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해조(海藻) 및 하수오(何首烏)가 비만유도(肥滿誘導) 어린 흰쥐에 미치는 영향(影響)
조형준,김덕곤,조규석,Cho Hyung-Jun,Kim Deog-Kon,Cho Gyu-Seok 대한한방소아과학회 2001 대한한방소아과학회지 Vol.15 No.2
Objective : These experimental studies were designed to investigate the effects of Sargassum extract and Polygoni multiflori radix extract on the weight and the lipid metabolism of the obese rats induced by 1% cholesterol diet. They were designed to detect changes in the serum and leptin levels in the infant rats. Methods : The serum and leptin levels were measured for a period of 8 weeks for obese SD rats induced by 1% cholesterol diet. Result : 1. The body weight showed a tendency to decrease in samples I & II(P>0.05). 2. The average size of the epididymal fat cell significantly decreased in sample II(p<0.05), and showed a tendency to decrease in sample I(P>0.05). 3. The leptin levels significantly decreased in samples I & II(P<0.05). 4. The total cholesterol levels significantly decreased in samples I & II(P<0.05). 5. The triglyceride levels significantly decreased in sample I & II(P<0.05). 6. The glucose levels significantly decreased in sample I & II(P<0.05).
지성보명단(至聖保命丹)의 항경련(抗痙攣) 작용에 관한 실험적 연구
이희성,김덕곤,Lee, Hee-Sung,Kim, Deog-Kon 대한한방소아과학회 2008 대한한방소아과학회지 Vol.22 No.1
Objectives In order to investigate the anticonvulsive effects of Jisungbomuyngtan, the experiments were done in mice. Methods After solid extracts of Jisungbomuyngtan was orally administered to mice, four types of convulsion were induced in mice by ECT, strychnine, picrotoxin, caffein. Each of the time to convulsion and death was measured. Results 1. The solid extracts of Jisungbomuyngtan showed a remarkable effect in delaying the onset of convulsion induced by ECT 2. In case of convulsion induced by strychnine, the solid extracts of Jisungbomuyngtan revealed a slight, but not statistically significant effect. 3. Considerable prolongation of time to death was observed in convulsion induced by picrotoxin due to the anticonvulsive effect of Jisungbomuyngtan. 4. The anticonvulsive effect of Jisungbomuyngtan was not found in convulsion induced by caffein. Conclusions Jisungbomuyngtan effect remarkably in delaying the onset of convulsion induced by ECT. But slightly effect by strychnine. And Jisungbomuyngtan effect in prolonging time to death in convulsion induced by picrotoxin, but not found in convulsion induced by caffein.
진경온담탕(鎭驚溫膽湯)의 항경련(抗痙攣) 작용(作用)에 관(關)한 실험적(實驗的) 연구(硏究)
김우연,김덕곤,Kim Woo-Yeoun,Kim Deog-Kon 대한한방소아과학회 1995 대한한방소아과학회지 Vol.9 No.1
In order to investigate the anticonvulsive effect of Jinkyungondamtang, the experiment were performed in mice. After solid exract of Jinkyungondamtang was orally administered to mice, four types of convulsion were induced in mice by electric shock, strychnine, picrotoxin, and caffeine. Each of the time to elicit the convulsion and to die was observed. Results were as follows: 1. In the case of convulsion induced by electric shock, the lapse of the time to elicit convulsion and the time to die were delayed by oral administration of Jinkyungondam-tang(P<0.05, P<0.025). 2. The solid extracts of Jinkyungondamtang were revealed rem- arkable effect in delaying the time to die induced by stry-chnine (P<0.05). 3. By oral administration of Jinkyungondamtang, the lapse of the time to elicit convulsion and to die were delayed significantly to elicit convulsion inducing by picrotoxin (P<0.05, P<0.05). 4. Considerable prolongation of the lapse of the time to elicit the convulsion was observed in convulsion induced caffeine due to the anticonvulsive effects of Jinkyungondamtang (P<0.05).
비만아 9례에 대한 곽향정기산 가미방의 치료효과에 대한 임상적 고찰
신동길,김덕곤,이진용,Shin Dong-Gil,Kim Deog-Kon,Lee Jin-Yong 대한한방소아과학회 2001 대한한방소아과학회지 Vol.15 No.1
Purpose : This Study was conducted to find out whether Gwakhyangjunggi-san gamibang has effects on obesity. Method : Before and after medication, we measured height, weight, Bioelectrical Impedance and calculate BMI, and obesity index from 9 obese children who participated in '2001 the 2nd Hur-jun children contest' sponsored by Kyunghee Oriental Medical Center and compared them. Results and Conclusions : 1) After medication, there was reduction of weight, but it has no statistical significance. 2) After medication, there was statistical significant reduction of BMI, obesity index. 3) After medication, there was statistical significant reduction of total fat weight and the percentage of body fat, and significant increase of muscle mass. As above statement, Gwakhyangjunggi-san gamibang has effects on obesity with significant and it is considered that additional and complement study is needed.
보양성장탕(補陽成長湯)이 생쥐와 흰쥐의 성장(成長)에 미치는 영향(影響)
구은정,김덕곤,Ku, Eun-Jeoung,Kim, Deog-Kon 대한한방소아과학회 2002 대한한방소아과학회지 Vol.16 No.1
This study was designed to observe the efficacy of Boyangsengjang-Tang(BST) on the growth of rats. The effects on growth, and the secretion of hormones in the serum was measure. Male BALA/C mice(weight 20-25g), and male ICR rats(weigh 120-150g), were each divided into 3 groups : Sample A, Sample B and a Control group. Each group consisted of 4 mice and 5 rats. Mice received $5{\mu}{\ell}$ BST, and rats received $50{\mu}{\ell}$ BST, daily. Sample A was administered with normal BST for 3 weeks. Sample B was was administered with 10 times the normal amount of BST for 3 weeks. Control group was administered with normal saline for 3 weeks. The body weight, body length, subcutaneous fat, length of femur, serum GH, serum IGFBP-3 and serum in TSH were measured at 1, 2, and 3 weeks. The results were as follows ; 1. The body weigh of the rats increased significantly in Sample A after 3 weeks when compared with control group. 2. The body length in rats increased significantly in Sample A when compared with control group. 3. The amount of subcutaneous fat in the mice increased significantly in Sample B after 1 week when compared with control group. The amount of subcutaneous fat in rats increased significantly in Sample A and Sample B after 3 weeks when compared with the control group. 4. The length of the femur in rats increased significantly in Sample in A and Sample B in 1, 2, and 3 weeks when compared with the control group. 5. The level of GH, IGFBP-3 and TSH in the serum was not statically different when compared with the control group. According to the above results, BST (which reinforces the Kidney's Yang and strengthens muscle and bone) increases body weight, body length, subcutaneous fat and the length of the femur when compaired with the control group. BST therefore seems to improve growth.
바이러스성 뇌수막염(Viral Encephalitis) 후유기(後遺期) 환아(患兒) 1례(例)에 대한 증례(症例)
김기훈,신동길,김덕곤,Kim, Ki-Hoon,Shin, Dong-Gil,Kim, Deog-Kon 대한한방소아과학회 2002 대한한방소아과학회지 Vol.16 No.1
Viral Encephalitis are a serious meningeal infection occurred by various chemical substance. Chief symptoms are headache. hyperesthesia in child and fretting. irritation in infant. Adolescence complain of a retrobulbar pain, fever, vomiturition, photophobia. Fever can cause choreic movement, mental disorder and seizure. Most of patients have complete recovery, but if there are brain lesions, it is bad prognosis. Occasionally patients complain of continuous headache, mental disorder, ataxia and marasmus. We report on a 4-year-old male patient with viral encephalitis. It has been 40 days since disease. He had disorientation mentality, dysphagia and fever.
황기탕이 생쥐의 불감증발(不感蒸發)을 통(通)한 수분손실(水分損失)에 미치는 실험적(實驗的) 연구(硏究)
신원규,이진용,김덕곤,Shin Weon-Kyoo,Lee Jin-Yong,Kim Deog-Kon 대한한방소아과학회 1993 대한한방소아과학회지 Vol.7 No.1
Experimental studies were done to know effect of insensible water loss of Hwangkitang(HKT) in mice. After administration of extract of HKT to the mice, changes of body temperature, body weight, serum Sodium and chloride ion was measured. And sametime, serum antibody to SRBC, delayed hypersensitivity and phagocytic activity of polymorphonuclear leukocytes(PMN) was measured to know immunologic effect. The results obtained as follows; 1. After exposure to $40^{\circ}C$ environment, increment of body temperature in treated group was slower than control group during first 40 minute, and no difference after 40 minute. 2. After exposured to $40^{\circ}C$ environment, decrement of body weight in treated group except administration group of 1.0g/kg extract of HKT was slower than control group during first 40 minute, and no difference after 40 minute. 3. After exposured to $40^{\circ}C$ environment, decrement of body weight in administration group of 4.0g/kg extract of HKT to mice was slower than control group during first 20 minute(p<0.005). 4. After exposure to $40^{\circ}C$ environment there was no stastical difference between treated group and control group in changes of serum sodium and chloride ion. 5. There was no statistical differences between treated group and control group in changes of serum antibody, delayed hypersensitivity and phagocytic activity of PMN.
키르키스탄 일부 초등학교 아동들의 요충 감염 양성율 보고
주종필,조유정,김덕곤,Chu Jong-Phil,Cho Yoo-Joung,Kim Deog-Kon 대한한방소아과학회 2001 대한한방소아과학회지 Vol.15 No.2
School children were examined for the presence of Enterobius vermicularis egg by perianal swab method at 52nd and 41st primary school between September 30, 1998 and October 7, 1998 in Kyrgyzstan, 281 children examined, 80(28.5%) were found to be positive for E. vermicularis egg. The egg positive rate of boys and girls were 41(29%) and 39(28%), respectively. Through this survey, we found that E. vericularis infection is still prevalent among children in Kyrgyzstan.
선방패독탕(仙方敗毒湯)이 아토피 피부염 환자 단핵세포의 Cytokine 분비능에 미치는 영향
신동길,김우연,이진용,김덕곤,Shin, Dong-Gil,Kim, Woo-Yeon,Lee, Jin-Yong,Kim, Deog-Kon 대한한방소아과학회 2002 대한한방소아과학회지 Vol.16 No.1
Effect of Sunbangpaedoktang, which has been used for atopic dermatitis(AD), on the cytokine secretory function of monocyte, which was isolated and cultured from peripheral blood of AD patients, were evaluated. The results were as follows: 1. In AD patients, Sunbangpaedoktang exhibits statistically significant inhibitory effect on IL-4. 2. In AD patients, Sunbangpaedoktang exhibits statistically significant inhibitory effect on IL-5(p<0.05). 3. In AD patients, Sunbangpaedoktang exhibits statistically significant inhibitory effect on $IFN-{\gamma}$(p<0.01). 4. In sample group, comparing the cytokine concentration change rate of AD patients with that of NAD patients IL-4 AD patients exhibits statistically significant decrease(p<0.05).