http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
인삼 추출물의 치매유도 동물모델에 대한 기억력 개선효과
김세찬(Se-Chan Kim) 산업기술교육훈련학회 2017 산업기술연구논문지 (JITR) Vol.22 No.2
This study investigated the effect of black ginseng on the learning and memory impairment induced by scopolamine (SCOP, 2 mg/kg) compared with white, red, and black ginseng (WGE, RGE, BGE, 200 mg/kg). Tacrine (10 mg/kg) was used as a positive control. Ginseng-treated groups significantly reversed scopolamine-induced memory impairment in passive avoidance test and also reduced escape latency in training trials of the Morris water maze test. The increased AChE activity induced by SCOP was significantly inhibited by oral treatment of WGE and RGE extract (p<0.001). SCOP administration did not change ChAT activity, but RGE and BGE significantly increased ChAT activity (p<0.05). These results suggest that black ginseng showed the potential cognitive-enhancing activity by regulating cholinergic marker protein.
김세찬(Se-Chan Kim) 산업기술교육훈련학회 2017 산업기술연구논문지 (JITR) Vol.22 No.3
This study investigated the essential process of the raspberry wine for efficient production. In the otimal K2O2S5 concentration experimetation with a view to control contamination, fermentation process must be controlled by sustaining more than 20ppm K2O2S5. In the optimal activation condition experiment for the dry yeast, The dry yeast need 5% sucrose concentraion solution and 40℃ for activation. In the optimal diatomite product ratio experimentation, Celite Hyflo supercel : Celite Standard supercel =1:1 are sutable for filtraion quality and production efficiency according as turbidity and filtering velocity. These results suggest that optimal process condition of the raspberry wine production.
위생관리 및 CIP(Cleaning in Place) 기술에 대한 일반적 고찰 및 제언
김세찬(Se-Chan Kim) 산업기술교육훈련학회 2010 산업기술연구논문지 (JITR) Vol.15 No.3
The modern plant can be host to macrobiological problems, such as rodents, insects and to microbiological problems, such as stray microorganism. By the same token pest control and sanitation must be considered together. Most rodent and insect control must be preceded cleaning and sanitation. At this point, with a view to produce the process control point and present the effective monitoring method through relative parameters for realizing hygienic plant, it is important to understand the control technique of rodent, insect, dust, man, foreign material and microorganism. Meanwhile it is useful to study cleaning in place(CIP) that is current technique for hygienic plant as cleaning and sanitizing a vessel or pipework without having to dismantle the equipment.
포도주스 침지를 이용하여 제조된 흑삼의 진세노사이드 Rg3 증진효과
김세찬(Se-Chan Kim) 산업기술교육훈련학회 2016 산업기술연구논문지 (JITR) Vol.21 No.4
This study was performed to develop the new method for enhancing ginsenoside Rg3 which is the abundant in blackginseng. Black ginsengIwas prepared by following the traditional method(repeated 9 times steaming and drying). Black ginsengII was made by steaming 3times at 120℃ for 30min after soaking into grape juice for 24h. Ginsenosides of white, red, black ginsengI,II were investigated using the HPLC method, respectively. In the black ginsengII, the contents of ginsenoside Rg3 which does not exist in white ginseng was 10.91mg/g, approximately 1.8times more than red ginseng. These results suggest that black ginseng show enhancing ginsenoside Rg3 which is bound up with anticancer and immune system.
Streptomyces sp. AO-0511이 생산하는 Herbimycin A 및 Dihydroherbimycin A의 이화학적 특성 및 생물 활성
장흥배,김세찬,김재헌,Chang, Hung-Bae,Kim, Se-Chan,Kim, Jae-Heon 한국미생물학회 2006 미생물학회지 Vol.42 No.1
한국 토양에서 방선균주를 분리하고 화학 분류 및 16S rDNA 염기서열을 통하여 Streptomyces 속 균주임을 알아내고 Streptomyces sp. AO-0511로 명명하였다. 이 균주가 생산하는 herbimycin A 및 dihydroherbimycin A의 몇 가지 이화학적 성질과 생물 활성을 측정하였다. 두 물질은 모두 산성 조건에서 안정성을 나타냈으며, dihydroherbimycin A는 herbimycin A에 비해 상대적으로 높은 열 안정성을 지니며 극성 또한 높은 물질로서 TLC 상의 Rf간이 낮았다. Herbimycin A와 dihydroherbimycin A는 모두 Bacillus subtilis ATCC 6633 및 Micrococcus luteus ATCC 9341에 대하여 약한 저해 활성을 나타내었고, 다른 미생물에 대해서는 저해 활성을 나타내지 앓았다. 항암 활성에 있어서 두 물질은 폐암 세포인 AS49세포와 백혈병 세포인 HL-60세포에 대해서 강력한 중식 저해 활성을 나타내었다. L5178Y및 P388세포를 사용하여 세포 독성을 측정하였다. 그 결과 두 물질은 대조 물질인 camptothecin에 비해서 항암 활성을 가지면서도 비교적 안전한 물질임을 알려 주고 있다. A streptomycete strain was isolated from the soil samples from Korea. The chemotaxonomy and 16S rDNA sequencing confirmed that the strain belonged to the genus Streptomyces and we named it Streptomyces sp. AO-0511. Two antibiotics, herbimycin A and dihydroherbimycin A produced by this strain were tested for their physico-chemical and biological characteristics. Both compounds were stable under acidic pH. Dihydroherbimycin A was more heat-stable and polar compared with herbimycin A. Only weak antibacterial activities were detected against Bacillus subtilus ATCC 6633 and Micrococcus luteus ATCC 9341. However, herbimycin A and dihydroherbimycin A showed strong inhibitory activities on lung cancer cells (A549 cells) and leukemia cells (HL-60). The cytotoxicity was determined using L5178Y and P388 cell lines. The results showed that herbimycin A and dihydroherbimycin A had lower toxic effects on the cells compared with the standard compounds, comptothecin and cyclosporin A. Therefore, both compounds could be good candidates for the development of new anticancer drugs.
In-Vitro, In-Vivo 동물모델에서 귀리 유래 수용성 베타-글루칸의 칼로리 제한 효과 작용기전 규명
강한나 ( Hanna Kang ),김세찬 ( Se-chan Kim ),강용수 ( Yong Soo Kang ),권영인 ( Young-in Kwon ) 한국식품영양학회 2017 韓國食品營養學會誌 Vol.30 No.6
In the current study, we investigated the inhibitory activity of water soluble β-glucan from oat (Avena sativa) against various digestive enzymes such as α-glucosidase, sucrase, maltase and glucoamylase. Inhibition of these enzymes involved in the absorption of disaccharide can significantly decrease the post-prandial increase of blood glucose level after a mixed carbohydrate diet. The β-glucan had the highest documented rate of small intestinal sucrase inhibitory activity (2.83 mg/mL, IC<sub>50</sub>) relevant for potentially managing post-prandial hyperglycemia. Furthermore, we evaluated the effects of β-glucan on the level of post-prandial blood glucose in animal model. The post-prandial blood glucose levels were tested two hours after sucrose/starch administration, with and without β- glucan (100, and 500 mg/kg-body weight). The maximum blood glucose levels (Cmax) of β-glucan administration group were decreased by about 23% (from 219.06±27.82 to 190.44±13.18, p<0.05) and 10% (from 182.44±13.77 to 165.64±10.59, p<0.01) in starch and sucrose loading test, respectively, when compared to control in pharmacodynamics study. The β -Glucan administration significantly lowered the mean, maximum, and minimum level of post-prandial blood glucose at 30 min after meal. In view of the foregoing, it is felt that our findings suggest that β-glucan from oat serves to reduce post-prandial blood glucose rise secondary to slower absorption of glucose in the small intestine, via carbohydrate hydrolyzing enzymes inhibition.