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        닭 특이 대사 경로 재확립

        김운수(Woon Su Kim),이세영(Se Young Lee),박혜선(Hye Sun Park),백운기(Woon Kee Baik),이준헌(Jun Heon Lee),서성원(Seongwon Seo) 韓國家禽學會 2010 韓國家禽學會誌 Vol.37 No.3

        닭의 대사 생리에 대한 연구는 산업적 가치 및 생물학, 의학적으로도 매우 중요하다. 닭의 유전체 염기서열 분석 결과는 2004년에 처음 발표되었고, 이러한 유전체 정보를 바탕으로 유전형과 표현형의 상관관계를 분석하는 연구가 필요하다. 따라서 본 연구는 닭 유전체 정보를 바탕으로 대사 경로를 재확립하고, 닭 특이 대사 경로?유전체 데이터베이스를 구축하였다. 이를 위해 Perl 언어를 기반으로 개발된 자동 파이프라인(pipeline)을 이용하여 여러 생물정보 데이터베이스에 산재해 있는 닭 유전체에 관한 정보를 통합한 닭 특이 통합 데이터베이스를 구축하였다. 또한, 구축된 닭 특이 통합 데이터베이스를기반으로PathoLogic 알고리즘을구현한Pathway Tools 소프트웨어를 이용하여 닭 특이 대사 경로를 재확립하였다. 결과적으로, 닭 유전체 Gallus_gallus-2.1에서 2,709개의 효소, 71개의 운반체(transporter)와 1,698개의 효소 반응, 8개의 운반 반응(transport reaction)이 도출되었다. 이를 통해 총 212개의 대사 경로가 재확립되었고, 1,360개의 화합물(compound)이 닭 특이 대사 데이터베이스에 포함되었다. 다른 종(사람, 생쥐, 소)과의 비교 분석을 통해 중요한 대사 경로가 닭 유전체에 보존되어 있음을 보였다. 또한, 닭 유전체의 assembly와 annotation의 질을 높이는 노력과 닭 및 조류에서 유전자 기능 및 대사 경로에 대한 연구가 필요한 것으로 나타났다. 결론적으로, 본 연구에서 재확립된 닭의 대사경로 및 데이터베이스는 닭 및 조류의 대사 연구뿐만 아니라 포유동물 및 미생물과의 비교 생물학적 접근을 통한 의학 및 생물학적 연구에 활용될 것으로 기대된다. Chicken is an important livestock as a valuable biomedical model as well as food for human, and there is a strong rationale for improving our understanding on metabolism and physiology of this organism. The first draft of chicken genome assembly was released in 2004, which enables elaboration on the linkage between genetic and metabolic traits of chicken. The objectives of this study were thus to reconstruct metabolic pathway of the chicken genome and to construct a chicken specific pathway genome database (PGDB). We developed a comprehensive genome database for chicken by integrating all the known annotations for chicken genes and proteins using a pipeline written in Perl. Based on the comprehensive genome annotations, metabolic pathways of the chicken genome were reconstructed using the PathoLogic algorithm in Pathway Tools software. We identified a total of 212 metabolic pathways, 2,709 enzymes, 71 transporters, 1,698 enzymatic reactions, 8 transport reactions, and 1,360 compounds in the current chicken genome build, Gallus_gallus-2.1. Comparative metabolic analysis with the human, mouse and cattle genomes revealed that core metabolic pathways are highly conserved in the chicken genome. It was indicated the quality of assembly and annotations of the chicken genome need to be improved and more researches are required for improving our understanding on function of genes and metabolic pathways of avian species. We conclude that the chicken PGDB is useful for studies on avian and chicken metabolism and provides a platform for comparative genomic and metabolic analysis of animal biology and biomedicine.

      • 신재생에너지 공급의무화제도 시행에 따른 서울형 햇빛발전지원제도 도입방안 연구

        김운수(Woonsoo Kim),정아(Jeongah Kim) 서울연구원 2012 서울연구원 정책과제연구보고서 Vol.- No.-

        It is no surprise that all developed countries and many developing ones around the world are in a fiercer green race for responding climate change issues and achieving promised low-carbon societies. The Korean government has met the strong needs for “low carbon, green growth” to cope with global climate changes, and is introducing the various policies for accelerating renewable energy generation systems. Seoul city had already prepared the grand vision for both climate protection and renewable energy generation initiative in 2030, thereby serving Seoul in implementing effective and practical actions in order to achieve its emission reduction and renewable energy production goals by 2030. In addition, Seoul city has recently announced the new movement to sustainable energy planning, “world-leading climate and environment capital city, Seoul”, including strategies of production of renewable energy, energy efficiency, citizen participation, and capacity building. These are expressed in forms of 10 core projects, resulting in energy savings and production effects equivalent to electricity generation of 1 nuclear power plant. Considering many local governments around the world, from the viewpoints of self-supporting energy system, have made it a policy priority to generate renewable energy, it’s more or less imperative for Seoul to follow such streams. Based on the current mandatory implementation of RPS system since 2012 year, the purpose of this study is given to possible introduction of Seoul-typed FIT system, as a subsidiary policy tool, thereby bringing a host of benefits to Seoul city’s renewable energy generation plan. Thus, Switching to cleaner energy sources, such as solar photovoltaic system of roof-top, might contribute to a better renewable energy production, and at the same time relieve Seoul’s dependence on fossil fuel-based energy. For possible introduction of Seoul-typed FIT with co-existence of RPS system, this study points out the comparative concluding remarks for solar photovoltaic in Seoul as follows:①subsidy to installation of solar photovoltaic system, ②additional support in proportion to amounts of traded REC, ③maintenance cost supporting of solar light equipment, and ④financial support with cheap capital. With the mandatory implementation of RPS policy, more preferred way might be the additional support in proportion to amounts of traded REC with co-existence of both RPS and Seoul-typed FIT system.

      • KCI등재후보
      • 서울시 온실가스 감축목표 성과관리 모니터링 방안 연구

        김운수 ( Woon Soo Kim ),전하나 ( Ha Na Jeon ),정남숙 ( Nam Sook Jeong ) 서울시정개발연구원 2011 연구보고서 Vol.2011 No.28

        Climate change is today recognized as one of the most serious challenges to the global and local community. The IPCC has concluded that most of the observed warming in global average surface temperature that has occurred since the mid-20th century is very likely a result of human activities. Our society has also experienced climate change; warmer winters, hotter summers and incidences of more extreme weather. Average temperature in Seoul has warmed at a rate of approximately 2.4°C from 1908 to 2007 that is almost triple the global rate in the past 100 years (1906-2005). Climate change is not only bringing subtropical diseases rarely found but also increasing flooding as rainfall become more intense during the summer in Seoul. Hotter temperatures will increase public health risks, particularly for vulnerable populations such as the elderly, and place further strains on our infrastructure. Seoul has already planned for a contribution to climate change and implemented action plans. The target of reducing Seoul`s GHG emissions by 25% of 1990 levels by 2020 and by 40% of 1990 levels by 2030, Seoul should know the strength and weakness in carrying out the plan by monitoring performance in order to successfully achieve greenhouse gas reduction goals. The aim of this study is to provide a monitoring framework for performance management meeting GHG emission reduction target and suggest policy-directions of improving an GHG target management in Seoul, The suggestions of this study are summarized as follows, 1. Seoul GHG Assessment Tool: This study suggests developing ``Seoul GHG Assessment Tool`` that all steps of reducing greenhouse gas are integrated into one system in Seoul:the steps include reporting GHG inventory, setting targets and action plans of GHG reduction, and evaluating performance of meeting the target. It is expected to enhance Seoul`s ability of managing performance, thus contribute much to meeting GHG reduction target in Seoul. 2. use of Seoul GHG Information Management System: In general, it needs to manage exceedingly mass data in order to devise strategy for reducing greenhouse gas and analysis the inventory. When it is extremely costly to produce a new system, it is able to use Seoul GHG Assessment Tool or GHG management systems established by government: NGMS (National Greenhousegas Management System) and GEIS (Greenhouse gas Emission Information System), etc. 3, establishment of monitoring system: The policy conditions and methodologies related to global warming have continuously modified, therefore we should enhance the flexibility for adapting the change in Seoul. For example, IPCC has modified and updated ``guidelines for national greenhouse gas inventories`` since the first report, so Seoul should also adapt its greenhouse gas inventory according to their revision. It is natural that the revisal has an effect on national and local target for climate change. 4, annual progress reporting of GHG reduction plans: New York and London have published the annual progress reports which show their achievement and performance of climate change plans. Those play an important role as informing the progress of plans to citizen and officer. It should be pointed out that local society take part in the action plans, thus Seoul have a duty to report the action plans and performance. 5, introduction of energy management system (ISO50001): According to the implementation of GHG and energy target management that divides the greenhouse gas target into public and private sectors in Korea, some experts predict to increase the works of management greenhouse gas reduction in local government. It is able to reduce the burden of the policy implementation as applying international standard of energy management system (ISO50001). The system stresses the involvement of executive leadership, saying that top management must establish, implement and maintain an energy policy. They must identify the scope of the system, communicate its importance, ensure that appropriate targets and performance indicators are established and ensure that results are measured.

      • 서울시 기후변화 고도적응 방안 연구

        김운수 ( Woon Soo Kim ),최유진 ( Yu Jin Choi ),정아 ( Jeong Ah Kim ) 서울시정개발연구원 2010 연구보고서 Vol.2010 No.2

        With the growing recognition that climate change is already underway and is affecting Seoul in general, adaptation strategy is becoming an important policy issue in Seoul. Such impacts range from urban climate change for higher temperature levels and reviews of rainfall intensity management strategies, to adjustments to climate change vulnerability environmental sector. Adaptation normally refers to efforts that respond to the impacts of climate change to minimize harm or take advantage of beneficial opportunities. The contents of this research is organized as follows:Chapter Ⅱ of this research examines the diagnosis and assessment of climate vulnerability that may result from the characteristics of climate adaptation components in Seoul. hapter Ⅲ deals with policy implications of climate adaptation based from climate changes described in Chapter Ⅱ. Chapter Ⅳ draws some policy implications through comparative foreign cities` adaptation strategies. And Chapter Ⅴ suggests policy-directions of climate adaptation strategies. In order to figure out Seoul city`s ability to manage its climate risks through adaptation, two approaches are adopted:hazardous-based and vulnerability-based approach. From the hazardous-based approach, while adaptation ability is positive sign, both climate exposure and sensitivity are showing yearly increasing pattern, thereby resulting in the higher vulnerability index in Seoul(see Fig. 1). Thus to effectively address the challenges that a changing climate will bring, Seoul city needs to begin adaptation responses to climate change already set in motion to maintain productivity of the Seoul`s ecosystems and economy, and the well-being of all citizens. fortunately, if introducing adaptation base variables such as budget expenditure, local ordinance, institution, etc., the vulnerability index which is a function of climate exposure, sensitivity, and adaptation capability variables, might be slightly enhancing to some extent. In terms of applying the vulnerability-based approach with expert questionnaire survey, it implies both policy priorities and their mix of adaptation strategies in Seoul(see Table 1). Especially urban heat waves, rainfall intensity, new health disease are the compelling troubles in adaptation process. While this study focuses on climate adaptation, it is clear that managing such impending climate risks(adaptation) must be critical in preparing adaptation strategies. To ensure a coordinated effort in adapting to the unavoidable impacts of climate change, the conclusion is divided into two parts based on findings. The first part is related with Seoul`s ability to manage its climate risks through adaptation process. The well-designed strategic framework, that is essential for making highly adaptative city, includes establishment of pre-evaluating and pre-responding system, enhancement of adaptative institution (i.e., vulnerability index application, climate-friendly urban development guidelines), securing social equity and public awareness, policy implementation connected with adaptive demands, and monitoring climate change impacts, etc. The second part, related with policy recommendation on climate change adaptation, includes: 1. Building Seoul`s Climate Adaptation Master Plan is essential to assess the long-term and short-term possible risks from climate change and prepare strategies to reduce those risks building on Seoul`s Climate Adaptation Strategy. Basic infrastructure such as monitoring climate change and information delivering system is also needed. 2. Developing the vulnerability index mapping responding to Seoul`s climate change and evaluating process is necessary to make Seoul highly-adaptive city. 3. Preparing urban development guidelines matching with climate change adaptation is desirable to make Seoul climate-friendly city. Especially, application of urban heat map to urban design process can be useful tool.

      • 서울시 기후변화대응 성과분석 및 비전수립

        김운수 ( Woon Soo Kin ),신성일 ( Seong Il Shin ),원주 ( Won Joo Kim ),정아 ( Jeong Gah Kim ) 서울시정개발연구원 2009 연구보고서 Vol.2009 No.1

        It is no surprise that all developed countries and many developing ones around the world are in a fiercer green race for responding climate change issues and achieving promised low-carbon societies. Each country`s bid for green leadership is just related with drawing his competitive power in the low-carbon age. In parallel, in light of the urgent need to take climate protection initiative, meet housing demand with low carbon communities, minimize threats to the environment and fulfill public`s aspiration for higher quality of life, designing cities to attain such high expectation standards should be targeted to deal successfully with all these challenges. The purpose of this study is to provide basis of Seoul city`s vision for climate protection initiative in 2030, thereby figuring out what kinds of strategies be adopted to meet pacesetting goal in such an optimized systematic way. In particular, as reborn to be a clean and charming world-leading city, Seoul city needs to act today more for better tomorrow based upon goal-oriented climate protecting guidelines. Thus the Seoul city`s vision for climate protection initiatives in 2030 can serve Seoul in implementing effective and practical greenhouse abatement actions in order to achieve its emission reduction goals by 2030, This study might be used as a ``living guideline`` to assist Seoul prepare actions and obtain the greatest benefits from climate protection activities, The findings of this study is summarized as follows.

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