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      • KCI등재후보

        A Case of Spinal Subdural Abscess Spreading from a Epidural Abscess

        김래상,김정묵 대한신경외과학회 2004 Journal of Korean neurosurgical society Vol.36 No.1

        We report a case of spinal subdural abscess spreading from a epidural abscess. A 70-year-old man was hospitalized for a mild fever, chill and severe back pain. Neurological examination on admission revealed back pain with numbness, sensory deficiency on left lower extremity and without bowel or bladder dysfunction. Lumbar magnetic resonance imaging(MRI) showed pyogenic spondylitis on L1,2,3 with epidural abscess. A patient was treated by empiric antibiotic therapy for 6 weeks. Six weeks later, follow-up MRI showed that the pyogenic spondylitis with epidural abscess had decreased, but a cylinder like subdural abscess after arachnoiditis. After surgery, the majority of the initial symptoms were relieved except a mild both lower extremities numbnes

      • SCOPUSSCIEKCI등재

        심한 요통과 급성 양하지 마비증상으로 나타난 복부 대동맥 폐쇄증 - 증 례 보 고 -

        김래상,한기수,이언,박철완,김영보,이상구,김우경,유찬종,Kim, Rae Sang,Han, Ki Soo,Lee, Uhn,Park, Chol Wan,Kim, Young Bo,Lee, Sang Gu,Kim, Woo Kyung,Yoo, Chan Jong 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.1

        Acute intraabdominal aortic obstruction ends in progressive fatal course or severe permanent disability unless it is diagnosed and treated promptly. However, the incidence of such disease is very rare, so there is very little chance for a neurosurgeon to encounter a patient with acute intraabdominal aortic obstruction. The authors present a case of 62-year-old man with severe low back pain and acute paraplegia caused by acute intraabdominal aortic obstruction.

      • KCI등재

        베이즈 리스크를 이용한 커널형 분류에서 평활모수의 선택

        김래상,강기훈,Kim, Rae-Sang,Kang, Kee-Hoon 한국통계학회 2008 Communications for statistical applications and me Vol.15 No.2

        커널밀도함수의 추정을 이용한 분류 문제에서 평활모수(smoothing parameter, bandwidth)의 선택은 핵심적으로 중요한 역할을 한다. 본 논문에서는 분류에서 베이즈 리스크를 최적화하기 위한 평활모수의 선택이 각 개별 확률밀도함수를 추정하기 위한 최적의 평활모수와 어떤 관계가 있는지 살펴보았다. 실제 상황에서 사용할 수 있는 평활모수의 선택 방법으로 붓스트랩(bootstrap)과 교차확인법(cross-validation)을 이용하는 것을 비교한 결과, 붓스트랩 방법은 Hall과 Kang (2005)에서 밝혀진 이론적인 성질에 부합하는 반면 교차확인법은 그렇지 못함을 확인하였다. 또한, 각 방법으로 정한 평활모수를 사용하여 오분류율을 조사해 본 결과에서도 붓스트랩 방법이 우월함을 알 수 있었다. Smoothing parameter or bandwidth plays a key role in nonparametric classification based on kernel density estimation. We consider choosing smoothing parameter in nonparametric classification, which optimize the Bayes risk. Hall and Kang (2005) clarified the theoretical properties of smoothing parameter in terms of minimizing Bayes risk and derived the optimal order of it. Bootstrap method was used in their exploring numerical properties. We compare cross-validation and bootstrap method numerically in terms of optimal order of bandwidth. Effects on misclassification rate are also examined. We confirm that bootstrap method is superior to cross-validation in both cases.

      • SCOPUSSCIEKCI등재

        본태성 수전증과 파킨슨병 환자에서 미토콘드리아 DNA 비교 분석

        김래상,유찬종,이상구,김우경,한기수,김영보,박철완,이언,Kim, Rae Sang,Yoo, Chan Jong,Lee, Sang-Gu,Kim, Woo-Kyung,Han, Ki-Soo,Kim, Young-Bo,Park, Cheol-Wan,Lee, Uhn 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.11

        Essential tremor(ET) is the most common movement disorder however there has been little agreement in the neurologic literature regarding diagnostic criteria for ET. Familial ET is an autosomal dominant disorder presenting as an isolated postural tremor. The main feature of ET is postural tremor of the arms with later involvement of the head, voice, or legs. In previous studies, it was reported that ET susceptibility was inherited in an autosomal dominant inheritance. As with previous results, it would suggest that ET might be associated with defect of mitochondrial or nuclear DNA. Recent studies are focusing molecular genetic detection of movement disorders, such as essential tremor and restless legs syndrome. Parkinson's disease(PD) is a neurodegenerative disease involving mainly the loss of dopaminergic neurons in substantia nigra by several factors. The cause of dopaminergic cell death is unknown. Recently, it has been suggested that Parkinson's disease many result from mitochondrial dysfunction. The authors have analysed mitochondrial DNA(mtDNA) from the blood cell of PD and ET patients via long and accurate polymerase chain reaction(LA PCR). Blood samples were collected from 9 PD and 9 ET patients. Total DNA was extracted twice with phenol followed by chloroform : isoamylalcohol. For the analysis of mtDNA, LA PCR was performed by mitochondrial specific primers. With LA PCR, 1/3 16s rRNA~1/3 ATPase 6/8 and COI~3/4 ND5 regions were observed in different patterns. But, in the COI~1/3 ATPase 6/8 region, the data of PCR were observed in same pattern. This study supports the data that ET and PD are genentic disorders with deficiency of mitochondrial DNA multicomplexes.

      • KCI등재

        한국인에서 고호모시스테인혈증과 뇌혈관질환

        윤부경,이철갑,김래상,차만진 대한가정의학회 2006 Korean Journal of Family Medicine Vol.27 No.1

        Hyperhomocysteinemia and Cerebrovascular Diseases in KoreansBu Kyoung Yoon, M.D., Chul Gab Lee, M.D.** †, Rae Sang Kim, M.D.*, Man Jin Cha, M.D. 우리나라에서 뇌혈관질환은 사망률이 1992년 10만명당 80.3명에서 2002년에는 77.2명으로 감소하였으나 암 다음으로 많은 사망원인이며1), 2002년 뇌출혈로 28,827명, 뇌경색으로 62,368명이 입원치료를 받았고, 뇌혈관질환으로 인한 진료비 지출은 2,934억원에 달하였다.2) 뇌혈관질환은 일단 발생하면 심각한 신경학적 장애를 남길 수 있기 때문에 이의 치료 및 재활은 환자 자신뿐 아니라 환자 가족이나 사회적으로도 중요한 사회적 문제가 된다.

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