악관절의 비정복성관절원판변위의 수조작 정복에 대한 이개측두신경 전달마취의 효과

김숙영,김지연,홍수민,김병국,박병주,임영관,Kim, Sook-Young,Kim, Ji-Yeon,Hong, Su-Min,Kim, Byung-Gook,Park, Byung-Ju,Im, Yeong-Gwan 대한안면통증구강내과학회 2011 Journal of Oral Medicine and Pain Vol.36 No.1

Aim: Disc displacement without reduction of the temporomandibular joint (TMJ) has been managed by mandibular manipulation to reduce the displaced disc but with a low success rate. The purpose of this study was to determine whether auriculotemporal nerve block anesthesia had an effect on the reduction of the displaced disc and to analyze the factors that influenced the result. Methods: 112 patients were diagnosed with disc displacement without reduction and treated by mandibular manipulation. Disc was recaptured in 35 patients. Among the 77 patients with whom disc recapture had failed, the auriculotemporal nerve was blocked with a local anesthetic in the 49 patients (mean $age \;{\pm}\; SD\; =\; 34.4\;{\pm}\; 15.1$; male 24, female 25) and then mandibular manipulation was performed again. Factors including age, elapsed time from the onset, and opening amount were analyzed in association with disc reduction rate with the auriculotemporal nerve block. Results: Among 49 patients who did not respond to manipulation only, manual reduction with auriculotemporal nerve block anesthesia was successful in 19 patients (38.8%). Maximum unassisted opening amount significantly increased in the 19 patients with successful recapture of the disc ($mean \;{\pm}\; SD\; =\; 46.1 \;{\pm}\; 4.5\; mm$), in contrast to the limited opening amount of the 49 patients before local anesthesia of the auriculotemporal nerve ($mean \;{\pm}\; SD\; =\; 25.7 \;{\pm}\; 6.0\; mm$). Age, elapsed time after the onset, and preoperative opening amount were not associated with the reduction rate. Conclusion: The results of this study suggest that auriculotemporal nerve block anesthesia increases the reduction rate of the disc displacement without reduction of the TMJ when combined with mandibular manipulation, and such anesthesia should be applied at the first stage of manual treatment of disc displacement without reduction.

The Stability of Microsomal Cytochrome P-450-dependent Monooxygenases from Rat Liver during Storage in Freezing

김숙영,박기현,Kim, Sook-Young,Park, Ki-Hyun 생화학분자생물학회 1988 한국생화학회지 Vol.21 No.4

이물질 대사에 관여하는 cytochrome P-450(P-450) 의존성 효소들은 동물 조직에서 microsome을 분리한 후 냉장고에 장기 보존하면서 연구 목적에 따라 microsomal monooxygenase 활성도를 관찰하는 경우가 적지 않다. 따라서 ${\beta}$-naphthoflavone을 처리한 흰 쥐의 간 microsome을 $-80^{\circ}C$에서 보존하면서 P-450, cytochrome $b_5(b_5$), 몇 종류의 cytochrome P-450-dependent monooxygenase와 NADPH-cytochrome P-450 reductase 둥의 안정성을 검토하였다. P-450과 $b_5$의 함량은 변화를 보이지 않았으며 aryl hydrocarbone hydroxylase, 7-ethoxycoumarin O-deethylase와 benzphetamine demethylase의 활성도 역시 변화가 없었으나 NADPH-cytochrome P-450 reductase의 활성도는 저장 4개월 이후 점차 증가하였다. 한편 testosterone $16{\alpha}$-hydroxylase를 포함한 testosterone의 hydroxylase들은 저장 5개월 후부터 점차로 감소하였는데 이는 P-450의 testosterone 결합분위의 어떤 변화 때문인 것으로 생각된다. The stability of cytochrome P-450, cytochrome $b_5$, cytochrome P-450-dependent monooxygenases, and NADPH-cytochrome P-450 reductase was observed in liver microsomes prepared from rats pretreated with ${\beta}$-naphthoflavone during the stored period of 8 months at $-80^{\circ}C$ The contents of P-450 and $b_5$ were not changed significantly and the activities of aryl hydrocarbon hydroxylase, 7-ethoxycoumarin O-deethylase, and benzphetamine demethylase were also stable for this period. However, the activities of NADPH-cytochrome P-450 reductase were increased gradually, whereas since 5th month, those of testosterone hydroxylases including $16{\alpha}$-hydroxylase were decreased. The decrease seems due to a certain change in testosterone binding site of P-450, not to the inactivation of one isozyme of P-450.

흰 쥐 Strain에 따른 간 마이크로좀의 Cytochrome P-450 동위 효소 특성

김숙영,박기현,Kim, Sook-Young,Park, Ki-Hyun 생화학분자생물학회 1986 한국생화학회지 Vol.19 No.3

Cytochrome P-450 (P-450) 동위 효소 유도 물질로서 phenobarbital (PB) 또는 3-methylcholanthrene (MC)을 처리한 흰 쥐 strain (Sprague-Dawley, Fischer, Wistar)의 간 마이크로좀에서 총 P-450 함량, aryl hydrocarbon hydroxylase 활성도의 유도 정도 및 P-450 동위 효소의 구성비 등은 strain에 따라 다소 차이를 보였으나, P-450-b type은 PB에 의해, c type은 MC에 의해 주로 유도되었으며, 이들 동위 효소의 기질 특이성, 단일 항체와의 결합에 의한 효소 활성도의 억제, 동위 효소의 항체 결합 부위 등은 strain의 종류와 상관관계가 없는 것으로 보였으며 P-450 동위 효소의 이러한 몇가지 특성들이 strain 사이에서 유전적으로 보존되고 있는 것으로 추정되었다. After i.p. administration of phenobarbital (PB) or 3-methylcholanthrene (MC) on the adult male rat strains, Wistar, Fischer, and Sprague-Dawley, we compared the properties of hepatic microsomal cytochrome P-450 (P-450) isozymes. Total P-450 contents, degree of induction of aryl hydrocarbon hydroxylase (AHH) activity and isozyme pattern of P-450 were slighly dependent on rat strains. The major form of P-450 isozymes in rats tested was P-450-b in the case of PB-microsomes and that of MC-microsomes was P-450-c. Substrate specificity of the isozymes and the inhibition of activity by the binding of P-450-specific monoclonal antibodies to the isozymes were not associated with rat strains. The results obtained from immunological assay using monoclonal antibodies indicated that the sensitivity of hepatic P-450-dependent AHH activity was rather influenced by the treatment of PB or MC as inducers than by the differences of strain. Thus, it seemed that such characteristics of P-450 isozymes have been genetically conserved among rat strains.

흰 쥐 간으로부터 분리된 Microsomal Cytochrome P - 450 dependent Monooxygenase 의 안정성

김숙영,박기현 ( Sook Young Kim,Ki Hyun Park ) 생화학분자생물학회 1988 BMB Reports Vol.21 No.4

The stability of cytochrome P-450, cytochrome b_5, cytochrome P-450-dependent monooxygenases, and NADPH-cytochrome P-450 reductase was observed in liver microsomes prepared from rats pretreated with β-naphthoflavone during the stored period of 8 months at -80℃. The contents of P-450 and b_5 were not changed significantly and the activities of aryl hydrocarbon hydroxylase, 7-ethoxycoumarin ο-deethylase, and benzphetamine demethylase were also stable for this period. However, the activities of NADPH-cytochrome P-450 reductase were increased gradually, whereas since 5th month, those of testosterone hydroxylases including 16α-hydroxylase were decreased. The decrease seems due to a certain change in testosterone binding site of P-450, not to the inactivation of one isozyme of P-450.

Flavone 투여로 흰쥐간에서 유도된 Microsomal Cytochrome P - 450 의 특성

김숙영,이동욱,박기현 ( Sook Young Kim,Dong Wook Lee,Ki Hyun Park ) 생화학분자생물학회 1990 BMB Reports Vol.23 No.4

Cytochrome P-450 (P-450) isozymes of flavone-pretreated rats were compared with those of partially purified microsomal proteins and liver microsomes from control rats and phenobarbital (PB)-, 3-methylcholanthrene(MC)-, and isosafrole(ISF)-pretreated rats. The activities of microsomal P-450 dependent aryl hydrocarbon hydroxylase(AHH) and ethoxycoumarin deethylase(ECDE) were more than three times of those of control. AHH and ECDE activities of partially purified P-450 with DE_(52) column chromatography were increased more than eight times of control. Monoclonal MC 1-7-1 antibody, which is specific to P-450 c and d isozyme, bound specifically to liver microsomal P-450 of flavone-rats in radioimmunoassay. Some properties of P-450 of flavone-rats were identical with those of P-450 d in spectral and electrophoretic studies. The absorption maximum of P-450-CO complex of flavone-rats was 448 nm (same as that of MC-pretreated rats), and molecular weight of partially purified P-450 from the major band of electrophoresis was 52,000 (same as that of PB-pretreated rats). Thus, it can be indicated that the pretreatment of flavone induces P-450 d or P-450 isozyme with similar immunochemical properties to P-450 d.

자료 통계 분석을 위한 MS 엑셀의 유용한 기능들에 관한 사례연구 (지하철 이용객 자료 분석)

김숙영,Kim, Sook-Young 한국컴퓨터산업학회 2008 컴퓨터産業敎育學會論文誌 Vol.9 No.5

A case study to show MS Excel's convenient and powerful functions was conducted to test hypotheses with subway data. Quantitative variables were described using descriptive menu, and qualitative variables were described using histogram menu of a MS Excel software. Relationships were tested using regression menu, differences were tested using t-test menu, and factors were tested using variance-layout menu of a Excel software. Data input, management, and statistical analysis were done successfully with only a MS Excel software. 엑셀이 자료 통계 분석에서 매우 편리하고 유용한 도구가 될 수 있음을 보여주기 위하여 지하철 이용객 자료로 가설을 검정하는 사례 연구를 시행하였다. 양적 자료는 엑셀의 기술통계량 메뉴에 의하여, 질적 자료는 히스토그램 메뉴에 의하여 기술되었고, 변수들간의 관계성 검정은 회귀 분석 메뉴에 의하여, 차이 검정은 T검정 메뉴에 의하여, 요인 검정은 분산배치법 메뉴에 의하여 전문적인 결과를 얻을 수 있었다. 엑셀만을 이용하여 자료 입력, 관리 및 통계 분석 결과를 편리하게 수행할 수 있는 사례가 되었다.

MS Excel 함수들을 이용한 회귀 분석 모형 추정 및 관계 분석 검정을 위한 매크로 개발 (지하철 전기요금 자료 회귀분석에 응용)

김숙영,Kim, Sook-Young 한국컴퓨터산업학회 2009 컴퓨터産業敎育學會論文誌 Vol.10 No.5

변수들간의 관계 모형을 설정하고 관계성 유무를 분석하는 회귀 분석은 거의 모든 조사 연구 및 실험연구들에서 필수적인 통계 분석 방법이다. 자료는 독립변수와 종속변수로 구성되므로 쌍으로 취급되며 모든 통계량 계산은 행렬 연산에 의하여 수행된다. 변수들 관계를 가장 잘 설명하는 모형 설정에 따라 회귀분석 결과의 정확성이 평가되므로 자료 수치들을 XY 평면상에서 점을 찍어 가장 적합한 함수 모형을 선택해야 한다. MS 엑셀의 그래픽 및 행렬 연산 기능의 메뉴들을 사용하면 수집된 자료에 가장 적합한 모형을 설정하고 필요한 모든 가설검정 작업을 쉽게 수행할 수 있다. 본 연구에서는 회귀 분석의 모형 설정 및 가설검정 결과들을 산출하는 엑셀 함수를 이용한 매크로를 개발하였다. 본 연구에서 개발한 회귀분석 매크로를 한 개의 종속변수와 3개의 독립 변수를 가진 지하철 전기요금 자료 분석에 적용하여 얻은 결과와 엑셀에 내장된 통계 회귀분석 메뉴를 적용한 결과를 비교한다. Regression analysis to estimate the fitted models and test hypotheses are basic statistical tools for survey data as well as experimental data. Data is collected as pairs of independent and dependent variables, and statistics are computed using matrix calculation. To estimate a best fitted model is a key to maximize reliability of regression analysis. To fit a regression model, plot data on XY axis and select the most fitted models. Researchers estimate the best model and test hypothesis with MS Excel's graph menu and matrix computation functions. In this study, I develop macros to estimate the fitted regression model and test hypotheses of relationship between variables. Subway electric charges data with one dependent variable and three independent variables are tested using developed macros, and compared with the results using built-in Excel of regression analysis.

MS 엑셀 프로그램의 통계분석결과 신뢰성 검증 및 매크로 보완 (분산분석 메뉴를 중심으로)

김숙영,Kim, Sook-Young 한국컴퓨터산업학회 2008 컴퓨터産業敎育學會論文誌 Vol.9 No.5

초장력 스프레드시트 기능의 엑셀 프로그램에서 자료를 통계적으로 분석하는 데이터분석 메뉴는 엑셀 2000 이후 수정 보완 되고 있지 않으며 그 활용도도 매우 저조하다. 본 연구에서는 엑셀 통계분석 메뉴 활용도 향상을 위하여 사용빈도가 높은 분산분석의 엑셀 메뉴 실행 결과와 계산식에 의한 이론 결과를 비교하고 고차원 분석 매크로를 개발하였다. 실자료를 엑셀 라이터분석 메뉴를 적용하여 얻은 결과와 계산식에 의한 이론 결과는 요인이 한개인 일원배치법이나 두개인 이원배치 법에서 모두 정확히 일치하였다. 즉 엑셀 데이터분석 메뉴의 신뢰성이 검증되었다. 고차원적인 분산분석법인 블록화된 분산분석 결과를 제공하는 매크로 및 일원분산분석법에서 평균 차이 있는 그룹들을 찾아내는 다중비교 분석방법 매크로를 엑셀 함수를 이용하여 개발하였다. Statistical analysis menus of MS Excel software, with powerful spreadsheet functions has not been modified since Excel 2000 Edition and its utilization is very low. To improve utilization of Excel menu for statistical analysis, this research compared outputs of Excel statistical menus and computed test statistics, and developed high-level macros. Outputs of Excel menus, both oneway layout and twoway layout, on real data are exactly same as the computed test statistics, and therefore, Excel menus for statistical analysis are reliable. Macros to provide results for Analysis of Variance with a block and multiple comparison of means are developed using Excel functions.

셀프 센싱 자기 베어링을 이용한 베어링리스 발전기의 설계 및 해석

김숙영(Kim Sook-young),백윤수(Baek yoon-su) 대한기계학회 2009 대한기계학회 춘추학술대회 Vol.2009 No.11

Generally the friction loss of the generator system is to be removed by using Passive Magnetic Bearings (PMBs) instead of the mechanical bearings, but the system with PMBs generate a vibration, which is not to be controlled easily. We propose a system which uses winding coils and permanent magnets for working as a generator and a selfsensing magnetic bearing simultaneously. The shaft levitation is achieved by PMB, and the shaft position is estimated by induced current through the winding coils. In this study, the vibration is controlled by self-sensing magnetic bearing which uses some of generated power. The modeling of the system has been done with Finite Element Analysis (FEA) and a prototype has been designed and fabricated. The proposed system has been validated by the experiments which proved that the energy used for the controlling vibration is smaller than the total energy generated by the system.

성인의 체질별 건강증진 행위 및 건강상태

김숙영(Kim Sook Young) 기본간호학회 2000 기본간호학회지 Vol.7 No.3