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- 저자 : 김동구(Dong-Goo Kim) (검색결과 76 건)
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스트레스성 궤양발생에 대한 중추 아드레날린성 활성도의 역할
김동구(Dong-Goo Kim),고창만(Chang Mann Ko),경춘호(Choon Ho Kyung),홍사석(Sa Suk Hong) 대한약리학회 1987 대한약리학잡지 Vol.23 No.2
스트레스로 인한 위궤양형성에 중추성 교감신경의 영향여부를 추구하기 위하여 norepinephrine, epinephrine, dopamine, isoproterenol 및 clonidine을 흰쥐의 뇌실내로 투여 하고 한냉 환경 (4˚C)에서 4시간 구속방치하여 위 분비기능의 변동과 궤양 발생 정도를 검색하여 다음과 같은 결과를 얻었다. 1. Norepinephrine, epinephrine, dopamine및 소량의 clonidine 처치로 궤양 발생이 현저하게 감소하였다. 2. Norepinephrine또는 epinephrine 처치군에서는 위액분비, 산분비 및 펩신 분비의 감소와 궤양 발생 감소가 초래되었다. 3. Dopamine혹은 소량의 clonidine 처치군에서는 궤양 발생의 감소와 위액분비 및 산분비 감소가 초래되었으나 펩신 분비는 변동 없었다. 4. Isoproterenol처치군에서는 궤양 발생과 펩신 분비는 대조군과 차이 없고, 위액분비 및 산분비의 감소만 나타났다. 5. 대량의 clonidine 투여군에서는 궤양발생, 산분비 및 펩신분비 모두 변동없이 약간의 위액분비 감소가 나타났다 이상의 결과로 보아 중추성 교감신경자극은 궤양 형성을 억압하는 작용이 있고, 이에는 교감신경성 α-수용체 및 도파민성 수용체가 관여된다고 믿어지며, 이 효과는 위액분비 감소 및 산 분비 감소작용과 아울러 또 다른 요인이 관여한다고 추측된다. The role of central adrenergic activity in the genesis of stress ulcers was investigated by intracerebroventricular (i.c.v.) administration of catecholamines and clonidine in pylorus-ligated rats restrained for 4 hours at a temperature of 4˚C. 1. The stress-induced ulceration was markedly decreased by the i.c.v. administration of norepinephrine, epinephrine, dopamine or low dose of clonidine. 2. After an i.c.v. administration of norepinephrine or epinephrine, the volume of gastric juice, and both acid and pepsin secretion were markedly decreased. 3. Dopamine or a low dose of clonidne decreased the volume of gastric juice and acid secretion but did not affect pepsin secretion. 4. Isoproterenol caused a decrease in the volume of gastric juice and acid secretion, however, the ulcerogenesis was similar to that of the control. 5. Gastric function as well as ulcerogenesis was little affected by a high dose of clonidine. From the above results, it is suggested that central adrenergic activation inhibits cold-restraint induced ulcerogenesis via adrenergic alpha and dopaminergic receptors, and that this effect may be mediated by a decrease in gastric acid secretion. It is also suggested that other factors may be involved in this antiulcerogenic effect.
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김동구 ( Dong Goo Kim ),배기상 ( Gi Sang Bae ),최선복 ( Sun Bok Choi ),조일주 ( Il Joo Jo ),신준연 ( Joon Yeon Shin ),이성곤 ( Sung Kon Lee ),김명진 ( Myoung Jin Kim ),김민준 ( Min Jun Kim ),추갑철 ( Gab Chul Choo ),송호준 ( Ho Jo 대한본초학회 2014 大韓本草學會誌 Vol.29 No.6
Objectives : Commiphora myrrha (CM) has been used in traditional medicine for treating disease such as obesity, hyperlipidemia, atherosclerosis, diabetes and osteoarthritis. However, the protective effects of CM on acute pancreatitis (AP) has not been reported. Thus, the aim of this study was to evaluate the protective effects of CM water extract on cerulein-induced AP. Methods : AP was induced in mice via intraperitoneal injection of supramaximal concentrations of the stable cholecystokinin analogue cerulein (50 μg/kg) every hour for 6 times. Water extract of CM (0.1, 0.2, or 0.5 g/kg) was administrated intraperitoneally 1 h prior to the first injection of cerulein. The mice were killed at 6 h after the final cerulein injection. Pancreas was rapidly removed for morphologic and histochemical examination, myeloperoxidase (MPO) assay. Blood samples were taken to determine serum amylase and lipase activities. Results : Administration of CM significantly inhibited pancreatic weight/body weight ratio, pancreas histological injury. And CM administration inhibited the serum digestive enzyme elevation such as amylase and lipase on cerulein-induced pancreatitis. In addition, Pancreas MPO activity which indicates neutrophil infiltration was inhibited by CM extract on cerulein-induced pancreatitis. Conclusions : In conclusion, our results could suggest that pre-treatment of CM reduces the severity of cerulein-induced AP. Therefore, CM could be used as a protective agent against AP. Also, this study could give a clinical basis that CM could be a drug or agent to prevent AP.
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The Role of Central Adrenergic Activity in Stress-induced Ulcerogenesis
김동구,고창만,경춘호,홍사석,Kim, Dong-Goo,Ko, Chang-Mann,Kyung, Choon-Ho,Hong, Sa-Suk The Korean Society of Pharmacology 1987 대한약리학잡지 Vol.23 No.2
The role of central adrenergic activity in the genesis of stress ulcers was investigated by intracerebroventricular (i.c.v.) administration of catecholamines and clonidine in pylorus-ligated rats restrained for 4 hours at a temperature of $4^{\circ}C$. 1. The stress-induced ulceration was markedly decreased by the i.c.v. administration of norepinephrine, epinephrine, dopamine or low dose of clonidine. 2. After an i.c.v. administration of norepinephrine or epinephrine, the volume of gastric juice, and both acid and pepsin secretion were markedly decreased. 3. Dopamine or a low dose of clonidne decreased the volume of gastric juice and acid secretion but did not affect pepsin secretion. 4. Isoproterenol caused a decrease in the volume of gastric juice and acid secretion, however, the ulcerogenesis was similar to that of the control. 5. Gastric function as well as ulcerogenesis was little affected by a high dose of clonidine. From the above results, it is suggested that central adrenergic activation inhibits cold-restraint induced ulcerogenesis via adrenergic alpha and dopaminergic receptors, and that this effect may be mediated by a decrease in gastric acid secretion. It is also suggested that other factors may be involved in this antiulcerogenic effect. 스트레스로 인한 위궤양형성에 중추성 교감신경의 영향여부를 추구하기 위하여 norepinephrine, epinephrine, dopamine, isoproterenol 및 clonidine을 흰쥐의 뇌실내로 투여 하고 한냉 환경 $(4^{\circ}C)$에서 4시간 구속방치하여 위 분비기능의 변동과 궤양 발생 정도를 검색하여 다음과 같은 결과를 얻었다. 1. Norepinephrine, epinephrine, dopamine및 소량의 clonidine 처치로 궤양 발생이 현저하게 감소하였다. 2. Norepinephrine또는 epinephrine 처치군에서는 위액분비, 산분비 및 펩신 분비의 감소와 궤양 발생 감소가 초래되었다. 3. Dopamine혹은 소량의 clonidine 처치군에서는 궤양 발생의 감소와 위액분비 및 산분비 감소가 초래되었으나 펩신 분비는 변동 없었다. 4. Isoproterenol처치군에서는 궤양 발생과 펩신 분비는 대조군과 차이 없고, 위액분비 및 산분비의 감소만 나타났다. 5. 대량의 clonidine 투여군에서는 궤양발생, 산분비 및 펩신분비 모두 변동없이 약간의 위액분비 감소가 나타났다 이상의 결과로 보아 중추성 교감신경자극은 궤양 형성을 억압하는 작용이 있고, 이에는 교감신경성 ${\alpha}$-수용체 및 도파민성 수용체가 관여된다고 믿어지며, 이 효과는 위액분비 감소 및 산 분비 감소작용과 아울러 또 다른 요인이 관여한다고 추측된다.
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김동구,Kim, Dong-Goo 한국정신신체의학회 1994 정신신체의학 Vol.2 No.1
Model' is one of the well-used, but poorly understood word in the neurobehavioral research. After Darwin's evolutionary theory, it has been generally believed that human is different from animals in terms of the complexity, not of the essential. This notion could be applied to the mind as well as body. Therefore, it became possible to establish animal models in the scientific field of mind. Experimental analysis of the animal behavior becomes an important area for establishing an animal model of human psychopathology because behavior is the ambassador of the mind. A model emphasizes a structural correspondence between sets of causally related variables in two different domains such as the animal and the human. The first selection of elements of the two domains in correspondence called the initial analogy. Once the initial analogy is formed. causally related variables in the two domains are examined and arrayed The structural parallel is the formal analogy of a model, and similarities between corresponding variables are called material analogy. Models may serve any of three major functions ; heuristic, evidential and representative. In many cases, utilizing models may be more practical than directly assessing the domain of primary interest, since technical and/or ethical problems are more serious in the human domain. Although modeling is important to study human psychopathology, rare animal models approved to be a good model for the human psychopathology up to now. Developing the appropriate model is urgent to solve many problems raised from human psychopathology.
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흰쥐에서 생애초기의 스트레스 경험이 성숙후 신경행동에 미치는 영향
김원주,이서울,김동구,김경환,Kim, Won-Joo,Lee, Seo-Ul,Kim, Dong-Goo,Kim, Kyung-Hwan 대한약리학회 1995 대한약리학잡지 Vol.31 No.2
This study aimed to determine whether exposure to stress during developmental period causes permanent behavioral and/or neurochemical alterations. Alterations of behavior were studied in young and aged rats which have been exposed to uncontrollable and unpredictable electric shocks on postnatal day(PND) 14 or PND 14 and 21. The concentrations of monoaminergic neurotransmitters were also measured to determine whether the behavioral alterations were accompanied by neurochemical changes. The results obtained are as follows: 1) The rate of increase in body weight was reduced at one day after exposure to the 1st series of shocks on PND14. However, these findings could not be observed after exposure to the 2nd series of shocks on PND 21. 2) Explorative activity decreased at one day after exposure to the 1st series of shocks on PND14. However this findings could not be observed after exposure to the 2nd series of shocks on PND 21. 3) At 100 days of age, there were little changes in the spontaneous locomotor activities measured for consecutive 23 hrs. However, there was positive correlation between the shock number showing the 1st helplessness during receiving the 1st series of shocks and the night time ambulatory activity of females, and was negative correlation between the shock number showing the 1st helplessness during receiving the 1st or 2nd series of shocks on PND 14 or 21 and the night time ambulatory activity of females. 4) At $360{\sim}390$ days of age, night time ambulatory activity decreased in female rats which have been exposed to shocks on PND 14 and 21, but not in males. 5) In the aged female rats, the concentrations of 5-HT, dopamine and their metabolites were not different among groups. However, the ratio of 5-HIAA/5-HT increased in the frontal cortices of rats exposed to shocks on PND 14 and 21. These results demonstrate that the early experience of serious stress results in persistent alterations of behavior accompanying altered neurochemistry, and aging may unmask a subtle neuronal deficit causes by the early experience of serious stress.
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