조현병 환자들의 일상적 의사결정 과정에서 무쾌감증 및 자아존중감의 영향

김수정,김민경,홍연주,이선구,김재진,Kim, Soo-Jeong,Kim, Min-Kyeong,Hong, Yeon-Ju,Lee, Seon-Koo,Kim, Jae-Jin 대한생물정신의학회 2017 생물정신의학 Vol.24 No.3

Objectives Decision-making in patients with schizophrenia has been known to be inefficient in both cognitive and affective aspects. The purpose of this study was to investigate the influence of anhedonia and self-esteem on the decision-making process in schizophrenia. Methods Twenty patients with schizophrenia and 21 healthy controls performed the 'apparel purchase decision-making task', during which they were asked to respond to the preference, fitness, and price suitability, before making the final purchase decision. Generalized estimating equation and correlation analysis were conducted to explore for the difference of decision making patterns and influential factors between the two groups. Results The patients showed lower odds ratio (OR) of the fitness on the apparel purchase decision than the controls [OR 0.190 ; 95% confidence interval (CI) 0.047-0.762, p = 0.019). In the patient group, there was no correlation between the number of purchased trials and the severity of anhedonia, but the number of purchased trials was negatively correlated with the Rosenberg Self-Esteem Scale score at a trend level (R = -0.436, p = 0.055). Conclusions Patients with schizophrenia considered the fitness of clothes less than healthy controls on apparel purchasing decisions. Schizophrenia patients with lower self-esteem were intended to buy more clothes.

경기도 일개 지역사회 대표집단에서 고호모시스테인혈증의 유병률 및 관련요인에 대한 단면조사연구

김수정,임경숙,송미숙,강연지,이순영,Kim, Soo-Jeong,Lim, Kyung-Sook,Song, Mi-Sook,Kang, Yeon-Ji,Lee, Soon-Young 대한예방의학회 2009 예방의학회지 Vol.42 No.5

Background : Many previous studies have shown that elevated homocysteine in the serum is a well known risk factor for cardiovascular disease and this is associated with other risk factors for cardiovascular disease, but any Korean data on this is limited. Objectives : This study aimed to calculate the prevalence of hyperhomocysteinemia and to analyze the relation between elevated homocysteine and the lifestyle factors of Korean adults. Methods : We conducted a cross-sectional survey that included 650 men and 743 women (age range, 20 to 79 years) who were residents of Gwangju City in Gyeonggi-do. These subjects participated in the health interview and examination survey from November to December 2005. The total homocysteine, total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglyceride in the serum were measured. All the participants had their body composition measured such as height and weight, and we obtained health-related behavioral information through the self-entry questionnaire. Results : Very right-handed skewed distributions of homocysteine were shown in men and women. The prevalence of hyperhomocysteinemia was 22.6% in men and 13.7% in women in Gwangju city. On the multiple logistic regression analysis, hyperhomocysteinemia was associated with age (OR=1.02, 95% CI=1.01-1.04), male gender (OR=1.60, 95% CI=1.02-2.52), severe general physical activity (OR=0.32, 95% CI=0.15-0.69) and nutrient consumption (OR=0.49, 95% CI=0.31-0.76). Conclusions : There is a great prevalence of hyperhomocysteinemia in adults of Gwangju City, Korea and it was associated with both genetic factors and lifestyle risk factors. This study can suggest that comprehensive lifestyle modification is needed in order to diminish the prevalence of hyperhomocysteinemia and to prevent CVD.

노각나무 잎과 가지 추출물의 항산화 효과

김혜수(Hye Soo Kim),박민정(Min Jeong Park),김수정(Soo Jeong Kim),김부경(Bu Kyung Kim),박준호(JunHo Park),김대현(DaeHyun Kim),조수정(Soo Jeong Cho) 한국생명과학회 2021 생명과학회지 Vol.31 No.2

본 연구에서는 우리나라 고유 수종인 노각나무(Stewartia koreana)의 부위별 이용 가능성을 알아보기 위하여 노각나무 잎과 가지를 70% 에탄올에 침지한 다음 부위별 항산화 활성을 조사하였다. 노각나무 가지 추출물(53.18±0.2 mg GAEs/extract g)에 비해 잎 추출물(162.57±0.9 mg GAEs/extract g)의 총 폴리페놀 함량이 높게 나타났고 플라보노이드 함량도 가지(4.7±0.1 mg QEs/extract g)에 비해 잎(59.1±0.9 mg QEs/extract g)에서 높게 나타났다. 노각나무 추출물의 DPPH 라디칼 소거능과 ABTS 라디칼 소거 활성은 잎과 가지 모두 농도 의존적으로 증가하였으며 가지보다는 잎에서 높게 나타났다. 노각나무 추출물 0.4 mg/ml의 농도에서 잎과 가지의 DPPH 라디칼 소거능은 각각 91.85±0.01%, 29.93±0.2%였으며 노각나무 잎 추출물은 양성대조구로 사용한 ascorbic acid (1mg/ml, 93.71±0.1%) 보다 낮은 농도에서 ascorbic acid와 유사한 DPPH 라디칼 소거능을 나타내었다. 노각나무추출물 0.4 mg/ml의 농도에서 잎과 가지의 ABTS 라디칼 소거능은 각각 94.77±0.34%, 25.13±0.15%였다. 노각나무잎과 가지의 ORAC 지수는 각각 104.13±0.48 μM TEs/ extract g과 57.36±0.35 μM TEs/extract g으로 가지보다는 잎의 ORAC 지수가 더 높게 나타났다. 노각나무 추출물의 세포 독성은 WST-1 assay를 이용하여 추출물이 섬유아세포 CCD-986sk에 미치는 영향으로 평가하였다. 이상의 결과를 종합해보면, 노각나무 잎 추출물은 가지에 비해 항산화 활성 지표인 총 폴리페놀과 플라보노이드 함량이 높고 항산화 활성이 높기 때문에 노각나무 잎 추출물은 항산화 활성이 우수한 기능성 식의약품소재나 화장품 소재로 사용될 수 있을 것으로 판단된다. This study was carried out to evaluate the antioxidant properties of the dried leaves and branches of Stewartia koreana Nakai. The dried leaf and branch of S. koreana were extracted with 70% ethanol at 80℃. The antioxidant activities of ethanol extracts of S. koreana leaf (EESL) and S. koreana branch (EESB) were analyzed. The total polyphenol contents in EESL and EESB were 162.57±0.9 mg of GAEs/extract g and 59.1±0.9 mg of GAEs/extract g, respectively. The flavonoid contents in EESL and EESB were 59.1±0.9 mg of QEs/extract g and 4.7±0.1 mg of QEs/extract g, respectively. EESL showed a better scavenging ability with DPPH and ABTS than EESB, at 0.4 mg/ml. Moreover, EESL were more effective according to ORAC values than EESL. The toxicity of EESL was investigated using a WST-1 assay on the human skin fibroblast cell line CCD-986sk. Therefore, EESL can be used as a potential source of functional, naturally-sourced material in cosmetics as well as food.

Porphyromonas gingivalis에 대한 노각나무 잎 추출물의 항균활성 및 생물막 형성 억제 효과

김혜수(Hye Soo Kim),박민정(Min Jeong Park),김수정(Soo Jeong Kim),김부경(Bu Kyung Kim),박준호(JunHo Park),김대현(DaeHyun Kim),조수정(Soo Jeong Cho) 한국생명과학회 2021 생명과학회지 Vol.31 No.3

본 연구에서는 천연물유래 구강건강 개선소재로써 노각나무의 이용 가능성을 알아보기 위해 노각나무 잎과 줄기를 에탄올에 추출한 다음 구강미생물에 대한 추출물의 항균활성을 조사하였다. 노각나무 잎과 줄기 추출물(1 mg/disc)은 구강미생물 중 P. gingivalis KCTC5352에 대해서만 항균활성을 나타내었으며 줄기보다는 잎 추출물의 항균활성이 우수하였다. 시판되고 있는 구강케어제품에 사용되고 있는 항균제와 노각나무 잎 추출물의 항균활성을 비교한 결과, P. gingivalis에 대한 노각나무 잎 추출물과 양성대조구로 사용한 triclosan의 항균활성은 유사하게 나타났으며. P. gingivalis에 대한 노각나무 잎 추출물의 MIC는 0.4 mg/ml이고 정균작용을 하였다. 노각나무 잎 추출물이 0.2-2.0 mg/ml 농도로 처리된 배양액에서 P. gingivalis KCTC5352의 생물막 형성과 세균 생육은 추출물의 농도가 증가할수록 농도의존적으로 억제되는 경향을 보였다. 또한 노각나무 잎 추출물(1 mg/ml) 처리가 P. gingivalis의 생물막 형성에 미치는 영향을 주사전자현미경으로 관찰한 결과에 의하면 추출물을 처리하지 않은 대조구는 추출물 처리구에 비해 P. gingivalis가 군집을 이루며 모여 있었고 세포 주변에서 생물막이 관찰되었지만 추출물을 처리한 처리구의 세포 주변에서는 생물막을 관찰할 수 없었다. qRT-PCR을 이용하여 생물막 형성 초기 과정에서 치면 부착에 필수적인 섬모(fimbriae)관련 mRNA 발현 양상을 0조사한 결과, 노각나무 잎 추출물이 0.2-2.0 mg/ml의 농도로 처리된 배양액에서 fimA와 mfa1 유전자 발현은 추출물의 농도가 높아질수록 농도의존적으로 억제되는 것을 확인할 수 있었다. 이상의 결과를 종합하면 노각나무 잎 추출물은 치주질환 원인균인 P. gingivalis에 대한 항균 활성과 생물막 형성 억제능이 우수하기 때문에 천연물유래 구강건강 개선소재로써 이용 가능성이 높을 것으로 판단된다. This study was conducted to investigate the potential of Stewartia koreana as oral healthcare materials. The antibacterial activity of ethanol extracts from leaves and branches of S. koreana against oral bacteria was confirmed. The leaf and branch extracts (1 mg/disc) showed antibacterial activity against P. gingivalis only among several tested oral bacteria. The leaf extracts showed higher antibacterial activity, with values similar to those of chlorhexidine, which was used as a positive control. The MIC of the leaf extract against P. gingivalis was 0.4 mg/ml and showed bacteriostatic action. The inhibitory effects of the extract on biofilm formation and on gene expression related to biofilm formation by P. gingivalis were determined by biofilm biomass staining, scanning electron microscopy (SEM), and qRT-PCR analysis. The biofilm production rate and cell growth of P. gingivalis in the cultures treated with 0.2-2.0 mg/ml of S. koreana leaf extracts were significantly decreased in a concentration-dependent manner. The inhibitory effect on the formation of P. gingivalis biofilms at concentrations of 1 mg/ml was confirmed by SEM. The qRT-PCR analysis showed concentration-dependent suppression of the fimA and fimB gene expression associated with fimbriae formation in the cultures treated with 0.2-2.0 mg/ml S. koreana leaf extract. These results support the conclusion that S. koreana leaf extracts can be used as oral healthcare materials derived from natural materials, as demonstrated by the antibacterial action and inhibition of biofilm formation of P. gingivalis.

한국 가족의 변화 양상에 따른 가족복지정책의 평가와 발전방향

김수정(Soo-Jeong Kim) 영남신학대학교 2005 신학과 목회 Vol.24 No.-

The Purpose of this paper is to review the Korea family welfare policy and to present the direction of Family Welfare Policy through the change of Korea family. For this purpose, First, this paper examined the reason that Korea family is changed by and conception of the 'Family' and 'family welfare policy'. On the basis of this, examine the present and problems of Korea family welfare policy and try to find improvement direction of Family Welfare Policy. Recently, Korea family has experienced a sudden change. Low fertility rate and aged society cause to increase a burden of support to family and to make weak family function of care. And, Participation of women in public affair provokes need to socialization of care labor and cause couple conflict around role and power apportionment. In addiction to, increased individualism values requires relationship change within family and cause a divorce. After the intensive analysis of the problems of family welfare policy reviewing the definition and category of family welfare policy, this paper examined the reason that couldn't develop the Korea family welfare policy in practical direction of improvement. Until now, Korea family welfare policy has been enforced for specific family and individual and intervene after the fact. Finally, this paper suggests the direction of development plan of the family policy in Korea and discuss the task of the family policy. The direction of development plan of the family policy is as follows. 1) We have to form social solidarity for family welfare. 2) A universal family welfare policy rather than a select one is made. And the family policy is planed on the basis of family view and gender-recognition view. So each family member has to be able to reconcile work and family.

Phenethyl Isothiocyanate가 Toll-Like Receptor Agonists에 의해 유도된 Nuclear Factor-κB 활성과 Cyclooxygenase-2, Inducible Nitric Oxide Synthase 발현에 미치는 효과

김수정 ( Soo Jung Kim ),박혜정 ( Hye Jeong Park ),신화정 ( Hwa Jeong Shin ),김지수 ( Ji Soo Kim ),안희진 ( Hee Jin Ahn ),민인순 ( In Soon Min ),윤형선 ( Hyung Sun Youn ) 한국응용생명화학회(구 한국농화학회) 2011 Journal of Applied Biological Chemistry (J. Appl. Vol.54 No.4

염증의 중요한 분자학적 기전에는 cyclooxygenase-2 (COX-2)에 의한 prostaglandins (PGs) 생성과 inducible nitric oxide synthase (iNOS)에 의한 nitric oxide (NO) 생성이 있다. 많은 종류의 박테리아나 바이러스가 전사요소인 nuclear factor-κB(NF-κB)를 활성화시켜 여러 타깃 유전자의 발현을 조절해 PGs나 NO와 같은 염증물질을 유도하게 된다. 우리는 이번 실험을 통하여 phenethyl isothiocyanate (PEITC)가 toll-like receptor (TLR) agonists에 의해 유도된 NF-κB활성과 COX-2, iNOS 발현에 어떠한 영향을 미치는지 알아 보았다. PEITC는 lipopolysaccharide (LPS)와 polyinosinic-polycytidylic acid (poly[I:C])에 의해 유도된 NF-κB활성을 억제시켰다. 또한 PEITC는 LPS와 Poly[I:C]에 의해 유도된 iNOS의 발현도 억제시켰다. 하지만 PEITC는 TLR agonists들인 LPS, Poly[I:C], 2kDa macrophage-activating lipopeptide (MALP-2), oligodeoxynucleotide 1668 (ODN1668)에 의한 COX-2 발현은 억제시키지 못하였다. 즉 PEITC가 TRIF-dependent 신호전달체계만을 조절하여 TRIF-dependent 신호전달체계에 의해 조절되는 iNOS는 억제하지만 MyD88-dependent 신호전달 체계에 의해 조절되는 COX-2는 억제하지 못한다는 것을 설명해준다. 이러한 결과는 iNOS와 COX-2가 서로 다른 메커니즘에 의해 조절된다는 것을 암시하며, PEITC가 여러 병원균들로부터 유도되는 염증반응이나 만성적인 질병들을 조절할 수 있음을 제시하는 중요한 결과이다. Toll-like receptors (TLRs) play an important role in induction of innate immune responses. The activation of TLRs triggers inflammatory responses that are essential for host defense against invading pathogens. Phenethyl isothiocyanate (PEITC) extracted from cruciferous vegetables has an effect on anti-inflammatory therapy. Dysregulated activation of nuclear factor-κB (NF-κB), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) has been shown to play important roles in the development of certain inflammatory disease. To evaluate the therapeutic potential of PEITC, NF-κB activation and COX-2 and iNOS expression induced by lipopolysaccharide (LPS, TLR4 agonist), polyinosinic-polycytidylic acid (Poly[I:C], TLR3 agonist), 2 kDa macrophageactivating lipopeptide (MALP-2, TLR2 and TLR6 agonist) or oligodeoxynucleotide 1668 (ODN1668, TLR9 agonist) were examined. PEITC inhibits the activation of NF-κB induced by LPS or Poly[I:C] but not by MALP-2 or ODN1668. PEITC also suppressed the iNOS expression induced by LPS or Poly[I:C]. However, PEITC did not suppress COX-2 expression induced by LPS, Poly[I:C], MALP-2, or ODN1668. These results suggest that PEITC has the specific mechanism for antiinflammatory responses.

PC방의 실내공기환경

김수정(Soo-Jeong Kim),전정윤(Chung-Yoon Chun) 한국생활환경학회 2004 한국생활환경학회지 Vol.11 No.1

The indoor air quality (IAQ) of the PC Room has grown more serious due to a sudden increase of internet use and popularization. The first aim of this study was to investigate the indoor air quality of the PC Room around the Shin-chon area in Seoul, by measuring the physical pollutant (carbon dioxide, carbon monoxide, airborne dust, formaldehyde, etc.). The second was to examine the correlation between the subjective air quality and the physical air quality. According to the result, the average of carbon dioxide slightly exceeded the standard (1000 ppm). Among 6 pc rooms, 4 ones almost approximated or exceeded it. The 3 places which showed the most uncomfortable air quality in the survey exceeded the formaldehyde standard. The average temperature was 25.35 degrees centigrade, and the relative humidity was below 30%. Airborne dust, temperature and formaldehyde showed close relation with subjective air quality that human feels. It seemed that airborne dust was recognized by turbidity and formaldehyde was felt through smelling. And the air in a low temperature was regarded as a fresher one than that in a relatively high temperature inspite of the same physical air pollution amount.

遺留分制度의 憲法的 根據와 法政策的 論議 - 獨逸 聯邦憲法裁判所 決定을 契機로 하여

김수정(Soo-jeong Kim) 한국가족법학회 2006 가족법연구 Vol.20 No.2

  In the decision of 2005. 4. 19, the German constitutional court(BVerfG) made his standpoint of forced share clear. Before this decision, the court leaved the problem uncertain, whether it is constitutionally required to create forced share provisions. In this case, the BVerfG decided that forced share is under the constitutional protection and absolute abolition of forced share would violate the German constitution.<BR>  One obvious argument for forced share is that a forced share for children could protect the decedent"s family more fully from a financial point of view. But because of social change which has happened after the enactment of German civil code, it is open to doubt whether the forced share in force is as before appropriate system. In my opinion the support function and consanguinity are still the strongest grounds for forced share. But more flexible way of balancing between the testamentary freedom and the forced heirship principle should be explored. Especially it should be taken into account that when the forced share is approved, even a successor can"t alter or deprive of it.<BR>  In common-law countries the family maintenance system provided the testator"s children and other dependents the opportunity to claim a part of the estate and this system is characterized by judicial discretion. In Germany this way of balancing is legislatively proposed, but the BVerfG refused this proposal clearly. But in my opinion legislature enjoy the wide discretion to enact concrete provisions, therefore even if the German forced share provisions adopted family maintenance system, this one would not violate necessarily the german constitution. And it should be considered that today the need to support testator"s children by forced share is greatly decreased.<BR>  And in this decision it was considered whether general clause should be enacted in forced share deprivation provisions. The BVerfG decided that a general clause, for example disruption clause or alienation clause is indefinite, therefore unconstitutional. But in modern society familial binding of estate is generally weakened, consequently forced share deprivation doesn"t have to be limited to extreme cases.

비행청소년과 일반청소년의 사회적 지지와 자기격려 및 자기낙담의 관계

김수정(Soo-Jeong Kim),이종연(Jongyeun Lee) 충북대학교 교육개발연구소 2012 한국교육논총 Vol.33 No.1

COVID-19 유행 전후 소비트렌드에 따른 공간 사용 변화 특성

김수정(Kim, Soo-Jeong),박수빈(Park, Soobeen) 한국실내디자인학회 2021 한국실내디자인학회 학술대회논문집 Vol.23 No.3