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김기만(K . M . Kim),김현수(H . S . Kim),김승인(S . I . Kim),김영일(Y . I . Kim) 한국약제학회 1987 Journal of Pharmaceutical Investigation Vol.17 No.4
Rifampicin sustained-release micropellets were prepared by spray congealing micropelleting technique using gelatin as the embedding matrix. The pellets were hardened by treating with formalin-isopropanol mixture. The in vitro release rates of rifampicin from the gelatin micropellets which were prepared with the different concentrations of formalin solution were determined in the following dissolution media for 8 hours; a) pH 1.2 buffer solution(USP XXI). b) distilled water. c) pH 7.4 buffer solution(USP XXI). d) pH 1.2 buffer solution for 1.5 hours and pH 7.4 for 6.5 hours thereafter. From the results of the dissolution study, following results were obtained; 1) It was observed that the rate of drug release from the prepared micropellts followed first-order release kinetics. 2) It was found that the change of the release rates was not dependent on the drug-gelatin ratio, but on the concentration of formalin and the time of hardening. 3) It could also be noticed that the increase in the release rates was more pronounced in pH 7.4 of dissolution medium rather than in pH 1.2. This fact might be attributed to the swelling property of gelatin in the dissolution medium.
이현정,오영국,김웅채,박수환,김형찬,김기만,Lee, H.J.,Oh, Y.K.,Kim, W.C.,Park, S.H.,Kim, H.C.,Kim, K. 한국초전도학회 2007 Progress in superconductivity Vol.8 No.2
Since the margins for the minimum quench energy and for the operating current in the superconducting magnet determine the operating regime of the magnet, a thermal stability analysis for the KSTAR superconducting magnet system is performed using 1-D Gandalf code. The result shows that the minimum quench energy is about 500 mJ/cc and the operating current margin is about 70 %. These values are larger than those of the KSTAR design criteria and the KSTAR superconducting magnet system can be operated stably under various experimental environments.