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한국인 전반적 급진성 치주염 환자에서 IL-6 유전자 다변성에 관한 연구
방선정,김일신,김옥수,김영준,정현주,Bang, Sun-Jung,Kim, Il-Shin,Kim, Ok-Su,Kim, Young-Jun,Chung, Hyun-Ju 대한치주과학회 2008 Journal of Periodontal & Implant Science Vol.38 No.4
Purpose: The purpose of this study was to investigate the association of generalized aggressive periodontitis with IL-6 promoter gene single nucleotide polymorphisms(SNP). Material and Methods: The study population consisted of 52 generalized aggressive periodontitis patients(GAP) and 30 periodontally healthy control subjects, who were systemically healthy non-smokers. Genomic DNA was obtained from buccal swab. The IL-6 promotor SNP at the positions of -597, -572, and -174 were genotyped by amplifying the polymorphic region using polymerase chain reaction(PCR), restriction enzyme digestion and gel electrophoresis. Result: The genotype distributions for G/G, G/A and A/A genotypes of IL-6 -597 were 30.8%, 40.4%, and 28.8% in the GAP group and 53.3%, 40%, and 6.7% in the control group and were statistically different between 2 groups(p<0.05). Allele 2 frequency of IL-6 -597 were significantly higher in the GAP group than the control group(p<0.01). At the position of IL-6 -572, the distribution for C/C, C/G and G/G genotypes were 23.1%, 55.8% and 21.2% in the GAP group and 20%, 33.3%, and 46.7% in the control group. In female subjects, the genotype distribution were significantly different between 2 groups(p<0.01). In male subjects, allele 2 frequency of IL-6-572 was significantly lower in the GAP group than the control group(p<0.05). The genotype distribution of IL-6 -174 in the GAP group were 96.2%, 3.8% for G/G, G/C genotypes whereas only the G/G genotype was detected in the control group. Conclusion: In conclusion, significant associations were found in IL-6 gene promoter(-597, -572) polymorphisms and generalized aggressive periodontitis. Further cohort study will be necessary in larger population.
제올라이트를 혼입한 모르타르의 강도 및 염화물 침투 저항 특성
김일순 ( Kim Il-sun ),최소영 ( Choi So-yeong ),양은익 ( Yang Eun-ik ) 한국구조물진단유지관리공학회 2022 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.26 No.2
본 연구에서는 제올라이트가 혼입된 모르타르의 휨 강도 및 압축 강도, 염화물 침투 저항성을 평가해 보았다. 실험결과, 제올라이트의 혼입율이 증가할수록 휨 강도와 압축 강도는 증가하는 경향을 나타내었다. 염화물 침투 저항성은 제올라이트 혼입율이 증가할수록 증가하는 경향을 나타내었다. 제올라이트 혼입에 따른 포졸란 반응이 모르타르의 강도 증가 및 염화물 침투 저항성을 개선시킨 것으로 판단된다.
김남동(Nam Dong Kim),권상옥(Sang Ok Kwon),김현수(Hyun Soo Kim),이동기(Dong Ki Lee),배선우(Sun Woo Bae),장우익(Woo Ick Jang),김호근(Ho Guen Kim),박찬일(Chan Il Park) 대한내과학회 1992 대한내과학회지 Vol.43 No.2
N/A Background: Alcoholic liver disease (ALD) is caused by chronic drinking. The amount and duration of drinking which develop ALD have been reported variously for the different studies. Also the state of liver is various from normal liver to liver cirrhosis or hepatoma for chronic drinkers. Even though the interest on the ALD is growing recently due to the increase of the drinking population and the alcohol consumption in Korea, the clinical research is still insufficient. So this study was started to get the characteristics of the histologic pattern of ALD, required minimum amount of alcohol to develop ALD and clinical differences in various types in Korea. Methods: Authors analysed drinking history, clinical and laboratory findings of 126 patients who were con- firmed as ALD by liver biopsy. Results: 1) In histologic types, 13 fatty liver, 2 alcoholic hepatitis, 69 alcoholic hepatic fibrosis, 18 alcoholic chronic active hepatitis and 24 liver cirrhosis were found. 2) The subjects were 42. 7 years old in average with no difference in types, all male except 2 cases. 3) 106 patients whose drinking history was known drank 149.9 gm per day and 808.3 kg in total amout in average. Alcoholic chronic active hepatitis or liver cirrhosis patients drank more than fatty liver patients in daily amount (p < 0. 05), but the duration of drinking had no difference in types with 16.9 years in average. Also 98.1% of the subjects drank more than 45 gm of alcohol in daily average and 99.1% of the subjects had been drinking for more than 3 years. 4) Symptoms were various such as fatigue or general weakness, abdominal pain, nausea or vomiting, anorexia. Physical signs were also various such as hepatomegaly, jaundice and spider angioma. But any statistical meaning between types cannot be given due to the small number of subjects. 5) In hematologic and biochemical tests, the albumin level was lower in liver cirrhosis than fatty liver or alcoholic hepatic fibrosis (p<0.05), and the platelet count was lower in alcoholic chronic active hepatitis or liver cirrhosis than fatty liver or alcoholic hepatic fibrosis (p<0.05), but there was no laboratory finding to distinguish the types. Conclusions: Results of this study suggest that alcoholic hepatitis is rare and alcoholic hepatic fibrosis is the most frequent in histologic types of ALD. 98,1% of the subjects drank more than 45 gm of alcohol in daily average for more than 3 years. The types of ALD cannot be distinguished by the symptoms, physical signs, hematologic and biochemical tests.
고 흡수성 플리머가 콘크리트의 공극 크기 분포에 미치는 영향
김일순 ( Kim Il-sun ),최소영 ( Choi So-yeong ),양은익 ( Yang Eun-ik ) 한국구조물진단유지관리공학회 2020 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.24 No.2
본 연구에서는 고 흡수성 폴리머를 혼입한 콘크리트의 공극 분포를 측정하여 SAP에 의한 공극의 영향을 평가하였다. 공극 분포 측정 결과, SAP과 AE제를 혼입하면 300㎛ 이하의 공극이 기분 배합보다 증가하는 것으로 나타났다. 한편, 기준 배합은 300㎛ 이상의 공극 비율이 다른 배합에 비해 상대적으로 높은 것으로 나타났다. AE제 및 SAP을 혼입하면 콘크리트의 큰 공극의 비율을 감소시켜 콘크리트의 내구성을 개선시킬 수 있을 것으로 판단된다.
김수관 ( Soo Kwan Kim ),김민영 ( Min Young Kim ),윤영선 ( Young Sun Yun ),김성일 ( Sung Il Kim ),송귀봉 ( Gui Bong Song ) 한국도서(섬)학회 2010 韓國島嶼硏究 Vol.22 No.1
The environment of Jeonbuk fisheries needs to cope with the radical change of fisheries environment. However, the branding of marine products in Jeonbuk fisheries has revealed a lot of problems from its characteristics. Therefore, it is a very urgent task for the improvement of processed fisheries branding in Jeonbuk to find out the problems in each phase, to solve them, ultimately to enhance the branding efficiency. In order to understand the problems in fisheries branding and to achieve the purpose of the study, as primary data, we instantly interviewed with the public officers and merchants in Buan, Gochang and Gunsan. A field survey has been implemented in terminal & train stations of Jeonju, Iksan and Gunsan cities from Feb. 23 to March. 11 of 2009. As a result of the empirical study, the `quality` was found affect mainly to brand asset and among the other affecting factors, `loyalty`, `attitude` and differentiation` influenced to brand assets. And then, the development of fisheries brand needs to focus continuously on improvement of product quality. The present condition of fisheries branding in Jeonbuk represent a lot of problems; insufficiency in quality, no existence of brand policy, insufficiency of brand infra & information, failure of brand differentiation, lack of understanding about brand in public officers & fishermen, difficulty of routine quality management & continuous supply of quantities, insufficiency of advertizing for cooperate brand, because of destitute of suppliers & fishermen`s organization, insufficient concern of public officers about fisheries origin, etc. If there were no systematic and grave unified co-brand approaches to solve the branding problems, it would be hard to anticipate an improvement of competitive fisheries branding in Jeonbuk. In this study, we positively advice the following categorical reform plans for the continuous improvement of fisheries branding in Jeonbuk, and establishment of concrete brand identity by develop unitary co-brand in each competitive fisheries in Jeonbuk. To improve fisheris branding a council of Jeonbuk fisheries brand should be founded with a lot of related people & organizations.
김일순 ( Kim Il-sun ),최소영 ( Choi So-yeong ),최은석 ( Choi Yoon-suk ),양은익 ( Yang Eun-ik ) 한국구조물진단유지관리공학회 2020 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.24 No.2
본 연구에서는 고 흡수성 폴리머의 혼입에 따른 콘크리트의 건조수축 특성을 평가하였다. 실험결과, 건조수축은 SAP 혼입율이 증가할수록 감소하는 경향을 나타냈으며, SAP 혼입 2.0%의 경우는 기준 배합에 비해 약 30∼40% 정도 감소하였다. 이는 SAP에 의한 영향인 것으로 판단되며, SAP 혼입에 따른 유효 물-시멘트 비 감소, 자기수축의 영향, 콘크리트 내부의 상대습도에 의한 영향이 복합적으로 작용하여 건조수축이 감소하는 것으로 판단된다.