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- 저자 : 김대중(Dai Joong Kim) (검색결과 4 건)
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Usefulness of Diagnostic Biomarkers in Heart Failure
Dai-Joong Kim(김대중),Chang-Eun Park(박창은) 한국엔터테인먼트산업학회 2013 한국엔터테인먼트산업학회논문지 Vol.7 No.3
순환형 생체 진단마커는 심부전을 동반한 위험군 환자에서 진단이 점점 더 중요하다. 높은 감도의 트로포닌 분석은 진단에 있어서 정확하고 심근 경색의 신속한 탐지를 개선해야 한다. 심근경색의 초기에 감별되는 심근 손상의 지표는 제한적이고 심장 기능을 유지하기 위해 항 혈전 치료에 매우 중요하게 영향을 미친다. 트로포닌은 급성 관상 동맥 증후군에서 진단적, 예후적 의미를 모두 갖는다. 관상동맥 증후군이 아닌 증상에서 증가된 트로포 닌 수치에 근본적인 원인과 직접적인 관리의 대안이 비혈전성 기전에 대한 평가를 즉시한다. 이에 심근 경색 환자의 평가에 트로포닌의 역할과, 급성관상동맥증후군으로 추정되는 비 외상성 흉부통증 환자에서 도착 즉시, 트로포닌과 copeptin의 측정을 통해 심근 경색의 존재를 신속하고 안전하게 추정할 수 있다 이는 두 번째로 활용되는 바이오마커이다. 이동 구급차의 경우, 검사실보다 현장에서 사용했을때 . 바이오마커의 분석 결과를 제공하여 타당도, 실용도, 임상적 유용성이 유의성 있게 높이 평가되고 있다. 심부전의 마커는 심혈관질환과 관련된 다양한 생체지표로 활용할 수 있으며, 심부전 마커는 심혈관 질환의 위험 지표와 생체의 평가에 추가 할 수 있는 항목으로 가능성이 있다. 분석 및 임상 검증을 통해 심부전을 명확히 진단하고 지속적으로 임상 및 실험적 문제를 해결하기 위해 필요하다. 이러한 문제는 다양한 바이오마커의 사용을 통해 뿐만 아니라, 급성 관상 동맥질환의 지표로서 사용에 연관된다. Circulating biomarkers have become increasingly important in diagnosing and risk-stratifying patients with heart failure (HF). There is increasing interest in utilizing novel markers of cardiovascular disease risk and consequently, there is a need to assess the value of their use. High-sensitivity troponin assays are improving the diagnostic accuracy and rapid detection of myocardial infarction. The early identification of MI is vital for the institution of anti-thrombotic therapy to limit myocardial damage and preserve cardiac function. Troponin has both diagnostic and prognostic significance in the setting of acute coronary syndrome (ACS). Increased troponin levels in the absence of ACS should prompt an evaluation for an alternative, non-thrombotic mechanism of troponin elevation and direct management at the underlying cause. This describes the role of troponin in the evaluation of patients with suspected myocardial infarction. Also, In emergency department (ED), for nontraumatic chest pain (NTCP) is suggestive of acute coronary syndrome (ACS). The determination of copeptin on arrival to the ED in patients with NTCP suggestive of ACS, When used in the field than the laboratory. Analysis of biomarkers by providing the validity, utility, clinical usefulness is significantly appreciated. There is potential that a marker of heart failure can add to the value of existing indicators and biomarkers of cardiovascular disease risk. Additional analytical and clinical validations are needed to fully elucidate cardiac failure and resolve ongoing clinical and laboratory issues. While these issues are directed to the use of various biomarker in primary care, were relevant to the use of biomarker in acute coronary syndromes.
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김대중 ( Dai Joong Kim ),성현호 ( Hyun Ho Sung ),박창은 ( Chang Eun Park ) 대한임상검사과학회 2016 대한임상검사과학회지(KJCLS) Vol.48 No.1
Red blood cell (RBC) alloimmunization results from genetic disparity of RBC antigens between donor and recipients. The discrepancy of RBC antibody screening test occurs when the results of red cell tests do not agree with those of the serum test. In order to select the proper blood units for transfusion, clarification of the cause of discrepancies is essential. The RBC antibody screening test is an easy, quick, and reliable method for detection of clinically significant antibodies. Antibody screening and identification is recommended prior to transfusion to determine whether there is blood group incompatibility. We reported that phenotyping for E, D, M, E+c, and C+e antibody screening test should be extended. Therefore, these results indicate that anti-D and anti-E alloantibodies were major risk factors for haemolytic disease of the newborn or delayed haemolytic transfusion reactions in this study population. We suggested that its antibody screening be adapted to blood safety interventions. Targeted screening of selected recipients at risk offers less value than universal antibody screening, and more research is needed to determine the real incidence of this national condition.
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윤준 ( Joon Yoon ),김대중 ( Dai-joong Kim ),성현호 ( Hyun-ho Sung ),조윤경 ( Yoon-kyung Jo ) 대한임상검사과학회 2016 대한임상검사과학회지(KJCLS) Vol.48 No.4
This study was performed to evaluate the effect of hemoglobin (Hb) on bone mineral density (BMD) in university students by performing a quantitative analysis. The subjects included healthy university students aged 20 to 30 years. Although osteoporosis has traditionally been considered as a disease of aging women, it is becoming an increasingly concerning male health problem. Diagnosis of osteoporosis is calculated with a quantitative assessment of BMD. Laboratory blood and urine tests are mainly used with low BMD or fragility fractures to identify any possible causes of bone metabolism disorders. In this study, there was no difference in BMD according to gender. The average red blood cell (RBC), Hb, and Hematocrit (HCT) were significantly higher in males (p<0.01). The correlation between lumbar spine, skeletal muscle mass (SMM), and basal metabolic rate (BMR) was statistically significant (p<0.01). Hb showed a 51.7% statistical influence on BMD by multiple regression analysis. These findings are useful to understand the relationship between BMD and Hb; lower Hb level is associated with lower BMD. The Hb level was the strongest predictor of abnormal BMD. In conclusion, this study showed that a low Hb value was significantly correlated with low bone mass, suggesting that a low Hb value is a risk factor for changes in bone turnover that leads to a decrease bone density.
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출혈성 신증후군 환자의 혈장 Atrial Natriuretic Polypeptide 농도 변화
박정의(Jeong Euy Park),차대룡(Dae Ryong Cha),김종웅(Jong Woong Kim),표희정(Heui Jung Pyo),이호왕(Ho Wang Lee),문정식(Jung Sik Moon),황흥곤(Heung Kon Hwang),김대중(Dai Joong Kim) 대한내과학회 1991 대한내과학회지 Vol.41 No.2
N/A Hemorrhagic fever with renal syndrome (HFRS) is characterized clinically by acute renal failure and pathologically by dense hemorrhage in the right atrium and medulla of the kidneys. To investigate whether there is any significant relationship between the changes of plasma atrial natriuretic polypeptide (ANP) and the clinical course, the plasma ANP was measured in 21 patients with HFRS. The plasma ANP was normal to low during the early oliguric phase (94.6±37.0 pg/ml), went up to a very high level (292.4±190.4 pg/ml) at the beginning of diuresis, then fell to a near normal level in a few days. The plasma renin activity (PRA) was very high during the early oliguric phase and fell rapidly in an opposite direction to the plasma ANP as the patients began diuresis. The rapid increase of plasma ANP and decrease of PRA seem to play an important role in the beginning of diuresis in HFRS.
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