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Influence of L-Tyrosine on Blood Pressure and Heart Rate
Kim, Kyoon-Hong,Choi, Cheol-Hee,Kim, Sang-Hoon,Choi, Dong-Joon,Kim, Bong-Han,Lee, Jong-Jin,Kim, Yong-Tae,Lim, Dong-Yoon 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.1
The present study was aimed to investigate the effect of L-tyrosine on the cardiovascular effects in rats anesthetized with pentobarbital and to clarify the mechanism of action . L-Tyrosine at lower dose (0.1 mg / kg) given into a femoral vein of the rat caused significantly tachycardic and hypertensive effents while higher doses (0.3, 1.0 and 3.0 mg / kg) of it produced a dose-related bradycardic and hypotensive responses. L-Tyrosine-induced hypertensive effect was significantly attenuated by pretreatment with phentolamine, clonidine and chlorisondamine but not influenced by bilateral vagotomization, debrisoquin, propranolol, cyproheptadine or diphenhydramine. The hypertension is also enhanced by atropine-pretreatment. Hypotension induced by L-tyrosine was greatly inhibited by premedication of phentolamine, debrisoquin and chlorisondarnine, while it was not affected in the presence of effects by bilateral vagatomization, atropine, clonidine, propranolol, cyproheptadine and diphenhydramine. Pretreatment with propranolol or chloisondarnine led to significant inhibition or both bradycardia and tachycardia evoked by L-tyrosine. However, there was no influence on these effects of L-tyrosine by prior administration of bilateral vagotomy, atropine, phentolamine, debrisoquin, clonidine, cyproheptadine or diphenhydramine. From these experimental data, it is thought that L-tyrosine given intravenously in the pentobarbital-anesthetized rats causes bradycardic and depressor responses at higher doses and slight tachycardic and pressor effects at smaller dose. It seems that the cardiovascular effects evoked by L-tyrosine may be mediated through sympathetic nervous system in a dose -dependent manner rather than parasympathetic dominance. L-Tyrosine이 pentobarital마취 흰쥐에서 혈압 및 심박에 대한 작용을 검토하고 그 작용의 본태를 규명하고자 본 연구를 시행하여 다음과 같은 결과를 얻었다. L-Tyrosine은 일측 대퇴정맥내로 투여시 적은용량(0.1㎎/㎏)에서는 약한 혈압상승과 심박증가작용을 나타내었으나 보다 많은 용량(0.3, 1.0및 3.0㎎/㎏) 에서는 현저한 혈압하강과 심박감소 작용을 용량 의존적으로 나타내었다. L-Tyrosine의 혈압상승작용은 phentolamine, clonidine 및 hlorisondamine 등의 전처치로 뚜렷이 약화되었으나 양측 미주신경절단이나 debrisoquin, propranolol, cyproheptadine 및 diphenhydramine등의 전처치에 의해서 별다른 영향을 받지 않았다. 한편, atropine 전처치로 L-tyrosine의 혈압상승작용은 상당히 증강됨을 나타내었다. L-Tyrosine의 혈압강하작용은 phentolamine, debhsoquin 및 Ch10risondamine등의 전처치에 의해서 현저히 억제되었으나, 미주신경절단이나 atropine, clonidine, Propranolol, cyproptadine, 및 diphenhydramine등의 존재하에서 영향을 받지 않았다. L-Tyrosine에 의한 심박감소 및 증가작용은 propranolol 이나 chlorisondamine 전처치로 현저히 감약되었으나 미주신경절단, atropine, phentolamine, debrisoquin, clonidine, cyproheptadine, 및 diphenhydramine 등의 전처치로 별다른 영향을 받지 않았다. 이상의 연구결과로보아, L-tyrosine은 마취 흰쥐정맥내로 투여시 비교적 높은 용량에서는 혈압하강과 심박감소작용을, 낮은 용량에서 약한 혈압상승 및 심박증가작용을 나타내며, 이러한 작용은 부교감신경을 통한 작용보다는 교감신경작용을 통해서 기인되는 것으로 사료된다.
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O,p'-DDD가 흰쥐의 신장에 미치는 독성에 관한 면역조직화학적 및 초미세형태학적 연구
배재웅,최종범,임성철,김균홍,기근홍,박동수,전호종,박규호 朝鮮大學校 附設 醫學硏究所 1989 The Medical Journal of Chosun University Vol.14 No.2
o,P'-DDD, a derivative of insecticide DDT, which reveals the toxicity and adrenostatic effet by cortisol biosynthesis in the zona fasciculata of adrenal cortex has been used for the treatment of unoperable adrenocortical carcinoma. Adverse effects of o,P'-DDD were usually dose-related and reversible. Most untoward effects include gastrointestinal disturbances, neuromuscular disorders, depression of central nervous system and skin rash but there is a few reports on its nephrotoxicities. o,P'-DDD in corn oil was administered orally to rats for 28 days to investigate its nephrotoxicity by observation of the ultrastructural changes and immunoglobulin deposition in renal glomeuli. The results obtained were as follows. 1. The ultimate destructive target of intracytoplasmic organelle in endothelium and epithelium of renal glomeruli was mitochondria. The severity of the mitochondrial alterations was dependent of the dosages of o,p'-DDD. 2. The characteristic ultrastructural changes in endothelium of glomerular capillary were swelling and detachment from underlying basement membrane. The splitting and complete separations between endothelium and basement membrane were observed in more advanced lesions by the increased dosage of administration of o,p'-DDD and basement membrane in capillary wall of renal glomeruli was irregular and partly thickened. 3. Amorphous double ring formation, electron dense deposits and multiple myelin figures in mitochondria were characteristic ultrastructural findings in the epithelium of glomeruli. 4. Ig G and Ig M depositions were clearly observed in the capillary lumen, subendothelial area and epithelial cells of proximal convoluted tubule. These depositions were more prominent by the increased of o,p'-DDD dosage. From the above results it is suggested that o,P'-DDD exhibits nephrotoxicity by mitochondrial destruction in epithelium and endothelium of glomerular capillary and the severity of mitochondrial alterations was dose dependent of o,p'-DDD.
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흰쥐에 있어서 Paraquat의 毒性에 미치는 抗酸化劑의 影響
尹鎰漢,李章熙,金宗大,金均鴻,鄭耀翰 大韓産業醫學會 1989 대한직업환경의학회지 Vol.1 No.1
This study was designed to examine the influences of antioxidants on toxicity of paraquat in male rats. Paraquat and ascorbic acid were given orally ad libitum with tap water containing paraquat 30 ppm and 100 ppm and ascorbic acid 1000ppm for 10 days, respectively.α-tocopherol(60mg/kg) was administered orally by sonde at 2 days intervals for 10 days. Paraquat at given doses produced markedly a dose-related reduction in water-intake, ratio of liver weight/body weight and glutathione along with the increased aspartate aminotransferase, alkaline phosphatase, serum lipid and ratio of lung weight/body weight. However the combined administration of ascorbic acid and paraquat did not affect the toxic effects of paraquat, whereas combined administration of paraquat and α-tocopherol showed reduction in the toxicities of paraquat. From these experimental results, it could be concluded that α-tocopherol has detoxifying effect on paraquat poisoning as the antioxidant, meanwhile ascorbic acid, one of the antioxidance, does not exert any detoxifying effects.
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