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      • KCI등재후보

        관성/확산필터를 이용한 나노입자의 분류기술 연구

        김용구,이상열,김한나,노학재,봉춘근,김대성,Kim, Yonggu,Lee, Sangyul,Kim, Hannah,Noh, Hakjae,Bong, Choonkeun,Kim, Daesung 한국입자에어로졸학회 2015 Particle and Aerosol Research Vol.11 No.2

        The purpose of this research is to find out the collection property of nanoparticle in diffusion filter to know particle size dispersion of nanomaterial using inertial force and principle of Brownian diffusion motion. We used inertial filters which are two different type and diffusion filters made by various kinds of Wiremesh and the different pieces of filter to compare with particle size distribution using NaCl particles. Finally, We made a conclusion as follows : (1) the bigger available charging volume is and the larger specific surface area of inertial filter is, the better collection efficiency is. (2) The higher wire-mesh number of filter is, the more collection efficiency of small particle is increasing because the wire of the higher Wiremesh number filter is thinner and denser. (3) The more pieces of wire-mesh filter, the more collection efficiency is increasing because it makes the residence time longer.

      • 기술이전의 양론에 관한 전망

        김용구,Kim, Yong-Gu 한국방위산업진흥회 1985 國防과 技術 Vol.- No.74

        오늘날 선진국들은 그들의 첨단기술이 해외로 무단히 유출되는 것을 방지하기 위해, 그리고 개발도상국들은 그 첨단기술을 어떠한 수단으로든지 획득하기 위해 전력을 다하고 있다. 그러면 선진국중에서도 대표적 선진국인 미국은 과연, 국내외 기술이전에 관해서 어떠한 견해를 갖고 있으며, 어떠한 방책을 강구하고 있는지, 우리로서는 지대한 관심사가 아닐 수 없다. 여기에 미육군 유도탄사령부(MICOM)에서 기술이전의 특별참모직을 맡고 있는 Mr. Howard C, Race(예비역육군대령)의 논문을 번역 소개하니 참고하기 바란다.

      • KCI등재

        자살을 시도한 정신과 환자에서 낮은 혈청 콜레스테롤 농도와 심각한 자살 수행과의 연관성

        김용구,이헌정,김지연,최소현,이민수,Kim, Yong Ku,Lee, Heon Jeong,Kim, Ji Yeon,Choi, So Hyun,Lee, Min Soo 대한생물정신의학회 1999 생물정신의학 Vol.6 No.2

        자살 시도군 231명, 환자 대조군 231명, 정상대조군 231명을 대상으로 혈청 콜레스테롤 농도를 측정하여 다음의 결과를 얻었다. 1) 자살 시도군이 환자대조군 혹은 정상대조군보다 혈청 콜레스테롤 농도의 유의한 저하를 보였다. 2) 진단별로는 우울증과 인격장애에서 자살 시도군이 환자대조군보다 콜레스테롤 농도의 유의한 저하를 보였으나, 정신분열병과 양극성 정동장애 조증형에선 차이가 없었다. 3) 자살 시도군의 남녀별로 비교시, 남자가 여자보다 콜레스테롤 농도의 유의한 저하를 보였으며, 진단별로는 우울증에서만 유의한 차이를 보였다. 4) 자살 시도군에서 낮은 콜레스테롤 농도는 심각한 자살 수행과 연관성이 있었다. 5) 자살 시도군에서 치료전에 비해 치료후 혈청 콜레스테롤 농도의 유의한 증가를 보였다. 본 연구의 결과는 자살 시도의 예측인자로서 혈청 콜레스테롤이 이용될 수 있음을 시사한다. 향후 콜레스테롤 농도에 미치는 변인들을 통제한 전향적 방법을 통해 원인적 측면에서 혈청 콜레스테롤 농도와 세로토닌, 인터루킨-2, 멜라토닌 간의 연관성에 관한 연구가 이루어져야 하겠다. An association of low total cholesterol in blood with psychiatric diseases and suicidal behavior has been suggested. As part of an attempt to further explore this relationship, we examine first, whether serum cholesterol levels in psychiatric patients with suicidal attempt would be lower than in non-suicidal psychiatric inpatients or normal controls, second, whether such significant difference of cholesterol levels would be present when the diagnostic groups are analyzed separately, third, whether low cholesterol level would be associated with a history of serious suicidal attempts, and finally, whether low cholesterol level in suicide attempters is a state or a trait marker. We determined the serum cholesterol levels in 231 patients admitted to an emergency room following an suicidal attempt, in the same numbers of age-, sex- and diagnosis- matched non-suicidal psychiatric controls, and in the same numbers of age-, sex matched normal controls. The seriousness of an attempt was divided into 5 grades according to the degree of the resulting medical injury. Total cholesterol levels in suicide attempters were significantly lower compared with both psychiatric and normal controls, when sex, age, and nutritional status (i.e., body mass index) were controlled for. This significant relationship was observed in major depressive disorders and personality disorders, but not in schizophrenia and bipolar type I disorders. The severity of suicide by a lowering of blood cholesterol was related to the magnitude of the cholesterol reduction. After treatment of their psychiatric ailments, the cholesterol levels in suicide attempters were significantly increased. This result suggests that low cholesterol level in psychiatric patients might be a potential biological marker of suicide risk. It is hypothesized that low cholesterol levels is associated with the suicide by modifying the serotonin metabolism, the production of interleukin-2 and melatonin metabolism in psychiatric patients.

      • TCSC의 $H_{\infty}$ 제어에 의한 대규모 전력계통의 지역간 저주파진동 억제 PartI : 설치지점 선정

        김용구,심관식,송성근,김영환,남해곤,Kim, Yong-Gu,Sim, Gwan-Sik,Song, Seong-Geun,Kim, Yeong-Hwan,Nam, Hae-Gon 대한전기학회 2000 전기학회논문지A Vol.49 No.5

        This paper presents application results of the augmented matrix eigen-sensitivity theories to TCSC siting problem for damping the inter-area low frequency oscillation in the large KEPCO system. First and second-order eigen-sensitivities of the inter-area low frequency oscillation in the large KEPCO system. First and second-order eigen-sensitivities of the inter-area mode are computed fro changes in susceptance of the transmission lines. The lines having high sensitivity are chosen as the initial candidates for installing TCSC. Then for each of the chosen candidates, Bodeplot of the transfer function with line susceptance as the input and the bus voltage at one side of the line as the output is computed. Using the Bode plots, the lines having any zeros near the inter-area mode are screened out since design of TCSC controller is very difficult in such a case. The $H_{\infty}$ TCSC controller installed at any finally chosen candidate is found to be effective in damping the inter-area oscillation, and the proposed TCSC siting algorithm is proved to be valid. Design of $H_{\infty}$ controller is described in Part IIof this paper.

      • KCI등재

        정신분열증 환자에서 Interleukin-$1{\beta}$, -2, -6 생산능과 혈청농도 변화에 관한 연구

        김용구,이민수,서광윤,Kim, Yong-Ku,Lee, Min-Soo,Suh, Kwang-Yoon 대한생물정신의학회 1994 생물정신의학 Vol.1 No.1

        The etiology and pathophysiology of schizophrenia remain unknown. It has been postulated that infectious-autoimmune process may play a role in the pathogenesis of symptoms in some schizophrenic patients. Findings of altered interleukin(IL) regulation have been regarded as additional proof that schzophrenia has an infectious-autoimmune background. In the present study, we measured mitogen-stimulated production of and serum level of IL-$1{\beta}$, IL-2, IL-6 using ELISA in 16 neuroleptic-free schizophrenic patients and in 16 age, sex matched healthy controls. The results were as follows : 1) There was a significant decrease of IL-2 production in schizophrenic patients than in normal controls(respectively $1.90{\pm}0.13ng/m{\ell}$, $2.79{\pm}0.14ng/m{\ell}$, p<0.001). But there was no significant difference of IL-$1{\beta}$ production and IL-6 production between schizophrenic patients and normal controls. 2) There was a significant increase of serum level of IL-2 in schizophrenic pateitns than in normal controls(respectively $184.8{\pm}12.8pg/m{\ell}$, $104.2{\pm}34.2pg/m{\ell}$, p<0.01). Serum level of IL-$1{\beta}$ was partially detected in both groups and serum level of IL-6 was not detected in both groups. 3) There was no significant differences of IL-$1{\beta}$, -2, -6 production & serum level of IL-2 according to male vs female, paranoid type vs undifferentiated type, drug-naive group vs drug-free group in schizophrenic patients. 4) There was significant correlation between IL-$1{\beta}$ and IL-6 production(r=0.86, p<0.001). No correlation between IL-$1{\beta}$, -2, -6 production, serum level of IL-2 and age, duration of illness, and BPRS score was found. It has been suggested that the low lymphocyte production of IL-2 in the patients with autoimmune disease occurs because the T cells are activated and lymphocyte-derived IL-2 has been released into the serum. The authors suggest that decreased IL-2 production in our schizophrenic patients is due to increased IL-2 serum level in those patients. Thus our finding of low IL-2 production and high serum level of IL-2 in our schizophrenic patients is compatible with the possibility that our patients have an autoimmune process. Further study on relationship between IL alteration and other immunological abnormalities(the presence of serum autoantibody and of anti-brain antibody, $CD4^+$, $CD8^+$ cell index, etc) in schizophrenic patients will be warranted.

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