등 복합적 결과를 낳았다. 전후 고도성장기 도심인구 증가는 취업자수 증가로 인해 발생했던 반면, 1990년대 중반 이후는 도심 내 직장 및 캠퍼스가 있는 정착층이 형성되어 차이를 보인다. 도쿄도 츄오구는 고층맨션의 확대와 지가상승이 현저한 추세를 보이는 대표적 지역이다. 향후 일본 대도시권 도심부 중상류층의 거주 증가는 공간적 양극화를 심화시킬 전망이다. This study is to examine the changes of spatial structure and Japanese gentrification since the mid-1990s. The gentrification in western context has brought the changes the spatial restructuring, built environment, and urban community mostly, and there are two different opinions on the gentification like the emancipatory city thesis and revanchist city thesis. The urbanization and suburbanization in Japan were expanded in high growth period, intensified because of the Land-value rising effect (giageya) in bubble period. However, the urban core areas have revived in population over the last twenty years After the Collapse of the Bubble Economy, it happened the increase of mansion housing, the siting of commercial facilities, the relocation of college campus etc. Meanwhile the population growth in urban core areas was the cause of employment growth in high growth period, the population revival in mid-1990s was promoted by residents for cutting the commute time and students for attending the campus. Especially, the Chuo-ward in Tokyo is the largest population in gentirification, it has happened that the high-rising mansions and land value increase. The upper-middle class has been increased in urban core areas of metropolitan areas, the spatial polarization will be deepened in Japan.

무용전공자를 위한 고등교육 진로개입 실태분석

김은혜 ( Kim Eun Hye ),남진희 ( Nam Jin Hee ),박재근 ( Park Jae Keun ) 한국무용과학회 2018 한국무용과학회지 Vol.35 No.3

대학 무용전공자의 다각화된 진로개발을 위해서는 직업지도, 진로교육, 진로상담을 포함하는 진로개입(Career Intervention)을 교육현장에서 체계적으로 수행하는 것이 필수적이다. 이에 본 연구의 목적은 대학 무용전공자를 위한 진로개입 실태를 확인하고 발전 방향을 제시하는 것이다. 이를 위하여 최근 무용전공 졸업생들의 취업 실태를 분석하였으며, 무용학과 내 진로·취업 관련 교과목의 현황과 특성을 분석하였다. 이 연구는 현재 무용학과 또는 무용 전공이 개설된 4년제 대학 36개교를 연구의 대상으로 조사하였고, 이 중 30개교(83%)를 대상으로 진로개입에 관한 설문조사를 실시하였다. 분석결과를 바탕으로 도출된 결론은 다음과 같다. 대학 무용전공자를 위한 진로개입은 외형적으로 확대된 모습을 보이고 있으나 체계적인 진로개입을 위한 접근 방안은 미비한 것으로 나타났다. 먼저, 무용전공자를 위한 직업지도를 충분히 지원할 수 있는 정보나 프로그램이 부족한 것으로 나타났다. 다음으로, 대학 무용전공자를 위한 진로교육은 실천적인 형태로 학생들의 진로의사결정에 실재적이고 직접적인 기여를 하기 보다는 형식적인 절차에 의해 이루어지고 있는 것으로 나타났다. 마지막으로 대학무용 전공자를 위한 진로상담은 직업지도와 진로교육에 비해 비교적 잘 이루어지고 있는 것으로 나타났다. 이를 토대로 이 연구는 대학 무용전공자를 위한 진로개입 발전 방안으로 무용직업군 직업표준체계 및 진로흥미검사를 위한 도구, 진로교육을 위한 체계적인 콘텐츠와 진로상담 가이드라인의 개발이 절실하다는 것을 제안하였다. The purpose of this study is to examine the actual status of career intervention for university dance majors and present a direction for development. The employment rate of dance major graduates was analyzed through literature analysis, and the characteristics of the curriculum subjects in dance departments related to career path and employment were analyzed. In addition, a survey on career intervention was conducted with administrative professionals working in university dance departments. Findings drawn from the analysis of the current state of career intervention for dance majors are as follows: Career intervention for dance majors appears to have expanded, but results showed that approaches to systematic career intervention are still lacking. First, there were not enough information or programs that fully support Vocational guidance for dance majors. Next, career education for dance majors were being carried out merely as formality. Finally, career counseling for dance majors were being conducted at a better level compared to career guidance and career education. Based on these findings, this study suggested career intervention development measures for dance majors.

인삼의 항산화 작용

김은혜(Eun-Hye Kim),이동권(Dong-Kwon Rhee) 고려인삼학회 2009 Journal of Ginseng Research Vol.33 No.1

우리 몸의 많은 기관을 비롯하여 장기들은 반복적이거나 혹은 급성 스트레스를 이겨내지 못하고 만성 스트레스로 이어질 경우 질병이 생기게 된다. 특히 강하고 지속적인 스트레스에 노출되면 뇌의 해마 수지상 세포(hippocampal dendrites)가 위축되거나 크기가 작아진다. 이렇게 스트레스로 인하여 증가된 글루코 코티코이드 호르몬은 뉴런 흥분제인 glutamate를 유도하거나 에너지 대사를 변형시켜 신경 독작용을 일으킨다. 이러한 연속적인 반응은 TNF-α convertase(TACE)를 활성화시켜 TNF-α가 분비되도록 하여 전사 조절자인 NF-κB가 핵내로 전이되고 신경 손상을 일으키는 iNOS와 COX-2와 같은 효소를 유도한다. 이런 산화적 스트레스의 상위조절인자 TACE는 스트레스에 의한 여러 가지 염증성 질환 및 숙주방어에서 가장 중요한 조절자인 TNF-alpha 를 수용체로부터 “유리(shedding)” 시키는 역할을 한다. 따라서 이런 신호 전달계를 자극하는 TACE의 발현 양과 이로 인한 지속적인 처리과정이 중요한 문제로 대두되고 있다.63,64) 특히 여러 스트레스중에서 고정화 스트레스 및 신체적 구속 스트레스에 대한 연구는 뇌에서 산화물 생성을 증가시키지만30) 인삼이 뇌의 산화물질 생성에 어떤 영향을 미치는지 체계적인 연구가 진행된 바 없다. 따라서 염증을 매개하는 TNF-alpha의 생산에 중요한 역할을 하는 TACE의 발현 조절 및 TNF-alpha 신호전달을 연구함으로써 인삼의 항산화 기전을 분자 수준에서 규명할 수 있게 될 것으로 기대된다. Clinical and animal studies have shown that free radical overload is an important cause for a variety of diseases. Although ginseng has been recognized as antioxidant, how it modulates anti-oxidative process at the molecular level remains unknown. Free radical production is induced by tumor necrosis factor-α (TNF-α) under the stress condition, and TNF-α release is activated by TNF-α-converting enzyme (TACE). Since TACE inhibitor is also well known for antiinflammatory agent, ginseng seems to show anti-oxidative activity by repressing TACE pathway. Further studies on signal transduction would be warranted to elucidate molecular action mechanisms of ginseng on anti-oxidation and anti-inflammation.

A Study on Establishment of Basic Safety and Essential Performance Criteria of Mobile Computed Tomography

김은혜(Eun Hye Kim),박혜민(Hye Min Park),김정민(Jung Min Kim) 대한방사선과학회(구 대한방사선기술학회) 2021 방사선기술과학 Vol.44 No.3

As the number of Coronavirus Disease-19 (COVID-19) patients increases in a global pandemic situation, the usefulness of mobile computed tomography (CT) is gaining attention. Currently, mobile CT follows the basic safety and essential performance evaluation criteria of whole-body or limited-view X-ray CT in order to obtain device approval and evaluation in the Republic of Korea. Unlike stationary CT, mobile CT is not operated in shielded areas but rather areas such as intensive care units, operating rooms, or isolation rooms. Therefore, it requires a different basic safety and essential performance evaluation standard than stationary CT. In this study, four derived basic safety evaluation criteria related to electrical, mechanical, and radiation safety were included (dose indication test, protection against stray radiation, safety measures against excessive X-rays, half-value layer measurement); and seven essential performance evaluation criteria were included (tube voltage accuracy, mAs accuracy, radiation dose reproducibility, CT number of water, noise, uniformity, and spatial resolution); total eleven basic safety and essential performance evaluation criteria were selected. This study aims to establish appropriate basic safety and essential performance evaluation criteria for simultaneously obtaining images with diagnostic value and reducing the exposure of nearby patients, medical staff, and radiologic technologists during the use of mobile CT.