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강구형,백승희,김미여,박종현 대한동의병리학회 2001 동의생리병리학회지 Vol.15 No.3
This experiment was carried out to evaluate the clinical effects of Ophicephalus argus and Crubita moschate which have been traditionally applied to postpartum care in Korea, and compare them with the effect of Saengwhatang. Thirty two Sprague-Dawley female rats weighing 250-300g were divided into four groups: a non-pregnant group (normal), a normal saline-treated group (control), a Saenghwa-tang-treated group (sample A), an Ophicephalus argus-treated group (sample B), and a Crubita moschate-treated group (sample C). Except for the normal group, each extract was administered for one week to each group after delivery. We measured the WBC count, RBC count, serum levels of hemoglobin and hematocrit, the platelet count, serum levels of fibrinogen, albumin, thyroxine, and urine levels of sodium and potassium. The Saenghwa-tang-treated group showed a significant decrease of WBC count and urine levels of sodium and potassium and a significant increase of hemoglobin and albumin in comparison with those of the control group. The Ophicephalus argus-treated group showed a significant decrease of WBC count and the significant increase of albumin in comparison with those of the control group. The Crubita moschate-treated group showed a significant increase of albumin in comparison with that of the control group. These results suggest that Saenghwa-tang is more effective than Ophicephalus argus and Crubita moschate for postpartum recuperation although they also have some effects on recuperation of deteriorative blood components after delivery. Therefore, these findings indicate that further investigation for the other effects of Ophicephalus argus and Crubita moschate is necessary.
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補骨脂가 卵巢摘出로 誘發된 흰쥐의 骨多孔症에 미치는 影響
權爀泰,徐富一,金先熙,金美麗 대한본초학회 1997 大韓本草學會誌 Vol.12 No.2
This study was performed to investigate the effects of Psoraleae Fructus in ovariectomized osteoporosis. The rat model of osteoporosis was induced by ovariectomy of rats. And liquid extract of Psoraleae Fructus was utilized in this experiment, this extract was administered orally 1 time per day during 4 weeks. And then I measured osteocalcine, estradiol, 1, 25-Vitamin D, ALP, phosphorus, calcium of the serum and calcium, phosphorus, deoxyphridinoline of the urine. The results of this experiment were summarized as follows: 1. In the level of serum osteocalcine, the result of Control group was 0.33±0.03ng/㎖, but the result of Psoraleae Fructus group was 0.28±0.007ng/㎖. And the result of Psoraleae Fructus group showed decrease in comparison with Control group, but this result showed no efficacy. 2. In the level of serum estradiol, the result of Control group was 12.46±1.48pg/㎖, but the result of Psoraleae Fructus group was 12.56±0.69pg/㎖. And the result of Psoraleae Fructus group showed a little increase in comparison with Control group, but this result showed no efficacy. 3. In the level of serum 1,25-Vitamin D, the result of Control group was 38.35±7.85pg/㎖, but the result of Psoraleae Fructus group was 60.15±3.99pg/㎖. And the result of Psoraleae Fructus group showed a significant increase in comparison with Control group. 4. In the level of serum ALP, the result of Control group was 14.40±1.41(K-A Unit), but the result of Psoraleae Fructus group was 15.87±1.03(K-A Unit). And the result of Psoraleae Fructus group showed a little increase in comparison with Control group, but this result showed no efficacy. 5. In the level of serum phosphorus, the result of Control group was 6.81±0.31㎎/㎗, but the result of Psoraleae Fructus group was 5.69±0.17㎎/㎗. And the result of Psoraleae Fructus group showed a significant decrease in comparison with Control group. 6. In the level of serum calcium, the result of Control group was 11.50±0.20㎎/㎗, but the result of Psoraleae Fructus group was 11.89±0.13㎎/㎗. And the result of Psoraleae Fructus group showed a increase in comparison with Control group, but this result showed no efficacy. 7. In the level of urine phosphorus, the result of Control group was 7.42±0.58㎎/day, but the result of Psoraleae Fructus group was 7.71±0.50㎎/day. And the result of Psoraleae Fructus group showed a little increase in comparison with Control group, but this result showed no efficacy. 8. In the level of urine calcium, the result of Control group was 2.03±0.37㎎/day, but the result of Psoraleae Fructus group was 0.76±0.10㎎/day. And the result of Psoraleae Fructus group showed a significant decrease in comparison with Control group. 9. In teh level of urine deoxypyridinoline, the result of Control group was 396.33±34.64nM, but the result of Psoraleae Fructus group was 345.82±35.58nM. And the result of Psoraleae Fructus group showed a decrease in comparison with Control group, but this result showed no efficacy. According to above these results, Psoraleae Fructus has shown to be capable of preventing and curing osteoporosis caused by old-aged and postmenopause.
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