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생약복합제 SKI306X 의 랫드에 대한 4 주 경구 반복투여 독성연구
김훈택(Hun Taek Kim),안재석(Jae Suk Ahn),정인호(In Ho Jeong),김택수(Taek Soo Kim),류근호(Keun Ho Ryu),임광진(Guang Jin Im),조용백(Yong Baik Cho),김대기(Dae Kee Kim),김환수(Hwan Su Kim),박광식(Kwang Sik Park),김기협(Key H . Kim),박병욱(P 한국응용약물학회 1996 Biomolecules & Therapeutics(구 응용약물학회지) Vol.4 No.1
This study was performed to determine the subacute toxicities of SKI306X, an antiinflammatory herbal extract, in rats. SKI306X was administered orally to rats once a day for 4 weeks at doses of 0.3, 1.0, and 3.0 g/㎏/ day. Each group consisted of 20 male and 20 female rats, including 5 male and 5 female rats per group for an interim study at the end of 2-week administration and for a 2-week recovery study, respectively. Throughout the study, all rats survived and no adverse clinical signs were observed. Although male rats treated with high dose (3.0 g/㎏/day) of SKI306X showed slight loss of body weight (approximately 5%) in comparison with control animals during the administration period, their body weight loss was normally restored during the recovery period. No significant change was found in all hematological parameters of SKI306X-treated groups except for the decreased number of red blood cells in all female groups at the interim study. Statistically significant changes were observed in several blood enzyme levels of SKI306X-treated groups; however, most of these significant changes were within normal range and statistically significant values did not show dose-related responses. In SKI306X-treated groups, the absolute and relative weights of liver, heart, and stomach were statistically different from those of control group, but these differences disappeared at the end of recovery period and also drug-related gross and histopathological findings in these organs were not found. No other drug-related gross and histopathological findings were observed. It is concluded from the results of this study that non-toxic dose of SKI306X was estimated to be between 0.3 and 1.0 g/㎏/day and the maximum tolerated dose of SKI306X was assumed to be higher than 3.0 g/㎏/day.
김환수(Hwan Su Kim),박병욱(Pyeong Uk Park),김기협(Key H. Kim),박광식(Kwang Sik Park) 대한약학회 1995 약학회지 Vol.39 No.1
The acetone precipitates of the hot water extract of Torilis fructus showed strong hemostatic activity which was not inhibited by aspirin. This activity was not through platelet activation but possibly through activating some coagulation factors in plasma. The hemostatic action of the precipitates was not active by oral adminitration and no behavioral toxicity appeared in treated mice. However, mice treated with the acetone precipitates through tail vein showed serious tremor and then were killed probably by the thrombus produced in the body. The hemostatic activity was still remained after treatment with beta-glucosidase, beta-galactosidase, alpha-amylase, subtilisin BPN'', or trypsin but completely lost by acid hydrolysis. The active components seemed to be a complex of unidentified macromolecules to which some phenolic compounds were strongly bound.
항염작용을 갖는 신규 생약복합제 SKI306X의 분리 및 항염작용
박광식(Kwang Sik Park),김환수(Hwan Su Kim),안재석(Jea Suk Ahn),김택수(Taek Soo Kim),박병욱(Pyeong Uk Park),곽의종(Wie Jong Kwak),한창균(Chang Kyun Han),조용백(Yong Baik Cho),김기협(Key H. Kim) 대한약학회 1995 약학회지 Vol.39 No.4
Antiinflammatory activities of the solvent fractionates of several herbal medicines were investigated and SKI306X was prepared from the active principles of three herbal medicines, Prunella vulgaris, Trichosanthes kirilowii and Clematis mandshurica. SKI306X was shown to have strong inhibitory effects on acetic acid-induced pain, carrageenan-induced paw edema and adjuvant-induced arthritis. LD50 of SKI306X was more than 5g/kg in rat, so generally nontoxic. Chemical analysis revealed that oleanolic acid and rutin, which are known to have various antiinflammatory activities, were contained in it. These results suggest SKI306X may become a useful drug for the treatment of inflammatory diseases such as rheumatoid arthritis.
류근호,한창균,이해인,김택수,정인호,이성재,임광진,이강진,정기원,김대기,김기협,조용백,Ryu, Keun-Ho,Han, Chang-Kyun,Rhee, Hae-In,Kim, Taek-Soo,Jung, In-Ho,Lee, Sung-Jae,Im, Guang-Jin,Lee, Kang-Jin,Jeong, Ki-Won,Kim, Dae-Kee,Kim, Key-H.,Cho 한국생약학회 1999 생약학회지 Vol.30 No.4
The anti-asthmatic activities of the extract of Lonicera japonica (BuOH fraction) and its mode of action were investigated using several in vitro and in vivo models. Lonicera japonica was extracted with 30% ethanol (v/v) and successively partitioned into BuOH. The BuOH fraction reduced antigen-induced contraction of isolated trachea from sensitized guinea pigs in a concentration-dependent manner. The BuOH fraction also inhibited histamine release from rat peritoneal mast cells induced by antigen or calcium ionophore A23187 ($IC_{50}=0.26$ and 0.32mg/ml, respectively). Eosinophil infiltration into bronchoalveolar lavage fluids induced by aeroallergen challenge in passively sensitized guinea pigs was inhibited by the BuOH fraction at a dose of 800mg/kg (51.7%). In addition, the BuOH fraction inhibited leukotriene $B_4$ prodution in rat basophilic leukemia cells ($IC_{50}=0.42\;mg/ml$) as well as phosphodiesterase 4 (PDE4) isolated from rat brain ($IC_{50}=0.015\;mg/ml$). All results from this study strongly suggest that the BuOH fraction of Lonicera japonica may be useful in the treatment of asthma and its mode of action may be related with inhibition of both 5-lipoxygenase and PDE4 enzyme.